DE2104344B2 - Protrahiert wirkendes Sekretin-Präparat - Google Patents
Protrahiert wirkendes Sekretin-PräparatInfo
- Publication number
- DE2104344B2 DE2104344B2 DE2104344A DE2104344A DE2104344B2 DE 2104344 B2 DE2104344 B2 DE 2104344B2 DE 2104344 A DE2104344 A DE 2104344A DE 2104344 A DE2104344 A DE 2104344A DE 2104344 B2 DE2104344 B2 DE 2104344B2
- Authority
- DE
- Germany
- Prior art keywords
- secretin
- solution
- derivative
- isotonicity
- polyphloretin phosphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100037505 Secretin Human genes 0.000 title claims description 21
- 108010086019 Secretin Proteins 0.000 title claims description 21
- 229960002101 secretin Drugs 0.000 title claims description 21
- OWMZNFCDEHGFEP-NFBCVYDUSA-N secretin human Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(N)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)C1=CC=CC=C1 OWMZNFCDEHGFEP-NFBCVYDUSA-N 0.000 title claims description 21
- 238000002360 preparation method Methods 0.000 title claims description 4
- 229920000159 gelatin Polymers 0.000 claims description 15
- 235000019322 gelatine Nutrition 0.000 claims description 15
- 108010010803 Gelatin Proteins 0.000 claims description 11
- 229910019142 PO4 Inorganic materials 0.000 claims description 11
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 11
- 239000008273 gelatin Substances 0.000 claims description 11
- 235000011852 gelatine desserts Nutrition 0.000 claims description 11
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 11
- 239000010452 phosphate Substances 0.000 claims description 11
- 239000000243 solution Substances 0.000 claims description 10
- 230000000694 effects Effects 0.000 claims description 6
- 241000282472 Canis lupus familiaris Species 0.000 claims description 5
- 210000001819 pancreatic juice Anatomy 0.000 claims description 5
- 230000028327 secretion Effects 0.000 claims description 5
- 239000011780 sodium chloride Substances 0.000 claims description 5
- 230000007935 neutral effect Effects 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 230000015556 catabolic process Effects 0.000 claims description 2
- 238000004132 cross linking Methods 0.000 claims description 2
- 238000006731 degradation reaction Methods 0.000 claims description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
- 238000007920 subcutaneous administration Methods 0.000 claims description 2
- 210000000496 pancreas Anatomy 0.000 claims 2
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 claims 2
- 241001550206 Colla Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 210000000941 bile Anatomy 0.000 claims 1
- 210000000038 chest Anatomy 0.000 claims 1
- 230000011382 collagen catabolic process Effects 0.000 claims 1
- 210000001953 common bile duct Anatomy 0.000 claims 1
- XLJMAIOERFSOGZ-UHFFFAOYSA-M cyanate Chemical compound [O-]C#N XLJMAIOERFSOGZ-UHFFFAOYSA-M 0.000 claims 1
- 125000005442 diisocyanate group Chemical group 0.000 claims 1
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 claims 1
- 210000001198 duodenum Anatomy 0.000 claims 1
- 210000003191 femoral vein Anatomy 0.000 claims 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims 1
- 210000004051 gastric juice Anatomy 0.000 claims 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 235000013923 monosodium glutamate Nutrition 0.000 claims 1
- 210000000277 pancreatic duct Anatomy 0.000 claims 1
- 229960001412 pentobarbital Drugs 0.000 claims 1
- 229920003023 plastic Polymers 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- -1 polyethylene Polymers 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 210000001187 pylorus Anatomy 0.000 claims 1
- 229940073490 sodium glutamate Drugs 0.000 claims 1
- 238000005303 weighing Methods 0.000 claims 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 239000001828 Gelatine Substances 0.000 description 4
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 239000003405 delayed action preparation Substances 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 239000005057 Hexamethylene diisocyanate Substances 0.000 description 1
- HTLZVHNRZJPSMI-UHFFFAOYSA-N N-ethylpiperidine Chemical compound CCN1CCCCC1 HTLZVHNRZJPSMI-UHFFFAOYSA-N 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2104344A DE2104344B2 (de) | 1971-01-30 | 1971-01-30 | Protrahiert wirkendes Sekretin-Präparat |
| NL7200984A NL7200984A (enrdf_load_stackoverflow) | 1971-01-30 | 1972-01-25 | |
| CA133,272A CA984291A (en) | 1971-01-30 | 1972-01-27 | Secretin preparation having prolonged action and the procedure of manufacture |
| US00221414A US3749774A (en) | 1971-01-30 | 1972-01-27 | Secretin preparation having prolonged action and the procedure of manufacture |
| DK39872AA DK129387B (da) | 1971-01-30 | 1972-01-28 | Fremgangsmåde til fremstilling af et sekretinpræparat med protraherende virkning. |
| AT67472A AT312805B (de) | 1971-01-30 | 1972-01-28 | Verfahren zur Herstellung eines Sekretin-Präparates |
| SE7201016A SE405805B (sv) | 1971-01-30 | 1972-01-28 | Forfarande for framstellning av ett sekretinpreparat med protraherad verkan |
| IL38655A IL38655A (en) | 1971-01-30 | 1972-01-28 | Secretin preparation having prolonged action and the procedure of manufacture |
| IE118/72A IE36042B1 (en) | 1971-01-30 | 1972-01-28 | A secretin preparation having prolonged action and a process for its manufacture |
| BE778744A BE778744A (fr) | 1971-01-30 | 1972-01-31 | Medicament a base de secretine a effet prolonge et sa preparation |
| GB441172A GB1372284A (en) | 1971-01-30 | 1972-01-31 | Secretin preparation having prolonged action and a process for its manufacture |
| FR7203099A FR2123547B1 (enrdf_load_stackoverflow) | 1971-01-30 | 1972-01-31 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2104344A DE2104344B2 (de) | 1971-01-30 | 1971-01-30 | Protrahiert wirkendes Sekretin-Präparat |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2104344A1 DE2104344A1 (de) | 1972-08-17 |
| DE2104344B2 true DE2104344B2 (de) | 1975-08-21 |
Family
ID=5797346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2104344A Granted DE2104344B2 (de) | 1971-01-30 | 1971-01-30 | Protrahiert wirkendes Sekretin-Präparat |
Country Status (12)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5029005B2 (enrdf_load_stackoverflow) * | 1972-05-08 | 1975-09-19 | ||
| FR2185416A1 (en) * | 1972-05-25 | 1974-01-04 | Sandoz Sa | Isotonic injectable ACTH compsns - with low content of polyphloretin phosphate, but with prolonged activity |
| DE2758578A1 (de) * | 1977-12-29 | 1979-07-05 | Hoechst Ag | Stabile sekretinzubereitung, verfahren zu ihrer herstellung und ihre verwendung |
| ES8101891A1 (es) * | 1979-06-13 | 1980-12-16 | Hoechst Ag | Procedimiento para la preparacion de un preparado de secre- tina con efecto reforzado y retardado |
| EP0086627B1 (en) * | 1982-02-12 | 1985-08-28 | Unitika Ltd. | Anti-cancer device |
| DE3402466A1 (de) * | 1984-01-25 | 1985-08-01 | Hoechst Ag, 6230 Frankfurt | Sekretin und dieses enthaltende mittel zur prophylaxe des aspirations-syndroms |
-
1971
- 1971-01-30 DE DE2104344A patent/DE2104344B2/de active Granted
-
1972
- 1972-01-25 NL NL7200984A patent/NL7200984A/xx not_active Application Discontinuation
- 1972-01-27 CA CA133,272A patent/CA984291A/en not_active Expired
- 1972-01-27 US US00221414A patent/US3749774A/en not_active Expired - Lifetime
- 1972-01-28 IE IE118/72A patent/IE36042B1/xx unknown
- 1972-01-28 IL IL38655A patent/IL38655A/xx unknown
- 1972-01-28 SE SE7201016A patent/SE405805B/xx unknown
- 1972-01-28 AT AT67472A patent/AT312805B/de not_active IP Right Cessation
- 1972-01-28 DK DK39872AA patent/DK129387B/da unknown
- 1972-01-31 FR FR7203099A patent/FR2123547B1/fr not_active Expired
- 1972-01-31 GB GB441172A patent/GB1372284A/en not_active Expired
- 1972-01-31 BE BE778744A patent/BE778744A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL38655A (en) | 1975-03-13 |
| IE36042B1 (en) | 1976-08-04 |
| DK129387B (da) | 1974-10-07 |
| FR2123547B1 (enrdf_load_stackoverflow) | 1975-03-14 |
| FR2123547A1 (enrdf_load_stackoverflow) | 1972-09-08 |
| DK129387C (enrdf_load_stackoverflow) | 1975-02-24 |
| BE778744A (fr) | 1972-07-31 |
| NL7200984A (enrdf_load_stackoverflow) | 1972-08-01 |
| GB1372284A (en) | 1974-10-30 |
| US3749774A (en) | 1973-07-31 |
| IE36042L (en) | 1972-07-30 |
| IL38655A0 (en) | 1972-03-28 |
| DE2104344A1 (de) | 1972-08-17 |
| AT312805B (de) | 1974-01-25 |
| SE405805B (sv) | 1979-01-08 |
| CA984291A (en) | 1976-02-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) | ||
| E77 | Valid patent as to the heymanns-index 1977 | ||
| 8339 | Ceased/non-payment of the annual fee |