AR049108A1 - Fenil esteres aminosulfonil o aminosulfonilamino sustituidos como prodrogas de estriol o esterol - Google Patents
Fenil esteres aminosulfonil o aminosulfonilamino sustituidos como prodrogas de estriol o esterolInfo
- Publication number
- AR049108A1 AR049108A1 ARP050102085A ARP050102085A AR049108A1 AR 049108 A1 AR049108 A1 AR 049108A1 AR P050102085 A ARP050102085 A AR P050102085A AR P050102085 A ARP050102085 A AR P050102085A AR 049108 A1 AR049108 A1 AR 049108A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- alkyl
- cycloalkyl
- hydrogen
- hydrogen atom
- Prior art date
Links
- PROQIPRRNZUXQM-UHFFFAOYSA-N (16alpha,17betaOH)-Estra-1,3,5(10)-triene-3,16,17-triol Natural products OC1=CC=C2C3CCC(C)(C(C(O)C4)O)C4C3CCC2=C1 PROQIPRRNZUXQM-UHFFFAOYSA-N 0.000 title abstract 2
- 229930182558 Sterol Natural products 0.000 title abstract 2
- PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 title abstract 2
- 229960001348 estriol Drugs 0.000 title abstract 2
- 150000003432 sterols Chemical class 0.000 title abstract 2
- 235000003702 sterols Nutrition 0.000 title abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 3
- 101100240526 Caenorhabditis elegans nhr-20 gene Proteins 0.000 abstract 3
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 3
- 125000005275 alkylenearyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000002560 nitrile group Chemical group 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004469 siloxy group Chemical group [SiH3]O* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940011871 estrogen Drugs 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004025985A DE102004025985A1 (de) | 2004-05-21 | 2004-05-21 | Estriol- und Estetrol-Prodrugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR049108A1 true AR049108A1 (es) | 2006-06-28 |
Family
ID=34969311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050102085A AR049108A1 (es) | 2004-05-21 | 2005-05-20 | Fenil esteres aminosulfonil o aminosulfonilamino sustituidos como prodrogas de estriol o esterol |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1747231A1 (https=) |
| JP (1) | JP2007538027A (https=) |
| AR (1) | AR049108A1 (https=) |
| DE (1) | DE102004025985A1 (https=) |
| GT (1) | GT200500120A (https=) |
| PA (1) | PA8633801A1 (https=) |
| PE (1) | PE20060314A1 (https=) |
| SV (1) | SV2006002122A (https=) |
| TW (1) | TW200612962A (https=) |
| UY (1) | UY28910A1 (https=) |
| WO (1) | WO2005113576A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10027887A1 (de) | 2000-05-31 | 2001-12-13 | Jenapharm Gmbh | Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
| US7534780B2 (en) | 2004-05-21 | 2009-05-19 | Bayer Schering Pharma Aktiengesellschaft | Estradiol prodrugs |
| DE102004025966A1 (de) * | 2004-05-21 | 2005-12-15 | Schering Ag | Estradiol-Prodrugs |
| DE102005057224A1 (de) * | 2005-11-29 | 2007-05-31 | Bayer Schering Pharma Ag | Prodrugs ERß-selektiver Substanzen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
| DE102005057408A1 (de) * | 2005-11-30 | 2007-05-31 | Bayer Schering Pharma Ag | Sulfamoylsulfonat-Prodrugs |
| CN100396693C (zh) * | 2006-11-08 | 2008-06-25 | 浙江大学 | 1,4-孕二烯-16β-甲基-17α,21-二羟基物的制备方法 |
| CN102079771B (zh) * | 2010-12-10 | 2012-10-03 | 郑州大学 | 具有抗肿瘤活性的雌甾氨基酸酯化合物及其合成方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1238739A (fr) * | 1958-08-04 | 1960-08-19 | Chimiotherapie Lab Franc | Procédé de préparation de dérivés hydrosolubles de testostérone |
| FR8290M (https=) * | 1968-12-31 | 1970-11-09 | Rech Chimiques Et Ind Mar Lab | |
| US5001234A (en) * | 1987-04-16 | 1991-03-19 | The Upjohn Company | Cyclic hydrocarbons with an aminoalkyl sidechain |
| US5116828A (en) * | 1989-10-26 | 1992-05-26 | Nippon Zoki Pharmaceutical Co., Ltd. | Pharmaceutical composition for treatment of osteoporosis |
| US5571933A (en) * | 1994-11-17 | 1996-11-05 | Duquesne University Of The Holy Ghost | Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use |
| DE19712488A1 (de) * | 1997-03-25 | 1998-10-01 | Knoell Hans Forschung Ev | Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben |
| JPWO2001081364A1 (ja) * | 2000-04-24 | 2004-01-08 | 協和醗酵工業株式会社 | エストラ−１，３，５（１０）−トリエン誘導体 |
| DE10027887A1 (de) * | 2000-05-31 | 2001-12-13 | Jenapharm Gmbh | Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
| GB0015876D0 (en) * | 2000-06-28 | 2000-08-23 | Novartis Ag | Organic compounds |
| GB0316290D0 (en) * | 2003-07-11 | 2003-08-13 | Glaxo Group Ltd | Novel compounds |
| TWI331154B (en) * | 2003-11-12 | 2010-10-01 | Solvay Pharm Gmbh | Novel 17-hydroxysteroid dehydrogenase type i inhibitors |
| DE102004025966A1 (de) * | 2004-05-21 | 2005-12-15 | Schering Ag | Estradiol-Prodrugs |
-
2004
- 2004-05-21 DE DE102004025985A patent/DE102004025985A1/de not_active Ceased
-
2005
- 2005-05-10 JP JP2007517048A patent/JP2007538027A/ja active Pending
- 2005-05-10 EP EP05747926A patent/EP1747231A1/de not_active Withdrawn
- 2005-05-10 WO PCT/EP2005/005258 patent/WO2005113576A1/de not_active Ceased
- 2005-05-19 UY UY28910A patent/UY28910A1/es not_active Application Discontinuation
- 2005-05-20 PA PA20058633801A patent/PA8633801A1/es unknown
- 2005-05-20 AR ARP050102085A patent/AR049108A1/es unknown
- 2005-05-20 TW TW094116505A patent/TW200612962A/zh unknown
- 2005-05-20 PE PE2005000555A patent/PE20060314A1/es not_active Application Discontinuation
- 2005-05-20 GT GT200500120A patent/GT200500120A/es unknown
- 2005-05-23 SV SV2005002122A patent/SV2006002122A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| SV2006002122A (es) | 2006-05-09 |
| WO2005113576A1 (de) | 2005-12-01 |
| EP1747231A1 (de) | 2007-01-31 |
| TW200612962A (en) | 2006-05-01 |
| UY28910A1 (es) | 2005-12-30 |
| PE20060314A1 (es) | 2006-05-25 |
| JP2007538027A (ja) | 2007-12-27 |
| DE102004025985A1 (de) | 2005-12-15 |
| GT200500120A (es) | 2006-01-24 |
| PA8633801A1 (es) | 2006-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |