DE102008036060A1 - Zellbasiertes Verfahren und Mittel zum Knochenaufbau - Google Patents

Zellbasiertes Verfahren und Mittel zum Knochenaufbau Download PDF

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Publication number
DE102008036060A1
DE102008036060A1 DE102008036060A DE102008036060A DE102008036060A1 DE 102008036060 A1 DE102008036060 A1 DE 102008036060A1 DE 102008036060 A DE102008036060 A DE 102008036060A DE 102008036060 A DE102008036060 A DE 102008036060A DE 102008036060 A1 DE102008036060 A1 DE 102008036060A1
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DE
Germany
Prior art keywords
bone
osteoclasts
cells
osteoblasts
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE102008036060A
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German (de)
English (en)
Inventor
Bernard Hoflack
Maria Arantzazu Sanchez Fernandez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TU Dresden
Original Assignee
TU Dresden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TU Dresden filed Critical TU Dresden
Priority to DE102008036060A priority Critical patent/DE102008036060A1/de
Priority to PCT/EP2009/060078 priority patent/WO2010015619A2/en
Priority to JP2011521559A priority patent/JP2011529756A/ja
Priority to EP09781459A priority patent/EP2318518A2/en
Priority to US13/057,482 priority patent/US20110189289A1/en
Publication of DE102008036060A1 publication Critical patent/DE102008036060A1/de
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3821—Bone-forming cells, e.g. osteoblasts, osteocytes, osteoprogenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3847—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0643—Osteoclasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/185—Osteoprotegerin; Osteoclast differentiation factor (ODF, RANKL)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Botany (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
DE102008036060A 2008-08-04 2008-08-04 Zellbasiertes Verfahren und Mittel zum Knochenaufbau Ceased DE102008036060A1 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE102008036060A DE102008036060A1 (de) 2008-08-04 2008-08-04 Zellbasiertes Verfahren und Mittel zum Knochenaufbau
PCT/EP2009/060078 WO2010015619A2 (en) 2008-08-04 2009-08-04 Cell-based method and means for rebuilding bone
JP2011521559A JP2011529756A (ja) 2008-08-04 2009-08-04 骨を再建するための細胞ベースの方法及び手段
EP09781459A EP2318518A2 (en) 2008-08-04 2009-08-04 Cell-based method for rebuilding bone
US13/057,482 US20110189289A1 (en) 2008-08-04 2009-08-04 Cell-Based Method and Means for Rebuilding Bone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102008036060A DE102008036060A1 (de) 2008-08-04 2008-08-04 Zellbasiertes Verfahren und Mittel zum Knochenaufbau

Publications (1)

Publication Number Publication Date
DE102008036060A1 true DE102008036060A1 (de) 2010-02-25

Family

ID=41279459

Family Applications (1)

Application Number Title Priority Date Filing Date
DE102008036060A Ceased DE102008036060A1 (de) 2008-08-04 2008-08-04 Zellbasiertes Verfahren und Mittel zum Knochenaufbau

Country Status (5)

Country Link
US (1) US20110189289A1 (cg-RX-API-DMAC7.html)
EP (1) EP2318518A2 (cg-RX-API-DMAC7.html)
JP (1) JP2011529756A (cg-RX-API-DMAC7.html)
DE (1) DE102008036060A1 (cg-RX-API-DMAC7.html)
WO (1) WO2010015619A2 (cg-RX-API-DMAC7.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013305947A1 (en) * 2012-08-20 2015-03-05 Boston Medical Center Corporation Assays, systems, and methods for obtaining personalized anabolic profiles
WO2014033325A1 (en) * 2012-09-03 2014-03-06 Universitätsspital Basel Rechtsdienst Cell-based activation of devitalized engineered grafts for tissue repair
EP2974753A1 (en) * 2014-07-18 2016-01-20 Institut National De La Sante Et De La Recherche Medicale (Inserm) Bone regenerating biomaterials with selected cells from peripheral blood
CN116726049A (zh) * 2022-03-02 2023-09-12 四川大学华西医院 一种龛细胞和/或其分泌物在治疗骨缺损和/或骨重建异常疾病的药物中的用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE288477T1 (de) * 1998-04-08 2005-02-15 Shionogi & Co Verfahren um vorläuferzellen von osteoklasten zu isolieren und ihre differenzierung in osteoklasten zu induzieren.
WO2001012785A1 (en) * 1999-08-13 2001-02-22 University Of Rochester Ex vivo generation of functional osteoclasts from bone marrow in a three-dimensional bioreactor
WO2006128029A2 (en) * 2005-05-25 2006-11-30 University Of Virginia Patent Foundation Production of osteoclasts from adipose tissues
JP2009508650A (ja) * 2005-09-21 2009-03-05 ダスク テクノロジーズ， エルエルシー 臓器および組織機能のための方法および組成

Non-Patent Citations (21)

* Cited by examiner, † Cited by third party
Title
Aguila H. L. and Rowe D. W. (2005) Skeletal development, bone remodeling, and hematopoiesis. Immunol Rev 208: 7-18
Bonnelye E. et al. (2008) Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro. Bone 42: 129-138
Boyle W. J. et al. (2003) Osteoclast differentiation and activation. Nature 423: 337-342
Bruzzaniti A. and Baron R. (2006) Molecular regulation of osteoclast activity. Rev Endocr Metab Disord 7: 123-139
Czupalla C. et al. (2006)
Czupalla C. et al. (2006) Proteomic analysis of lysosomal acid hydrolases secreted by osteoclasts: implications for lytic enzyme transport and bone metabolism. Mol Cell Proteomics 5: 134-143
Falk W. et al. (1980) A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration. J Immunol Methods 33: 239-247
Fiedler J. et al. (2004) To go or not to go: Migration of human mesenchymal progenitor cells stimulated by isoforms of PDGF. J Cell Biochem 93: 990-998
Harada S. and Rodan G. A. (2003) Control of osteoblast function and regulation of bone mass. Nature 423: 349-355
Kawamata A. et al. (2008) JunD suppresses bone formation and contributes to low bone mass induced by estrogen depletion. J Cell Biochem 103: 1037-1045
Lee S. H. et al. (2006) v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation. Nat Med 12: 1403-1409
Li L. and Xie T. (2005) Stem cell niche: structure and function. Annu Rev Cell Dev Biol 21: 605-631
Mayr-Wohlfart U. et al. (2002) Vascular endothelial growth factor stimulates chemotactic migration of primary human osteoblasts. Bone 30: 472-477
Plose One, Oktober 2008, Vol.3, Issue 10, e3537, S.1-8 *
Plose One, Oktober 2008, Vol.3, Issue 10, e3537, S.1-8 Proteomics 2005, S.3868-3875
Proteomics 2005, S.3868-3875 *
Teitelbaum S. L. (2000) Bone resorption by osteoclasts. Science 289: 1504-1508
Teitelbaum S. L. (2007) Osteoclasts: what do they do and how do they do it? Am J Pathol 170: 427-435
Wagner EF (2002) Functions of AP1 (Fos/Jun) in bone development. Ann Rheum Dis 61 Suppl 2: ii40-42
Yin T. and Li L. (2006) The stem cell niches in bone. J Clin Invest 116: 1195-1201
Zhao C. et al. (2006) Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. Cell Metab 4: 111-121

Also Published As

Publication number Publication date
JP2011529756A (ja) 2011-12-15
EP2318518A2 (en) 2011-05-11
WO2010015619A3 (en) 2010-04-01
US20110189289A1 (en) 2011-08-04
WO2010015619A2 (en) 2010-02-11

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