DE19736772A1 - Cyclopeptidderivate - Google Patents

Cyclopeptidderivate

Info

Publication number
DE19736772A1
DE19736772A1 DE19736772A DE19736772A DE19736772A1 DE 19736772 A1 DE19736772 A1 DE 19736772A1 DE 19736772 A DE19736772 A DE 19736772A DE 19736772 A DE19736772 A DE 19736772A DE 19736772 A1 DE19736772 A1 DE 19736772A1
Authority
DE
Germany
Prior art keywords
formula
compounds
acid
salts
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19736772A
Other languages
German (de)
English (en)
Inventor
Guenter Dr Hoelzemann
Simon Dr Goodman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Priority to DE19736772A priority Critical patent/DE19736772A1/de
Priority to RU2000107122/04A priority patent/RU2200166C2/ru
Priority to AU95319/98A priority patent/AU734829B2/en
Priority to PL98341090A priority patent/PL341090A1/xx
Priority to JP2000507697A priority patent/JP2001514186A/ja
Priority to IDW20000532A priority patent/ID23952A/id
Priority to SK213-2000A priority patent/SK2132000A3/sk
Priority to CN98808380A priority patent/CN1267306A/zh
Priority to EP98948833A priority patent/EP1007545A2/de
Priority to PCT/EP1998/005161 priority patent/WO1999010371A2/de
Priority to BR9811992-3A priority patent/BR9811992A/pt
Priority to HU0003500A priority patent/HUP0003500A3/hu
Priority to KR1020007001430A priority patent/KR20010022828A/ko
Priority to CA002301182A priority patent/CA2301182A1/en
Priority to TW087113657A priority patent/TW477793B/zh
Priority to ZA987558A priority patent/ZA987558B/xx
Priority to ARP980104136A priority patent/AR013650A1/es
Publication of DE19736772A1 publication Critical patent/DE19736772A1/de
Priority to NO20000860A priority patent/NO20000860D0/no
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19736772A 1997-08-23 1997-08-23 Cyclopeptidderivate Withdrawn DE19736772A1 (de)

Priority Applications (18)

Application Number Priority Date Filing Date Title
DE19736772A DE19736772A1 (de) 1997-08-23 1997-08-23 Cyclopeptidderivate
PCT/EP1998/005161 WO1999010371A2 (de) 1997-08-23 1998-08-14 Cyclopeptidderivate als adhäsionsinhibitoren
BR9811992-3A BR9811992A (pt) 1997-08-23 1998-08-14 Derivados de ciclopeptìdeos
PL98341090A PL341090A1 (en) 1997-08-23 1998-08-14 Cyclic derivatives of peptides as adhesion inhibitors
JP2000507697A JP2001514186A (ja) 1997-08-23 1998-08-14 接着インヒビターとしてのシクロペプチド誘導体
IDW20000532A ID23952A (id) 1997-08-23 1998-08-14 Turunan-turunan siklopeptida
SK213-2000A SK2132000A3 (en) 1997-08-23 1998-08-14 Cyclopeptide derivatives as adhesion inhibitors
CN98808380A CN1267306A (zh) 1997-08-23 1998-08-14 作为粘着抑制剂的环肽衍生物
EP98948833A EP1007545A2 (de) 1997-08-23 1998-08-14 Cyclopeptidderivate als adhäsionsinhibitoren
RU2000107122/04A RU2200166C2 (ru) 1997-08-23 1998-08-14 Производные циклопептидов в качестве ингибиторов адгезии
AU95319/98A AU734829B2 (en) 1997-08-23 1998-08-14 Cyclopeptide derivatives
HU0003500A HUP0003500A3 (en) 1997-08-23 1998-08-14 Cyclopeptide derivatives as adhesion inhibitors, pharmaceutical composition containing thereof, process for production thereof and their use
KR1020007001430A KR20010022828A (ko) 1997-08-23 1998-08-14 유착 억제제로서의 시클로펩티드 유도체
CA002301182A CA2301182A1 (en) 1997-08-23 1998-08-14 Cyclopeptide derivatives
TW087113657A TW477793B (en) 1997-08-23 1998-08-19 Cyclopeptide derivatives
ZA987558A ZA987558B (en) 1997-08-23 1998-08-20 Cyclopeptide derivatives
ARP980104136A AR013650A1 (es) 1997-08-23 1998-08-21 Derivados de peptidos ciclicos, sus enantiomeros y diastereomeros, un procedimiento para su preparacion, su empleo para preparar un medicamento, laspreparaciones farmaceuticas que los contienen y un procedimiento para obtener estas preparaciones farmaceuticas
NO20000860A NO20000860D0 (no) 1997-08-23 2000-02-22 Syklopeptidderivater som adhesjonsinhibitorer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19736772A DE19736772A1 (de) 1997-08-23 1997-08-23 Cyclopeptidderivate

Publications (1)

Publication Number Publication Date
DE19736772A1 true DE19736772A1 (de) 1999-02-25

Family

ID=7839977

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19736772A Withdrawn DE19736772A1 (de) 1997-08-23 1997-08-23 Cyclopeptidderivate

Country Status (18)

Country Link
EP (1) EP1007545A2 (zh)
JP (1) JP2001514186A (zh)
KR (1) KR20010022828A (zh)
CN (1) CN1267306A (zh)
AR (1) AR013650A1 (zh)
AU (1) AU734829B2 (zh)
BR (1) BR9811992A (zh)
CA (1) CA2301182A1 (zh)
DE (1) DE19736772A1 (zh)
HU (1) HUP0003500A3 (zh)
ID (1) ID23952A (zh)
NO (1) NO20000860D0 (zh)
PL (1) PL341090A1 (zh)
RU (1) RU2200166C2 (zh)
SK (1) SK2132000A3 (zh)
TW (1) TW477793B (zh)
WO (1) WO1999010371A2 (zh)
ZA (1) ZA987558B (zh)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA43823C2 (uk) * 1992-07-06 2002-01-15 Мерк Патент Геселлшафт Міт Бесшренктер Хафтунг ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ДЛЯ ІНГІБУВАННЯ ІНТЕГРИН <font face="Symbol">a</font><sub>V</sub><font face="Symbol">b</font><sub>3</sub>-ОПОСЕРЕДКОВАНОЇ КЛІТИННОЇ АДГЕЗІЇ КЛІТИН ССАВЦІВ, СПОСІБ ЛІКУВАННЯ ТА ПРОФІЛАКТИКИ ЗАХВОРЮВАННЯ, АСОЦІЙОВАНОГО З ПОРУШЕННЯМ АДГЕЗІЇ КЛІТИН, СПОСІБ БЛОКУВАННЯ ЗВ'ЯЗУВАННЯ ФІБРИНОГЕНОМ ІНТЕГРИНУ, КОМПОЗИЦІЯ ДЛЯ ЗАГОЄННЯ РАН
DE4310643A1 (de) * 1993-04-01 1994-10-06 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren
DE4415310A1 (de) * 1994-04-30 1995-11-02 Merck Patent Gmbh Cyclopeptide
JPH07316193A (ja) * 1994-05-24 1995-12-05 Asahi Glass Co Ltd ペプチド誘導体およびその用途

Also Published As

Publication number Publication date
NO20000860L (no) 2000-02-22
HUP0003500A3 (en) 2001-12-28
NO20000860D0 (no) 2000-02-22
ZA987558B (en) 1999-02-23
HUP0003500A2 (hu) 2001-02-28
PL341090A1 (en) 2001-03-26
AR013650A1 (es) 2001-01-10
AU9531998A (en) 1999-03-16
AU734829B2 (en) 2001-06-21
ID23952A (id) 2000-06-08
CN1267306A (zh) 2000-09-20
TW477793B (en) 2002-03-01
BR9811992A (pt) 2000-09-05
CA2301182A1 (en) 1999-03-04
WO1999010371A2 (de) 1999-03-04
RU2200166C2 (ru) 2003-03-10
JP2001514186A (ja) 2001-09-11
KR20010022828A (ko) 2001-03-26
WO1999010371A3 (de) 1999-05-27
EP1007545A2 (de) 2000-06-14
SK2132000A3 (en) 2000-09-12

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Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee