DE102005033902B3 - Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel - Google Patents

Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel Download PDF

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Publication number
DE102005033902B3
DE102005033902B3 DE102005033902A DE102005033902A DE102005033902B3 DE 102005033902 B3 DE102005033902 B3 DE 102005033902B3 DE 102005033902 A DE102005033902 A DE 102005033902A DE 102005033902 A DE102005033902 A DE 102005033902A DE 102005033902 B3 DE102005033902 B3 DE 102005033902B3
Authority
DE
Germany
Prior art keywords
groups
mmol
general formula
metal complexes
och
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE102005033902A
Other languages
German (de)
English (en)
Inventor
Heiko Schirmer
Hanns-Joachim Weinmann
Johannes Platzek
Ludwig Zorn
Bernd Misselwitz
Jörg MEDING
Heribert Schmitt-Willich
Thomas Brumby
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Epix Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE102005033902A priority Critical patent/DE102005033902B3/de
Application filed by Schering AG, Epix Pharmaceuticals Inc filed Critical Schering AG
Priority to EP06791535A priority patent/EP1904463A2/de
Priority to CA002615443A priority patent/CA2615443A1/en
Priority to AU2006272025A priority patent/AU2006272025A1/en
Priority to UY29664A priority patent/UY29664A1/es
Priority to RU2008105356/04A priority patent/RU2008105356A/ru
Priority to KR1020087001084A priority patent/KR20080043762A/ko
Priority to CNA2006800258905A priority patent/CN101223148A/zh
Priority to BRPI0613407-6A priority patent/BRPI0613407A2/pt
Priority to JP2008520780A priority patent/JP2009501174A/ja
Priority to PCT/EP2006/006777 priority patent/WO2007009638A2/de
Priority to DO2006000167A priority patent/DOP2006000167A/es
Priority to PE2006000844A priority patent/PE20070376A1/es
Priority to ARP060103020A priority patent/AR054865A1/es
Priority to GT200600313A priority patent/GT200600313A/es
Priority to TW095125755A priority patent/TW200706538A/zh
Priority to US11/487,604 priority patent/US7618957B2/en
Publication of DE102005033902B3 publication Critical patent/DE102005033902B3/de
Application granted granted Critical
Priority to IL187926A priority patent/IL187926A0/en
Priority to CR9645A priority patent/CR9645A/es
Priority to EC2008008100A priority patent/ECSP088100A/es
Priority to TNP2008000016A priority patent/TNSN08016A1/en
Priority to ZA200801523A priority patent/ZA200801523B/xx
Priority to NO20080813A priority patent/NO20080813L/no
Priority to US12/469,234 priority patent/US20090297454A1/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE102005033902A 2005-07-15 2005-07-15 Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel Expired - Fee Related DE102005033902B3 (de)

Priority Applications (24)

Application Number Priority Date Filing Date Title
DE102005033902A DE102005033902B3 (de) 2005-07-15 2005-07-15 Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel
CA002615443A CA2615443A1 (en) 2005-07-15 2006-07-11 Perfluoroalkyl-containing complexes, process for their production as well as their use
AU2006272025A AU2006272025A1 (en) 2005-07-15 2006-07-11 Complexes containing perfluoroalkyl, method for the production and use thereof
UY29664A UY29664A1 (es) 2005-07-15 2006-07-11 Complejos metalicos con contenido de prfluoroalquilo procedimientos para su preparacion, a´si como su uso
EP06791535A EP1904463A2 (de) 2005-07-15 2006-07-11 Perfluoralkylhaltige komplexe, verfahren zu deren herstellung sowie deren verwendung
RU2008105356/04A RU2008105356A (ru) 2005-07-15 2006-07-11 Перфторалкилсодержащие комплексы, способ их получения и их применение
KR1020087001084A KR20080043762A (ko) 2005-07-15 2006-07-11 퍼플루오로알킬 함유 착물, 그의 제조 방법 및 용도
CNA2006800258905A CN101223148A (zh) 2005-07-15 2006-07-11 含全氟烷基络合物、其制备方法及其应用
BRPI0613407-6A BRPI0613407A2 (pt) 2005-07-15 2006-07-11 Complexos contendo perfluoralquila, bem como composição farmacêutica, uso e processos de preparação dos mesmos
JP2008520780A JP2009501174A (ja) 2005-07-15 2006-07-11 ペルフルオロアルキル含有錯体、製造方法およびその使用
PCT/EP2006/006777 WO2007009638A2 (de) 2005-07-15 2006-07-11 Perfluoralkylhaltige komplexe, verfahren zu deren herstellung sowie deren verwendung
DO2006000167A DOP2006000167A (es) 2005-07-15 2006-07-13 Complejos metálicos con contenido de perfluoroalquilo, procedimientos para su preparación, así como su uso
PE2006000844A PE20070376A1 (es) 2005-07-15 2006-07-14 Complejos metalicos con contenido de perfluoroalquilo y procedimientos para su preparacion
ARP060103020A AR054865A1 (es) 2005-07-15 2006-07-14 Complejos metalicos con contenido de perfluoroalquilo, procedimientos para su preparacion, asi como su uso
GT200600313A GT200600313A (es) 2005-07-15 2006-07-14 Complejos metalicos con contenido de perfluoroalquilo, procedimientos para su preparacion, asi como su uso.
TW095125755A TW200706538A (en) 2005-07-15 2006-07-14 Perfluoroalkyl-containing complexes, process for their production as well as their use
US11/487,604 US7618957B2 (en) 2005-07-15 2006-07-17 Perfluoroalkyl-containing complexes, process for their production as well as their use
IL187926A IL187926A0 (en) 2005-07-15 2007-12-06 Complexes containing perfluoroalkyl, method for the production and use thereof
CR9645A CR9645A (es) 2005-07-15 2008-01-08 Complejos con contenido de perfluoroalquilo, procedimientos para su preparacion asi como su uso
EC2008008100A ECSP088100A (es) 2005-07-15 2008-01-11 Complejos con contenido de perfluoroalquilo, procedimientos para su preparación, así como su uso
TNP2008000016A TNSN08016A1 (en) 2005-07-15 2008-01-14 Complexes containing perfluoroalkyl, method for the production and use thereof
ZA200801523A ZA200801523B (en) 2005-07-15 2008-02-14 Complexes containing perfluoroalkyl, method for the production and use thereof
NO20080813A NO20080813L (no) 2005-07-15 2008-02-14 Komplekser inneholdende perfluoralkyl, fremgangsmate for fremstilling og anvendelse derav
US12/469,234 US20090297454A1 (en) 2005-07-15 2009-05-20 Perfluoroalkyl-Containing Complexes, Process For Their Production As Well As Their Use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005033902A DE102005033902B3 (de) 2005-07-15 2005-07-15 Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel

Publications (1)

Publication Number Publication Date
DE102005033902B3 true DE102005033902B3 (de) 2007-04-05

Family

ID=37057146

Family Applications (1)

Application Number Title Priority Date Filing Date
DE102005033902A Expired - Fee Related DE102005033902B3 (de) 2005-07-15 2005-07-15 Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel

Country Status (22)

Country Link
EP (1) EP1904463A2 (es)
JP (1) JP2009501174A (es)
KR (1) KR20080043762A (es)
CN (1) CN101223148A (es)
AR (1) AR054865A1 (es)
AU (1) AU2006272025A1 (es)
BR (1) BRPI0613407A2 (es)
CA (1) CA2615443A1 (es)
CR (1) CR9645A (es)
DE (1) DE102005033902B3 (es)
DO (1) DOP2006000167A (es)
EC (1) ECSP088100A (es)
GT (1) GT200600313A (es)
IL (1) IL187926A0 (es)
NO (1) NO20080813L (es)
PE (1) PE20070376A1 (es)
RU (1) RU2008105356A (es)
TN (1) TNSN08016A1 (es)
TW (1) TW200706538A (es)
UY (1) UY29664A1 (es)
WO (1) WO2007009638A2 (es)
ZA (1) ZA200801523B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007015598A1 (de) * 2007-03-29 2008-10-02 Heinrich-Heine-Universität Düsseldorf Verwendung von fluorhaltigen Verbindungen zu Diagnosezwecken mit Hilfe bildgebender Verfahren
TWI465251B (zh) 2008-01-08 2014-12-21 Lantheus Medical Imaging Inc 作為顯影劑的ｎ－烷氧基醯胺共軛物
US20210101905A1 (en) * 2019-10-04 2021-04-08 Llnited States Government as represented by the Department of Veterans Affairs Development of Imaging and Therapeutic Glucose Analogues for Sodium Dependent Glucose Transporters
EP4059925A1 (en) 2021-03-15 2022-09-21 Bayer Aktiengesellschaft New contrast agent for use in magnetic resonance imaging
CN114181164A (zh) * 2021-12-13 2022-03-15 武汉大学中南医院 基于Fe(Ⅱ)特异性MRI对比剂的合成方法及其应用
EP4335462A1 (en) 2022-09-09 2024-03-13 Bayer AG Contrast agents for use in diagnostic computed tomography imaging
EP4335840A1 (en) 2022-09-09 2024-03-13 Bayer Aktiengesellschaft New contrast agents for use in diagnostic imaging

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4317588A1 (de) * 1993-05-24 1994-12-01 Schering Ag Fluorhaltige makrocyclische Metallkomplexe
DE19603033A1 (de) * 1996-01-19 1997-07-24 Schering Ag Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
DE19744003A1 (de) * 1997-09-26 1999-07-15 Schering Ag Kontrastmittel für das Infarkt- und Nekroseimaging
DE19744004C1 (de) * 1997-09-26 1999-07-22 Schering Ag Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging
DE19914101C1 (de) * 1999-03-22 2000-10-12 Schering Ag Perfluoralkylamide, ihre Herstellung und ihre Verwendung in der Diagnostik
DE10040858A1 (de) * 2000-08-11 2002-03-28 Schering Ag Perfluoralkylhaltige Komplexe mit polaren Resten, Verfahren zu deren Herstellung und ihre Verwendung

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4317588A1 (de) * 1993-05-24 1994-12-01 Schering Ag Fluorhaltige makrocyclische Metallkomplexe
DE19603033A1 (de) * 1996-01-19 1997-07-24 Schering Ag Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
DE19744003A1 (de) * 1997-09-26 1999-07-15 Schering Ag Kontrastmittel für das Infarkt- und Nekroseimaging
DE19744004C1 (de) * 1997-09-26 1999-07-22 Schering Ag Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging
DE19914101C1 (de) * 1999-03-22 2000-10-12 Schering Ag Perfluoralkylamide, ihre Herstellung und ihre Verwendung in der Diagnostik
DE10040858A1 (de) * 2000-08-11 2002-03-28 Schering Ag Perfluoralkylhaltige Komplexe mit polaren Resten, Verfahren zu deren Herstellung und ihre Verwendung

Also Published As

Publication number Publication date
CR9645A (es) 2008-05-21
AU2006272025A1 (en) 2007-01-25
DOP2006000167A (es) 2007-02-28
ZA200801523B (en) 2008-11-26
IL187926A0 (en) 2008-03-20
EP1904463A2 (de) 2008-04-02
AR054865A1 (es) 2007-07-25
BRPI0613407A2 (pt) 2011-01-11
JP2009501174A (ja) 2009-01-15
WO2007009638A2 (de) 2007-01-25
GT200600313A (es) 2007-04-23
KR20080043762A (ko) 2008-05-19
CN101223148A (zh) 2008-07-16
ECSP088100A (es) 2008-05-30
NO20080813L (no) 2008-04-09
WO2007009638A3 (de) 2007-04-26
PE20070376A1 (es) 2007-04-20
RU2008105356A (ru) 2009-08-20
UY29664A1 (es) 2007-02-28
TNSN08016A1 (en) 2009-07-14
TW200706538A (en) 2007-02-16
CA2615443A1 (en) 2007-01-25

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Legal Events

Date Code Title Description
8100 Publication of patent without earlier publication of application
8327 Change in the person/name/address of the patent owner

Owner name: BAYER SCHERING PHARMA AG, 13353 BERLIN, DE

Owner name: EPIX PHARMACEUTICALS INC., CAMBRIDGE, MASS., US

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: EPIX PHARMACEUTICALS INC., CAMBRIDGE, MASS., US

Owner name: BAYER SCHERING PHARMA AKIENGESELLSCHAFT, 13353, DE

8327 Change in the person/name/address of the patent owner

Owner name: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT, 1335, DE

R119 Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee

Effective date: 20120201