CA2814369C - Pyrrolidinones as metap-2 inhibitors - Google Patents

Pyrrolidinones as metap-2 inhibitors Download PDF

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Publication number
CA2814369C
CA2814369C CA2814369A CA2814369A CA2814369C CA 2814369 C CA2814369 C CA 2814369C CA 2814369 A CA2814369 A CA 2814369A CA 2814369 A CA2814369 A CA 2814369A CA 2814369 C CA2814369 C CA 2814369C
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Prior art keywords
hydroxy
carboxylic acid
amide
chloro
oxo
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CA2814369A
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French (fr)
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CA2814369A1 (en
Inventor
Timo Heinrich
Frank Zenke
Michel Calderini
Djordje Musil
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Merck Patent GmbH
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Merck Patent GmbH
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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CA2814369A 2010-10-13 2011-09-14 Pyrrolidinones as metap-2 inhibitors Active CA2814369C (en)

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DE102010048374A DE102010048374A1 (de) 2010-10-13 2010-10-13 Pyrrolidinone als MetAP-2 Inhibitoren
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PCT/EP2011/004608 WO2012048775A1 (de) 2010-10-13 2011-09-14 Pyrrolidinone als metap-2 inhibitoren

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CN112851561A (zh) * 2021-01-29 2021-05-28 南京艾美斐生物医药科技有限公司 一种nr6a1蛋白受体抑制剂及其制备和应用
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