ATE288477T1 - Verfahren um vorläuferzellen von osteoklasten zu isolieren und ihre differenzierung in osteoklasten zu induzieren. - Google Patents

Verfahren um vorläuferzellen von osteoklasten zu isolieren und ihre differenzierung in osteoklasten zu induzieren.

Info

Publication number
ATE288477T1
ATE288477T1 AT99912113T AT99912113T ATE288477T1 AT E288477 T1 ATE288477 T1 AT E288477T1 AT 99912113 T AT99912113 T AT 99912113T AT 99912113 T AT99912113 T AT 99912113T AT E288477 T1 ATE288477 T1 AT E288477T1
Authority
AT
Austria
Prior art keywords
osteoclasts
preosteoclasts
cells
isolating
obtainable
Prior art date
Application number
AT99912113T
Other languages
English (en)
Inventor
Tomoko Maeda
Ryuji Suzuki
Takahiro Ochi
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Application granted granted Critical
Publication of ATE288477T1 publication Critical patent/ATE288477T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0643—Osteoclasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/21—Chemokines, e.g. MIP-1, MIP-2, RANTES, MCP, PF-4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT99912113T 1998-04-08 1999-04-06 Verfahren um vorläuferzellen von osteoklasten zu isolieren und ihre differenzierung in osteoklasten zu induzieren. ATE288477T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP9596298 1998-04-08
JP17040798 1998-06-18
PCT/JP1999/001803 WO1999053023A1 (fr) 1998-04-08 1999-04-06 Procedes permettant d'isoler des cellules precurseurs d'osteoclastes et d'induire la differenciation de ces dernieres sous forme d'osteoclastes

Publications (1)

Publication Number Publication Date
ATE288477T1 true ATE288477T1 (de) 2005-02-15

Family

ID=26437128

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99912113T ATE288477T1 (de) 1998-04-08 1999-04-06 Verfahren um vorläuferzellen von osteoklasten zu isolieren und ihre differenzierung in osteoklasten zu induzieren.

Country Status (7)

Country Link
US (2) US6861257B1 (de)
EP (1) EP1070757B1 (de)
JP (1) JP4271857B2 (de)
AT (1) ATE288477T1 (de)
AU (1) AU3056299A (de)
DE (1) DE69923550T2 (de)
WO (1) WO1999053023A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002097121A1 (en) * 2001-05-28 2002-12-05 Nordic Bioscience A/S Method for assaying osteoclast recruitment and resorption
WO2006128029A2 (en) * 2005-05-25 2006-11-30 University Of Virginia Patent Foundation Production of osteoclasts from adipose tissues
US20070082395A1 (en) * 2005-10-11 2007-04-12 Biancamaria Baroli Production of normal human osteoclasts
US8883507B2 (en) 2005-10-18 2014-11-11 The Regents Of The University Of Colorado Conditionally immortalized long-term hematopoietic stem cells and methods of making and using such cells
KR101803099B1 (ko) 2008-05-16 2017-11-30 타이가 바이오테크놀로지스, 인코포레이티드 항체 및 그 제조 방법
ES2525411T3 (es) 2008-07-21 2014-12-22 Taiga Biotechnologies, Inc. Células anucleadas diferenciadas y método para preparar las mismas
DE102008036060A1 (de) * 2008-08-04 2010-02-25 Technische Universität Dresden Zellbasiertes Verfahren und Mittel zum Knochenaufbau
JP5812861B2 (ja) 2008-08-28 2015-11-17 タイガ バイオテクノロジーズ，インク． Ｍｙｃの修飾物質、該ｍｙｃの修飾物質を使用する方法、およびｍｙｃを調節する薬剤を同定する方法
EP3868387A1 (de) 2012-07-20 2021-08-25 Taiga Biotechnologies, Inc. Verbesserte wiederherstellung und autorenkonstitution des hämatopoietischen abteils
US10272115B2 (en) 2013-03-11 2019-04-30 Taiga Biotechnologies, Inc. Production and use of red blood cells
US9365825B2 (en) 2013-03-11 2016-06-14 Taiga Biotechnologies, Inc. Expansion of adult stem cells in vitro
WO2017011456A1 (en) * 2015-07-16 2017-01-19 Velo3D, Inc. Material-fall three-dimensional printing
WO2018102678A1 (en) 2016-12-02 2018-06-07 Taiga Biotechnologies, Inc. Nanoparticle formulations
US10149898B2 (en) 2017-08-03 2018-12-11 Taiga Biotechnologies, Inc. Methods and compositions for the treatment of melanoma
US11478532B2 (en) 2017-12-03 2022-10-25 National Centre For Cell Science Therapeutic intervention for osteoporosis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5409825A (en) * 1991-04-09 1995-04-25 Indiana University Foundation Expansion of human hematopoietic progenitor cells in a liquid medium
ES2180539T3 (es) * 1991-10-23 2003-02-16 Nexell Therapeutics Inc Metodos para expandir selectivamente celulas madre.
US6103522A (en) * 1994-07-20 2000-08-15 Fred Hutchinson Cancer Research Center Human marrow stromal cell lines which sustain hematopoiesis
US5830682A (en) * 1994-09-09 1998-11-03 Zymogenetics Preparation of immortalized cells
EP0804554A1 (de) * 1994-09-09 1997-11-05 ZymoGenetics, Inc. Herstellung von immortalisierten zellen

Also Published As

Publication number Publication date
EP1070757A4 (de) 2003-04-09
US6861257B1 (en) 2005-03-01
EP1070757B1 (de) 2005-02-02
US20050003528A1 (en) 2005-01-06
DE69923550D1 (de) 2005-03-10
AU3056299A (en) 1999-11-01
JP4271857B2 (ja) 2009-06-03
DE69923550T2 (de) 2006-02-16
WO1999053023A1 (fr) 1999-10-21
EP1070757A1 (de) 2001-01-24

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