DE19882755T1 - Ein Fusionsprotein des hEGF und des humanen Angiogenins und ein Verfahren zu dessen Herstellung - Google Patents

Ein Fusionsprotein des hEGF und des humanen Angiogenins und ein Verfahren zu dessen Herstellung

Info

Publication number
DE19882755T1
DE19882755T1 DE19882755T DE19882755T DE19882755T1 DE 19882755 T1 DE19882755 T1 DE 19882755T1 DE 19882755 T DE19882755 T DE 19882755T DE 19882755 T DE19882755 T DE 19882755T DE 19882755 T1 DE19882755 T1 DE 19882755T1
Authority
DE
Germany
Prior art keywords
hegf
production
fusion protein
human angiogenin
angiogenin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19882755T
Other languages
English (en)
Other versions
DE19882755B4 (de
Inventor
Myung Hwan Park
Seung Kook Park
Jong Myung Yoon
Seung Hee Han
Oh Byung Kwon
Seung Ho Kim
Young Man Kim
Tai Young Koo
Byoung Kwang Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daewoong Pharmaceutical Co Ltd
Original Assignee
Daewoong Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daewoong Pharmaceutical Co Ltd filed Critical Daewoong Pharmaceutical Co Ltd
Publication of DE19882755T1 publication Critical patent/DE19882755T1/de
Application granted granted Critical
Publication of DE19882755B4 publication Critical patent/DE19882755B4/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE19882755T 1997-11-01 1998-10-30 Ein Fusionsprotein des hEGF und des humanen Angiogenins und ein Verfahren zu dessen Herstellung Expired - Fee Related DE19882755B4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1019970057603A KR100236977B1 (ko) 1997-11-01 1997-11-01 인간 상피세포 성장인자와 인간 안지오게닌의 융합독소단백질 및 그의 제조방법
KR1997/57603 1997-11-01
PCT/KR1998/000343 WO1999023112A1 (en) 1997-11-01 1998-10-30 A FUSION PROTEIN OF hEGF AND HUMAN ANGIOGENIN, AND PROCESS FOR PREPARING THE SAME

Publications (2)

Publication Number Publication Date
DE19882755T1 true DE19882755T1 (de) 2000-10-12
DE19882755B4 DE19882755B4 (de) 2004-11-18

Family

ID=19523991

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19882755T Expired - Fee Related DE19882755B4 (de) 1997-11-01 1998-10-30 Ein Fusionsprotein des hEGF und des humanen Angiogenins und ein Verfahren zu dessen Herstellung

Country Status (6)

Country Link
US (1) US6541619B1 (de)
JP (1) JP2001521733A (de)
KR (1) KR100236977B1 (de)
AU (1) AU9764698A (de)
DE (1) DE19882755B4 (de)
WO (1) WO1999023112A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1315411A2 (de) * 2000-08-28 2003-06-04 Bionox Inc. PROTOKOLLE ZUR HERSTELLUNG VON TRANSGENEN PFLANZEN MIT HOHER AUSBEUTE UND SUPERPRODUKTIVITäT, IN WELCHEN RAN/RAN-BINDENDE PROTEIN-VERMITTELTE ZELLULäRE PROZESSE GESTöRT SIND
KR20030021093A (ko) * 2001-09-05 2003-03-12 주식회사 대웅 곤충세포를 이용하여 인간 상피세포성장인자와 인간안지오게닌의 융합단백질 및 그의 유도체를 생산하는 방법
WO2005115477A2 (en) 2004-04-13 2005-12-08 Quintessence Biosciences, Inc. Non-natural ribonuclease conjugates as cytotoxic agents
JP2009541333A (ja) * 2006-06-23 2009-11-26 クインテセンス バイオサイエンシーズ インコーポレーティッド 修飾リボヌクレアーゼ
EP2049151A4 (de) 2006-07-17 2010-03-24 Quintessence Biosciences Inc Verfahren und zusammensetzungen zur behandlung von krebs
WO2008100833A2 (en) * 2007-02-13 2008-08-21 Auxilium International Holdings, Inc. Production of recombinant collagenases colg and colh in escherichia coli
CA2702043A1 (en) * 2007-10-08 2009-04-16 Quintessence Biosciences, Inc. Compositions and methods for ribonuclease-based therapies
EP2303311B1 (de) 2008-05-14 2018-08-01 Agriculture Victoria Services Pty Ltd Angiogenin zur verwendung zur behandlung von skelettmuskelerkrankungen
AU2013204721B2 (en) * 2008-05-14 2016-08-18 Agriculture Victoria Services Pty Ltd Methods for treating cachexia
WO2010039985A1 (en) 2008-10-01 2010-04-08 Quintessence Biosciences, Inc. Therapeutic Ribonucleases
EP2501411A4 (de) * 2009-11-18 2013-07-03 Murray Goulburn Coop Co Ltd Verfahren für verbesserte orale verabreichung
US8986956B2 (en) 2010-11-04 2015-03-24 Korea Research Institute Of Bioscience And Biotechnology Method for producing human epidermal growth factor in large volume from yeast
KR101323845B1 (ko) * 2011-01-21 2013-10-31 광주과학기술원 외막소포체를 유효성분으로 포함하는 항암용 약제학적 조성물
AU2013204740C1 (en) 2012-05-10 2015-10-01 Agriculture Victoria Services Pty Ltd Methods of treating cancer using angiogenin or an angiogenin agonist

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4545985A (en) * 1984-01-26 1985-10-08 The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services Pseudomonas exotoxin conjugate immunotoxins
EP0423641A3 (en) * 1989-10-18 1992-01-15 Nippon Mining Company Limited Expression vector, transformed microorganism, fusion protein and method for the production of platelet factor 4 or tgfalpha
US5840840A (en) 1990-04-17 1998-11-24 The United States Of America As Represented By The Department Of Health And Human Services Selective RNase cytotoxic reagents
US5916794A (en) * 1992-04-03 1999-06-29 Johns Hopkins University Methods for inactivating target DNA and for detecting conformational change in a nucleic acid

Also Published As

Publication number Publication date
DE19882755B4 (de) 2004-11-18
US6541619B1 (en) 2003-04-01
JP2001521733A (ja) 2001-11-13
KR100236977B1 (ko) 2000-01-15
AU9764698A (en) 1999-05-24
KR19990037999A (ko) 1999-06-05
WO1999023112A1 (en) 1999-05-14

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8607 Notification of search results after publication
8125 Change of the main classification

Ipc: C07K 19/00

8364 No opposition during term of opposition
R082 Change of representative

Representative=s name: GODEMEYER BLUM LENZE PARTNERSCHAFT, PATENTANWA, DE

Representative=s name: GODEMEYER BLUM LENZE PATENTANWAELTE, PARTNERSC, DE

R119 Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee

Effective date: 20140501