DE2143519B2 - Verfahren zur Wirbelschichtgranulation pulverförmiger pharmazeutischer Mischungen - Google Patents
Verfahren zur Wirbelschichtgranulation pulverförmiger pharmazeutischer MischungenInfo
- Publication number
- DE2143519B2 DE2143519B2 DE19712143519 DE2143519A DE2143519B2 DE 2143519 B2 DE2143519 B2 DE 2143519B2 DE 19712143519 DE19712143519 DE 19712143519 DE 2143519 A DE2143519 A DE 2143519A DE 2143519 B2 DE2143519 B2 DE 2143519B2
- Authority
- DE
- Germany
- Prior art keywords
- components
- component
- granulation
- fluidized bed
- inert
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims description 15
- 238000005469 granulation Methods 0.000 title claims description 12
- 230000003179 granulation Effects 0.000 title claims description 12
- 239000000203 mixture Substances 0.000 title claims 3
- 239000000843 powder Substances 0.000 title claims 3
- 239000008187 granular material Substances 0.000 claims description 19
- 239000002245 particle Substances 0.000 claims description 8
- 238000005245 sintering Methods 0.000 claims description 7
- 239000007921 spray Substances 0.000 claims description 5
- 238000009826 distribution Methods 0.000 claims description 3
- 238000007908 dry granulation Methods 0.000 claims description 3
- 239000004480 active ingredient Substances 0.000 claims 4
- 230000002776 aggregation Effects 0.000 claims 4
- 239000007788 liquid Substances 0.000 claims 4
- 238000005054 agglomeration Methods 0.000 claims 3
- 238000001035 drying Methods 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 238000004220 aggregation Methods 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000002360 explosive Substances 0.000 claims 1
- 239000003925 fat Substances 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 238000005272 metallurgy Methods 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 230000000704 physical effect Effects 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920002689 polyvinyl acetate Polymers 0.000 claims 1
- 239000011118 polyvinyl acetate Substances 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 238000009736 wetting Methods 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 229920002261 Corn starch Polymers 0.000 description 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 3
- 239000008120 corn starch Substances 0.000 description 3
- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- 229940041131 calcium lactate gluconate Drugs 0.000 description 2
- PWKNEBQRTUXXLT-ZBHRUSISSA-L calcium lactate gluconate Chemical compound [Ca+2].CC(O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O PWKNEBQRTUXXLT-ZBHRUSISSA-L 0.000 description 2
- UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- 239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 1
- 239000007938 effervescent tablet Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
- 229940057838 polyethylene glycol 4000 Drugs 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 229960001462 sodium cyclamate Drugs 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/16—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by suspending the powder material in a gas, e.g. in fluidised beds or as a falling curtain
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Glanulating (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19712143519 DE2143519B2 (de) | 1971-08-31 | 1971-08-31 | Verfahren zur Wirbelschichtgranulation pulverförmiger pharmazeutischer Mischungen |
| NL7211618A NL7211618A (enrdf_load_stackoverflow) | 1971-08-31 | 1972-08-25 | |
| FR7230798A FR2150986A1 (en) | 1971-08-31 | 1972-08-30 | Granulation of powders - by a dry method |
| JP8640972A JPS4834780A (enrdf_load_stackoverflow) | 1971-08-31 | 1972-08-30 | |
| IT2864572A IT972173B (it) | 1971-08-31 | 1972-08-30 | Processo per la granulazione in letto fluido di componenti pol verulenti granulari o parzial mente pre granulati |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19712143519 DE2143519B2 (de) | 1971-08-31 | 1971-08-31 | Verfahren zur Wirbelschichtgranulation pulverförmiger pharmazeutischer Mischungen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2143519A1 DE2143519A1 (de) | 1973-03-15 |
| DE2143519B2 true DE2143519B2 (de) | 1974-05-30 |
Family
ID=5818240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19712143519 Pending DE2143519B2 (de) | 1971-08-31 | 1971-08-31 | Verfahren zur Wirbelschichtgranulation pulverförmiger pharmazeutischer Mischungen |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS4834780A (enrdf_load_stackoverflow) |
| DE (1) | DE2143519B2 (enrdf_load_stackoverflow) |
| FR (1) | FR2150986A1 (enrdf_load_stackoverflow) |
| IT (1) | IT972173B (enrdf_load_stackoverflow) |
| NL (1) | NL7211618A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3535536A1 (de) * | 1985-10-04 | 1987-04-09 | Lentia Gmbh | Verfahren zum gleichzeitigen trocknen und granulieren von extraktstoffen aus enteiweisstem kaelberblut |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58214333A (ja) * | 1982-06-04 | 1983-12-13 | Dai Ichi Seiyaku Co Ltd | 粒状物 |
| ES2065680T3 (es) * | 1990-03-12 | 1995-02-16 | Du Pont | Granulos de plaguicida dispersables en agua o solubles en agua a partir de aglutinantes activados por calor. |
| IE65045B1 (en) * | 1990-04-28 | 1995-10-04 | Takeda Chemical Industries Ltd | Granulated preparations and method of producing the same |
| GB0514698D0 (en) * | 2005-07-18 | 2005-08-24 | Danisco | Process |
-
1971
- 1971-08-31 DE DE19712143519 patent/DE2143519B2/de active Pending
-
1972
- 1972-08-25 NL NL7211618A patent/NL7211618A/xx unknown
- 1972-08-30 IT IT2864572A patent/IT972173B/it active
- 1972-08-30 FR FR7230798A patent/FR2150986A1/fr active Granted
- 1972-08-30 JP JP8640972A patent/JPS4834780A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3535536A1 (de) * | 1985-10-04 | 1987-04-09 | Lentia Gmbh | Verfahren zum gleichzeitigen trocknen und granulieren von extraktstoffen aus enteiweisstem kaelberblut |
Also Published As
| Publication number | Publication date |
|---|---|
| NL7211618A (enrdf_load_stackoverflow) | 1973-03-02 |
| DE2143519A1 (de) | 1973-03-15 |
| JPS4834780A (enrdf_load_stackoverflow) | 1973-05-22 |
| FR2150986A1 (en) | 1973-04-13 |
| IT972173B (it) | 1974-05-20 |
| FR2150986B3 (enrdf_load_stackoverflow) | 1975-10-03 |
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