DE1417603A1 - Verfahren zur Gewinnung von Glutaminsaeure aus Glutaminsaeure-Fermentationsfluessigkeit - Google Patents
Verfahren zur Gewinnung von Glutaminsaeure aus Glutaminsaeure-FermentationsfluessigkeitInfo
- Publication number
- DE1417603A1 DE1417603A1 DE19611417603 DE1417603A DE1417603A1 DE 1417603 A1 DE1417603 A1 DE 1417603A1 DE 19611417603 DE19611417603 DE 19611417603 DE 1417603 A DE1417603 A DE 1417603A DE 1417603 A1 DE1417603 A1 DE 1417603A1
- Authority
- DE
- Germany
- Prior art keywords
- glutamic acid
- resin
- fermentation liquid
- liquid
- column
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 title claims description 43
- 235000013922 glutamic acid Nutrition 0.000 title claims description 41
- 239000004220 glutamic acid Substances 0.000 title claims description 41
- 239000007788 liquid Substances 0.000 title claims description 26
- 238000000855 fermentation Methods 0.000 title claims description 21
- 230000004151 fermentation Effects 0.000 title claims description 21
- 238000000034 method Methods 0.000 title claims description 20
- 238000004519 manufacturing process Methods 0.000 title description 3
- 229920005989 resin Polymers 0.000 claims description 34
- 239000011347 resin Substances 0.000 claims description 34
- 230000002378 acidificating effect Effects 0.000 claims description 30
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 12
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims description 8
- 239000003729 cation exchange resin Substances 0.000 claims description 6
- 239000003513 alkali Substances 0.000 claims description 5
- 239000012535 impurity Substances 0.000 claims description 3
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims description 2
- 239000000908 ammonium hydroxide Substances 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 125000002091 cationic group Chemical group 0.000 claims description 2
- 238000011084 recovery Methods 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 39
- 229960002989 glutamic acid Drugs 0.000 description 37
- 150000001768 cations Chemical class 0.000 description 12
- 229920001429 chelating resin Polymers 0.000 description 10
- 230000008929 regeneration Effects 0.000 description 10
- 238000011069 regeneration method Methods 0.000 description 10
- 150000002500 ions Chemical class 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 239000002253 acid Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 5
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 238000010828 elution Methods 0.000 description 4
- 239000003456 ion exchange resin Substances 0.000 description 4
- 229920003303 ion-exchange polymer Polymers 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- OZDAOHVKBFBBMZ-UHFFFAOYSA-N 2-aminopentanedioic acid;hydrate Chemical compound O.OC(=O)C(N)CCC(O)=O OZDAOHVKBFBBMZ-UHFFFAOYSA-N 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000012492 regenerant Substances 0.000 description 2
- 230000001172 regenerating effect Effects 0.000 description 2
- WHOZNOZYMBRCBL-OUKQBFOZSA-N (2E)-2-Tetradecenal Chemical compound CCCCCCCCCCC\C=C\C=O WHOZNOZYMBRCBL-OUKQBFOZSA-N 0.000 description 1
- 108010054404 Adenylyl-sulfate kinase Proteins 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- 102100039024 Sphingosine kinase 1 Human genes 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 238000005341 cation exchange Methods 0.000 description 1
- 229940023913 cation exchange resins Drugs 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 229910052754 neon Inorganic materials 0.000 description 1
- GKAOGPIIYCISHV-UHFFFAOYSA-N neon atom Chemical compound [Ne] GKAOGPIIYCISHV-UHFFFAOYSA-N 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 229940044654 phenolsulfonic acid Drugs 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/14—Glutamic acid; Glutamine
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/04—Processes using organic exchangers
- B01J39/05—Processes using organic exchangers in the strongly acidic form
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2566960 | 1960-05-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1417603A1 true DE1417603A1 (de) | 1968-10-10 |
Family
ID=12172175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19611417603 Pending DE1417603A1 (de) | 1960-05-30 | 1961-05-30 | Verfahren zur Gewinnung von Glutaminsaeure aus Glutaminsaeure-Fermentationsfluessigkeit |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US3173949A (enExample) |
| BE (1) | BE604404A (enExample) |
| CH (1) | CH401987A (enExample) |
| DE (1) | DE1417603A1 (enExample) |
| GB (1) | GB947797A (enExample) |
| NL (2) | NL265337A (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3331828A (en) * | 1964-09-30 | 1967-07-18 | Merck & Co Inc | Isolation of gamma-l-glutamyl dipeptides from glutamic acid fermentation broths by ion exchange |
| IL116848A (en) * | 1996-01-22 | 2000-06-01 | Amylum Nv | Process for producing glutamic acid |
| IL118892A (en) * | 1996-07-18 | 2000-08-13 | Amylum Nv | Process for the production of crystalline aspartic acid |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1973574A (en) * | 1931-04-29 | 1934-09-11 | Larrowe Suzuki Company | Process for manufacturing and recovering glutamic acid |
| US2738353A (en) * | 1951-11-24 | 1956-03-13 | Int Minerals & Chem Corp | Purification and recovery of pyrrolidone carboxylic acid |
| US3015655A (en) * | 1955-07-18 | 1962-01-02 | John B Stark | Separation of nitrogenous organic compounds |
-
0
- NL NL123588D patent/NL123588C/xx active
- NL NL265337D patent/NL265337A/xx unknown
-
1961
- 1961-05-29 GB GB19375/61A patent/GB947797A/en not_active Expired
- 1961-05-29 US US113078A patent/US3173949A/en not_active Expired - Lifetime
- 1961-05-30 DE DE19611417603 patent/DE1417603A1/de active Pending
- 1961-05-30 BE BE604404A patent/BE604404A/fr unknown
- 1961-05-30 CH CH627261A patent/CH401987A/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH401987A (fr) | 1965-11-15 |
| NL265337A (enExample) | |
| BE604404A (fr) | 1961-09-18 |
| US3173949A (en) | 1965-03-16 |
| NL123588C (enExample) | |
| GB947797A (en) | 1964-01-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69216297T2 (de) | Verfahren zur Herstellung von gereinigte Milchsäure enthaltenden wässrigen Lösungen aus Fermentationsbrühen | |
| DE2418801C2 (de) | Verfahren zur Gewinnung von Mannit und Sorbit aus einer wäßrigen Lösung | |
| DE1417603A1 (de) | Verfahren zur Gewinnung von Glutaminsaeure aus Glutaminsaeure-Fermentationsfluessigkeit | |
| DE1518522B2 (enExample) | ||
| EP1176131B1 (de) | Verfahren zur Herstellung von Sorbitolen aus Standard-Glucose | |
| EP0377430A1 (de) | Verfahren zur Abtrennung von Säuren aus salz- und kohlenhydrathaltigen Substraten | |
| DE3702689C2 (enExample) | ||
| DE3852876T2 (de) | Verfahren zur Herstellung eines Lactulosesirups mit einem hohen Reinheitsgrad und der so gewonnene Sirup. | |
| DE1079620B (de) | Verfahren zum Kristallisieren von Adipinsaeure | |
| DE1206872B (de) | Verfahren zur Herstellung von Bariumhydroxyd hohen Reinheitsgrades durch Ionenaustausch | |
| EP0045080B1 (de) | Verfahren zur Reinigung von Nicotinsäureamid II | |
| DE1290928B (de) | Verfahren zur Wiedergewinnung des Katalysators aus den Mutterlaugen der Adipinsaeureherstellung | |
| DE2222027A1 (de) | Verfahren zur erzeugung von hydroxylamin und von gesaettigten zyklischen ketoximen | |
| DE1034611B (de) | Verfahren zum Reinigen von Pentraerythrit | |
| WO2006072360A1 (de) | Verfahren zur reduktion von chlorhaltigen komponenten in organischen isocyanaten | |
| DE1288590B (de) | Verfahren zur Herstellung von Harnstoff mit niedrigem Biuretgehalt | |
| DE4033875C2 (de) | Verfahren zur Herstellung stabiler Kieselsole | |
| DE1929661A1 (de) | Verfahren zur Reinigung von Cadmiumloesungen | |
| DE1467193C3 (de) | Verfahren zur Herstellung von Hydrazinen | |
| DE1140912B (de) | Verfahren zur Herstellung von Borsaeure aus waessrigen Loesungen von Natriumborat | |
| DE900097C (de) | Verfahren zur Herstellung von Hexamethylen-1, 6-bis-trimethylammoniumbitartrat | |
| AT262953B (de) | Verfahren zur Herstellung von L-Arginin-L-asparaginat | |
| DE1518033C3 (de) | Verfahren zur Herstellung von L-Arginin-L-asparaginat | |
| DE2224680C3 (de) | Verfahren zur Herstellung von La ctulose sirup | |
| CH371438A (de) | Verfahren zur Reinigung von Adipinsäure durch Umkristallisation |