DE10326821A1 - Pharmazeutische Kombinationspräparate zur Krebstherapie - Google Patents
Pharmazeutische Kombinationspräparate zur Krebstherapie Download PDFInfo
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- DE10326821A1 DE10326821A1 DE10326821A DE10326821A DE10326821A1 DE 10326821 A1 DE10326821 A1 DE 10326821A1 DE 10326821 A DE10326821 A DE 10326821A DE 10326821 A DE10326821 A DE 10326821A DE 10326821 A1 DE10326821 A1 DE 10326821A1
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- Prior art keywords
- glutaminase
- preparation according
- combination
- antineoplastic
- activity
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- 230000007775 late Effects 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 201000005296 lung carcinoma Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 208000037841 lung tumor Diseases 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- HAWPXGHAZFHHAD-UHFFFAOYSA-N mechlorethamine Chemical class ClCCN(C)CCCl HAWPXGHAZFHHAD-UHFFFAOYSA-N 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 229960001428 mercaptopurine Drugs 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000011278 mitosis Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 150000003833 nucleoside derivatives Chemical class 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 239000006201 parenteral dosage form Substances 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 150000003057 platinum Chemical class 0.000 description 1
- 230000004983 pleiotropic effect Effects 0.000 description 1
- 229960000624 procarbazine Drugs 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- JXLYSJRDGCGARV-CFWMRBGOSA-N vinblastine Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-CFWMRBGOSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10326821A DE10326821A1 (de) | 2003-06-11 | 2003-06-11 | Pharmazeutische Kombinationspräparate zur Krebstherapie |
| CA002528897A CA2528897A1 (en) | 2003-06-11 | 2004-06-11 | Combined pharmaceutical preparations for the treatment of cancer, containing glutaminase and antineoplastic anthracyclines or platinum compounds |
| JP2006515900A JP2006527232A (ja) | 2003-06-11 | 2004-06-11 | グルタミナーゼ及び抗新生物性のアントラサイクリン類又は白金化合物を含有する癌治療のための薬剤学的な組合せ製剤 |
| DE502004002561T DE502004002561D1 (de) | 2003-06-11 | 2004-06-11 | Pharmazeutische kombinationspräparate zur krebstherapie enthaltend glutaminase und antineoplastische anthracycline oder platinverbindungen |
| EP04739811A EP1633394B1 (de) | 2003-06-11 | 2004-06-11 | Pharmazeutische kombinationspräparate zur krebstherapie enthaltend glutaminase und antineoplastische anthracycline oder platinverbindungen |
| US10/560,317 US20060263346A1 (en) | 2003-06-11 | 2004-06-11 | Combined pharmaceutical preparations for the treatment of cancer, containing glutaminase and antineoplastic anthracyclines or platinum compounds |
| AU2004244755A AU2004244755B9 (en) | 2003-06-11 | 2004-06-11 | Combined pharmaceutical preparations for the treatment of cancer, containing glutaminase and antineoplastic anthracyclines or platinum compounds |
| AT04739811T ATE350054T1 (de) | 2003-06-11 | 2004-06-11 | Pharmazeutische kombinationspräparate zur krebstherapie enthaltend glutaminase und antineoplastische anthracycline oder platinverbindungen |
| PCT/EP2004/006320 WO2004108153A1 (de) | 2003-06-11 | 2004-06-11 | Pharmazeutische kombinationspräparate zur krebstherapie enthaltend glutaminase und antineoplastische anthracycline oder platinverbindungen |
| ES04739811T ES2280972T3 (es) | 2003-06-11 | 2004-06-11 | Preparaciones farmaceuticas combinadas que contienen glutaminasa y antraciclinas o compuestos de platino antineoplasicos para la terapia del cancer. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10326821A DE10326821A1 (de) | 2003-06-11 | 2003-06-11 | Pharmazeutische Kombinationspräparate zur Krebstherapie |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE10326821A1 true DE10326821A1 (de) | 2005-01-05 |
Family
ID=33495036
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10326821A Ceased DE10326821A1 (de) | 2003-06-11 | 2003-06-11 | Pharmazeutische Kombinationspräparate zur Krebstherapie |
| DE502004002561T Expired - Lifetime DE502004002561D1 (de) | 2003-06-11 | 2004-06-11 | Pharmazeutische kombinationspräparate zur krebstherapie enthaltend glutaminase und antineoplastische anthracycline oder platinverbindungen |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE502004002561T Expired - Lifetime DE502004002561D1 (de) | 2003-06-11 | 2004-06-11 | Pharmazeutische kombinationspräparate zur krebstherapie enthaltend glutaminase und antineoplastische anthracycline oder platinverbindungen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20060263346A1 (enExample) |
| EP (1) | EP1633394B1 (enExample) |
| JP (1) | JP2006527232A (enExample) |
| AT (1) | ATE350054T1 (enExample) |
| AU (1) | AU2004244755B9 (enExample) |
| CA (1) | CA2528897A1 (enExample) |
| DE (2) | DE10326821A1 (enExample) |
| ES (1) | ES2280972T3 (enExample) |
| WO (1) | WO2004108153A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009536173A (ja) | 2006-05-10 | 2009-10-08 | メディカル エンザイムズ アクチエンゲゼルシャフト | グルタドン |
| US8173686B2 (en) | 2006-11-06 | 2012-05-08 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8168661B2 (en) | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8168662B1 (en) | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8178564B2 (en) | 2006-11-06 | 2012-05-15 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| EP2047858A1 (en) * | 2007-10-10 | 2009-04-15 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Combination products for treating cancer |
| EP3092235A2 (en) | 2014-01-06 | 2016-11-16 | Rhizen Pharmaceuticals S.A. | Novel inhibitors of glutaminase |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4955857A (en) * | 1988-07-18 | 1990-09-11 | Shettigar Udipi R | Multi-enzyme bioreactor therapy for cancer |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020094542A1 (en) * | 1988-04-15 | 2002-07-18 | Peter Leskovar | Drugs and methods for treating cancer |
| US5776458A (en) * | 1990-12-05 | 1998-07-07 | Pharmacia & Upjohn S.P.A. | Anthracycline-conjugates |
| DE4140003C2 (de) * | 1991-12-04 | 1994-09-29 | Joseph Prof Dr Roberts | Gentechnisch hergestellte Glutaminase und ihre Verwendung bei der antiviralen und Anti-Krebstherapie |
| ATE361984T1 (de) * | 1992-12-04 | 2007-06-15 | Me Medical Enzymes Ag | Gentechnologisch hergestellte glutaminase und ihre verwendung in therapie |
| DE69332637T2 (de) * | 1993-03-04 | 2003-10-23 | Matsushita Electric Industrial Co., Ltd. | Kokainderivat,Proteinkonjugat,davon,einen monoklonalen Antikörper produzierende Hybridom-Zellinie, Verfahren zur Herstellung der Hybridom-Zellinie und des monoklonalen Antikörpers |
| US20020115609A1 (en) * | 1997-07-14 | 2002-08-22 | Hayat Onyuksel | Materials and methods for making improved micelle compositions |
| US6200754B1 (en) * | 1998-03-19 | 2001-03-13 | Variagenics, Inc. | Inhibitors of alternative alleles of genes encoding products that mediate cell response to environmental changes |
| CA2465949A1 (en) * | 2001-11-02 | 2003-05-15 | Dana-Farber Cancer Institute | Methods and compositions for the diagnosis of cancer susceptibilities and defective dna repair mechanisms and treatment thereof |
| WO2003039545A2 (en) * | 2001-11-07 | 2003-05-15 | Millennium Pharmaceuticals, Inc. | Carboline derivatives as inhibitors of ikb in the treatment of multiple myeloma and others cancers |
-
2003
- 2003-06-11 DE DE10326821A patent/DE10326821A1/de not_active Ceased
-
2004
- 2004-06-11 AT AT04739811T patent/ATE350054T1/de active
- 2004-06-11 EP EP04739811A patent/EP1633394B1/de not_active Expired - Lifetime
- 2004-06-11 AU AU2004244755A patent/AU2004244755B9/en not_active Ceased
- 2004-06-11 JP JP2006515900A patent/JP2006527232A/ja active Pending
- 2004-06-11 DE DE502004002561T patent/DE502004002561D1/de not_active Expired - Lifetime
- 2004-06-11 CA CA002528897A patent/CA2528897A1/en not_active Abandoned
- 2004-06-11 ES ES04739811T patent/ES2280972T3/es not_active Expired - Lifetime
- 2004-06-11 US US10/560,317 patent/US20060263346A1/en not_active Abandoned
- 2004-06-11 WO PCT/EP2004/006320 patent/WO2004108153A1/de not_active Ceased
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4955857A (en) * | 1988-07-18 | 1990-09-11 | Shettigar Udipi R | Multi-enzyme bioreactor therapy for cancer |
Non-Patent Citations (2)
| Title |
|---|
| Holcenberg, J. [u.a.]: In: Cancer Res., 1983, Vol. 43, S. 1381-1388 * |
| Roberts, J. [u.a.]: In: Cancer Treatment Reports, 1979, Vol. 63, S. 1045-1054 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1633394B1 (de) | 2007-01-03 |
| ES2280972T3 (es) | 2007-09-16 |
| WO2004108153A1 (de) | 2004-12-16 |
| AU2004244755B9 (en) | 2009-12-24 |
| DE502004002561D1 (de) | 2007-02-15 |
| AU2004244755B2 (en) | 2009-06-25 |
| JP2006527232A (ja) | 2006-11-30 |
| US20060263346A1 (en) | 2006-11-23 |
| EP1633394A1 (de) | 2006-03-15 |
| ATE350054T1 (de) | 2007-01-15 |
| AU2004244755A1 (en) | 2004-12-16 |
| CA2528897A1 (en) | 2004-12-16 |
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