DE102005061430A1 - Substituierte Imidazolin-Derivate - Google Patents

Substituierte Imidazolin-Derivate Download PDF

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Publication number
DE102005061430A1
DE102005061430A1 DE102005061430A DE102005061430A DE102005061430A1 DE 102005061430 A1 DE102005061430 A1 DE 102005061430A1 DE 102005061430 A DE102005061430 A DE 102005061430A DE 102005061430 A DE102005061430 A DE 102005061430A DE 102005061430 A1 DE102005061430 A1 DE 102005061430A1
Authority
DE
Germany
Prior art keywords
phenyl
dihydro
methyl
dimethylamino
imidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE102005061430A
Other languages
German (de)
English (en)
Inventor
Beatrix Dr. Merla
Stefan Dr. Oberbörsch
Bernd Dr. Sundermann
Werner Dr. Englberger
Hagen-Heinrich Dr. Hennies
Heinz Dr. Graubaum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Priority to DE102005061430A priority Critical patent/DE102005061430A1/de
Priority to PT06841028T priority patent/PT1963278E/pt
Priority to EP06841028A priority patent/EP1963278B1/de
Priority to ES06841028T priority patent/ES2336833T3/es
Priority to AU2006334743A priority patent/AU2006334743B2/en
Priority to CNA2006800532577A priority patent/CN101384557A/zh
Priority to DE502006005426T priority patent/DE502006005426D1/de
Priority to SI200630546T priority patent/SI1963278T1/sl
Priority to DK06841028.1T priority patent/DK1963278T3/da
Priority to PCT/EP2006/012221 priority patent/WO2007079927A1/de
Priority to RU2008129377/04A priority patent/RU2427571C2/ru
Priority to PL06841028T priority patent/PL1963278T3/pl
Priority to HK09101807.2A priority patent/HK1122019B/xx
Priority to AT06841028T priority patent/ATE449075T1/de
Priority to CA002633918A priority patent/CA2633918A1/en
Priority to JP2008546224A priority patent/JP2009523124A/ja
Publication of DE102005061430A1 publication Critical patent/DE102005061430A1/de
Priority to IL192268A priority patent/IL192268A0/en
Priority to US12/143,566 priority patent/US7728028B2/en
Priority to CY20101100093T priority patent/CY1110465T1/el
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE102005061430A 2005-12-22 2005-12-22 Substituierte Imidazolin-Derivate Withdrawn DE102005061430A1 (de)

Priority Applications (19)

Application Number Priority Date Filing Date Title
DE102005061430A DE102005061430A1 (de) 2005-12-22 2005-12-22 Substituierte Imidazolin-Derivate
PCT/EP2006/012221 WO2007079927A1 (de) 2005-12-22 2006-12-19 Substituierte imidazolin-derivate
RU2008129377/04A RU2427571C2 (ru) 2005-12-22 2006-12-19 ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ ИМИДАЗОЛИНА, ОБЛАДАЮЩИЕ АФФИНОСТЬЮ К µ-ОПИАТНОМУ РЕЦЕПТОРУ
ES06841028T ES2336833T3 (es) 2005-12-22 2006-12-19 Derivados de imidazolina sustituidos.
AU2006334743A AU2006334743B2 (en) 2005-12-22 2006-12-19 Substituted imidazoline derivatives
CNA2006800532577A CN101384557A (zh) 2005-12-22 2006-12-19 取代的咪唑啉衍生物
DE502006005426T DE502006005426D1 (de) 2005-12-22 2006-12-19 Substituierte imidazolin-derivate
SI200630546T SI1963278T1 (sl) 2005-12-22 2006-12-19 Substituirani imidazolinski derivati
DK06841028.1T DK1963278T3 (da) 2005-12-22 2006-12-19 Substituerede imidazolinderivater
PT06841028T PT1963278E (pt) 2005-12-22 2006-12-19 Derivados substituídos de imidazolina
EP06841028A EP1963278B1 (de) 2005-12-22 2006-12-19 Substituierte imidazolin-derivate
PL06841028T PL1963278T3 (pl) 2005-12-22 2006-12-19 Podstawione pochodne imidazoliny
HK09101807.2A HK1122019B (en) 2005-12-22 2006-12-19 Substituted imidazoline derivatives
AT06841028T ATE449075T1 (de) 2005-12-22 2006-12-19 Substituierte imidazolin-derivate
CA002633918A CA2633918A1 (en) 2005-12-22 2006-12-19 Substituted imidazoline derivatives
JP2008546224A JP2009523124A (ja) 2005-12-22 2006-12-19 置換されたイミダゾリン誘導体
IL192268A IL192268A0 (en) 2005-12-22 2008-06-18 Substituted imidazoline derivatives
US12/143,566 US7728028B2 (en) 2005-12-22 2008-06-20 Substituted imidazoline compounds
CY20101100093T CY1110465T1 (el) 2005-12-22 2010-02-02 Υποκατεστημενα παραγωγα ιμιδαζολινης

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005061430A DE102005061430A1 (de) 2005-12-22 2005-12-22 Substituierte Imidazolin-Derivate

Publications (1)

Publication Number Publication Date
DE102005061430A1 true DE102005061430A1 (de) 2007-07-05

Family

ID=37946192

Family Applications (2)

Application Number Title Priority Date Filing Date
DE102005061430A Withdrawn DE102005061430A1 (de) 2005-12-22 2005-12-22 Substituierte Imidazolin-Derivate
DE502006005426T Active DE502006005426D1 (de) 2005-12-22 2006-12-19 Substituierte imidazolin-derivate

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE502006005426T Active DE502006005426D1 (de) 2005-12-22 2006-12-19 Substituierte imidazolin-derivate

Country Status (17)

Country Link
US (1) US7728028B2 (https=)
EP (1) EP1963278B1 (https=)
JP (1) JP2009523124A (https=)
CN (1) CN101384557A (https=)
AT (1) ATE449075T1 (https=)
AU (1) AU2006334743B2 (https=)
CA (1) CA2633918A1 (https=)
CY (1) CY1110465T1 (https=)
DE (2) DE102005061430A1 (https=)
DK (1) DK1963278T3 (https=)
ES (1) ES2336833T3 (https=)
IL (1) IL192268A0 (https=)
PL (1) PL1963278T3 (https=)
PT (1) PT1963278E (https=)
RU (1) RU2427571C2 (https=)
SI (1) SI1963278T1 (https=)
WO (1) WO2007079927A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5599774B2 (ja) 2008-03-27 2014-10-01 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング ヒドロキシメチルシクロヘキシルアミン類
ATE537143T1 (de) 2008-03-27 2011-12-15 Gruenenthal Gmbh Spiro(5.5)undecan derivate
PT2260042E (pt) 2008-03-27 2011-12-06 Gruenenthal Gmbh Derivados de ciclo-hexano espirocíclicos substituídos
WO2009118174A1 (de) 2008-03-27 2009-10-01 Grünenthal GmbH Substituierte cyclohexyldiamine
CA2719735A1 (en) 2008-03-27 2009-10-01 Gruenenthal Gmbh Substituted 4-aminocyclohexane derivatives
AU2009228637B2 (en) 2008-03-27 2013-12-19 Grunenthal Gmbh (Hetero-)aryl cyclohexane derivatives

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003101969A1 (en) * 2002-05-31 2003-12-11 Michigan State University Multi-substituded imidazolines and method of use thereof
EP1486490A1 (en) * 2002-02-28 2004-12-15 Takeda Chemical Industries, Ltd. Azole compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2302294A1 (en) * 1997-08-28 1999-03-04 Harlan Edgar Shannon Method for treating pain
US5952360A (en) * 1997-08-28 1999-09-14 Eli Lilly And Company Method for treating neuropathic pain
DE10000312A1 (de) 2000-01-05 2001-07-12 Gruenenthal Gmbh Substituierte Aminomethyl-Phenyl-Cyclohexanderivate
US7345078B2 (en) * 2002-05-31 2008-03-18 The Board Of Trustees Of Michigan State University NF-κB inhibitors and uses thereof
DE102005061429A1 (de) * 2005-12-22 2007-06-28 Grünenthal GmbH Substituierte Oxazol-Derivate

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1486490A1 (en) * 2002-02-28 2004-12-15 Takeda Chemical Industries, Ltd. Azole compounds
WO2003101969A1 (en) * 2002-05-31 2003-12-11 Michigan State University Multi-substituded imidazolines and method of use thereof

Also Published As

Publication number Publication date
AU2006334743B2 (en) 2011-07-07
JP2009523124A (ja) 2009-06-18
WO2007079927A1 (de) 2007-07-19
ATE449075T1 (de) 2009-12-15
ES2336833T3 (es) 2010-04-16
US7728028B2 (en) 2010-06-01
CN101384557A (zh) 2009-03-11
CA2633918A1 (en) 2007-07-19
PL1963278T3 (pl) 2010-04-30
SI1963278T1 (sl) 2010-03-31
CY1110465T1 (el) 2015-04-29
IL192268A0 (en) 2008-12-29
HK1122019A1 (zh) 2009-05-08
PT1963278E (pt) 2009-12-16
RU2008129377A (ru) 2010-03-27
US20090048323A1 (en) 2009-02-19
EP1963278B1 (de) 2009-11-18
EP1963278A1 (de) 2008-09-03
AU2006334743A1 (en) 2007-07-19
DK1963278T3 (da) 2010-03-29
DE502006005426D1 (de) 2009-12-31
RU2427571C2 (ru) 2011-08-27

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Legal Events

Date Code Title Description
OM8 Search report available as to paragraph 43 lit. 1 sentence 1 patent law
R119 Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee

Effective date: 20110701