DE2257533A1 - Gesamtsynthese von prostaglandin e tief 1 - Google Patents

Gesamtsynthese von prostaglandin e tief 1

Info

Publication number
DE2257533A1
DE2257533A1 DE2257533A DE2257533A DE2257533A1 DE 2257533 A1 DE2257533 A1 DE 2257533A1 DE 2257533 A DE2257533 A DE 2257533A DE 2257533 A DE2257533 A DE 2257533A DE 2257533 A1 DE2257533 A1 DE 2257533A1
Authority
DE
Germany
Prior art keywords
oxo
acid
hydroxy
ester
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE2257533A
Other languages
German (de)
English (en)
Inventor
Harry Lovell Slates
David Taub
Norman Lord Wendler
Zbigniew Stanislaw Zelawski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE2257533A1 publication Critical patent/DE2257533A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE2257533A 1971-11-24 1972-11-23 Gesamtsynthese von prostaglandin e tief 1 Ceased DE2257533A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00201979A US3833612A (en) 1971-11-24 1971-11-24 Derivatives of 5-oxo-1 beta-cyclopentane-heptanoic acid,5-ethylene acetals

Publications (1)

Publication Number Publication Date
DE2257533A1 true DE2257533A1 (de) 1973-05-30

Family

ID=22748073

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2257533A Ceased DE2257533A1 (de) 1971-11-24 1972-11-23 Gesamtsynthese von prostaglandin e tief 1

Country Status (5)

Country Link
US (1) US3833612A (enExample)
CH (1) CH577993A5 (enExample)
DE (1) DE2257533A1 (enExample)
FR (1) FR2161027B1 (enExample)
GB (1) GB1384900A (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3925419A (en) * 1970-06-22 1975-12-09 Merck & Co Inc 5-Cyclic ethylene acetals of 5-oxocyclopentane heptanoic acids and esters
GB1350971A (en) * 1971-05-11 1974-04-24 Imp Chemi Als Ind Ltd Cyclopentane derivatives
US3891676A (en) * 1972-09-20 1975-06-24 Merck & Co Inc 2-Alpha-carboxy-3-alpha(hydroxyethyl)-5-oxocyclopentane derivatives
US3950359A (en) * 1972-11-24 1976-04-13 Merck & Co., Inc. Prostaglandins and methods of making same
DE2365101A1 (de) * 1973-12-21 1975-07-10 Schering Ag Neue prostansaeurederivate und verfahren zu ihrer herstellung
US3992413A (en) * 1975-07-25 1976-11-16 Merck & Co., Inc. Intermediates in the synthesis of prostaglandins
US4358603A (en) * 1981-04-16 1982-11-09 Syntex (U.S.A.) Inc. Acetal stabilized prostaglandin compositions

Also Published As

Publication number Publication date
CH577993A5 (enExample) 1976-07-30
US3833612A (en) 1974-09-03
FR2161027A1 (enExample) 1973-07-06
FR2161027B1 (enExample) 1980-04-18
GB1384900A (en) 1975-02-26

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Legal Events

Date Code Title Description
OD Request for examination
8131 Rejection