DE102004025985A1 - Estriol- und Estetrol-Prodrugs - Google Patents

Estriol- und Estetrol-Prodrugs Download PDF

Info

Publication number
DE102004025985A1
DE102004025985A1 DE102004025985A DE102004025985A DE102004025985A1 DE 102004025985 A1 DE102004025985 A1 DE 102004025985A1 DE 102004025985 A DE102004025985 A DE 102004025985A DE 102004025985 A DE102004025985 A DE 102004025985A DE 102004025985 A1 DE102004025985 A1 DE 102004025985A1
Authority
DE
Germany
Prior art keywords
group
triene
sulfamoylbenzoate
trihydroxyestra
tert
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE102004025985A
Other languages
German (de)
English (en)
Inventor
Ralf Dr. Wyrwa
Sven Ring
Peter Dr. Droescher
Alexander Dr. Hillisch
Walter Dr. Elger
Birgitt Schneider
Gudrun Reddersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34969311&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE102004025985(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering AG filed Critical Schering AG
Priority to DE102004025985A priority Critical patent/DE102004025985A1/de
Priority to PCT/EP2005/005258 priority patent/WO2005113576A1/de
Priority to JP2007517048A priority patent/JP2007538027A/ja
Priority to EP05747926A priority patent/EP1747231A1/de
Priority to UY28910A priority patent/UY28910A1/es
Priority to GT200500120A priority patent/GT200500120A/es
Priority to PE2005000555A priority patent/PE20060314A1/es
Priority to PA20058633801A priority patent/PA8633801A1/es
Priority to TW094116505A priority patent/TW200612962A/zh
Priority to ARP050102085A priority patent/AR049108A1/es
Priority to SV2005002122A priority patent/SV2006002122A/es
Priority to US11/134,618 priority patent/US20050277625A1/en
Publication of DE102004025985A1 publication Critical patent/DE102004025985A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE102004025985A 2004-05-21 2004-05-21 Estriol- und Estetrol-Prodrugs Ceased DE102004025985A1 (de)

Priority Applications (12)

Application Number Priority Date Filing Date Title
DE102004025985A DE102004025985A1 (de) 2004-05-21 2004-05-21 Estriol- und Estetrol-Prodrugs
PCT/EP2005/005258 WO2005113576A1 (de) 2004-05-21 2005-05-10 Aminosulfonyl- oder aminosulfonylamino-substituierte phenyl-ester als estriol-und estetrol-prodrugs
JP2007517048A JP2007538027A (ja) 2004-05-21 2005-05-10 エストリオール及びエステトロールプロドラッグ類
EP05747926A EP1747231A1 (de) 2004-05-21 2005-05-10 Aminosulfonyl- oder aminosulfonylamino-substituierte phenyl-ester als estriol- und estetrol-prodrugs
UY28910A UY28910A1 (es) 2004-05-21 2005-05-19 Prodrogas de estriol y estetrol
ARP050102085A AR049108A1 (es) 2004-05-21 2005-05-20 Fenil esteres aminosulfonil o aminosulfonilamino sustituidos como prodrogas de estriol o esterol
PE2005000555A PE20060314A1 (es) 2004-05-21 2005-05-20 Prodrogas de estriol y estetrol
GT200500120A GT200500120A (es) 2004-05-21 2005-05-20 Prodrogas de estriol y estetrol
PA20058633801A PA8633801A1 (es) 2004-05-21 2005-05-20 Derivados de sulfamoilbenzoato y sulfamoilaminobenzoato de estriol, y derivados de sulfamoilbenzoato y sulfamoilaminobenzoato de estetrol
TW094116505A TW200612962A (en) 2004-05-21 2005-05-20 Estriol and estetrol prodrugs
SV2005002122A SV2006002122A (es) 2004-05-21 2005-05-23 Prodrogas de estriol y estetrol ref. p-sv-78.343/msu
US11/134,618 US20050277625A1 (en) 2004-05-21 2005-05-23 Estriol and estetrol prodrugs

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004025985A DE102004025985A1 (de) 2004-05-21 2004-05-21 Estriol- und Estetrol-Prodrugs

Publications (1)

Publication Number Publication Date
DE102004025985A1 true DE102004025985A1 (de) 2005-12-15

Family

ID=34969311

Family Applications (1)

Application Number Title Priority Date Filing Date
DE102004025985A Ceased DE102004025985A1 (de) 2004-05-21 2004-05-21 Estriol- und Estetrol-Prodrugs

Country Status (11)

Country Link
EP (1) EP1747231A1 (https=)
JP (1) JP2007538027A (https=)
AR (1) AR049108A1 (https=)
DE (1) DE102004025985A1 (https=)
GT (1) GT200500120A (https=)
PA (1) PA8633801A1 (https=)
PE (1) PE20060314A1 (https=)
SV (1) SV2006002122A (https=)
TW (1) TW200612962A (https=)
UY (1) UY28910A1 (https=)
WO (1) WO2005113576A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10027887A1 (de) 2000-05-31 2001-12-13 Jenapharm Gmbh Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE102004025966A1 (de) * 2004-05-21 2005-12-15 Schering Ag Estradiol-Prodrugs
US7534780B2 (en) 2004-05-21 2009-05-19 Bayer Schering Pharma Aktiengesellschaft Estradiol prodrugs
DE102005057224A1 (de) * 2005-11-29 2007-05-31 Bayer Schering Pharma Ag Prodrugs ERß-selektiver Substanzen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE102005057408A1 (de) * 2005-11-30 2007-05-31 Bayer Schering Pharma Ag Sulfamoylsulfonat-Prodrugs
CN100396693C (zh) * 2006-11-08 2008-06-25 浙江大学 1,4-孕二烯-16β-甲基-17α,21-二羟基物的制备方法
CN102079771B (zh) * 2010-12-10 2012-10-03 郑州大学 具有抗肿瘤活性的雌甾氨基酸酯化合物及其合成方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5001234A (en) * 1987-04-16 1991-03-19 The Upjohn Company Cyclic hydrocarbons with an aminoalkyl sidechain
DE19712488A1 (de) * 1997-03-25 1998-10-01 Knoell Hans Forschung Ev Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben
US5866603A (en) * 1994-11-17 1999-02-02 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1238739A (fr) * 1958-08-04 1960-08-19 Chimiotherapie Lab Franc Procédé de préparation de dérivés hydrosolubles de testostérone
FR8290M (https=) * 1968-12-31 1970-11-09 Rech Chimiques Et Ind Mar Lab
US5116828A (en) * 1989-10-26 1992-05-26 Nippon Zoki Pharmaceutical Co., Ltd. Pharmaceutical composition for treatment of osteoporosis
US6953785B2 (en) * 2000-04-24 2005-10-11 Kyowa Hakko Kogyo Co., Ltd. Estra-1,3,5(10)-triene derivatives
DE10027887A1 (de) * 2000-05-31 2001-12-13 Jenapharm Gmbh Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
GB0015876D0 (en) * 2000-06-28 2000-08-23 Novartis Ag Organic compounds
GB0316290D0 (en) * 2003-07-11 2003-08-13 Glaxo Group Ltd Novel compounds
TWI331154B (en) * 2003-11-12 2010-10-01 Solvay Pharm Gmbh Novel 17-hydroxysteroid dehydrogenase type i inhibitors
DE102004025966A1 (de) * 2004-05-21 2005-12-15 Schering Ag Estradiol-Prodrugs

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5001234A (en) * 1987-04-16 1991-03-19 The Upjohn Company Cyclic hydrocarbons with an aminoalkyl sidechain
US5866603A (en) * 1994-11-17 1999-02-02 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
DE19712488A1 (de) * 1997-03-25 1998-10-01 Knoell Hans Forschung Ev Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben

Also Published As

Publication number Publication date
PE20060314A1 (es) 2006-05-25
EP1747231A1 (de) 2007-01-31
JP2007538027A (ja) 2007-12-27
SV2006002122A (es) 2006-05-09
WO2005113576A1 (de) 2005-12-01
UY28910A1 (es) 2005-12-30
TW200612962A (en) 2006-05-01
PA8633801A1 (es) 2006-03-24
AR049108A1 (es) 2006-06-28
GT200500120A (es) 2006-01-24

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8127 New person/name/address of the applicant

Owner name: BAYER SCHERING PHARMA AG, 13353 BERLIN, DE

8127 New person/name/address of the applicant

Owner name: BAYER SCHERING PHARMA AKIENGESELLSCHAFT, 13353, DE

8131 Rejection