CN114667447B - 用于多参数x射线荧光成像的方法、设备和标记物质套件 - Google Patents

用于多参数x射线荧光成像的方法、设备和标记物质套件

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Publication number
CN114667447B
CN114667447B CN202080074754.5A CN202080074754A CN114667447B CN 114667447 B CN114667447 B CN 114667447B CN 202080074754 A CN202080074754 A CN 202080074754A CN 114667447 B CN114667447 B CN 114667447B
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substance
sample
ray
marker
fluorescence
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CN114667447A (zh
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F·格吕纳
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Universitaet Hamburg
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Universitaet Hamburg
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/22—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material
    • G01N23/223—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material by irradiating the sample with X-rays or gamma-rays and by measuring X-ray fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414—Particles, beads, capsules or spheres
    • A61K49/0423—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/22—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/22—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material
    • G01N23/2202—Preparing specimens therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2223/00—Investigating materials by wave or particle radiation
    • G01N2223/07—Investigating materials by wave or particle radiation secondary emission
    • G01N2223/076—X-ray fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2223/00—Investigating materials by wave or particle radiation
    • G01N2223/40—Imaging
    • G01N2223/401—Imaging image processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2223/00—Investigating materials by wave or particle radiation
    • G01N2223/60—Specific applications or type of materials
    • G01N2223/612—Specific applications or type of materials biological material

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Nanotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Nuclear Medicine (AREA)
CN202080074754.5A 2019-10-25 2020-10-23 用于多参数x射线荧光成像的方法、设备和标记物质套件 Active CN114667447B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102019128842.8A DE102019128842A1 (de) 2019-10-25 2019-10-25 Verfahren, Vorrichtung und Markersubstanz-Kit zur multiparametrischen Röntgenfluoreszenz-Bildgebung
DE102019128842.8 2019-10-25
PCT/EP2020/079909 WO2021078950A1 (de) 2019-10-25 2020-10-23 Verfahren, vorrichtung und markersubstanz-kit zur multiparametrischen röntgenfluoreszenz-bildgebung

Publications (2)

Publication Number Publication Date
CN114667447A CN114667447A (zh) 2022-06-24
CN114667447B true CN114667447B (zh) 2025-11-18

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Country Status (7)

Country Link
US (1) US20220370645A1 (https=)
EP (1) EP4049011A1 (https=)
JP (1) JP7635224B2 (https=)
KR (1) KR20220091515A (https=)
CN (1) CN114667447B (https=)
DE (1) DE102019128842A1 (https=)
WO (1) WO2021078950A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116577358B (zh) * 2023-05-18 2024-01-23 杭州宇称电子技术有限公司 基于x射线k-吸收边的书画文物颜料成像方法及其应用
CN118961777B (zh) * 2024-07-19 2025-11-28 中国科学院金属研究所 一种准原位追踪高温合金微量元素分布的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015104225A1 (en) * 2014-01-07 2015-07-16 Jettec Ab X-ray micro imaging

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1603459A1 (en) 2003-03-07 2005-12-14 Philips Intellectual Property & Standards GmbH Method and imaging system for imaging the spatial distribution of an x-ray fluorescence marker
JP5557266B2 (ja) 2008-07-17 2014-07-23 国立大学法人 筑波大学 蛍光エックス線検出装置
WO2011084625A1 (en) * 2009-12-16 2011-07-14 Georgia Tech Research Corporation Systems and methods for x-ray flourescence computed tomography imaging with nanoparticles
JP5761102B2 (ja) 2012-03-29 2015-08-12 コニカミノルタ株式会社 高輝度半導体ナノ粒子集積体
FR2989280B1 (fr) 2012-04-13 2017-02-24 Univ Claude Bernard Lyon Nanoparticules ultrafines comme agent de contraste multimodal
WO2015031675A1 (en) * 2013-08-28 2015-03-05 The Regents Of The University Of California Nanoparticle assisted scanning focusing x-ray fluorescence imaging and enhanced treatment
DE102017003517A1 (de) 2017-04-11 2018-10-11 Universität Hamburg Verfahren und Messvorrichtung zur Röntgenfluoreszenz-Messung
CN108469445B (zh) * 2018-03-29 2020-09-01 福州大学 用于无背景检测血液中癌症抗原含量的基于x射线激发的镧系荧光纳米粒子的试剂盒及制备
JP2019183047A (ja) 2018-04-13 2019-10-24 Ａｇｃ株式会社 蛍光ナノ粒子およびその製造方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015104225A1 (en) * 2014-01-07 2015-07-16 Jettec Ab X-ray micro imaging

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HOSSAIN MAINUL 等.Multiplexed biomarker detection using x-ray fluorescence of composition-encoded nanoparticles.APPLIED PHYSICS LETTERS.2010,第97卷(第26期),263704 - 263704. *
Multiplexed biomarker detection using x-ray fluorescence of composition-encoded nanoparticles;HOSSAIN MAINUL 等;APPLIED PHYSICS LETTERS;20101230;第97卷(第26期);263704 - 263704 *

Also Published As

Publication number Publication date
JP2022553761A (ja) 2022-12-26
DE102019128842A1 (de) 2021-04-29
CN114667447A (zh) 2022-06-24
WO2021078950A1 (de) 2021-04-29
KR20220091515A (ko) 2022-06-30
EP4049011A1 (de) 2022-08-31
US20220370645A1 (en) 2022-11-24
JP7635224B2 (ja) 2025-02-25

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