CA2615443A1 - Perfluoroalkyl-containing complexes, process for their production as well as their use - Google Patents
Perfluoroalkyl-containing complexes, process for their production as well as their use Download PDFInfo
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- CA2615443A1 CA2615443A1 CA002615443A CA2615443A CA2615443A1 CA 2615443 A1 CA2615443 A1 CA 2615443A1 CA 002615443 A CA002615443 A CA 002615443A CA 2615443 A CA2615443 A CA 2615443A CA 2615443 A1 CA2615443 A1 CA 2615443A1
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- 238000000034 method Methods 0.000 title claims abstract description 31
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 25
- 230000008569 process Effects 0.000 title claims description 19
- 125000005010 perfluoroalkyl group Chemical group 0.000 title claims description 10
- 229910052751 metal Inorganic materials 0.000 claims abstract description 33
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 2
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- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 2
- 125000003277 amino group Chemical group 0.000 claims description 2
- 229910052794 bromium Inorganic materials 0.000 claims description 2
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- 238000004458 analytical method Methods 0.000 description 86
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- 239000002904 solvent Substances 0.000 description 73
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- 239000000126 substance Substances 0.000 description 61
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- JXMHAXQPVIMQLA-UHFFFAOYSA-N 3-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]propanoylamino]propanoic acid Chemical compound OC(=O)CCNC(=O)C(C)N1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 JXMHAXQPVIMQLA-UHFFFAOYSA-N 0.000 description 19
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- KVCGISUBCHHTDD-UHFFFAOYSA-M sodium;4-methylbenzenesulfonate Chemical compound [Na+].CC1=CC=C(S([O-])(=O)=O)C=C1 KVCGISUBCHHTDD-UHFFFAOYSA-M 0.000 description 1
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- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 1
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- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 description 1
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- AWSFICBXMUKWSK-UHFFFAOYSA-N ytterbium(3+) Chemical compound [Yb+3] AWSFICBXMUKWSK-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Radiology & Medical Imaging (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005033902.6 | 2005-07-15 | ||
| DE102005033902A DE102005033902B3 (de) | 2005-07-15 | 2005-07-15 | Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel |
| PCT/EP2006/006777 WO2007009638A2 (de) | 2005-07-15 | 2006-07-11 | Perfluoralkylhaltige komplexe, verfahren zu deren herstellung sowie deren verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2615443A1 true CA2615443A1 (en) | 2007-01-25 |
Family
ID=37057146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002615443A Abandoned CA2615443A1 (en) | 2005-07-15 | 2006-07-11 | Perfluoroalkyl-containing complexes, process for their production as well as their use |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1904463A2 (es) |
| JP (1) | JP2009501174A (es) |
| KR (1) | KR20080043762A (es) |
| CN (1) | CN101223148A (es) |
| AR (1) | AR054865A1 (es) |
| AU (1) | AU2006272025A1 (es) |
| BR (1) | BRPI0613407A2 (es) |
| CA (1) | CA2615443A1 (es) |
| CR (1) | CR9645A (es) |
| DE (1) | DE102005033902B3 (es) |
| DO (1) | DOP2006000167A (es) |
| EC (1) | ECSP088100A (es) |
| GT (1) | GT200600313A (es) |
| IL (1) | IL187926A0 (es) |
| NO (1) | NO20080813L (es) |
| PE (1) | PE20070376A1 (es) |
| RU (1) | RU2008105356A (es) |
| TN (1) | TNSN08016A1 (es) |
| TW (1) | TW200706538A (es) |
| UY (1) | UY29664A1 (es) |
| WO (1) | WO2007009638A2 (es) |
| ZA (1) | ZA200801523B (es) |
Families Citing this family (7)
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|---|---|---|---|---|
| DE102007015598A1 (de) * | 2007-03-29 | 2008-10-02 | Heinrich-Heine-Universität Düsseldorf | Verwendung von fluorhaltigen Verbindungen zu Diagnosezwecken mit Hilfe bildgebender Verfahren |
| CA2711426C (en) | 2008-01-08 | 2018-05-22 | Lantheus Medical Imaging, Inc. | N-alkoxyamide conjugates as imaging agents |
| CA3153519A1 (en) * | 2019-10-04 | 2021-04-08 | Bryan J. Traughber | Development of imaging and therapeutic glucose analogues for sodium dependent glucose transporters |
| EP4059925A1 (en) | 2021-03-15 | 2022-09-21 | Bayer Aktiengesellschaft | New contrast agent for use in magnetic resonance imaging |
| CN114181164A (zh) * | 2021-12-13 | 2022-03-15 | 武汉大学中南医院 | 基于Fe(Ⅱ)特异性MRI对比剂的合成方法及其应用 |
| EP4335840A1 (en) | 2022-09-09 | 2024-03-13 | Bayer Aktiengesellschaft | New contrast agents for use in diagnostic imaging |
| EP4335462A1 (en) | 2022-09-09 | 2024-03-13 | Bayer AG | Contrast agents for use in diagnostic computed tomography imaging |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4317588C2 (de) * | 1993-05-24 | 1998-04-16 | Schering Ag | Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung |
| DE19603033A1 (de) * | 1996-01-19 | 1997-07-24 | Schering Ag | Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik |
| DE19744004C1 (de) * | 1997-09-26 | 1999-07-22 | Schering Ag | Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging |
| DE19744003B4 (de) * | 1997-09-26 | 2004-07-08 | Schering Ag | Kontrastmittel für das Infarkt- und Nekroseimaging |
| DE19914101C1 (de) * | 1999-03-22 | 2000-10-12 | Schering Ag | Perfluoralkylamide, ihre Herstellung und ihre Verwendung in der Diagnostik |
| DE10040858C2 (de) * | 2000-08-11 | 2003-12-18 | Schering Ag | Perfluoralkylhaltige Komplexe mit polaren Resten, Verfahren zu deren Herstellung und ihre Verwendung |
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2005
- 2005-07-15 DE DE102005033902A patent/DE102005033902B3/de not_active Expired - Fee Related
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2006
- 2006-07-11 BR BRPI0613407-6A patent/BRPI0613407A2/pt not_active Application Discontinuation
- 2006-07-11 EP EP06791535A patent/EP1904463A2/de not_active Withdrawn
- 2006-07-11 KR KR1020087001084A patent/KR20080043762A/ko not_active Application Discontinuation
- 2006-07-11 RU RU2008105356/04A patent/RU2008105356A/ru not_active Application Discontinuation
- 2006-07-11 CA CA002615443A patent/CA2615443A1/en not_active Abandoned
- 2006-07-11 AU AU2006272025A patent/AU2006272025A1/en not_active Abandoned
- 2006-07-11 WO PCT/EP2006/006777 patent/WO2007009638A2/de active Application Filing
- 2006-07-11 UY UY29664A patent/UY29664A1/es not_active Application Discontinuation
- 2006-07-11 JP JP2008520780A patent/JP2009501174A/ja not_active Withdrawn
- 2006-07-11 CN CNA2006800258905A patent/CN101223148A/zh active Pending
- 2006-07-13 DO DO2006000167A patent/DOP2006000167A/es unknown
- 2006-07-14 AR ARP060103020A patent/AR054865A1/es unknown
- 2006-07-14 TW TW095125755A patent/TW200706538A/zh unknown
- 2006-07-14 PE PE2006000844A patent/PE20070376A1/es not_active Application Discontinuation
- 2006-07-14 GT GT200600313A patent/GT200600313A/es unknown
-
2007
- 2007-12-06 IL IL187926A patent/IL187926A0/en unknown
-
2008
- 2008-01-08 CR CR9645A patent/CR9645A/es unknown
- 2008-01-11 EC EC2008008100A patent/ECSP088100A/es unknown
- 2008-01-14 TN TNP2008000016A patent/TNSN08016A1/en unknown
- 2008-02-14 ZA ZA200801523A patent/ZA200801523B/xx unknown
- 2008-02-14 NO NO20080813A patent/NO20080813L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ECSP088100A (es) | 2008-05-30 |
| EP1904463A2 (de) | 2008-04-02 |
| CR9645A (es) | 2008-05-21 |
| GT200600313A (es) | 2007-04-23 |
| DOP2006000167A (es) | 2007-02-28 |
| UY29664A1 (es) | 2007-02-28 |
| KR20080043762A (ko) | 2008-05-19 |
| PE20070376A1 (es) | 2007-04-20 |
| WO2007009638A2 (de) | 2007-01-25 |
| TW200706538A (en) | 2007-02-16 |
| NO20080813L (no) | 2008-04-09 |
| BRPI0613407A2 (pt) | 2011-01-11 |
| WO2007009638A3 (de) | 2007-04-26 |
| IL187926A0 (en) | 2008-03-20 |
| RU2008105356A (ru) | 2009-08-20 |
| AR054865A1 (es) | 2007-07-25 |
| DE102005033902B3 (de) | 2007-04-05 |
| TNSN08016A1 (en) | 2009-07-14 |
| ZA200801523B (en) | 2008-11-26 |
| CN101223148A (zh) | 2008-07-16 |
| JP2009501174A (ja) | 2009-01-15 |
| AU2006272025A1 (en) | 2007-01-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |