DE10206505A1 - Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und EGFR-Kinase-Hemmern - Google Patents
Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und EGFR-Kinase-HemmernInfo
- Publication number
- DE10206505A1 DE10206505A1 DE10206505A DE10206505A DE10206505A1 DE 10206505 A1 DE10206505 A1 DE 10206505A1 DE 10206505 A DE10206505 A DE 10206505A DE 10206505 A DE10206505 A DE 10206505A DE 10206505 A1 DE10206505 A1 DE 10206505A1
- Authority
- DE
- Germany
- Prior art keywords
- amino
- oxo
- quinazoline
- chloro
- buten
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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Classifications
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (24)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10206505A DE10206505A1 (de) | 2002-02-16 | 2002-02-16 | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und EGFR-Kinase-Hemmern |
| US10/360,064 US20030158196A1 (en) | 2002-02-16 | 2003-02-07 | Pharmaceutical compositions based on anticholinergics and EGFR kinase inhibitors |
| NZ535166A NZ535166A (en) | 2002-02-16 | 2003-02-12 | New medicinal compositions on the basis of anticholinergic agents and EGFR kinase inhibitors |
| JP2003567444A JP2005517039A (ja) | 2002-02-16 | 2003-02-12 | 抗コリン作動薬およびｅｇｆｒキナーゼ阻害剤を主成分とする新規医薬組成物 |
| AT03704593T ATE430581T1 (de) | 2002-02-16 | 2003-02-12 | Neue arzneimittelkompositionen auf der basis von anticholinergika und egfr-kinase-hemmern |
| PCT/EP2003/001357 WO2003068264A1 (de) | 2002-02-16 | 2003-02-12 | Neue arzneimittelkompositionen auf der basis von anticholinergika und egfr-kinase-hemmern |
| CA2476127A CA2476127C (en) | 2002-02-16 | 2003-02-12 | New pharmaceutical compositions based on anticholinergics and egfr kinase inhibitors |
| RU2004127869/15A RU2004127869A (ru) | 2002-02-16 | 2003-02-12 | Новые лекарственные композиции на основе антихолинергических средств и ингибиторов egfr-киназы |
| DE50311496T DE50311496D1 (de) | 2002-02-16 | 2003-02-12 | Neue arzneimittelkompositionen auf der basis von anticholinergika und egfr-kinase-hemmern |
| MXPA04007813A MXPA04007813A (es) | 2002-02-16 | 2003-02-12 | Nuevas composiciones de medicamentos sobre base de agentes anticolinergicos y de agentes inhibidores de cinasa del egfr. |
| KR10-2004-7012713A KR20040083519A (ko) | 2002-02-16 | 2003-02-12 | 콜린억제제 및 ｅｇｆｒ 키나제 억제제를 기제로 하는신규한 의약 조성물 |
| BR0307703-9A BR0307703A (pt) | 2002-02-16 | 2003-02-12 | Composições de medicamentos na base de agentes anticolinérgicos e inibidores de quinase de egfr |
| ES03704593T ES2326968T3 (es) | 2002-02-16 | 2003-02-12 | Nuevas composiciones de medicamentos a base de anticolinergicos e inhibidores de la cinasa del egfr. |
| PL03369736A PL369736A1 (en) | 2002-02-16 | 2003-02-12 | New medicinal compositions on the basis of anticholinergic agents and egfr kinase inhibitors |
| CNA038039427A CN1633305A (zh) | 2002-02-16 | 2003-02-12 | 基于抗胆碱能剂和egfr激酶抑制剂的新颖药物组合物 |
| ARP030100439A AR038494A1 (es) | 2002-02-16 | 2003-02-12 | Composiciones de medicamentos sobre la base de agentes anticolinergicos y de agentes inhibidores de la cinasa del egfr |
| EP03704593A EP1478398B1 (de) | 2002-02-16 | 2003-02-12 | Neue arzneimittelkompositionen auf der basis von anticholinergika und egfr-kinase-hemmern |
| AU2003206881A AU2003206881B2 (en) | 2002-02-16 | 2003-02-12 | New medicinal compositions on the basis of anticholinergic agents and EGFR kinase inhibitors |
| TW092103090A TW200400036A (en) | 2002-02-16 | 2003-02-14 | New pharmaceutical compositions based on anticholinergics and EGFR kinase inhibitors |
| UY27670A UY27670A1 (es) | 2002-02-16 | 2003-02-14 | Nuevas composiciones de medicamentos sobre la base de agentes anticolinérgicos y de agentes inhibidores de la cinasa del egfr |
| PE2003000163A PE20030859A1 (es) | 2002-02-16 | 2003-02-14 | Composiciones de medicamentos sobre la base de agentes anticolinergicos y de agentes inhibidores de la cinasa del egfr |
| ZA200404787A ZA200404787B (en) | 2002-02-16 | 2004-06-17 | New medicinal compositions on the basis of anticholinergic agents and EGFR kinase inhibitors. |
| CO04090723A CO5611134A2 (es) | 2002-02-16 | 2004-09-13 | Composiciones farmaceuticas que contienen sales de tiotropio y nuevos agentes inhibidores de la cinasa egfr |
| US11/006,940 US7776315B2 (en) | 2000-10-31 | 2004-12-08 | Pharmaceutical compositions based on anticholinergics and additional active ingredients |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10206505A DE10206505A1 (de) | 2002-02-16 | 2002-02-16 | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und EGFR-Kinase-Hemmern |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE10206505A1 true DE10206505A1 (de) | 2003-08-28 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10206505A Withdrawn DE10206505A1 (de) | 2000-10-31 | 2002-02-16 | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und EGFR-Kinase-Hemmern |
| DE50311496T Expired - Lifetime DE50311496D1 (de) | 2002-02-16 | 2003-02-12 | Neue arzneimittelkompositionen auf der basis von anticholinergika und egfr-kinase-hemmern |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE50311496T Expired - Lifetime DE50311496D1 (de) | 2002-02-16 | 2003-02-12 | Neue arzneimittelkompositionen auf der basis von anticholinergika und egfr-kinase-hemmern |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1478398B1 (enExample) |
| JP (1) | JP2005517039A (enExample) |
| KR (1) | KR20040083519A (enExample) |
| CN (1) | CN1633305A (enExample) |
| AR (1) | AR038494A1 (enExample) |
| AT (1) | ATE430581T1 (enExample) |
| AU (1) | AU2003206881B2 (enExample) |
| BR (1) | BR0307703A (enExample) |
| CA (1) | CA2476127C (enExample) |
| CO (1) | CO5611134A2 (enExample) |
| DE (2) | DE10206505A1 (enExample) |
| ES (1) | ES2326968T3 (enExample) |
| MX (1) | MXPA04007813A (enExample) |
| NZ (1) | NZ535166A (enExample) |
| PE (1) | PE20030859A1 (enExample) |
| PL (1) | PL369736A1 (enExample) |
| RU (1) | RU2004127869A (enExample) |
| TW (1) | TW200400036A (enExample) |
| UY (1) | UY27670A1 (enExample) |
| WO (1) | WO2003068264A1 (enExample) |
| ZA (1) | ZA200404787B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10230751A1 (de) * | 2002-07-09 | 2004-01-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittelkompositionen auf der Basis neuer Anticholinergika und EGFR-Kinase-Hemmern |
| US7569577B2 (en) | 2003-09-16 | 2009-08-04 | Astrazeneca Ab | Quinazoline derivatives as tyrosine kinase inhibitors |
| DE102004001607A1 (de) * | 2004-01-09 | 2005-08-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittelkombinationen auf der Basis von Scopin- oder Tropensäureestern mit EGFR-Kinase-Hemmern |
| US20060035893A1 (en) * | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
| WO2007029251A2 (en) * | 2005-09-06 | 2007-03-15 | T.K. Signal Ltd. | Polyalkylene glycol derivatives of 4- (phenylamino)quinazolines useful as irreversible inhibitors of epidermal gr0wth fact0r receptor tyrosine kinase |
| KR100832593B1 (ko) * | 2005-11-08 | 2008-05-27 | 한미약품 주식회사 | 신호전달 저해제로서의 퀴나졸린 유도체 및 이의 제조방법 |
| US8507502B2 (en) | 2008-11-10 | 2013-08-13 | National Health Research Institutes | Fused bicyclic and tricyclic pyrimidine compounds as tyrosine kinase inhibitors |
| US20120220557A1 (en) * | 2011-02-17 | 2012-08-30 | Chiesi Farmaceutici S.P.A. | Liquid propellant-free formulation comprising an antimuscarinic drug |
| US10710968B2 (en) | 2016-01-13 | 2020-07-14 | Hadasit Medical Research Services And Development Ltd. | Radiolabeled erlotinib analogs and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9508538D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| GB9622363D0 (en) * | 1996-10-28 | 1997-01-08 | Celltech Therapeutics Ltd | Chemical compounds |
| DE19921693A1 (de) * | 1999-05-12 | 2000-11-16 | Boehringer Ingelheim Pharma | Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika |
| DE19911509A1 (de) * | 1999-03-15 | 2000-09-21 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE10042062A1 (de) * | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Hertellung |
-
2002
- 2002-02-16 DE DE10206505A patent/DE10206505A1/de not_active Withdrawn
-
2003
- 2003-02-12 DE DE50311496T patent/DE50311496D1/de not_active Expired - Lifetime
- 2003-02-12 KR KR10-2004-7012713A patent/KR20040083519A/ko not_active Ceased
- 2003-02-12 CN CNA038039427A patent/CN1633305A/zh active Pending
- 2003-02-12 PL PL03369736A patent/PL369736A1/xx not_active Application Discontinuation
- 2003-02-12 MX MXPA04007813A patent/MXPA04007813A/es not_active Application Discontinuation
- 2003-02-12 ES ES03704593T patent/ES2326968T3/es not_active Expired - Lifetime
- 2003-02-12 BR BR0307703-9A patent/BR0307703A/pt not_active IP Right Cessation
- 2003-02-12 AU AU2003206881A patent/AU2003206881B2/en not_active Ceased
- 2003-02-12 RU RU2004127869/15A patent/RU2004127869A/ru unknown
- 2003-02-12 NZ NZ535166A patent/NZ535166A/en unknown
- 2003-02-12 JP JP2003567444A patent/JP2005517039A/ja active Pending
- 2003-02-12 CA CA2476127A patent/CA2476127C/en not_active Expired - Fee Related
- 2003-02-12 WO PCT/EP2003/001357 patent/WO2003068264A1/de not_active Ceased
- 2003-02-12 AR ARP030100439A patent/AR038494A1/es not_active Application Discontinuation
- 2003-02-12 AT AT03704593T patent/ATE430581T1/de active
- 2003-02-12 EP EP03704593A patent/EP1478398B1/de not_active Expired - Lifetime
- 2003-02-14 TW TW092103090A patent/TW200400036A/zh unknown
- 2003-02-14 UY UY27670A patent/UY27670A1/es not_active Application Discontinuation
- 2003-02-14 PE PE2003000163A patent/PE20030859A1/es not_active Application Discontinuation
-
2004
- 2004-06-17 ZA ZA200404787A patent/ZA200404787B/en unknown
- 2004-09-13 CO CO04090723A patent/CO5611134A2/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| UY27670A1 (es) | 2003-09-30 |
| JP2005517039A (ja) | 2005-06-09 |
| AU2003206881B2 (en) | 2009-02-26 |
| ZA200404787B (en) | 2005-08-11 |
| CA2476127C (en) | 2011-06-14 |
| EP1478398B1 (de) | 2009-05-06 |
| KR20040083519A (ko) | 2004-10-02 |
| AU2003206881A1 (en) | 2003-09-04 |
| ES2326968T3 (es) | 2009-10-22 |
| CA2476127A1 (en) | 2003-08-21 |
| RU2004127869A (ru) | 2005-08-27 |
| BR0307703A (pt) | 2005-01-04 |
| PL369736A1 (en) | 2005-05-02 |
| AR038494A1 (es) | 2005-01-19 |
| DE50311496D1 (de) | 2009-06-18 |
| TW200400036A (en) | 2004-01-01 |
| CO5611134A2 (es) | 2006-02-28 |
| EP1478398A1 (de) | 2004-11-24 |
| CN1633305A (zh) | 2005-06-29 |
| PE20030859A1 (es) | 2003-11-18 |
| WO2003068264A1 (de) | 2003-08-21 |
| NZ535166A (en) | 2007-01-26 |
| ATE430581T1 (de) | 2009-05-15 |
| MXPA04007813A (es) | 2004-10-15 |
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