DE1795823C3 - Desacetylvincaleukoblastin und seine Salze mit Säuren - Google Patents

Desacetylvincaleukoblastin und seine Salze mit Säuren

Info

Publication number
DE1795823C3
DE1795823C3 DE1795823A DE1795823A DE1795823C3 DE 1795823 C3 DE1795823 C3 DE 1795823C3 DE 1795823 A DE1795823 A DE 1795823A DE 1795823 A DE1795823 A DE 1795823A DE 1795823 C3 DE1795823 C3 DE 1795823C3
Authority
DE
Germany
Prior art keywords
methylene dichloride
mixture
salts
residue
vlb
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE1795823A
Other languages
German (de)
English (en)
Other versions
DE1795823B2 (de
DE1795823A1 (de
Inventor
William Walter Indianapolis Ind. Hargrove
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Priority to DE1795823A priority Critical patent/DE1795823C3/de
Publication of DE1795823A1 publication Critical patent/DE1795823A1/de
Publication of DE1795823B2 publication Critical patent/DE1795823B2/de
Application granted granted Critical
Publication of DE1795823C3 publication Critical patent/DE1795823C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE1795823A 1964-03-09 1965-03-08 Desacetylvincaleukoblastin und seine Salze mit Säuren Expired DE1795823C3 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE1795823A DE1795823C3 (de) 1964-03-09 1965-03-08 Desacetylvincaleukoblastin und seine Salze mit Säuren

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US350519A US3392173A (en) 1964-03-09 1964-03-09 Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
DE1795823A DE1795823C3 (de) 1964-03-09 1965-03-08 Desacetylvincaleukoblastin und seine Salze mit Säuren

Publications (3)

Publication Number Publication Date
DE1795823A1 DE1795823A1 (de) 1976-02-05
DE1795823B2 DE1795823B2 (de) 1981-04-30
DE1795823C3 true DE1795823C3 (de) 1982-04-15

Family

ID=23377073

Family Applications (3)

Application Number Title Priority Date Filing Date
DE1795763A Expired DE1795763C3 (de) 1964-03-09 1965-03-08 Verfahren zur Herstellung von Vincaleukoblastin- und Leurocristinderivaten
DE1795823A Expired DE1795823C3 (de) 1964-03-09 1965-03-08 Desacetylvincaleukoblastin und seine Salze mit Säuren
DE1545760A Expired DE1545760C3 (de) 1964-03-09 1965-03-08 Vincaleukoblastinderivate

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE1795763A Expired DE1795763C3 (de) 1964-03-09 1965-03-08 Verfahren zur Herstellung von Vincaleukoblastin- und Leurocristinderivaten

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE1545760A Expired DE1545760C3 (de) 1964-03-09 1965-03-08 Vincaleukoblastinderivate

Country Status (9)

Country Link
US (1) US3392173A (US08080257-20111220-C00005.png)
BE (1) BE660843A (US08080257-20111220-C00005.png)
CH (1) CH507970A (US08080257-20111220-C00005.png)
DE (3) DE1795763C3 (US08080257-20111220-C00005.png)
ES (1) ES310240A1 (US08080257-20111220-C00005.png)
FR (2) FR1449628A (US08080257-20111220-C00005.png)
GB (1) GB1095833A (US08080257-20111220-C00005.png)
NL (1) NL6502977A (US08080257-20111220-C00005.png)
SE (1) SE330700B (US08080257-20111220-C00005.png)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899493A (en) * 1972-12-29 1975-08-12 Richter Gedeon Vegyeszet Chromic acid oxidation of vinblastine sulfate to form vincristine
HU165986B (US08080257-20111220-C00005.png) * 1973-02-16 1974-12-28
US4012390A (en) * 1974-10-16 1977-03-15 Eli Lilly And Company Vinblastinoic acid
US3954773A (en) * 1974-11-21 1976-05-04 Eli Lilly And Company 4-Desacetoxyvinblastine
US3944554A (en) * 1975-01-09 1976-03-16 Eli Lilly And Company 4-Desacetoxy-3-hydroxyvinblastine
US4029663A (en) * 1975-07-10 1977-06-14 Eli Lilly And Company Dimeric anhydro-vinca derivatives
US4209443A (en) * 1976-02-13 1980-06-24 Richter Gedeon Vegyeszeti Gyar Rt. Process for separating pharmaceutically active diindole alkaloids
US4143041A (en) * 1977-01-19 1979-03-06 Eli Lilly And Company 4'-Deoxyvincristine and related compounds
HU178084B (en) * 1977-05-31 1982-03-28 Richter Gedeon Vegyeszet New process for the extraction of native vindoline,catharantine,3',4'-anhydrovinblastine,leurosine and,if desired,of other diinodle alkaloids from vinca rosea l.drogue
US4195022A (en) * 1978-03-27 1980-03-25 Eli Lilly And Company 4-Desacetoxy-4α-hydroxyvinblastine and related compounds
US4166810A (en) * 1978-04-20 1979-09-04 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide
HU178706B (en) * 1979-04-23 1982-06-28 Richter Gedeon Vegyeszet Process for preparing bis-indole alkaloids and acid addition salts thereof
FR2461714A1 (fr) 1979-07-17 1981-02-06 Anvar Nouvelle classe de composes bis-indoliques utiles comme medicaments et procede pour leur preparation
DK167984A (da) * 1983-03-30 1984-10-01 Lilly Industries Ltd Alkaloidderivater
US4522750A (en) * 1984-02-21 1985-06-11 Eli Lilly And Company Cytotoxic compositions of transferrin coupled to vinca alkaloids
HU193318B (en) * 1985-06-12 1987-09-28 Richter Gedeon Vegyeszet Process for producing new bis- indol derivatives
HU198074B (en) * 1985-06-12 1989-07-28 Richter Gedeon Vegyeszet Process for producing new bis-indole derivatives and pharmaceutical compositions comprising these compounds
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4801688A (en) * 1986-05-27 1989-01-31 Eli Lilly And Company Hydrazone immunoglobulin conjugates
HUT76925A (hu) * 1995-04-04 1998-01-28 MTA Enzimológiai Intézet Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények
US6326402B1 (en) 1998-08-12 2001-12-04 Octamer, Inc. Methods for treating viral infections using a compound capable of inhibiting microtubules
DE60231868D1 (de) 2001-04-24 2009-05-20 Purdue Research Foundation Folat-mimetika und deren folatrezeptorbindende konjugate
WO2003097647A1 (en) * 2002-05-15 2003-11-27 Endocyte, Inc. Vitamin-mitomycin conjugates
DK1592457T3 (da) 2003-01-27 2012-10-22 Endocyte Inc Folat-vinblastin-konjugat som lægemiddel
JP5149620B2 (ja) 2004-07-23 2013-02-20 エンドサイト，インコーポレイテッド ２価リンカーおよびその結合体
US8044200B2 (en) * 2005-03-16 2011-10-25 Endocyte, Inc. Synthesis and purification of pteroic acid and conjugates thereof
AU2006279304A1 (en) 2005-08-19 2007-02-22 Endocyte, Inc. Multi-drug ligand conjugates
EP2382995A3 (en) 2005-08-19 2013-09-25 Endocyte, Inc. Ligand conjugates of Vinca alkaloids, analogs and derivatives
WO2008101231A2 (en) * 2007-02-16 2008-08-21 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
WO2008112873A2 (en) * 2007-03-14 2008-09-18 Endocyte, Inc. Binding ligand linked drug delivery conjugates of tubulysins
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
CN104383553A (zh) * 2007-06-25 2015-03-04 恩多塞特公司 含有亲水性间隔区接头的共轭物
EP2209374B1 (en) 2007-10-25 2014-12-03 Endocyte, Inc. Tubulysins and processes for preparing
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
BR112015008365A2 (pt) 2012-10-16 2017-07-04 Endocyte Inc composto da fórmula b-l(d)x, ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto, composição de forma de dosagem unitária ou dose unitária, composição para tratar um câncer em um paciente, e método para tratar um câncer em um paciente

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine
US3169968A (en) * 1962-05-08 1965-02-16 Ciba Geigy Corp Esters of ajmaline and related compounds
US3225053A (en) * 1963-01-10 1965-12-21 Lilly Co Eli Quebrachidine and derivatives

Also Published As

Publication number Publication date
US3392173A (en) 1968-07-09
ES310240A1 (es) 1965-10-16
FR6668M (US08080257-20111220-C00005.png) 1969-02-03
DE1795763B2 (de) 1977-11-10
DE1795823B2 (de) 1981-04-30
DE1545760A1 (de) 1969-11-27
GB1095833A (en) 1967-12-20
DE1545760C3 (de) 1978-10-05
NL6502977A (US08080257-20111220-C00005.png) 1965-09-10
DE1795763A1 (de) 1974-11-21
DE1795763C3 (de) 1978-06-29
BE660843A (US08080257-20111220-C00005.png) 1965-09-09
FR1449628A (fr) 1966-08-19
CH507970A (de) 1971-05-31
DE1545760B2 (de) 1978-02-09
SE330700B (US08080257-20111220-C00005.png) 1970-11-30
DE1795823A1 (de) 1976-02-05

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