DE2213957A1 - Therapeutische Mittel und ihre Herstellung - Google Patents
Therapeutische Mittel und ihre HerstellungInfo
- Publication number
- DE2213957A1 DE2213957A1 DE19722213957 DE2213957A DE2213957A1 DE 2213957 A1 DE2213957 A1 DE 2213957A1 DE 19722213957 DE19722213957 DE 19722213957 DE 2213957 A DE2213957 A DE 2213957A DE 2213957 A1 DE2213957 A1 DE 2213957A1
- Authority
- DE
- Germany
- Prior art keywords
- sulfaethoxypyridazine
- ethyl cellulose
- delayed
- release
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims description 7
- 229940124597 therapeutic agent Drugs 0.000 title claims description 6
- 238000004519 manufacturing process Methods 0.000 title description 6
- 238000002360 preparation method Methods 0.000 claims description 38
- 230000003111 delayed effect Effects 0.000 claims description 31
- 239000001856 Ethyl cellulose Substances 0.000 claims description 29
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 29
- 229920001249 ethyl cellulose Polymers 0.000 claims description 29
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 29
- FFJIWWBSBCOKLS-UHFFFAOYSA-N sulfaethoxypyridazine Chemical compound N1=NC(OCC)=CC=C1NS(=O)(=O)C1=CC=C(N)C=C1 FFJIWWBSBCOKLS-UHFFFAOYSA-N 0.000 claims description 28
- 229910000014 Bismuth subcarbonate Inorganic materials 0.000 claims description 16
- MGLUJXPJRXTKJM-UHFFFAOYSA-L bismuth subcarbonate Chemical compound O=[Bi]OC(=O)O[Bi]=O MGLUJXPJRXTKJM-UHFFFAOYSA-L 0.000 claims description 16
- 229940036358 bismuth subcarbonate Drugs 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 14
- VLYWMPOKSSWJAL-UHFFFAOYSA-N sulfamethoxypyridazine Chemical compound N1=NC(OC)=CC=C1NS(=O)(=O)C1=CC=C(N)C=C1 VLYWMPOKSSWJAL-UHFFFAOYSA-N 0.000 claims description 11
- 229960004936 sulfamethoxypyridazine Drugs 0.000 claims description 11
- 241001465754 Metazoa Species 0.000 claims description 10
- HWSISDHAHRVNMT-UHFFFAOYSA-N Bismuth subnitrate Chemical compound O[NH+]([O-])O[Bi](O[N+]([O-])=O)O[N+]([O-])=O HWSISDHAHRVNMT-UHFFFAOYSA-N 0.000 claims description 9
- 229960001482 bismuth subnitrate Drugs 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
- 229920002472 Starch Polymers 0.000 claims description 5
- 239000008107 starch Substances 0.000 claims description 5
- 235000019698 starch Nutrition 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 230000001225 therapeutic effect Effects 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 230000000844 anti-bacterial effect Effects 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 150000008280 chlorinated hydrocarbons Chemical class 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000036765 blood level Effects 0.000 description 16
- 239000008280 blood Substances 0.000 description 15
- 210000004369 blood Anatomy 0.000 description 15
- 244000309466 calf Species 0.000 description 11
- 239000008187 granular material Substances 0.000 description 11
- 229940124530 sulfonamide Drugs 0.000 description 11
- 150000003456 sulfonamides Chemical class 0.000 description 11
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 10
- 230000037396 body weight Effects 0.000 description 8
- 229960002135 sulfadimidine Drugs 0.000 description 8
- ASWVTGNCAZCNNR-UHFFFAOYSA-N sulfamethazine Chemical compound CC1=CC(C)=NC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 ASWVTGNCAZCNNR-UHFFFAOYSA-N 0.000 description 8
- 238000011282 treatment Methods 0.000 description 8
- 239000004480 active ingredient Substances 0.000 description 7
- 238000010586 diagram Methods 0.000 description 7
- 239000003826 tablet Substances 0.000 description 7
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 6
- 235000021355 Stearic acid Nutrition 0.000 description 5
- 235000019359 magnesium stearate Nutrition 0.000 description 5
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 5
- 239000008117 stearic acid Substances 0.000 description 5
- 238000013268 sustained release Methods 0.000 description 5
- 239000012730 sustained-release form Substances 0.000 description 5
- 241000283690 Bos taurus Species 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- QIVUCLWGARAQIO-OLIXTKCUSA-N (3s)-n-[(3s,5s,6r)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2-oxospiro[1h-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-carboxamide Chemical compound C1([C@H]2[C@H](N(C(=O)[C@@H](NC(=O)C=3C=C4C[C@]5(CC4=NC=3)C3=CC=CN=C3NC5=O)C2)CC(F)(F)F)C)=C(F)C=CC(F)=C1F QIVUCLWGARAQIO-OLIXTKCUSA-N 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- -1 QBLETSv- ' Substances 0.000 description 1
- 241000282849 Ruminantia Species 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229960004667 ethyl cellulose Drugs 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007942 layered tablet Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 229960001576 octopamine Drugs 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 210000004767 rumen Anatomy 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12702471A | 1971-03-22 | 1971-03-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2213957A1 true DE2213957A1 (de) | 1972-09-28 |
Family
ID=22427933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19722213957 Pending DE2213957A1 (de) | 1971-03-22 | 1972-03-22 | Therapeutische Mittel und ihre Herstellung |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3758680A (enExample) |
| JP (1) | JPS5713522B2 (enExample) |
| AU (1) | AU462695B2 (enExample) |
| CA (1) | CA983391A (enExample) |
| DE (1) | DE2213957A1 (enExample) |
| ES (1) | ES401083A1 (enExample) |
| FR (1) | FR2130559B1 (enExample) |
| GB (1) | GB1338541A (enExample) |
| IT (1) | IT1043890B (enExample) |
| ZA (1) | ZA718319B (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5968551A (en) * | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
| CN109568282A (zh) * | 2018-12-28 | 2019-04-05 | 河北威远动物药业有限公司 | 一种含乙酰氨基阿维菌素的瘤胃缓释片剂及制备方法 |
-
1971
- 1971-03-22 US US00127024A patent/US3758680A/en not_active Expired - Lifetime
- 1971-12-10 CA CA129,902A patent/CA983391A/en not_active Expired
- 1971-12-13 ZA ZA718319A patent/ZA718319B/xx unknown
- 1971-12-15 AU AU36890/71A patent/AU462695B2/en not_active Expired
-
1972
- 1972-02-29 IT IT48661/72A patent/IT1043890B/it active
- 1972-03-13 GB GB1167472A patent/GB1338541A/en not_active Expired
- 1972-03-22 FR FR7210061A patent/FR2130559B1/fr not_active Expired
- 1972-03-22 DE DE19722213957 patent/DE2213957A1/de active Pending
- 1972-03-22 ES ES401083A patent/ES401083A1/es not_active Expired
- 1972-03-22 JP JP2888972A patent/JPS5713522B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IT1043890B (it) | 1980-02-29 |
| ZA718319B (en) | 1972-09-27 |
| JPS4852913A (enExample) | 1973-07-25 |
| AU3689071A (en) | 1973-06-21 |
| FR2130559A1 (enExample) | 1972-11-03 |
| GB1338541A (en) | 1973-11-28 |
| ES401083A1 (es) | 1975-10-01 |
| CA983391A (en) | 1976-02-10 |
| FR2130559B1 (enExample) | 1975-06-20 |
| JPS5713522B2 (enExample) | 1982-03-17 |
| US3758680A (en) | 1973-09-11 |
| AU462695B2 (en) | 1975-07-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OD | Request for examination | ||
| OHW | Rejection |