JP7635224B2 - マルチパラメトリックｘ線蛍光イメージングのための方法および装置 - Google Patents

マルチパラメトリックｘ線蛍光イメージングのための方法および装置 Download PDF

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JP7635224B2
JP7635224B2 JP2022524594A JP2022524594A JP7635224B2 JP 7635224 B2 JP7635224 B2 JP 7635224B2 JP 2022524594 A JP2022524594 A JP 2022524594A JP 2022524594 A JP2022524594 A JP 2022524594A JP 7635224 B2 JP7635224 B2 JP 7635224B2
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nanoparticles
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JP2022553761A (ja
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グリュナー，フロリアン
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Universitaet Hamburg
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/22—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material
    • G01N23/223—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material by irradiating the sample with X-rays or gamma-rays and by measuring X-ray fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414—Particles, beads, capsules or spheres
    • A61K49/0423—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/22—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/22—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material
    • G01N23/2202—Preparing specimens therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2223/00—Investigating materials by wave or particle radiation
    • G01N2223/07—Investigating materials by wave or particle radiation secondary emission
    • G01N2223/076—X-ray fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2223/00—Investigating materials by wave or particle radiation
    • G01N2223/40—Imaging
    • G01N2223/401—Imaging image processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2223/00—Investigating materials by wave or particle radiation
    • G01N2223/60—Specific applications or type of materials
    • G01N2223/612—Specific applications or type of materials biological material

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Nanotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Nuclear Medicine (AREA)
JP2022524594A 2019-10-25 2020-10-23 マルチパラメトリックｘ線蛍光イメージングのための方法および装置 Active JP7635224B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102019128842.8A DE102019128842A1 (de) 2019-10-25 2019-10-25 Verfahren, Vorrichtung und Markersubstanz-Kit zur multiparametrischen Röntgenfluoreszenz-Bildgebung
DE102019128842.8 2019-10-25
PCT/EP2020/079909 WO2021078950A1 (de) 2019-10-25 2020-10-23 Verfahren, vorrichtung und markersubstanz-kit zur multiparametrischen röntgenfluoreszenz-bildgebung

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JP2022553761A JP2022553761A (ja) 2022-12-26
JP2022553761A5 JP2022553761A5 (https=) 2023-10-18
JP7635224B2 true JP7635224B2 (ja) 2025-02-25

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US (1) US20220370645A1 (https=)
EP (1) EP4049011A1 (https=)
JP (1) JP7635224B2 (https=)
KR (1) KR20220091515A (https=)
CN (1) CN114667447B (https=)
DE (1) DE102019128842A1 (https=)
WO (1) WO2021078950A1 (https=)

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CN116577358B (zh) * 2023-05-18 2024-01-23 杭州宇称电子技术有限公司 基于x射线k-吸收边的书画文物颜料成像方法及其应用
CN118961777B (zh) * 2024-07-19 2025-11-28 中国科学院金属研究所 一种准原位追踪高温合金微量元素分布的方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060182217A1 (en) 2003-03-07 2006-08-17 Koninklijke Philips Electronics N.V. Method and imaging system for imaging the spatial distrubution of an x-ray fluorescence marker
JP2010025711A (ja) 2008-07-17 2010-02-04 Univ Of Tsukuba 蛍光エックス線検出装置
JP2013204004A (ja) 2012-03-29 2013-10-07 Konica Minolta Inc 高輝度半導体ナノ粒子集積体
JP2017095480A (ja) 2012-04-13 2017-06-01 ユニベルシテ・クロード・ベルナール・リヨン・プルミエ マルチモーダル造影剤としての超微細ナノ粒子
WO2018189051A1 (de) 2017-04-11 2018-10-18 Universität Hamburg Verfahren und messvorrichtung zur röntgenfluoreszenz-messung
JP2019183047A (ja) 2018-04-13 2019-10-24 Ａｇｃ株式会社 蛍光ナノ粒子およびその製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011084625A1 (en) * 2009-12-16 2011-07-14 Georgia Tech Research Corporation Systems and methods for x-ray flourescence computed tomography imaging with nanoparticles
WO2015031675A1 (en) * 2013-08-28 2015-03-05 The Regents Of The University Of California Nanoparticle assisted scanning focusing x-ray fluorescence imaging and enhanced treatment
EP3091903B1 (en) * 2014-01-07 2018-10-03 Jettec AB X-ray micro imaging
CN108469445B (zh) * 2018-03-29 2020-09-01 福州大学 用于无背景检测血液中癌症抗原含量的基于x射线激发的镧系荧光纳米粒子的试剂盒及制备

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060182217A1 (en) 2003-03-07 2006-08-17 Koninklijke Philips Electronics N.V. Method and imaging system for imaging the spatial distrubution of an x-ray fluorescence marker
JP2006519647A (ja) 2003-03-07 2006-08-31 コーニンクレッカ　フィリップス　エレクトロニクス　エヌ　ヴィ Ｘ線蛍光マーカの空間分布をイメージングする方法及びイメージングシステム
JP2010025711A (ja) 2008-07-17 2010-02-04 Univ Of Tsukuba 蛍光エックス線検出装置
JP2013204004A (ja) 2012-03-29 2013-10-07 Konica Minolta Inc 高輝度半導体ナノ粒子集積体
JP2017095480A (ja) 2012-04-13 2017-06-01 ユニベルシテ・クロード・ベルナール・リヨン・プルミエ マルチモーダル造影剤としての超微細ナノ粒子
WO2018189051A1 (de) 2017-04-11 2018-10-18 Universität Hamburg Verfahren und messvorrichtung zur röntgenfluoreszenz-messung
JP2020516915A (ja) 2017-04-11 2020-06-11 アクシオム・インサイツ・ゲーエムベーハー 蛍光ｘ線測定のための方法および測定装置
JP2019183047A (ja) 2018-04-13 2019-10-24 Ａｇｃ株式会社 蛍光ナノ粒子およびその製造方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Liyuan MA et al.，"Multiplexed highly sensitive detections of cancer biomarkers in thermal space using encapsulated phase change nanoparticles"，Applied Physics Letters，2009年07月27日，Vol. 95, No. 4，DOI: 10.1063/1.3189082
Mainul HOSSAIN et al.，"Multiplexed biomarker detection using x-ray fluorescence of composition-encoded nanoparticles"，Applied Physics Letters，2010年12月27日，Vol. 97, No. 26，DOI: 10.1063/1.3533817

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Publication number Publication date
JP2022553761A (ja) 2022-12-26
DE102019128842A1 (de) 2021-04-29
CN114667447A (zh) 2022-06-24
WO2021078950A1 (de) 2021-04-29
KR20220091515A (ko) 2022-06-30
CN114667447B (zh) 2025-11-18
EP4049011A1 (de) 2022-08-31
US20220370645A1 (en) 2022-11-24

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