DE19741051A1 - Hetero-Tetrahydrochinoline - Google Patents

Hetero-Tetrahydrochinoline

Info

Publication number
DE19741051A1
DE19741051A1 DE19741051A DE19741051A DE19741051A1 DE 19741051 A1 DE19741051 A1 DE 19741051A1 DE 19741051 A DE19741051 A DE 19741051A DE 19741051 A DE19741051 A DE 19741051A DE 19741051 A1 DE19741051 A1 DE 19741051A1
Authority
DE
Germany
Prior art keywords
chain
carbon atoms
straight
phenyl
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19741051A
Other languages
German (de)
English (en)
Inventor
Juergen Dipl Ing Stoltefus
Michael Dr Loegers
Gunter Dr Schmidt
Arndt Dr Brandes
Carsten Dr Schmeck
Klaus-Dieter Dr Bremm
Hilmar Dr Bischoff
Delf Dr Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to DE19741051A priority Critical patent/DE19741051A1/de
Priority to JP2000511764A priority patent/JP2001516757A/ja
Priority to DK98948919T priority patent/DK1017692T3/da
Priority to US09/508,399 priority patent/US6387929B1/en
Priority to PCT/EP1998/005656 priority patent/WO1999014215A1/de
Priority to ES98948919T priority patent/ES2216316T3/es
Priority to AT98948919T priority patent/ATE260910T1/de
Priority to EP98948919A priority patent/EP1017692B1/de
Priority to DE59810922T priority patent/DE59810922D1/de
Priority to AU95368/98A priority patent/AU9536898A/en
Priority to PT98948919T priority patent/PT1017692E/pt
Priority to HN1998000143A priority patent/HN1998000143A/es
Publication of DE19741051A1 publication Critical patent/DE19741051A1/de
Priority to US09/999,233 priority patent/US6958346B2/en
Priority to US11/257,931 priority patent/US7192971B2/en
Priority to US11/677,790 priority patent/US20070142420A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
DE19741051A 1997-09-18 1997-09-18 Hetero-Tetrahydrochinoline Withdrawn DE19741051A1 (de)

Priority Applications (15)

Application Number Priority Date Filing Date Title
DE19741051A DE19741051A1 (de) 1997-09-18 1997-09-18 Hetero-Tetrahydrochinoline
EP98948919A EP1017692B1 (de) 1997-09-18 1998-09-07 4-heteroaryl-tetrahydrochinoline und ihre verwendung als inhibitoren des cholesterin-ester-transfer-proteins (ctep)
DE59810922T DE59810922D1 (de) 1997-09-18 1998-09-07 4-heteroaryl-tetrahydrochinoline und ihre verwendung als inhibitoren des cholesterin-ester-transfer-proteins (ctep)
US09/508,399 US6387929B1 (en) 1997-09-18 1998-09-07 4-heteroaryl-tetrahydroquinolines and their use as inhibitors of the cholesterin-ester transfer protein
PCT/EP1998/005656 WO1999014215A1 (de) 1997-09-18 1998-09-07 4-heteroaryl-tetrahydrochinoline und ihre verwendung als inhibitoren des cholesterin-ester-transfer-proteins (ctep)
ES98948919T ES2216316T3 (es) 1997-09-18 1998-09-07 4-heteroaril-tetrahidroquinolinas y su uso como inhibidores de la proteina de transferencia de esteres del colesterol (cetp).
AT98948919T ATE260910T1 (de) 1997-09-18 1998-09-07 4-heteroaryl-tetrahydrochinoline und ihre verwendung als inhibitoren des cholesterin-ester- transfer-proteins (ctep)
JP2000511764A JP2001516757A (ja) 1997-09-18 1998-09-07 ４−ヘテロアリール−テトラヒドロキノリン及びコレステリン−エステル輸送タンパク質のインヒビターとしてのそれらの使用
DK98948919T DK1017692T3 (da) 1997-09-18 1998-09-07 4-Heteroaryl-tetrahydroquinoliner og deres anvendelse som inhibitorer af cholesterolester-transferproteiner
AU95368/98A AU9536898A (en) 1997-09-18 1998-09-07 4-heteroaryl-tetrahydroquinolines and their use as inhibitors of the holesterin-ester transfer protein
PT98948919T PT1017692E (pt) 1997-09-18 1998-09-07 4-heteroaril-tetrahidroquinolinas e sua aplicacao como inibidores da proteina de transferencia de ester de colesterol (ctep)
HN1998000143A HN1998000143A (es) 1997-09-18 1998-09-18 Tetrahidronaftalenos substituidos y compuestos analogos.
US09/999,233 US6958346B2 (en) 1997-09-18 2001-10-31 4-heteroaryl-tetrahydroquinolines and their use as inhibitors of the cholesterin-ester transfer protein
US11/257,931 US7192971B2 (en) 1997-09-18 2005-10-25 4-Heteroaryl-tetrahydroquinolines and their use as inhibitors of the cholesterin-ester transfer protein
US11/677,790 US20070142420A1 (en) 1997-09-18 2007-02-22 4-heteroaryl-tetrahydroquinolines and their use as inhibitors of the cholesterin-ester transfer protein

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19741051A DE19741051A1 (de) 1997-09-18 1997-09-18 Hetero-Tetrahydrochinoline

Publications (1)

Publication Number Publication Date
DE19741051A1 true DE19741051A1 (de) 1999-03-25

Family

ID=7842737

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19741051A Withdrawn DE19741051A1 (de) 1997-09-18 1997-09-18 Hetero-Tetrahydrochinoline
DE59810922T Expired - Fee Related DE59810922D1 (de) 1997-09-18 1998-09-07 4-heteroaryl-tetrahydrochinoline und ihre verwendung als inhibitoren des cholesterin-ester-transfer-proteins (ctep)

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59810922T Expired - Fee Related DE59810922D1 (de) 1997-09-18 1998-09-07 4-heteroaryl-tetrahydrochinoline und ihre verwendung als inhibitoren des cholesterin-ester-transfer-proteins (ctep)

Country Status (11)

Country Link
US (4) US6387929B1 (https=)
EP (1) EP1017692B1 (https=)
JP (1) JP2001516757A (https=)
AT (1) ATE260910T1 (https=)
AU (1) AU9536898A (https=)
DE (2) DE19741051A1 (https=)
DK (1) DK1017692T3 (https=)
ES (1) ES2216316T3 (https=)
HN (1) HN1998000143A (https=)
PT (1) PT1017692E (https=)
WO (1) WO1999014215A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2275091A1 (en) 2001-06-22 2011-01-19 Pfizer Products Inc. Pharmaceutical compositions comprising adsorbates of an amorphous drug
EP2283822A2 (en) 2003-08-04 2011-02-16 Bend Research, Inc. Spray drying processes for forming solid amorphous dispersions of drugs and polymers
WO2012027331A1 (en) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
EP2548894A1 (en) 2005-02-03 2013-01-23 Bend Research, Inc. Pharmaceutical compositions with enhanced performance
US9468604B2 (en) 2001-06-22 2016-10-18 Bend Research, Inc. Pharmaceutical compositions of dispersions of drug and neutral polymers

Families Citing this family (38)

* Cited by examiner, † Cited by third party
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US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
DE19741051A1 (de) * 1997-09-18 1999-03-25 Bayer Ag Hetero-Tetrahydrochinoline
WO2000038721A1 (en) 1998-12-23 2000-07-06 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications
US7115279B2 (en) 2000-08-03 2006-10-03 Curatolo William J Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors
EP1269994A3 (en) 2001-06-22 2003-02-12 Pfizer Products Inc. Pharmaceutical compositions comprising drug and concentration-enhancing polymers
DE10148436A1 (de) * 2001-10-01 2003-04-17 Bayer Ag Tetrahydrochinoline
US6817530B2 (en) 2001-12-18 2004-11-16 Digimarc Id Systems Multiple image security features for identification documents and methods of making same
IL162533A0 (en) 2001-12-19 2005-11-20 Atherogenics Inc Chalcone derivatives and their use to treat diseases
WO2003053359A2 (en) 2001-12-19 2003-07-03 Atherogenics, Inc. 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders
US7728048B2 (en) 2002-12-20 2010-06-01 L-1 Secure Credentialing, Inc. Increasing thermal conductivity of host polymer used with laser engraving methods and compositions
US6852753B2 (en) 2002-01-17 2005-02-08 Pharmacia Corporation Alkyl/aryl hydroxy or keto thiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake
DE60320940D1 (de) 2002-02-01 2008-06-26 Pfizer Prod Inc Pharmazeutische zusammensetzungen amorpher dispersionen von wirkstoffen und lipophiler mikrophasenbildender materialien
AR038375A1 (es) 2002-02-01 2005-01-12 Pfizer Prod Inc Composiciones farmaceuticas de inhibidores de la proteina de transferencia de esteres de colesterilo
US7824029B2 (en) 2002-05-10 2010-11-02 L-1 Secure Credentialing, Inc. Identification card printer-assembler for over the counter card issuing
JP2006513186A (ja) 2002-12-20 2006-04-20 ファイザー・プロダクツ・インク Ｃｅｔｐ阻害剤およびｈｍｇ−ｃｏａレダクターゼ阻害剤を含む剤形
PT1603553E (pt) 2003-03-17 2012-02-03 Japan Tobacco Inc Composições farmacêuticas de inibidores de cetp
DE602004030434D1 (de) 2003-04-16 2011-01-20 L 1 Secure Credentialing Inc Dreidimensionale datenspeicherung
TWI494102B (zh) * 2003-05-02 2015-08-01 Japan Tobacco Inc 包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合
BRPI0413277A (pt) 2003-08-04 2006-10-10 Pfizer Prod Inc composições farmacêuticas de adsorvatos de medicamentos amorfos e materiais que formam microfases lipofìlicas
MXPA06003357A (es) * 2003-09-26 2006-06-08 Japan Tobacco Inc Metodo para inhibir la produccion de lipoproteina remanente.
EP1720893B1 (en) * 2004-02-26 2014-08-13 Baylor Research Institute Compositions and methods for the systemic treatment of arthritis
US8127137B2 (en) 2004-03-18 2012-02-28 Digimarc Corporation Watermark payload encryption for media including multiple watermarks
US20060116369A1 (en) * 2004-10-25 2006-06-01 Shyamlal Ramchandani Certain compounds, compositions, and methods
WO2006065842A2 (en) * 2004-12-13 2006-06-22 Synta Pharmaceuticals Corp. 5,6,7,8-tetrahydroquinolines and related compounds and uses thereof
ES2384980T3 (es) * 2004-12-18 2012-07-16 Bayer Pharma Aktiengesellschaft Derivados de tetrahidroquinolina sustituidos en 4 con cicloalquilo y su uso como medicamentos
BRPI0519566A2 (pt) * 2004-12-18 2009-01-27 Bayer Healthcare Ag derivados de (5s)-3-[(s)-fléor(4-trifluormetilfenil)metil]-5,6,7,8-tet raidroquinolin-5-ol e seu uso como inibidores de cetp
WO2006098394A1 (ja) * 2005-03-14 2006-09-21 Japan Tobacco Inc. 脂質吸収抑制方法および脂質吸収抑制剤
US7737155B2 (en) 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
JP2009512715A (ja) 2005-10-21 2009-03-26 ノバルティス アクチエンゲゼルシャフト レニン阻害剤と抗異脂肪血症剤および／または抗肥満症剤の組み合わせ
DE102006012548A1 (de) * 2006-03-18 2007-09-20 Bayer Healthcare Ag Substituierte Chromanol-Derivate und ihre Verwendung
BRPI0909105A2 (pt) * 2008-03-05 2015-08-25 Boehringer Ingelheim Int Derivados de piridina tricíclicos, composição farmacêutica e uso dos mesmos, bem como processos para preparar os ditos compostos e a dita composição farmacêutica
EP2379547A1 (en) 2008-12-16 2011-10-26 Schering Corporation Pyridopyrimidine derivatives and methods of use thereof
US20110243940A1 (en) 2008-12-16 2011-10-06 Schering Corporation Bicyclic pyranone derivatives and methods of use thereof
UY33229A (es) 2010-02-19 2011-09-30 Boehringer Ingelheim Int Derivados de piridina tricíclicos, medicamentos que contienen tales compuestos, su uso y proceso pa ra su preparación
CA2804924C (en) * 2010-07-09 2016-06-28 Daiichi Sankyo Company, Limited Substituted pyridine compound
EP2760868B1 (en) 2011-08-17 2018-04-25 Boehringer Ingelheim International GmbH Furo[3,4-c]quinoline derivatives, medicaments containing such compounds, their use and process for their preparation
TWI570118B (zh) * 2012-01-06 2017-02-11 第一三共股份有限公司 經取代之吡啶化合物的酸加成鹽
US20230227410A1 (en) * 2022-01-17 2023-07-20 King Abdulaziz University Tetrahydroquinoline derivatives and a process of preparation thereof

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
US5169857A (en) 1988-01-20 1992-12-08 Bayer Aktiengesellschaft 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis
CA1336714C (en) * 1987-08-20 1995-08-15 Yoshihiro Fujikawa Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis
DE68918713T2 (de) 1988-01-18 1995-03-16 Toshiba Kawasaki Kk Interne Pumpe für Kernreaktor.
NO177005C (no) * 1988-01-20 1995-07-05 Bayer Ag Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen
DE19627431A1 (de) 1996-07-08 1998-01-15 Bayer Ag Heterocyclisch kondensierte Pyridine
DE19709125A1 (de) 1997-03-06 1998-09-10 Bayer Ag Substituierte Chinoline
DE19741051A1 (de) * 1997-09-18 1999-03-25 Bayer Ag Hetero-Tetrahydrochinoline

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2275091A1 (en) 2001-06-22 2011-01-19 Pfizer Products Inc. Pharmaceutical compositions comprising adsorbates of an amorphous drug
US8389006B2 (en) 2001-06-22 2013-03-05 Bend Research, Inc. Pharmaceutical compositions of adsorbates of amorphous drug
US8703199B2 (en) 2001-06-22 2014-04-22 Bend Research, Inc. Pharmaceutical compositions of adsorbates of amorphous drug
US9468604B2 (en) 2001-06-22 2016-10-18 Bend Research, Inc. Pharmaceutical compositions of dispersions of drug and neutral polymers
EP2283822A2 (en) 2003-08-04 2011-02-16 Bend Research, Inc. Spray drying processes for forming solid amorphous dispersions of drugs and polymers
EP2548894A1 (en) 2005-02-03 2013-01-23 Bend Research, Inc. Pharmaceutical compositions with enhanced performance
WO2012027331A1 (en) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders

Also Published As

Publication number Publication date
US6387929B1 (en) 2002-05-14
PT1017692E (pt) 2004-06-30
DK1017692T3 (da) 2004-07-12
US6958346B2 (en) 2005-10-25
EP1017692A1 (de) 2000-07-12
WO1999014215A1 (de) 1999-03-25
US20020062024A1 (en) 2002-05-23
US20070142420A1 (en) 2007-06-21
ATE260910T1 (de) 2004-03-15
DE59810922D1 (de) 2004-04-08
US7192971B2 (en) 2007-03-20
ES2216316T3 (es) 2004-10-16
HN1998000143A (es) 1999-04-09
JP2001516757A (ja) 2001-10-02
US20060069112A1 (en) 2006-03-30
AU9536898A (en) 1999-04-05
EP1017692B1 (de) 2004-03-03

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