DE2136067C3 - 3-Fluor-D-alanin, 3-Fluor-D-alanin-2-d, deren Salze und diese Verbindungen enthaltende Arzneimittel - Google Patents

3-Fluor-D-alanin, 3-Fluor-D-alanin-2-d, deren Salze und diese Verbindungen enthaltende Arzneimittel

Info

Publication number
DE2136067C3
DE2136067C3 DE2136067A DE2136067A DE2136067C3 DE 2136067 C3 DE2136067 C3 DE 2136067C3 DE 2136067 A DE2136067 A DE 2136067A DE 2136067 A DE2136067 A DE 2136067A DE 2136067 C3 DE2136067 C3 DE 2136067C3
Authority
DE
Germany
Prior art keywords
alanine
fluoro
antibacterial
salts
effectiveness
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2136067A
Other languages
German (de)
English (en)
Other versions
DE2136067A1 (de
DE2136067B2 (de
Inventor
Frederick Marvin Rahway Kahan
Janos Westfield Kollonitsch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE2136067A1 publication Critical patent/DE2136067A1/de
Publication of DE2136067B2 publication Critical patent/DE2136067B2/de
Application granted granted Critical
Publication of DE2136067C3 publication Critical patent/DE2136067C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/38—Polysiloxanes modified by chemical after-treatment
    • C08G77/382—Polysiloxanes modified by chemical after-treatment containing atoms other than carbon, hydrogen, oxygen or silicon
    • C08G77/385—Polysiloxanes modified by chemical after-treatment containing atoms other than carbon, hydrogen, oxygen or silicon containing halogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C07C17/12—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the ring of aromatic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/19—Acids containing three or more carbon atoms
    • C07C53/21—Acids containing three or more carbon atoms containing fluorine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/38—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE2136067A 1970-08-03 1971-07-19 3-Fluor-D-alanin, 3-Fluor-D-alanin-2-d, deren Salze und diese Verbindungen enthaltende Arzneimittel Expired DE2136067C3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6064570A 1970-08-03 1970-08-03
US14981471A 1971-06-03 1971-06-03

Publications (3)

Publication Number Publication Date
DE2136067A1 DE2136067A1 (de) 1972-02-10
DE2136067B2 DE2136067B2 (de) 1980-01-17
DE2136067C3 true DE2136067C3 (de) 1980-09-11

Family

ID=26740157

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2136067A Expired DE2136067C3 (de) 1970-08-03 1971-07-19 3-Fluor-D-alanin, 3-Fluor-D-alanin-2-d, deren Salze und diese Verbindungen enthaltende Arzneimittel

Country Status (13)

Country Link
JP (1) JPS565217B1 (it)
AU (1) AU468229B2 (it)
BE (1) BE770888A (it)
CA (1) CA956646A (it)
CH (1) CH563961A5 (it)
DE (1) DE2136067C3 (it)
FR (1) FR2101198B1 (it)
GB (1) GB1367674A (it)
HK (1) HK86379A (it)
IE (1) IE35489B1 (it)
IL (1) IL37429A (it)
IT (1) IT1061753B (it)
NL (1) NL174248C (it)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ211490A (en) * 1984-03-23 1988-10-28 Commw Scient Ind Res Org Deuterated compounds and arthropodicidal compositions
CA2646229A1 (en) * 2006-03-16 2007-09-27 Vertex Pharmaceuticals Incorporated Deuterated hepatitis c protease inhibitors
RU2465264C2 (ru) * 2006-03-16 2012-10-27 Вертекс Фармасьютикалз Инкорпорейтед Дейтерированные ингибиторы протеазы гепатита с
EP2295401A3 (en) * 2006-03-16 2012-07-25 Vertex Pharmaceuticals Incorporated Deuterated hepatitis C protease inhibitors

Also Published As

Publication number Publication date
FR2101198B1 (it) 1975-08-01
BE770888A (fr) 1972-02-03
CH563961A5 (it) 1975-07-15
HK86379A (en) 1979-12-28
DE2136067A1 (de) 1972-02-10
IL37429A (en) 1975-05-22
GB1367674A (en) 1974-09-18
DE2136067B2 (de) 1980-01-17
NL7109947A (it) 1972-02-07
AU3146471A (en) 1973-01-25
NL174248C (nl) 1984-05-16
AU468229B2 (en) 1976-01-08
NL174248B (nl) 1983-12-16
JPS565217B1 (it) 1981-02-04
FR2101198A1 (it) 1972-03-31
IL37429A0 (en) 1971-11-29
CA956646A (en) 1974-10-22
IT1061753B (it) 1983-04-30
IE35489L (en) 1972-02-03
IE35489B1 (en) 1976-03-03

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Legal Events

Date Code Title Description
OD Request for examination
C3 Grant after two publication steps (3rd publication)