DE19729810C2 - Mittel zur Sepsistherapie, seine Herstellung und seine Verwendung - Google Patents

Mittel zur Sepsistherapie, seine Herstellung und seine Verwendung

Info

Publication number
DE19729810C2
DE19729810C2 DE19729810A DE19729810A DE19729810C2 DE 19729810 C2 DE19729810 C2 DE 19729810C2 DE 19729810 A DE19729810 A DE 19729810A DE 19729810 A DE19729810 A DE 19729810A DE 19729810 C2 DE19729810 C2 DE 19729810C2
Authority
DE
Germany
Prior art keywords
lbp
sepsis
therapy
lps
composition according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE19729810A
Other languages
German (de)
English (en)
Other versions
DE19729810A1 (de
Inventor
Ralf Reiner Schumann
Norbert Lamping
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Delbrück Center for Molecular Medicine
Original Assignee
Max Delbrück Center for Molecular Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE19729810A priority Critical patent/DE19729810C2/de
Application filed by Max Delbrück Center for Molecular Medicine filed Critical Max Delbrück Center for Molecular Medicine
Priority to ES98928139T priority patent/ES2183376T3/es
Priority to EP98928139A priority patent/EP0999849B1/de
Priority to DK98928139T priority patent/DK0999849T3/da
Priority to JP2000501768A priority patent/JP2001509488A/ja
Priority to PCT/DE1998/000964 priority patent/WO1999002178A1/de
Priority to DE59805440T priority patent/DE59805440D1/de
Priority to AT98928139T priority patent/ATE223227T1/de
Priority to PT98928139T priority patent/PT999849E/pt
Publication of DE19729810A1 publication Critical patent/DE19729810A1/de
Application granted granted Critical
Priority to US09/484,121 priority patent/US6949512B1/en
Publication of DE19729810C2 publication Critical patent/DE19729810C2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1751—Bactericidal/permeability-increasing protein [BPI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Saccharide Compounds (AREA)
DE19729810A 1997-07-11 1997-07-11 Mittel zur Sepsistherapie, seine Herstellung und seine Verwendung Expired - Fee Related DE19729810C2 (de)

Priority Applications (10)

Application Number Priority Date Filing Date Title
DE19729810A DE19729810C2 (de) 1997-07-11 1997-07-11 Mittel zur Sepsistherapie, seine Herstellung und seine Verwendung
PT98928139T PT999849E (pt) 1997-07-11 1998-04-04 Utilizacao de lbp no tratamento da septicemia
DK98928139T DK0999849T3 (da) 1997-07-11 1998-04-04 Anvendelse af LBP til sepsisbehandling
JP2000501768A JP2001509488A (ja) 1997-07-11 1998-04-04 敗血症治療薬、その製造及び使用
PCT/DE1998/000964 WO1999002178A1 (de) 1997-07-11 1998-04-04 Mittel zur sepsistherapie, seine herstellung und seine verwendung
DE59805440T DE59805440D1 (de) 1997-07-11 1998-04-04 Verwendung von lbp zur sepsistherapie
ES98928139T ES2183376T3 (es) 1997-07-11 1998-04-04 Uso de lbp para el tratamiento de la septicemia.
EP98928139A EP0999849B1 (de) 1997-07-11 1998-04-04 Verwendung von lbp zur sepsistherapie
AT98928139T ATE223227T1 (de) 1997-07-11 1998-04-04 Verwendung von lbp zur sepsistherapie
US09/484,121 US6949512B1 (en) 1997-07-11 2000-01-13 Therapeutic agent for the treatment of septicaemia its preparation and use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19729810A DE19729810C2 (de) 1997-07-11 1997-07-11 Mittel zur Sepsistherapie, seine Herstellung und seine Verwendung

Publications (2)

Publication Number Publication Date
DE19729810A1 DE19729810A1 (de) 1999-01-14
DE19729810C2 true DE19729810C2 (de) 2000-01-13

Family

ID=7835437

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19729810A Expired - Fee Related DE19729810C2 (de) 1997-07-11 1997-07-11 Mittel zur Sepsistherapie, seine Herstellung und seine Verwendung
DE59805440T Expired - Lifetime DE59805440D1 (de) 1997-07-11 1998-04-04 Verwendung von lbp zur sepsistherapie

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59805440T Expired - Lifetime DE59805440D1 (de) 1997-07-11 1998-04-04 Verwendung von lbp zur sepsistherapie

Country Status (9)

Country Link
US (1) US6949512B1 (enExample)
EP (1) EP0999849B1 (enExample)
JP (1) JP2001509488A (enExample)
AT (1) ATE223227T1 (enExample)
DE (2) DE19729810C2 (enExample)
DK (1) DK0999849T3 (enExample)
ES (1) ES2183376T3 (enExample)
PT (1) PT999849E (enExample)
WO (1) WO1999002178A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2108372A1 (en) * 2008-04-09 2009-10-14 Forschungszentrum Borstel Leibniz-Zentrum für Medizin und Biowissenschaften Novel antimicrobial peptides

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994025476A1 (en) * 1993-04-30 1994-11-10 Incyte Pharmaceuticals, Inc. Recombinant bpi-based and lbp-based proteins, nucleic acid molecules encoding same, methods of producing same, and uses thereof
WO1995005393A2 (en) * 1993-08-18 1995-02-23 Morphosys Gesellschaft Für Proteinoptimierung Mbh Lipopolysaccharide-binding and neutralizing peptides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995008560A1 (en) * 1993-09-24 1995-03-30 Centocor, Inc. Novel peptides useful for inhibiting binding of lipopolysaccharides (lps) by lipopolysaccharide binding protein (lbp)
US5837810A (en) * 1994-03-15 1998-11-17 The Scripps Research Institute Polypeptides of lipopolysaccharide binding protein
US5990082A (en) * 1997-10-22 1999-11-23 Xoma Corporation Uses of lipopolysaccharide binding protein

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994025476A1 (en) * 1993-04-30 1994-11-10 Incyte Pharmaceuticals, Inc. Recombinant bpi-based and lbp-based proteins, nucleic acid molecules encoding same, methods of producing same, and uses thereof
WO1995005393A2 (en) * 1993-08-18 1995-02-23 Morphosys Gesellschaft Für Proteinoptimierung Mbh Lipopolysaccharide-binding and neutralizing peptides

Also Published As

Publication number Publication date
EP0999849B1 (de) 2002-09-04
ES2183376T3 (es) 2003-03-16
DK0999849T3 (da) 2003-01-06
DE19729810A1 (de) 1999-01-14
US6949512B1 (en) 2005-09-27
JP2001509488A (ja) 2001-07-24
EP0999849A1 (de) 2000-05-17
PT999849E (pt) 2003-01-31
WO1999002178A1 (de) 1999-01-21
ATE223227T1 (de) 2002-09-15
DE59805440D1 (de) 2002-10-10

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee