DE19850015A1 - Proteine der Stomatinfamilie und ihre Verwendung als Zielproteine für die Schm erztherapie - Google Patents
Proteine der Stomatinfamilie und ihre Verwendung als Zielproteine für die Schm erztherapieInfo
- Publication number
- DE19850015A1 DE19850015A1 DE1998150015 DE19850015A DE19850015A1 DE 19850015 A1 DE19850015 A1 DE 19850015A1 DE 1998150015 DE1998150015 DE 1998150015 DE 19850015 A DE19850015 A DE 19850015A DE 19850015 A1 DE19850015 A1 DE 19850015A1
- Authority
- DE
- Germany
- Prior art keywords
- stomatin
- proteins
- use according
- development
- family
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000048514 Stomatin Human genes 0.000 title claims abstract description 34
- 108700037714 Stomatin Proteins 0.000 title claims abstract description 34
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 22
- 102000004169 proteins and genes Human genes 0.000 title claims abstract description 19
- 238000002560 therapeutic procedure Methods 0.000 title claims abstract description 7
- 208000002193 Pain Diseases 0.000 claims abstract description 12
- 239000002299 complementary DNA Substances 0.000 claims abstract description 8
- 229940035674 anesthetics Drugs 0.000 claims abstract description 6
- 239000003193 general anesthetic agent Substances 0.000 claims abstract description 6
- 238000009007 Diagnostic Kit Methods 0.000 claims abstract description 5
- 150000001413 amino acids Chemical class 0.000 claims abstract description 5
- 229940035676 analgesics Drugs 0.000 claims abstract description 4
- 239000000730 antalgic agent Substances 0.000 claims abstract description 4
- 239000003814 drug Substances 0.000 claims abstract description 4
- 239000000126 substance Substances 0.000 claims abstract description 3
- 229940124597 therapeutic agent Drugs 0.000 claims abstract description 3
- 239000012634 fragment Substances 0.000 claims description 5
- 102000054765 polymorphisms of proteins Human genes 0.000 claims description 4
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000004043 responsiveness Effects 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 abstract description 2
- 125000003729 nucleotide group Chemical group 0.000 abstract description 2
- 210000005036 nerve Anatomy 0.000 description 6
- 239000000835 fiber Substances 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 210000002569 neuron Anatomy 0.000 description 5
- 210000001044 sensory neuron Anatomy 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 4
- 230000036982 action potential Effects 0.000 description 4
- 210000000170 cell membrane Anatomy 0.000 description 4
- 210000003743 erythrocyte Anatomy 0.000 description 4
- 101100456536 Caenorhabditis elegans mec-2 gene Proteins 0.000 description 3
- 102000004310 Ion Channels Human genes 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 210000003050 axon Anatomy 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000011813 knockout mouse model Methods 0.000 description 3
- 108091026890 Coding region Proteins 0.000 description 2
- 208000004454 Hyperalgesia Diseases 0.000 description 2
- 108010052285 Membrane Proteins Proteins 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 206010053552 allodynia Diseases 0.000 description 2
- 230000003321 amplification Effects 0.000 description 2
- 210000003169 central nervous system Anatomy 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- 241000244203 Caenorhabditis elegans Species 0.000 description 1
- 208000000094 Chronic Pain Diseases 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- 229910001111 Fine metal Inorganic materials 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 101000820460 Homo sapiens Stomatin Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 210000004292 cytoskeleton Anatomy 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 230000023077 detection of light stimulus Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000010195 expression analysis Methods 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 102000058183 human STOM Human genes 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000007901 in situ hybridization Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 230000008058 pain sensation Effects 0.000 description 1
- 229940124707 pain therapeutics Drugs 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 230000015541 sensory perception of touch Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1998150015 DE19850015A1 (de) | 1998-10-30 | 1998-10-30 | Proteine der Stomatinfamilie und ihre Verwendung als Zielproteine für die Schm erztherapie |
| PCT/DE1999/003434 WO2000026362A2 (fr) | 1998-10-30 | 1999-10-28 | Proteines de la famille de la stomatine et leur utilisation comme proteines cibles pour le traitement de la douleur |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1998150015 DE19850015A1 (de) | 1998-10-30 | 1998-10-30 | Proteine der Stomatinfamilie und ihre Verwendung als Zielproteine für die Schm erztherapie |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE19850015A1 true DE19850015A1 (de) | 2000-05-04 |
Family
ID=7886124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1998150015 Withdrawn DE19850015A1 (de) | 1998-10-30 | 1998-10-30 | Proteine der Stomatinfamilie und ihre Verwendung als Zielproteine für die Schm erztherapie |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE19850015A1 (fr) |
| WO (1) | WO2000026362A2 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2813499B1 (fr) | 2000-09-04 | 2004-11-26 | Pasteur Institut | Mammifere non-humain mutant pour l'expression de la sous- unite alpha6 du recepteur nicotinique de l'acetylcholine et utilisation pour le criblage de substances susceptibles d'interagir avec ce recepteur |
| IL151980A0 (en) * | 2002-09-29 | 2003-04-10 | Yeda Res & Dev | Resistin binding proteins, their preparation and use |
| WO2004040299A2 (fr) * | 2002-10-30 | 2004-05-13 | Max-Delbrück-Centrum Für Molekulare Medizin (Mdc) Berlin-Buch | Technique d'identification de composes inhibiteurs de la transduction mecanique dans les neurones |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5763589A (en) * | 1997-01-09 | 1998-06-09 | Incyte Pharmaceuticals, Inc. | Human membrane protein |
| JP2001523453A (ja) * | 1997-11-13 | 2001-11-27 | ジェンセット | 分泌タンパク質の伸長ｃＤＮＡ |
-
1998
- 1998-10-30 DE DE1998150015 patent/DE19850015A1/de not_active Withdrawn
-
1999
- 1999-10-28 WO PCT/DE1999/003434 patent/WO2000026362A2/fr active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000026362A3 (fr) | 2000-06-22 |
| WO2000026362A2 (fr) | 2000-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8130 | Withdrawal |