DE10260730A1 - Neue substituierte stickstoffhaltige Heterobicyclen, deren Herstellung und deren Verwendung als Arzneimittel - Google Patents

Neue substituierte stickstoffhaltige Heterobicyclen, deren Herstellung und deren Verwendung als Arzneimittel Download PDF

Info

Publication number
DE10260730A1
DE10260730A1 DE10260730A DE10260730A DE10260730A1 DE 10260730 A1 DE10260730 A1 DE 10260730A1 DE 10260730 A DE10260730 A DE 10260730A DE 10260730 A DE10260730 A DE 10260730A DE 10260730 A1 DE10260730 A1 DE 10260730A1
Authority
DE
Germany
Prior art keywords
alkyl
group
amino
substituted
alkylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10260730A
Other languages
German (de)
English (en)
Inventor
Henning Dr. Priepke
Roland Dr. Pfau
Kai Dr. Gerlach
Uwe Dr. Ries
Wolfgang Dr. Wienen
Eckhart Dr. Bauer
Herbert Dr. Nar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Priority to DE10260730A priority Critical patent/DE10260730A1/de
Priority to PE2003001281A priority patent/PE20040806A1/es
Priority to AU2003298192A priority patent/AU2003298192A1/en
Priority to EP03795904A priority patent/EP1583757A1/de
Priority to CA002511349A priority patent/CA2511349A1/en
Priority to JP2004562769A priority patent/JP2006515301A/ja
Priority to PCT/EP2003/014378 priority patent/WO2004058743A1/de
Priority to US10/739,172 priority patent/US7429597B2/en
Priority to CL200302697A priority patent/CL2003002697A1/es
Priority to UY28143A priority patent/UY28143A1/es
Priority to TW092136403A priority patent/TW200424194A/zh
Priority to ARP030104807A priority patent/AR043685A1/es
Publication of DE10260730A1 publication Critical patent/DE10260730A1/de
Priority to US12/176,692 priority patent/US20090181958A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE10260730A 2002-12-23 2002-12-23 Neue substituierte stickstoffhaltige Heterobicyclen, deren Herstellung und deren Verwendung als Arzneimittel Withdrawn DE10260730A1 (de)

Priority Applications (13)

Application Number Priority Date Filing Date Title
DE10260730A DE10260730A1 (de) 2002-12-23 2002-12-23 Neue substituierte stickstoffhaltige Heterobicyclen, deren Herstellung und deren Verwendung als Arzneimittel
PE2003001281A PE20040806A1 (es) 2002-12-23 2003-12-12 COMPUESTOS HETEROBICICLOS NITROGENADOS SUSTITUIDOS COMO INHIBIDORES DEL FACTOR Xa
AU2003298192A AU2003298192A1 (en) 2002-12-23 2003-12-17 Novel substituted nitrogen-containing heterobicycles and use thereof as factor xa inhibitors
EP03795904A EP1583757A1 (de) 2002-12-23 2003-12-17 Neue substituierte stickstoffhaltige heterobicyclen und deren verwendung als faktor xa inhibitoren
CA002511349A CA2511349A1 (en) 2002-12-23 2003-12-17 New substituted nitrogen-containing heterobicycles, the preparation thereof and their use as pharmaceutical compositions
JP2004562769A JP2006515301A (ja) 2002-12-23 2003-12-17 新規置換窒素含有二環式複素環化合物、これらの調製及び医薬組成物としてのそれらの使用
PCT/EP2003/014378 WO2004058743A1 (de) 2002-12-23 2003-12-17 Neue substituierte stickstoffhaltige heterobicyclen und deren verwendung als faktor xa inhibitoren
US10/739,172 US7429597B2 (en) 2002-12-23 2003-12-18 Substituted nitrogen-containing heterobicycles, the preparation thereof and their use as pharmaceutical compositions
CL200302697A CL2003002697A1 (es) 2002-12-23 2003-12-19 Compuestos derivados de heterobiciclos nitrogenados sustituidos, sus sales, procedimiento de preparacion, composicion farmaceutica util para tener un efecto inhibidor del factor xa y/o un aceto inhibidor de serina proteasas.
UY28143A UY28143A1 (es) 2002-12-23 2003-12-22 Nuevos heterobiciclos nitrogenados sustituidos, su preparación y su uso como medicamento
TW092136403A TW200424194A (en) 2002-12-23 2003-12-22 New substituted nitrogen-containing heterobicycles, the preparation thereof and their use as pharmaceutical compositions
ARP030104807A AR043685A1 (es) 2002-12-23 2003-12-23 Heterobiciclos nitrogenados sustituidos, su preparacion y su uso como medicamento
US12/176,692 US20090181958A1 (en) 2002-12-23 2008-07-21 Substituted nitrogen-containing heterobicycles, the preparation thereof and their use as pharmaceutical compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10260730A DE10260730A1 (de) 2002-12-23 2002-12-23 Neue substituierte stickstoffhaltige Heterobicyclen, deren Herstellung und deren Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
DE10260730A1 true DE10260730A1 (de) 2004-07-01

Family

ID=32404214

Family Applications (1)

Application Number Title Priority Date Filing Date
DE10260730A Withdrawn DE10260730A1 (de) 2002-12-23 2002-12-23 Neue substituierte stickstoffhaltige Heterobicyclen, deren Herstellung und deren Verwendung als Arzneimittel

Country Status (11)

Country Link
EP (1) EP1583757A1 (ja)
JP (1) JP2006515301A (ja)
AR (1) AR043685A1 (ja)
AU (1) AU2003298192A1 (ja)
CA (1) CA2511349A1 (ja)
CL (1) CL2003002697A1 (ja)
DE (1) DE10260730A1 (ja)
PE (1) PE20040806A1 (ja)
TW (1) TW200424194A (ja)
UY (1) UY28143A1 (ja)
WO (1) WO2004058743A1 (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005299693B2 (en) 2004-10-26 2012-07-05 Janssen Pharmaceutica, N.V. Factor Xa compounds
EP2220079A2 (en) 2007-11-15 2010-08-25 Boehringer Ingelheim International GmbH Substituted amides, manufacturing and use thereof as medicaments
CN103265524B (zh) * 2013-05-15 2016-01-20 华东师范大学 β-氨基-2,5-二氧六环内酯衍生物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9514265D0 (en) 1995-07-13 1995-09-13 Wellcome Found Hetrocyclic compounds
PE121699A1 (es) 1997-02-18 1999-12-08 Boehringer Ingelheim Pharma Heterociclos biciclicos disustituidos como inhibidores de la trombina
US20030114448A1 (en) * 2001-05-31 2003-06-19 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
PE20040804A1 (es) * 2002-12-19 2004-12-31 Boehringer Ingelheim Pharma DERIVADOS DE CARBOXAMIDAS COMO INHIBIDORES DEL FACTOR Xa

Also Published As

Publication number Publication date
AR043685A1 (es) 2005-08-10
JP2006515301A (ja) 2006-05-25
AU2003298192A1 (en) 2004-07-22
PE20040806A1 (es) 2004-12-23
WO2004058743A1 (de) 2004-07-15
UY28143A1 (es) 2004-07-30
EP1583757A1 (de) 2005-10-12
TW200424194A (en) 2004-11-16
CL2003002697A1 (es) 2005-01-14
CA2511349A1 (en) 2004-07-15

Similar Documents

Publication Publication Date Title
EP0966454B1 (de) Disubstituierte bicyclische heterocyclen, ihre herstellung und ihre verwendung als arzneimittel
DE69829879T2 (de) Indolderivate als faktor xa inhibitoren
DE69920888T2 (de) Disubstituierte pyrazoline und triazoline als faktor xa inhibitoren
DE19753522A1 (de) Substituierte Indole, ihre Herstellung und ihre Verwendung als Arzneimittel
EP2051975A2 (de) Substituierte prolinamide, deren herstellung und deren verwendung als arzneimittel
EP1100795A1 (de) Disubstituierte bicyclische heterocyclen mit insbesondere eine thrombinhemmende wirkung
EP1987021B1 (de) Substituierte prolinamide, deren herstellung und deren verwendung als arzneimittel
DE10259244A1 (de) N-(Indolethyl-)cycloamin-Verbindungen
DE10130374A1 (de) Substituierte N-Acyl-anilinderivate, deren Herstellung und deren Verwendung als Arzneimittel
DE10235639A1 (de) Neue Prodrugs von 1-Methyl-2-(4-amidinophenylaminomethyl)-benzimidazol-5-yl-carbonsäure-(N-2-pyridyl-N-2-hydroxycarbonylethyl)-amid, ihre Herstellung und ihre Verwendung als Arzneimittel
EP1910345A1 (de) Substituierte amide, deren herstellung und deren verwendung als arzneimittel
DE10111842A1 (de) Antithrombotische Carbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel
EP2069288B1 (de) TARTRATDERIVATE ALS INHIBITOREN DES KOAGULATIONSFAKTORS IXa
EP1244636A1 (de) Benzimidazole, deren herstellung und deren verwendung als antithrombotika
EP1390357A2 (de) Antithrombotische verbindungen, deren herstellung und deren verwendung als arzneimittel
DE10260730A1 (de) Neue substituierte stickstoffhaltige Heterobicyclen, deren Herstellung und deren Verwendung als Arzneimittel
WO2005121103A1 (de) Benzimidazole, verfahren zu deren herstellung und deren verwendung als arzneimittel
EP1748996A1 (de) Substituierte thiophencarbonsäureamide, deren herstellung und deren verwendung als arzneimittel
WO2004080970A1 (de) Neue aromatische bicyclen, deren herstellung und deren verwendung insbesondereals als inhibitoren von faktor xa
EP1360170A1 (de) Carbonsäureamide, deren herstellung und deren verwendung als arzneimittel
US20040077729A1 (en) New carboxylic acid amides, the preparation thereof and their use as pharmaceutical compositions
DE10259407A1 (de) Neue Carbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel
DE10104598A1 (de) Carbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel
DE10234057A1 (de) Neue Carbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel
DE10335545A1 (de) Neue Carbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel

Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8139 Disposal/non-payment of the annual fee