DE102010048374A1 - Pyrrolidinone als MetAP-2 Inhibitoren - Google Patents

Pyrrolidinone als MetAP-2 Inhibitoren Download PDF

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Publication number
DE102010048374A1
DE102010048374A1 DE102010048374A DE102010048374A DE102010048374A1 DE 102010048374 A1 DE102010048374 A1 DE 102010048374A1 DE 102010048374 A DE102010048374 A DE 102010048374A DE 102010048374 A DE102010048374 A DE 102010048374A DE 102010048374 A1 DE102010048374 A1 DE 102010048374A1
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Germany
Prior art keywords
het
compounds
formula
unsubstituted
mono
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DE102010048374A
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German (de)
English (en)
Inventor
Dr. Heinrich Timo
Dr. Zenke Frank
Dr. Calderini Michel
Dr. Musil Djordje
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Merck Patent GmbH
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Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Priority to DE102010048374A priority Critical patent/DE102010048374A1/de
Priority to JP2013533102A priority patent/JP5931885B2/ja
Priority to ES11761005T priority patent/ES2563317T3/es
Priority to US13/878,574 priority patent/US8895535B2/en
Priority to CA2814369A priority patent/CA2814369C/en
Priority to CN201180049753.6A priority patent/CN103153951B/zh
Priority to HUE11761005A priority patent/HUE027149T2/en
Priority to SI201130753T priority patent/SI2627631T1/sl
Priority to EP11761005.5A priority patent/EP2627631B1/de
Priority to KR1020137011998A priority patent/KR101803126B1/ko
Priority to BR112013008886-9A priority patent/BR112013008886B1/pt
Priority to RS20160123A priority patent/RS54629B1/sr
Priority to PL11761005T priority patent/PL2627631T3/pl
Priority to DK11761005.5T priority patent/DK2627631T3/en
Priority to PCT/EP2011/004608 priority patent/WO2012048775A1/de
Priority to AU2011316199A priority patent/AU2011316199B2/en
Priority to MX2013004004A priority patent/MX2013004004A/es
Priority to SG2013026133A priority patent/SG189853A1/en
Priority to EA201300442A priority patent/EA022299B1/ru
Priority to HRP20160249TT priority patent/HRP20160249T1/hr
Priority to HK13113621.5A priority patent/HK1186179B/xx
Priority to ARP110103781A priority patent/AR083402A1/es
Publication of DE102010048374A1 publication Critical patent/DE102010048374A1/de
Priority to IL225626A priority patent/IL225626A0/en
Priority to CY20161100221T priority patent/CY1117287T1/el
Withdrawn legal-status Critical Current

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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DE102010048374A DE102010048374A1 (de) 2010-10-13 2010-10-13 Pyrrolidinone als MetAP-2 Inhibitoren
RS20160123A RS54629B1 (sr) 2010-10-13 2011-09-14 Pirolidinoni kao metap-2-inhibitori
DK11761005.5T DK2627631T3 (en) 2010-10-13 2011-09-14 Pyrrolidinone AS METAP-2 INHIBITORS
US13/878,574 US8895535B2 (en) 2010-10-13 2011-09-14 Pyrrolidinones as MetAP-2 inhibitors
CA2814369A CA2814369C (en) 2010-10-13 2011-09-14 Pyrrolidinones as metap-2 inhibitors
CN201180049753.6A CN103153951B (zh) 2010-10-13 2011-09-14 作为MetAP-2抑制剂的吡咯烷酮
HUE11761005A HUE027149T2 (en) 2010-10-13 2011-09-14 Pyrrolidinones as Metap-2 inhibitors
SI201130753T SI2627631T1 (sl) 2010-10-13 2011-09-14 Pirolidinoni kot zaviralci metap2
EP11761005.5A EP2627631B1 (de) 2010-10-13 2011-09-14 Pyrrolidinone als metap-2 inhibitoren
KR1020137011998A KR101803126B1 (ko) 2010-10-13 2011-09-14 Ｍｅｔａｐ2 억제제로서의 피롤리디논
BR112013008886-9A BR112013008886B1 (pt) 2010-10-13 2011-09-14 Pirrolidinonas, seu uso e seu processo de preparação, e medicamentos
JP2013533102A JP5931885B2 (ja) 2010-10-13 2011-09-14 ＭｅｔＡＰ２阻害剤としてのピロリジノン
PL11761005T PL2627631T3 (pl) 2010-10-13 2011-09-14 Pirrolidynony jako inhibitory metap2
AU2011316199A AU2011316199B2 (en) 2010-10-13 2011-09-14 Pyrrolidinones as MetAP2 inhibitors
PCT/EP2011/004608 WO2012048775A1 (de) 2010-10-13 2011-09-14 Pyrrolidinone als metap-2 inhibitoren
HK13113621.5A HK1186179B (en) 2010-10-13 2011-09-14 Pyrrolidinones as metap2 inhibitors
MX2013004004A MX2013004004A (es) 2010-10-13 2011-09-14 Pirrolidinonas como inhibidores de metionina aminopeptidasa (metap-2).
SG2013026133A SG189853A1 (en) 2010-10-13 2011-09-14 Pyrrolidinones as metap2 inhibitors
EA201300442A EA022299B1 (ru) 2010-10-13 2011-09-14 ПИРРОЛИДИНОНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ MetAP-2
HRP20160249TT HRP20160249T1 (hr) 2010-10-13 2011-09-14 Pirolidinoni kao inhibitori metap2
ES11761005T ES2563317T3 (es) 2010-10-13 2011-09-14 Pirrolidinonas como inhibidores de MetAP-2
ARP110103781A AR083402A1 (es) 2010-10-13 2011-10-13 Pirrolidinonas como inhibidores de metap-2
IL225626A IL225626A0 (en) 2010-10-13 2013-04-08 The history of pyrrolidinone, their preparation and remote preparations containing them
CY20161100221T CY1117287T1 (el) 2010-10-13 2016-03-15 Πυρρολιδινονη ως αναστολεις metap-2

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016020031A1 (en) * 2014-08-04 2016-02-11 Merck Patent Gmbh Pyrrolidinone derivatives as metap-2 inhibitors

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8575349B2 (en) * 2010-11-22 2013-11-05 International Flavors & Fragrances Inc. Derivatives of 1-alkyl-6-oxo-piperidine-3-carboxylic acids and 1-alkyl-5-oxo-pyrrolidine-3-carboxylic acids and their uses as cooling compounds
PT2573073E (pt) * 2011-09-26 2015-02-05 Sanofi Sa Derivados de pirazoloquinolinona, sua preparação e sua utilização terapêutica
JP6042060B2 (ja) * 2011-09-26 2016-12-14 サノフイ ピラゾロキノリノン誘導体、その調製および治療上の使用
DE102012006884A1 (de) * 2012-04-04 2013-10-10 Merck Patent Gmbh Cyclische Amide als MetAP-2 Inhibitoren
EP3045448A4 (en) * 2013-09-12 2017-01-25 Sumitomo Chemical Company Limited Nitrogen-containing saturated heterocyclic compound
WO2017084096A1 (en) * 2015-11-20 2017-05-26 Eli Lilly And Company Pyrrolidinone compounds
WO2017004797A1 (en) * 2015-07-08 2017-01-12 Eli Lilly And Company Pyrrolidinone compounds
AU2017280099A1 (en) * 2016-06-21 2019-01-17 The University Of Melbourne Activators of HIV latency
WO2018098781A1 (en) * 2016-12-01 2018-06-07 Eli Lilly And Company Pyrrolidinone compounds
US11365194B2 (en) * 2017-09-27 2022-06-21 Kagoshima University Analgesic drug using PAC1 receptor antagonistic drug
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ES2934986T3 (es) * 2019-01-22 2023-02-28 Merck Patent Gmbh Derivados heterocíclicos
SI3994134T1 (sl) 2019-07-03 2024-06-28 Merck Patent Gmbh Postopek za izdelavo (s)-3-hidroksi-1-(1h-indol-5-il)-2-okso-pirolidin-3-karboksilne kisline 3,5-difluoro-benzilamida
CN112480100B (zh) * 2019-09-11 2022-10-14 康威(广州)生物科技有限公司 吡咯烷酮衍生物
CN110759843A (zh) * 2019-09-30 2020-02-07 东北师范大学 一种氟叠氮取代的四元杂环化合物的制备和应用
CN115989027A (zh) 2020-07-09 2023-04-18 默克专利股份公司 甲硫氨酸氨肽酶2抑制剂和vegfr/vegf抑制剂的组合
CN112851561A (zh) * 2021-01-29 2021-05-28 南京艾美斐生物医药科技有限公司 一种nr6a1蛋白受体抑制剂及其制备和应用
KR20230170693A (ko) * 2021-03-28 2023-12-19 캔웰 바이오테크 리미티드 Metap-2 억제제, 약제학적 조성물 및 이의 치료 방법
WO2023144053A1 (en) 2022-01-26 2023-08-03 Merck Patent Gmbh Heterocyclic derivatives

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6069134A (en) 1991-03-06 2000-05-30 Board Of Regents, The University Of Texas System Methods and compositions comprising DNA damaging agents and p53
WO2000050032A1 (en) 1999-02-25 2000-08-31 Pharmacia & Upjohn S.P.A. Antitumour synergistic composition
WO2001079157A1 (en) 2000-04-14 2001-10-25 Abbott Laboratories Hydrazide and alkoxyamide angiogenesis inhibitors
WO2002081415A2 (en) 2001-04-03 2002-10-17 Smithkline Beecham Corporation Method for inhibiting metap2
WO2008011114A2 (en) 2006-07-21 2008-01-24 Praecis Pharmaceuticals Incorporated Methionine aminopeptidase-2 inhibitors and methods of use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030225054A1 (en) * 2002-06-03 2003-12-04 Jingwu Duan Combined use of tace inhibitors and COX2 inhibitors as anti-inflammatory agents
AU2003274037A1 (en) 2002-10-18 2004-05-13 Basf Aktiengesellschaft 1-phenylpyrrolidine-2-one-3-carboxamides
JP2006104280A (ja) 2004-10-04 2006-04-20 Toyo Tire & Rubber Co Ltd 高熱伝導性加硫ゴム成形体及びダイアフラム
US20090264650A1 (en) 2005-03-31 2009-10-22 Nobuo Cho Prophylactic/Therapeutic Agent for Diabetes
US20070123508A1 (en) 2005-05-27 2007-05-31 Roger Olsson PAR2-modulating compounds and their use
UY31984A (es) * 2008-07-16 2010-02-26 Boehringer Ingelheim Int DERIVADOS DE 1-(3,4-difluorobencil)-6-oxo-1,6-dihidropirimidin-5-carboxamidas N-sustituidas y de 2-(3,4-difluorobencil)-3-oxo-2,3-dihidro-1H-pirazol-4-carboxamidas N-sustituidas.
US8815309B2 (en) 2010-01-08 2014-08-26 Zafgen, Inc. Methods of treating a subject with benign prostate hyperplasia
BR112012016793A2 (pt) 2010-01-08 2018-07-31 Zafgen Corp compostos tipo fumagilol e métodos de fazer e usar os mesmos

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6069134A (en) 1991-03-06 2000-05-30 Board Of Regents, The University Of Texas System Methods and compositions comprising DNA damaging agents and p53
WO2000050032A1 (en) 1999-02-25 2000-08-31 Pharmacia & Upjohn S.P.A. Antitumour synergistic composition
WO2001079157A1 (en) 2000-04-14 2001-10-25 Abbott Laboratories Hydrazide and alkoxyamide angiogenesis inhibitors
WO2002081415A2 (en) 2001-04-03 2002-10-17 Smithkline Beecham Corporation Method for inhibiting metap2
WO2008011114A2 (en) 2006-07-21 2008-01-24 Praecis Pharmaceuticals Incorporated Methionine aminopeptidase-2 inhibitors and methods of use thereof

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
A. Morabito et al. Crit. Rev. Oncol./Hematol. 2004, 49, 91
Analytica Chimica Acta (1987), 202, 167-74
Angew. Chem. 92, 129 (1980)
B. Nicholson et al. Cancer Metastas. Rev. 2001, 20, 297
E. Ng et al. Can. J. Ophthalmol. 2005, 23, 3706
F. Spinella et al. J. Cardiovasc. Pharmacol. 2004, 44, S140
Houben-Weyl, Methoden der organischen Chemie, Georg-Thieme-Verlag, Stuttgart
Int. J. Pharm. 115, 61-67 (1995)
J. Chem. Soc. (1965), (Oct.), 5551-6
J. Chem. Soc. (1965), (Oct.), 5556-62
Journal of Electroanalytical Chemistry and Interfacial Electrochemistry (1988), 239(1-2), 161-73
Zeitschrift fuer Naturfor. Teil B: Anorg. Chem. Org. Chem (1978), 336(12), 1540-6
Zeitschrift für Naturforschung, B: Chemical Sciences (1994), 49(11), 1586-95

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016020031A1 (en) * 2014-08-04 2016-02-11 Merck Patent Gmbh Pyrrolidinone derivatives as metap-2 inhibitors
US10005756B2 (en) 2014-08-04 2018-06-26 Merck Patent Gmbh Pyrrolidinone derivatives as MetAP-2 inhibitors
AU2015299431B2 (en) * 2014-08-04 2019-11-07 Merck Patent Gmbh Pyrrolidinone derivatives as metAP-2 inhibitors

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