DE2117852A1 - Tablette mit Retardwirkung und Verfahren zu ihrer Herstellung - Google Patents
Tablette mit Retardwirkung und Verfahren zu ihrer HerstellungInfo
- Publication number
- DE2117852A1 DE2117852A1 DE19712117852 DE2117852A DE2117852A1 DE 2117852 A1 DE2117852 A1 DE 2117852A1 DE 19712117852 DE19712117852 DE 19712117852 DE 2117852 A DE2117852 A DE 2117852A DE 2117852 A1 DE2117852 A1 DE 2117852A1
- Authority
- DE
- Germany
- Prior art keywords
- resin
- tablets
- tablet
- iron
- resins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims description 14
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 239000011347 resin Substances 0.000 claims description 42
- 229920005989 resin Polymers 0.000 claims description 42
- 239000003826 tablet Substances 0.000 claims description 36
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 16
- 239000000126 substance Substances 0.000 claims description 12
- 238000013268 sustained release Methods 0.000 claims description 10
- 239000012730 sustained-release form Substances 0.000 claims description 10
- 239000004859 Copal Substances 0.000 claims description 8
- 230000000694 effects Effects 0.000 claims description 8
- 239000000314 lubricant Substances 0.000 claims description 8
- 235000019359 magnesium stearate Nutrition 0.000 claims description 8
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 238000000576 coating method Methods 0.000 claims description 6
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 6
- 239000011148 porous material Substances 0.000 claims description 6
- 239000011248 coating agent Substances 0.000 claims description 5
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 5
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims description 5
- 239000000025 natural resin Substances 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 230000001427 coherent effect Effects 0.000 claims description 2
- 238000003825 pressing Methods 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 239000007939 sustained release tablet Substances 0.000 claims description 2
- 241000782205 Guibourtia conjugata Species 0.000 claims 2
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 claims 1
- -1 coherent Substances 0.000 claims 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 10
- 239000004480 active ingredient Substances 0.000 description 9
- 240000000972 Agathis dammara Species 0.000 description 8
- 241000016649 Copaifera officinalis Species 0.000 description 6
- 229920001800 Shellac Polymers 0.000 description 6
- 239000004208 shellac Substances 0.000 description 6
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 6
- 229940113147 shellac Drugs 0.000 description 6
- 235000013874 shellac Nutrition 0.000 description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 229910052742 iron Inorganic materials 0.000 description 5
- 241000736873 Tetraclinis articulata Species 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 238000003860 storage Methods 0.000 description 3
- 239000004277 Ferrous carbonate Substances 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 240000007597 Hymenaea verrucosa Species 0.000 description 2
- 235000014018 Hymenaea verrucosa Nutrition 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- RAQDACVRFCEPDA-UHFFFAOYSA-L ferrous carbonate Chemical compound [Fe+2].[O-]C([O-])=O RAQDACVRFCEPDA-UHFFFAOYSA-L 0.000 description 2
- 235000019268 ferrous carbonate Nutrition 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 229910000015 iron(II) carbonate Inorganic materials 0.000 description 2
- 238000002386 leaching Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- RFBYLSCVRUTUSB-ZZMNMWMASA-L (2r)-2-[(1s)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2h-furan-4-olate;iron(2+) Chemical compound [Fe+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] RFBYLSCVRUTUSB-ZZMNMWMASA-L 0.000 description 1
- QIVUCLWGARAQIO-OLIXTKCUSA-N (3s)-n-[(3s,5s,6r)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2-oxospiro[1h-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-carboxamide Chemical compound C1([C@H]2[C@H](N(C(=O)[C@@H](NC(=O)C=3C=C4C[C@]5(CC4=NC=3)C3=CC=CN=C3NC5=O)C2)CC(F)(F)F)C)=C(F)C=CC(F)=C1F QIVUCLWGARAQIO-OLIXTKCUSA-N 0.000 description 1
- BMUDPLZKKRQECS-UHFFFAOYSA-K 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid iron(3+) hydroxide Chemical compound [OH-].[Fe+3].[N-]1C2=C(C)C(CCC(O)=O)=C1C=C([N-]1)C(CCC(O)=O)=C(C)C1=CC(C(C)=C1C=C)=NC1=CC(C(C)=C1C=C)=NC1=C2 BMUDPLZKKRQECS-UHFFFAOYSA-K 0.000 description 1
- 241001116439 Araucariaceae Species 0.000 description 1
- 241000226624 Boea Species 0.000 description 1
- 244000248349 Citrus limon Species 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical compound [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 description 1
- 241000350151 Guibourtia demeusei Species 0.000 description 1
- 206010022971 Iron Deficiencies Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 102100026933 Myelin-associated neurite-outgrowth inhibitor Human genes 0.000 description 1
- 241000199627 Rhynchonelliformea Species 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- MDXRFOWKIZPNTA-UHFFFAOYSA-L butanedioate;iron(2+) Chemical compound [Fe+2].[O-]C(=O)CCC([O-])=O MDXRFOWKIZPNTA-UHFFFAOYSA-L 0.000 description 1
- VAMMNAAZSNNEDJ-UHFFFAOYSA-N butanedioic acid;iron Chemical compound [Fe].OC(=O)CCC(O)=O VAMMNAAZSNNEDJ-UHFFFAOYSA-N 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000004222 ferrous gluconate Substances 0.000 description 1
- 235000013924 ferrous gluconate Nutrition 0.000 description 1
- 229960001604 ferrous succinate Drugs 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 229940109738 hematin Drugs 0.000 description 1
- VRIVJOXICYMTAG-IYEMJOQQSA-L iron(ii) gluconate Chemical compound [Fe+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O VRIVJOXICYMTAG-IYEMJOQQSA-L 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000002966 varnish Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB09963/70A GB1300426A (en) | 1970-04-25 | 1970-04-25 | Sustained release haematinic tablets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2117852A1 true DE2117852A1 (de) | 1971-11-18 |
Family
ID=10138050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19712117852 Pending DE2117852A1 (de) | 1970-04-25 | 1971-04-13 | Tablette mit Retardwirkung und Verfahren zu ihrer Herstellung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3822343A (enExample) |
| BE (1) | BE766080A (enExample) |
| CA (1) | CA940452A (enExample) |
| DE (1) | DE2117852A1 (enExample) |
| ES (1) | ES390407A1 (enExample) |
| FR (1) | FR2092088B1 (enExample) |
| GB (1) | GB1300426A (enExample) |
| NL (1) | NL170920C (enExample) |
| ZA (1) | ZA712472B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2344884C3 (de) * | 1973-09-06 | 1980-08-14 | Gewerkschaft Victor Chemische Werke, 4620 Castrop-Rauxel | Depot-Tablette für Saugferkel zur Prophylaxe gegen Mangelerscheinungen |
| US3992515A (en) * | 1973-12-05 | 1976-11-16 | Johnson Vernon S | Composition for indicating and method of removing dental undercuts and the like |
| GB2141023B (en) * | 1983-06-06 | 1986-09-03 | Robins Co Inc A H | Delayed release formulations |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US344489A (en) * | 1886-06-29 | Letter-box | ||
| FR1371751A (fr) * | 1959-04-30 | 1964-09-11 | Wellcome Found | Procédé de préparation de compositions pharmaceutiques à effet prolongé |
| GB1153324A (en) * | 1966-05-19 | 1969-05-29 | Fisons Pharmaceuticals Ltd | Sustained Release Tablets |
-
1970
- 1970-04-25 GB GB09963/70A patent/GB1300426A/en not_active Expired
-
1971
- 1971-04-07 NL NLAANVRAGE7104717,A patent/NL170920C/xx not_active IP Right Cessation
- 1971-04-13 DE DE19712117852 patent/DE2117852A1/de active Pending
- 1971-04-16 US US00134874A patent/US3822343A/en not_active Expired - Lifetime
- 1971-04-19 ZA ZA712472A patent/ZA712472B/xx unknown
- 1971-04-21 ES ES390407A patent/ES390407A1/es not_active Expired
- 1971-04-21 BE BE766080A patent/BE766080A/xx not_active IP Right Cessation
- 1971-04-23 CA CA111,226A patent/CA940452A/en not_active Expired
- 1971-04-23 FR FR7114463A patent/FR2092088B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES390407A1 (es) | 1974-07-01 |
| FR2092088A1 (enExample) | 1972-01-21 |
| BE766080A (fr) | 1971-10-21 |
| CA940452A (en) | 1974-01-22 |
| US3822343A (en) | 1974-07-02 |
| NL7104717A (enExample) | 1971-10-27 |
| FR2092088B1 (enExample) | 1974-09-06 |
| ZA712472B (en) | 1972-01-26 |
| NL170920B (nl) | 1982-08-16 |
| NL170920C (nl) | 1983-01-17 |
| GB1300426A (en) | 1972-12-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0032562B1 (de) | Neue Dipyridamol-Retardformen und Verfahren zu ihrer Herstellung | |
| DE2031871C3 (de) | Überzugsmasse für Arzneiformen | |
| EP0069259B1 (de) | Bromhexin-Retardform und Verfahren zu ihrer Herstellung | |
| EP1029892B1 (de) | Beta-1,3-Glucan aus Euglena enthaltendes gefriergetrocknetes Erzeugnis, seine Herstellung und Verwendung | |
| EP0122574B2 (de) | Teilbare Tablette mit verzögerter Wirkstofffreigabe und Verfahren zu deren Herstellung | |
| DE2224534A1 (de) | Pharmazeutisches Präparat mit langsamer Wirkstoffabgabe | |
| EP0281778A1 (de) | Mehrteilige implantierbare Arzneizubereitung mit Langzeitwirkung | |
| DE4037604A1 (de) | Verwendung von anti-tnf-antikoerpern als arzneimittel bei der behandlung von ischaemien und deren folgen | |
| DE1467781A1 (de) | Verfahren zur Herstellung von Dragees mit verlaengerter Wirkstofffreigabe | |
| DE1467906A1 (de) | Verfahren zur Herstellung von sich langsam loesenden Tabletten | |
| DE2128461A1 (de) | Pharmazeutisches Präparat | |
| DE2706660A1 (de) | Ascorbinsaeure enthaltende granulate und verfahren zu ihrer herstellung | |
| DE3150557C2 (enExample) | ||
| EP0108882A1 (de) | Presslinge mit retardierter Wirkstofffreisetzung und Verfahren zu deren Herstellung | |
| DE2117852A1 (de) | Tablette mit Retardwirkung und Verfahren zu ihrer Herstellung | |
| EP0164571B1 (de) | Retardformen des alpha-(2,5-Dimethoxy-phenyl)-beta-lycinamido-äthanols und Verfahren zu ihrer Herstellung | |
| DE2344884B2 (de) | Depot-Tablette für Saugferkel zur Prophylaxe gegen Mangelerscheinungen | |
| DE2126533A1 (de) | Verfahren zur Herstellung pharma zeutischer Zubereitungen | |
| AT383270B (de) | Verfahren zur herstellung von oralen retardformen des alpha-(2,5-dimethoxy-phenyl)-betaglycinamido|thanols | |
| EP0043548A1 (de) | Salz aus Furosemid oder Piretanid als Säurekomponente und Penbutolol als Basenkomponente sowie Arzneimittel, das beide Komponenten enthält | |
| DE69103724T2 (de) | Pharmazeutische zusammensetzungen mit verzögerter freisetzung zur oralen verabreichung sowie deren herstellungsverfahren. | |
| DE2621906C2 (enExample) | ||
| DE2404257C3 (de) | Verfahren zur Herstellung von Arzneimittelgranulaten mit Depotwirkung | |
| DE2707763A1 (de) | Verwendung von vincamin zur behandlung von kreislauferkrankungen des gehirns und dazu geeignetes arzneimittel | |
| DE2800110A1 (de) | Verfahren zur herstellung neuer antidiarrhoica |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHA | Expiration of time for request for examination |