GB1385563A - Aminophthalazine derivatives and pharmaceutical uses thereof - Google Patents

Aminophthalazine derivatives and pharmaceutical uses thereof

Info

Publication number
GB1385563A
GB1385563A GB2794972A GB2794972A GB1385563A GB 1385563 A GB1385563 A GB 1385563A GB 2794972 A GB2794972 A GB 2794972A GB 2794972 A GB2794972 A GB 2794972A GB 1385563 A GB1385563 A GB 1385563A
Authority
GB
United Kingdom
Prior art keywords
aminophthalazine
derivatives
halogen
formula
quaternary ammonium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2794972A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aspro Nicholas Ltd
Original Assignee
Aspro Nicholas Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aspro Nicholas Ltd filed Critical Aspro Nicholas Ltd
Priority to GB2794972A priority Critical patent/GB1385563A/en
Publication of GB1385563A publication Critical patent/GB1385563A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1385563 Aminophthalazine derivatives and pharmaceutical uses thereof ASPRO-NICHOLAS Ltd 31 Aug 1973 [15 June 1972] 27949/72 Heading C2C The invention comprises compounds of formula wherein R<SP>1</SP> represents -CF 3 , n represents 0 or an integer, R 3 and R 4 independently represent hydrogen, halogen or -CF 3 provided that when n represents 0 at least one of R 3 and R 4 is other than hydrogen, or an acid addition or quaternary ammonium salt thereof. These compounds may be obtained by treating a compound of formula with an electron withdrawing leaving group, e.g. halogen, or alkyl- or phenyl-thio, -sulphinyl or -sulphonyl group, with dimethylamine and if desired, converting the resultant product into an acid addition salt or quaternary ammonium salt thereof. The invention also relates to a pharmaceutical composition which contains as an active ingredient a compound according to the invention together with a pharmaceutically acceptable carrier.
GB2794972A 1972-06-15 1972-06-15 Aminophthalazine derivatives and pharmaceutical uses thereof Expired GB1385563A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2794972A GB1385563A (en) 1972-06-15 1972-06-15 Aminophthalazine derivatives and pharmaceutical uses thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2794972A GB1385563A (en) 1972-06-15 1972-06-15 Aminophthalazine derivatives and pharmaceutical uses thereof

Publications (1)

Publication Number Publication Date
GB1385563A true GB1385563A (en) 1975-02-26

Family

ID=10267871

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2794972A Expired GB1385563A (en) 1972-06-15 1972-06-15 Aminophthalazine derivatives and pharmaceutical uses thereof

Country Status (1)

Country Link
GB (1) GB1385563A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989007599A2 (en) * 1988-02-09 1989-08-24 Georgia State University Foundation, Inc. Novel diazines and their method of preparation
US4963676A (en) * 1988-02-09 1990-10-16 Georgia State University Foundation, Inc. Di-substituted phthalazines
EP1745039A2 (en) * 2004-05-08 2007-01-24 Neurogen Corporation 3-aryl-5,6-disubstituted pyridazines

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989007599A2 (en) * 1988-02-09 1989-08-24 Georgia State University Foundation, Inc. Novel diazines and their method of preparation
WO1989007599A3 (en) * 1988-02-09 1989-10-19 Univ Georgia State Novel diazines and their method of preparation
US4929726A (en) * 1988-02-09 1990-05-29 Georgia State University Foundation, Inc. Novel diazines and their method of preparation
US4963676A (en) * 1988-02-09 1990-10-16 Georgia State University Foundation, Inc. Di-substituted phthalazines
US5304647A (en) * 1988-02-09 1994-04-19 Georgia State University Foundation, Inc. Method of preparation of halogenated diazines
EP1745039A2 (en) * 2004-05-08 2007-01-24 Neurogen Corporation 3-aryl-5,6-disubstituted pyridazines
EP1745039A4 (en) * 2004-05-08 2009-07-22 Neurogen Corp 3-aryl-5,6-disubstituted pyridazines
US8338591B2 (en) 2004-05-08 2012-12-25 Novartis International Pharmaceutical Ltd. 3-aryl-5,6-disubstituted pyridazines

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees