DE102019128842A1 - Verfahren, Vorrichtung und Markersubstanz-Kit zur multiparametrischen Röntgenfluoreszenz-Bildgebung - Google Patents

Verfahren, Vorrichtung und Markersubstanz-Kit zur multiparametrischen Röntgenfluoreszenz-Bildgebung Download PDF

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Publication number
DE102019128842A1
DE102019128842A1 DE102019128842.8A DE102019128842A DE102019128842A1 DE 102019128842 A1 DE102019128842 A1 DE 102019128842A1 DE 102019128842 A DE102019128842 A DE 102019128842A DE 102019128842 A1 DE102019128842 A1 DE 102019128842A1
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Prior art keywords
sample
ray fluorescence
marker
marker substance
molecules
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DE102019128842.8A
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German (de)
English (en)
Inventor
Florian Grüner
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Universitaet Hamburg
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Universitaet Hamburg
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Application filed by Universitaet Hamburg filed Critical Universitaet Hamburg
Priority to DE102019128842.8A priority Critical patent/DE102019128842A1/de
Priority to EP20797446.0A priority patent/EP4049011A1/de
Priority to CN202080074754.5A priority patent/CN114667447B/zh
Priority to JP2022524594A priority patent/JP7635224B2/ja
Priority to US17/771,460 priority patent/US20220370645A1/en
Priority to PCT/EP2020/079909 priority patent/WO2021078950A1/de
Priority to KR1020227017433A priority patent/KR20220091515A/ko
Publication of DE102019128842A1 publication Critical patent/DE102019128842A1/de
Withdrawn legal-status Critical Current

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/22Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material
    • G01N23/223Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material by irradiating the sample with X-rays or gamma-rays and by measuring X-ray fluorescence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0409Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414Particles, beads, capsules or spheres
    • A61K49/0423Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/22Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/22Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material
    • G01N23/2202Preparing specimens therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2223/00Investigating materials by wave or particle radiation
    • G01N2223/07Investigating materials by wave or particle radiation secondary emission
    • G01N2223/076X-ray fluorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2223/00Investigating materials by wave or particle radiation
    • G01N2223/40Imaging
    • G01N2223/401Imaging image processing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2223/00Investigating materials by wave or particle radiation
    • G01N2223/60Specific applications or type of materials
    • G01N2223/612Specific applications or type of materials biological material

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Nanotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Nuclear Medicine (AREA)
DE102019128842.8A 2019-10-25 2019-10-25 Verfahren, Vorrichtung und Markersubstanz-Kit zur multiparametrischen Röntgenfluoreszenz-Bildgebung Withdrawn DE102019128842A1 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE102019128842.8A DE102019128842A1 (de) 2019-10-25 2019-10-25 Verfahren, Vorrichtung und Markersubstanz-Kit zur multiparametrischen Röntgenfluoreszenz-Bildgebung
EP20797446.0A EP4049011A1 (de) 2019-10-25 2020-10-23 Verfahren, vorrichtung und markersubstanz-kit zur multiparametrischen röntgenfluoreszenz-bildgebung
CN202080074754.5A CN114667447B (zh) 2019-10-25 2020-10-23 用于多参数x射线荧光成像的方法、设备和标记物质套件
JP2022524594A JP7635224B2 (ja) 2019-10-25 2020-10-23 マルチパラメトリックx線蛍光イメージングのための方法および装置
US17/771,460 US20220370645A1 (en) 2019-10-25 2020-10-23 Method, device and marker substance kit for multi-parametric x-ray fluorescence imaging
PCT/EP2020/079909 WO2021078950A1 (de) 2019-10-25 2020-10-23 Verfahren, vorrichtung und markersubstanz-kit zur multiparametrischen röntgenfluoreszenz-bildgebung
KR1020227017433A KR20220091515A (ko) 2019-10-25 2020-10-23 다중-파라미터 x-선 형광 이미징을 위한 방법, 장치 및 마커 물질 키트

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102019128842.8A DE102019128842A1 (de) 2019-10-25 2019-10-25 Verfahren, Vorrichtung und Markersubstanz-Kit zur multiparametrischen Röntgenfluoreszenz-Bildgebung

Publications (1)

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DE102019128842A1 true DE102019128842A1 (de) 2021-04-29

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DE102019128842.8A Withdrawn DE102019128842A1 (de) 2019-10-25 2019-10-25 Verfahren, Vorrichtung und Markersubstanz-Kit zur multiparametrischen Röntgenfluoreszenz-Bildgebung

Country Status (7)

Country Link
US (1) US20220370645A1 (https=)
EP (1) EP4049011A1 (https=)
JP (1) JP7635224B2 (https=)
KR (1) KR20220091515A (https=)
CN (1) CN114667447B (https=)
DE (1) DE102019128842A1 (https=)
WO (1) WO2021078950A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116577358B (zh) * 2023-05-18 2024-01-23 杭州宇称电子技术有限公司 基于x射线k-吸收边的书画文物颜料成像方法及其应用
CN118961777B (zh) * 2024-07-19 2025-11-28 中国科学院金属研究所 一种准原位追踪高温合金微量元素分布的方法

Citations (3)

* Cited by examiner, † Cited by third party
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US20120307962A1 (en) * 2009-12-16 2012-12-06 Georgia Tech Resarch Corporation Systems and methods for x-ray fluorescence computed tomography imaging with nanoparticles
US20160252471A1 (en) * 2013-08-28 2016-09-01 The Regents Of The University Of California Nanoparticle assisted scanning focusing x-ray fluorescence imaging and enhanced treatment
DE102017003517A1 (de) * 2017-04-11 2018-10-11 Universität Hamburg Verfahren und Messvorrichtung zur Röntgenfluoreszenz-Messung

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EP1603459A1 (en) 2003-03-07 2005-12-14 Philips Intellectual Property & Standards GmbH Method and imaging system for imaging the spatial distribution of an x-ray fluorescence marker
JP5557266B2 (ja) 2008-07-17 2014-07-23 国立大学法人 筑波大学 蛍光エックス線検出装置
JP5761102B2 (ja) 2012-03-29 2015-08-12 コニカミノルタ株式会社 高輝度半導体ナノ粒子集積体
FR2989280B1 (fr) 2012-04-13 2017-02-24 Univ Claude Bernard Lyon Nanoparticules ultrafines comme agent de contraste multimodal
EP3091903B1 (en) * 2014-01-07 2018-10-03 Jettec AB X-ray micro imaging
CN108469445B (zh) * 2018-03-29 2020-09-01 福州大学 用于无背景检测血液中癌症抗原含量的基于x射线激发的镧系荧光纳米粒子的试剂盒及制备
JP2019183047A (ja) 2018-04-13 2019-10-24 Agc株式会社 蛍光ナノ粒子およびその製造方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120307962A1 (en) * 2009-12-16 2012-12-06 Georgia Tech Resarch Corporation Systems and methods for x-ray fluorescence computed tomography imaging with nanoparticles
US20160252471A1 (en) * 2013-08-28 2016-09-01 The Regents Of The University Of California Nanoparticle assisted scanning focusing x-ray fluorescence imaging and enhanced treatment
DE102017003517A1 (de) * 2017-04-11 2018-10-11 Universität Hamburg Verfahren und Messvorrichtung zur Röntgenfluoreszenz-Messung

Non-Patent Citations (8)

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CORMODE, David P.; NAHA, Pratap C.; Fayad., Zahi A.: Nanoparticle contrast agents for computed tomography: a focus on micelles. In: Contrast Media & Molecular Imaging, 2014, No. 9, S. 37- 52. *
FIEDLER, Haidi D. [u.a.]: Simultaneous nondestructive analysis of palladium, rhodium, platinum, and gold nanoparticles using energy dispersive X-ray fluorescence. In: Analytical Chemistry, Bd. 85, 2013, H. 21, S. 10142-10148. ISSN 1520-6882 (E); 0003-2700 (P). DOI: 10.1021/ac402419r. *
GRÜNER, Florian [u.a.]: Localising functionalised gold-nanoparticles in murine spinal cords by X-ray fluorescence imaging and background-reduction through spatial filtering for human-sized objects. In: Scientific Reports, Bd. 8, 2018, Artikelnummer: 16561. ISSN 2045-2322 (E). DOI: 10.1038/s41598-018-34925-3. URL: https://www.nature.com/articles/s41598-018-34925-3.pdf [abgerufen am 11.12.2019]. *
HOSSAIN, Mainul; WANG, Chaoming; SU, Ming: Multiplexed biomarker detection using x-ray fluorescence of composition-encoded nanoparticles. In: Applied Physics Letters, Vol. 97, 2010, S. 263704-1-263704-3. *
KHRENNIKOV, K. [u.a.]: Tunable all-optical quasimonochromatic Thomson X-ray source in the nonlinear regime. In: PHYSICAL REVIEW LETTERS. 2015, Bd. 114, H. 19, Artikel-Nr. 195003. ISSN 0031-9007 (P); 1079-7114 (E). DOI: 10.1103/PhysRevLett.114.195003. URL: http://umu.diva-portal.org/smash/get/diva2:1093441/FULLTEXT01.pdf [abgerufen am 12.09.2017]. *
LI, Yuyang [et al.]: A Library of Potential Nanoparticle Contrast Agents for X-Ray Fluorescence Tomography Bioimaging. In: Contrast Media & Molecular Imaging, Vol. 2018, 2018, Article ID 8174820, S. 1-7. *
PELLEGRINO, Teresa [u.a.]: Hydrophobic nanocrystals coated with an amphiphilic polymer shell: A general route to water soluble nanocrystals. In: Nano Letters, Bd. 4, 2004, H. 4, S. 703-707. ISSN 1530-6992 (E); 1530-6984 (P). DOI: 10.1021/nl035172j. URL: https://pubs.acs.org/doi/pdf/10.1021/nl035172j [abgerufen am 11.12.2019]. *
ZHANG, Run [u.a.]: X-ray fluorescence imaging of metals and metalloids in biological systems. In: American Journal of Nuclear Medicine and Molecular Imaging, Bd. 8, 2018, H. 3, S. 169-188. ISSN 2160-8407 (E). URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056246/pdf/ajnmmi0008-0169.pdf [abgerufen am 11.12.2019]. *

Also Published As

Publication number Publication date
JP2022553761A (ja) 2022-12-26
CN114667447A (zh) 2022-06-24
WO2021078950A1 (de) 2021-04-29
KR20220091515A (ko) 2022-06-30
CN114667447B (zh) 2025-11-18
EP4049011A1 (de) 2022-08-31
US20220370645A1 (en) 2022-11-24
JP7635224B2 (ja) 2025-02-25

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