IE35489B1 - 3-fluoroalanines - Google Patents
3-fluoroalaninesInfo
- Publication number
- IE35489B1 IE35489B1 IE984/71A IE98471A IE35489B1 IE 35489 B1 IE35489 B1 IE 35489B1 IE 984/71 A IE984/71 A IE 984/71A IE 98471 A IE98471 A IE 98471A IE 35489 B1 IE35489 B1 IE 35489B1
- Authority
- IE
- Ireland
- Prior art keywords
- alanine
- fluoro
- deacetylation
- acetylation
- sequence
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/04—Polysiloxanes
- C08G77/38—Polysiloxanes modified by chemical after-treatment
- C08G77/382—Polysiloxanes modified by chemical after-treatment containing atoms other than carbon, hydrogen, oxygen or silicon
- C08G77/385—Polysiloxanes modified by chemical after-treatment containing atoms other than carbon, hydrogen, oxygen or silicon containing halogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
- C07C17/12—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the ring of aromatic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
- C07C53/19—Acids containing three or more carbon atoms
- C07C53/21—Acids containing three or more carbon atoms containing fluorine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/38—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/24—Anthracenes; Hydrogenated anthracenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
1367674 3-Fluoro-alanines MERCK & CO Inc 26 July 1971 [3 Aug 1970 3 June 1971] 34886/71 Heading C2C Novel D-isomers of the formula wherein each of x and y is 1 or 2 (thus each of x and y represent hydrogen or deuterium) and pharmaceutically acceptable salt thereof are prepared: (a) by the action of fluoroxyperfluoroalkane or fluoroxypentafluorosulphur on D- alanine under free radical initiation followed by chromatographic separation of the product to isolate 3-fluoro-alanine; (b) by the action of alanine racemase (an enzyme preparation from Staphylococcus aureus) in <SP>2</SP>H 2 O on L-alanine to incorporate deuterium into the alpha-position of D-alanine (the deuterated D-alanine is separated by the sequence N-acetylation, chromatographic separation and deacetylation), the thus produced 2-<SP>2</SP>H-D-alanine in subjected to the procedure under (a) above to form 2-<SP>2</SP>H-3-fluoro-D- alanine; and (c) 3,3,3-<SP>2</SP>H-D-alanine (obtained by the resolution of perdeutero alanine racemate using the sequence N-acetylation and deacetylation) is fluorinated as in (a) to form 3,3,2-<SP>2</SP>H- 3-fluoro-D-alanine. Pharmaceutical compositions and disinfectant compositions having anti-bacterial activity comprise the above novel compounds and a carrier therefore.
[GB1367674A]
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6064570A | 1970-08-03 | 1970-08-03 | |
US14981471A | 1971-06-03 | 1971-06-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
IE35489L IE35489L (en) | 1972-02-03 |
IE35489B1 true IE35489B1 (en) | 1976-03-03 |
Family
ID=26740157
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE984/71A IE35489B1 (en) | 1970-08-03 | 1971-08-03 | 3-fluoroalanines |
Country Status (13)
Country | Link |
---|---|
JP (1) | JPS565217B1 (en) |
AU (1) | AU468229B2 (en) |
BE (1) | BE770888A (en) |
CA (1) | CA956646A (en) |
CH (1) | CH563961A5 (en) |
DE (1) | DE2136067C3 (en) |
FR (1) | FR2101198B1 (en) |
GB (1) | GB1367674A (en) |
HK (1) | HK86379A (en) |
IE (1) | IE35489B1 (en) |
IL (1) | IL37429A (en) |
IT (1) | IT1061753B (en) |
NL (1) | NL174248C (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ211490A (en) * | 1984-03-23 | 1988-10-28 | Commw Scient Ind Res Org | Deuterated compounds and arthropodicidal compositions |
SG170729A1 (en) * | 2006-03-16 | 2011-05-30 | Vertex Pharma | Processes and intermediates for preparing steric compounds |
BRPI0709567A2 (en) * | 2006-03-16 | 2011-07-12 | Vertex Pharma | deuterated hepatitis c protease inhibitors |
RU2465264C2 (en) * | 2006-03-16 | 2012-10-27 | Вертекс Фармасьютикалз Инкорпорейтед | Deuterated hepatitis c protease inhibitors |
-
1971
- 1971-07-19 DE DE2136067A patent/DE2136067C3/en not_active Expired
- 1971-07-19 NL NLAANVRAGE7109947,A patent/NL174248C/en not_active IP Right Cessation
- 1971-07-20 AU AU31464/71A patent/AU468229B2/en not_active Expired
- 1971-07-21 CA CA118,804A patent/CA956646A/en not_active Expired
- 1971-07-22 IT IT51834/71A patent/IT1061753B/en active
- 1971-07-26 GB GB3488671A patent/GB1367674A/en not_active Expired
- 1971-08-03 IE IE984/71A patent/IE35489B1/en unknown
- 1971-08-03 BE BE770888A patent/BE770888A/en not_active IP Right Cessation
- 1971-08-03 IL IL37429A patent/IL37429A/en unknown
- 1971-08-03 JP JP5802771A patent/JPS565217B1/ja active Pending
- 1971-08-03 FR FR7128394A patent/FR2101198B1/fr not_active Expired
- 1971-08-03 CH CH1140771A patent/CH563961A5/xx not_active IP Right Cessation
-
1979
- 1979-12-20 HK HK863/79A patent/HK86379A/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU3146471A (en) | 1973-01-25 |
GB1367674A (en) | 1974-09-18 |
NL174248B (en) | 1983-12-16 |
DE2136067A1 (en) | 1972-02-10 |
IE35489L (en) | 1972-02-03 |
CA956646A (en) | 1974-10-22 |
BE770888A (en) | 1972-02-03 |
FR2101198B1 (en) | 1975-08-01 |
DE2136067C3 (en) | 1980-09-11 |
NL174248C (en) | 1984-05-16 |
JPS565217B1 (en) | 1981-02-04 |
CH563961A5 (en) | 1975-07-15 |
AU468229B2 (en) | 1976-01-08 |
IT1061753B (en) | 1983-04-30 |
FR2101198A1 (en) | 1972-03-31 |
DE2136067B2 (en) | 1980-01-17 |
NL7109947A (en) | 1972-02-07 |
HK86379A (en) | 1979-12-28 |
IL37429A0 (en) | 1971-11-29 |
IL37429A (en) | 1975-05-22 |
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