DE1617363B1 - Verfahren zur Herstellung hochaktiver Enzym-Verdauungspraeparate - Google Patents
Verfahren zur Herstellung hochaktiver Enzym-VerdauungspraeparateInfo
- Publication number
- DE1617363B1 DE1617363B1 DE1967B0095714 DEB0095714A DE1617363B1 DE 1617363 B1 DE1617363 B1 DE 1617363B1 DE 1967B0095714 DE1967B0095714 DE 1967B0095714 DE B0095714 A DEB0095714 A DE B0095714A DE 1617363 B1 DE1617363 B1 DE 1617363B1
- Authority
- DE
- Germany
- Prior art keywords
- preparations
- enzymes
- active
- digestive
- small intestine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000004190 Enzymes Human genes 0.000 title claims description 48
- 108090000790 Enzymes Proteins 0.000 title claims description 48
- 238000002360 preparation method Methods 0.000 title claims description 35
- 230000001079 digestive effect Effects 0.000 title claims description 16
- 238000000034 method Methods 0.000 title claims description 10
- 238000004519 manufacturing process Methods 0.000 title claims description 9
- 229940088598 enzyme Drugs 0.000 claims description 47
- 239000008187 granular material Substances 0.000 claims description 20
- 210000000813 small intestine Anatomy 0.000 claims description 15
- 239000008298 dragée Substances 0.000 claims description 14
- 230000000694 effects Effects 0.000 claims description 13
- 210000002784 stomach Anatomy 0.000 claims description 10
- 230000002496 gastric effect Effects 0.000 claims description 9
- 229920003023 plastic Polymers 0.000 claims description 9
- 239000004033 plastic Substances 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 7
- 239000002518 antifoaming agent Substances 0.000 claims description 7
- 108091005804 Peptidases Proteins 0.000 claims description 6
- 102000035195 Peptidases Human genes 0.000 claims description 6
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 6
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 6
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 6
- 108090001060 Lipase Proteins 0.000 claims description 5
- 102000004882 Lipase Human genes 0.000 claims description 5
- 239000004367 Lipase Substances 0.000 claims description 5
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 5
- 235000019421 lipase Nutrition 0.000 claims description 5
- 239000000047 product Substances 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 238000000576 coating method Methods 0.000 claims description 4
- 239000010410 layer Substances 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 239000011248 coating agent Substances 0.000 claims description 3
- 239000007884 disintegrant Substances 0.000 claims description 3
- 210000004211 gastric acid Anatomy 0.000 claims description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 3
- 230000001681 protective effect Effects 0.000 claims description 3
- 238000012360 testing method Methods 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 2
- 239000011241 protective layer Substances 0.000 claims description 2
- 238000003860 storage Methods 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims 14
- 239000002775 capsule Substances 0.000 claims 4
- 239000001828 Gelatine Substances 0.000 claims 2
- 239000011324 bead Substances 0.000 claims 2
- 239000007891 compressed tablet Substances 0.000 claims 2
- 229920000159 gelatin Polymers 0.000 claims 2
- 235000019322 gelatine Nutrition 0.000 claims 2
- 230000000968 intestinal effect Effects 0.000 claims 2
- 102000013142 Amylases Human genes 0.000 claims 1
- 108010065511 Amylases Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 235000019418 amylase Nutrition 0.000 claims 1
- 229940025131 amylases Drugs 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000011049 filling Methods 0.000 claims 1
- 206010016766 flatulence Diseases 0.000 claims 1
- 238000005469 granulation Methods 0.000 claims 1
- 230000003179 granulation Effects 0.000 claims 1
- 239000008188 pellet Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000002994 raw material Substances 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000013589 supplement Substances 0.000 claims 1
- 230000009747 swallowing Effects 0.000 claims 1
- 239000002966 varnish Substances 0.000 description 17
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 7
- 206010033645 Pancreatitis Diseases 0.000 description 6
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 description 6
- 229920000609 methyl cellulose Polymers 0.000 description 6
- 239000001923 methylcellulose Substances 0.000 description 6
- 235000010981 methylcellulose Nutrition 0.000 description 6
- 229910002012 Aerosil® Inorganic materials 0.000 description 5
- 241000228212 Aspergillus Species 0.000 description 5
- 235000019833 protease Nutrition 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 4
- 229920002125 Sokalan® Polymers 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 4
- 239000004584 polyacrylic acid Substances 0.000 description 4
- 239000008107 starch Substances 0.000 description 4
- 235000019698 starch Nutrition 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 229920000623 Cellulose acetate phthalate Polymers 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 229920003136 Eudragit® L polymer Polymers 0.000 description 3
- 229920003134 Eudragit® polymer Polymers 0.000 description 3
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 3
- 208000035467 Pancreatic insufficiency Diseases 0.000 description 3
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical group ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 description 3
- 229940081734 cellulose acetate phthalate Drugs 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- XINQFOMFQFGGCQ-UHFFFAOYSA-L (2-dodecoxy-2-oxoethyl)-[6-[(2-dodecoxy-2-oxoethyl)-dimethylazaniumyl]hexyl]-dimethylazanium;dichloride Chemical compound [Cl-].[Cl-].CCCCCCCCCCCCOC(=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(=O)OCCCCCCCCCCCC XINQFOMFQFGGCQ-UHFFFAOYSA-L 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 210000004051 gastric juice Anatomy 0.000 description 2
- 239000004922 lacquer Substances 0.000 description 2
- 235000019626 lipase activity Nutrition 0.000 description 2
- 239000003973 paint Substances 0.000 description 2
- 229950010604 pancreas powder Drugs 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 238000011533 pre-incubation Methods 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 208000000668 Chronic Pancreatitis Diseases 0.000 description 1
- 108090000317 Chymotrypsin Proteins 0.000 description 1
- 108010048312 Combizym Proteins 0.000 description 1
- 241000206672 Gelidium Species 0.000 description 1
- 108010050548 Nutrizym Proteins 0.000 description 1
- 208000000407 Pancreatic Cyst Diseases 0.000 description 1
- 206010033649 Pancreatitis chronic Diseases 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 229960002376 chymotrypsin Drugs 0.000 description 1
- 239000013066 combination product Substances 0.000 description 1
- 229940127555 combination product Drugs 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000002183 duodenal effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 239000000416 hydrocolloid Substances 0.000 description 1
- 235000015243 ice cream Nutrition 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1967B0095714 DE1617363B1 (de) | 1967-12-06 | 1967-12-06 | Verfahren zur Herstellung hochaktiver Enzym-Verdauungspraeparate |
| BE724945D BE724945A (enrdf_load_stackoverflow) | 1967-12-06 | 1968-12-05 | |
| NL6817564A NL6817564A (enrdf_load_stackoverflow) | 1967-12-06 | 1968-12-06 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1967B0095714 DE1617363B1 (de) | 1967-12-06 | 1967-12-06 | Verfahren zur Herstellung hochaktiver Enzym-Verdauungspraeparate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1617363B1 true DE1617363B1 (de) | 1972-05-31 |
Family
ID=6988295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1967B0095714 Pending DE1617363B1 (de) | 1967-12-06 | 1967-12-06 | Verfahren zur Herstellung hochaktiver Enzym-Verdauungspraeparate |
Country Status (3)
| Country | Link |
|---|---|
| BE (1) | BE724945A (enrdf_load_stackoverflow) |
| DE (1) | DE1617363B1 (enrdf_load_stackoverflow) |
| NL (1) | NL6817564A (enrdf_load_stackoverflow) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0021129A3 (en) * | 1979-06-08 | 1981-11-11 | Kali-Chemie Pharma Gmbh | Pancreatin pellets, process for their manufacture and medicines containing these pellets |
| EP0283442A1 (en) * | 1987-01-21 | 1988-09-21 | Sandoz S.A. | Process for the manufacture of gastro-resistant and enterosoluble small spheres of digestive enzyme and pharmaceutical preparation so obtained |
| DK154610B (da) * | 1975-06-10 | 1988-12-05 | Johnson & Johnson | Fremgangsmaade til fremstilling af et fordoejelsesenzympraeparat |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1598458A (en) * | 1977-04-01 | 1981-09-23 | Hoechst Uk Ltd | Tableting of microcapsules |
-
1967
- 1967-12-06 DE DE1967B0095714 patent/DE1617363B1/de active Pending
-
1968
- 1968-12-05 BE BE724945D patent/BE724945A/xx unknown
- 1968-12-06 NL NL6817564A patent/NL6817564A/xx unknown
Non-Patent Citations (1)
| Title |
|---|
| None * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK154610B (da) * | 1975-06-10 | 1988-12-05 | Johnson & Johnson | Fremgangsmaade til fremstilling af et fordoejelsesenzympraeparat |
| EP0021129A3 (en) * | 1979-06-08 | 1981-11-11 | Kali-Chemie Pharma Gmbh | Pancreatin pellets, process for their manufacture and medicines containing these pellets |
| DE2923279C2 (de) * | 1979-06-08 | 1987-07-09 | Kali-Chemie Pharma Gmbh, 3000 Hannover | Verfahren zur Herstellung von Pankreatin-Pellets und diese enthaltende Arzneimittel |
| EP0283442A1 (en) * | 1987-01-21 | 1988-09-21 | Sandoz S.A. | Process for the manufacture of gastro-resistant and enterosoluble small spheres of digestive enzyme and pharmaceutical preparation so obtained |
Also Published As
| Publication number | Publication date |
|---|---|
| NL6817564A (enrdf_load_stackoverflow) | 1969-06-10 |
| BE724945A (enrdf_load_stackoverflow) | 1969-06-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0068191B1 (de) | Orale Dipyridamolformen | |
| DE69531934T2 (de) | Hydrophobe arzneistoffabgabesysteme | |
| DE69825165T2 (de) | Arzneimittelform mit zwei überzugs-schichten | |
| AT393081B (de) | Verfahren zur herstellung von cefuroximaxetilfilmtabletten | |
| DE68909772T2 (de) | Diclofenac-Natrium-Arzneizubereitung mit verlängerter Wirkstoffabgabe. | |
| EP0083775B1 (de) | Gut lösliche 5-Aminosalicylsäure-Arzneimittelzubereitungen | |
| EP0720473A1 (de) | Budesonid-pellets mit kontrolliertem freigabeprofil und verfahren zu ihrer herstellung | |
| DE3024858A1 (de) | Anhaltend freigebende pharmazeutische zubereitung eines festen medikamentmaterials | |
| WO2002060474A2 (de) | Gemische von enzymen aus pilzen und deren verwendung zur behandlung der maldigestion | |
| DE3318649A1 (de) | Zweiphasenformulierung | |
| CH641357A5 (de) | Pharmazeutisches praeparat mit polymerbeschichtungen, enthaltend herzglykoside. | |
| CH641358A5 (de) | Pharmazeutisches praeparat, enthaltend ein herzglykosid in kombination mit einem polymeren und verfahren zur herstellung desselben. | |
| EP0184754B1 (de) | Pankreasenzympräparate und Verfahren zu deren Herstellung | |
| DE2517413A1 (de) | Dermatologisch verwendbares mittel | |
| EP0146863A2 (de) | Orale retardierte Acetylsalicylsäureformulierungen | |
| DE1617363B1 (de) | Verfahren zur Herstellung hochaktiver Enzym-Verdauungspraeparate | |
| DE19850445A1 (de) | Arzneimittel zur topischen Behandlung entzündlicher Darmerkrankungen | |
| DE2035739A1 (en) | Oral enzyme prepsn - consisting of granulate with gastric juices-resistant coating in tablet or capsule form | |
| AT283589B (de) | Verfahren zur Herstellung eines hochaktiven Enzym-Verdauungspräparates | |
| EP0043548B1 (de) | Salz aus Furosemid oder Piretanid als Säurekomponente und Penbutolol als Basenkomponente sowie Arzneimittel, das beide Komponenten enthält | |
| CH633715A5 (de) | Verfahren zur erzeugung einer antilithiatisch wirkenden substanz und ein antilithiaticum. | |
| DD209735A5 (de) | Verfahren zur herstellung eines neuen arzneimittelpraeparates | |
| EP3589275A1 (de) | Pharmazeutische zusammensetzung umfassend pankreatin und einen lipasehaltigen überzug | |
| JP3547783B2 (ja) | 胃炎、胃・十二指腸潰瘍の予防及び治療剤 | |
| DE4129874C1 (en) | Granulating humic acids and/or cpds. - by mixing with granulating fluid for wet or moist granulation, then pressing through matrix |