DE10130371A1 - Neue Arzneimittelkompositionen auf der Basis von Anticholinergika, Corticosteroiden und Betamimetika - Google Patents
Neue Arzneimittelkompositionen auf der Basis von Anticholinergika, Corticosteroiden und BetamimetikaInfo
- Publication number
- DE10130371A1 DE10130371A1 DE10130371A DE10130371A DE10130371A1 DE 10130371 A1 DE10130371 A1 DE 10130371A1 DE 10130371 A DE10130371 A DE 10130371A DE 10130371 A DE10130371 A DE 10130371A DE 10130371 A1 DE10130371 A1 DE 10130371A1
- Authority
- DE
- Germany
- Prior art keywords
- acid
- inhalation
- ethanol
- methyl
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 239000003246 corticosteroid Substances 0.000 title claims abstract description 9
- 239000000203 mixture Substances 0.000 title claims description 39
- 229960001334 corticosteroids Drugs 0.000 title abstract description 8
- 239000000808 adrenergic beta-agonist Substances 0.000 title description 15
- 229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 title description 5
- 239000000812 cholinergic antagonist Substances 0.000 title description 5
- 239000002547 new drug Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 claims abstract description 5
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 4
- 239000000443 aerosol Substances 0.000 claims description 42
- 239000003814 drug Substances 0.000 claims description 33
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- 150000001875 compounds Chemical class 0.000 claims description 23
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- 229960004017 salmeterol Drugs 0.000 claims description 18
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- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
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- 208000023504 respiratory system disease Diseases 0.000 claims description 6
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 5
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- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 5
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- 239000012141 concentrate Substances 0.000 claims description 5
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 5
- OEXHQOGQTVQTAT-JRNQLAHRSA-N ipratropium Chemical class O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 OEXHQOGQTVQTAT-JRNQLAHRSA-N 0.000 claims description 5
- NVOYVOBDTVTBDX-PMEUIYRNSA-N oxitropium Chemical class CC[N+]1(C)[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)[C@H](CO)C1=CC=CC=C1 NVOYVOBDTVTBDX-PMEUIYRNSA-N 0.000 claims description 5
- 239000003381 stabilizer Substances 0.000 claims description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 4
- DBCKRBGYGMVSTI-UHFFFAOYSA-N 2-oxo-7-[2-[2-[3-(2-phenylethoxy)propylsulfonyl]ethylazaniumyl]ethyl]-3h-1,3-benzothiazol-4-olate Chemical compound C1=2SC(=O)NC=2C(O)=CC=C1CCNCCS(=O)(=O)CCCOCCC1=CC=CC=C1 DBCKRBGYGMVSTI-UHFFFAOYSA-N 0.000 claims description 4
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- 150000001298 alcohols Chemical class 0.000 claims description 4
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 claims description 4
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10130371A DE10130371A1 (de) | 2001-06-23 | 2001-06-23 | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika, Corticosteroiden und Betamimetika |
| SI200230873T SI1408967T1 (sl) | 2001-06-23 | 2002-05-29 | Farmacevtski sestavki na osnovi tiotropija, ciklezonida in betamimetika za zdravljenje vnetnih in/ali obstrukcijskih bolezni dihalnih poti |
| EP02745329A EP1408967B1 (de) | 2001-06-23 | 2002-05-29 | ARZNEIMITTELKOMPOSITIONEN AUF DER BASIS VON Tiotropium, Ciclesonide UND einem BETAMIMETIKum ZUR BEHANDLUNG VON ENTZÜNDLICHEN UND/ODER OBSTRUKTIVEN ATEMWEGSERKRANKUNGEN |
| PT02745329T PT1408967E (pt) | 2001-06-23 | 2002-05-29 | Composições de medicamentos com base em tiotrópio, ciclesonida e um betamimético para o tratamento de doenças respiratórias inflamatórias e/ou obstrutivas |
| AU2002316935A AU2002316935A1 (en) | 2001-06-23 | 2002-05-29 | Novel pharmaceutical compositions based on anticholinergic agents, corticosteroids and betamimetic agents, for the treatment of inflammatory and/or obstructive respiratory tract diseases |
| DK02745329.9T DK1408967T3 (da) | 2001-06-23 | 2002-05-29 | Lægemiddelsammensætninger på basis af tiotropium, ciclesonide og et betamimetikum til behandling af inflammatoriske eller obstruktive luftvejssygdomme |
| PCT/EP2002/005896 WO2003000241A2 (de) | 2001-06-23 | 2002-05-29 | Neue arzneimittelkompositionen auf der basis von anticholinergika; corticosteroiden und betamimetika zur behandlung von entzündlichen und/oder obstruktiven atemwegserkrankungen |
| AT02745329T ATE446756T1 (de) | 2001-06-23 | 2002-05-29 | Arzneimittelkompositionen auf der basis von tiotropium, ciclesonide und einem betamimetikum zur behandlung von entzündlichen und/oder obstruktiven atemwegserkrankungen |
| CA2455167A CA2455167C (en) | 2001-06-23 | 2002-05-29 | New pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics |
| DE50213966T DE50213966D1 (de) | 2001-06-23 | 2002-05-29 | pium, Ciclesonide UND einem BETAMIMETIKum ZUR BEHAMWEGSERKRANKUNGEN |
| MXPA03011515A MXPA03011515A (es) | 2001-06-23 | 2002-05-29 | Nuevas composiciones de medicamentos sobre la base de agentes anticolinergicos, corticoesteroides y agentes betamimeticos. |
| ES02745329T ES2332883T3 (es) | 2001-06-23 | 2002-05-29 | Composiciones farmaceutcas a base de tiotropium, ciclesonide y un betamimetico para el tratamiento de enfermedades inflamatorias y/o obstructivas de las vias respiratorias. |
| JP2003506888A JP2005502608A (ja) | 2001-06-23 | 2002-05-29 | 抗コリン作用剤とコルチコステロイドとβ刺激剤を含む新規な医薬組成物 |
| US10/173,194 US20030018019A1 (en) | 2001-06-23 | 2002-06-17 | Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics |
| US11/267,354 US20060057074A1 (en) | 2001-06-23 | 2005-11-04 | Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics |
| US12/201,149 US20090088408A1 (en) | 2001-06-23 | 2008-08-29 | Pharmaceutical compositions on anticholinergics, corticosteroids and betamimetics |
| CY20101100016T CY1109712T1 (el) | 2001-06-23 | 2010-01-05 | Φαρμακευτικες συνθεσεις με βαση τιοτροπιο, κικλεσονιδη και ενα βητα μιμητικο για τη θεραπεια φλεγμονωδων και/ή αποφρακτικων παθησεων των αναπνευστικων οδων |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10130371A DE10130371A1 (de) | 2001-06-23 | 2001-06-23 | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika, Corticosteroiden und Betamimetika |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE10130371A1 true DE10130371A1 (de) | 2003-01-02 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10130371A Withdrawn DE10130371A1 (de) | 2001-06-23 | 2001-06-23 | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika, Corticosteroiden und Betamimetika |
| DE50213966T Expired - Lifetime DE50213966D1 (de) | 2001-06-23 | 2002-05-29 | pium, Ciclesonide UND einem BETAMIMETIKum ZUR BEHAMWEGSERKRANKUNGEN |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE50213966T Expired - Lifetime DE50213966D1 (de) | 2001-06-23 | 2002-05-29 | pium, Ciclesonide UND einem BETAMIMETIKum ZUR BEHAMWEGSERKRANKUNGEN |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20090088408A1 (https=) |
| EP (1) | EP1408967B1 (https=) |
| JP (1) | JP2005502608A (https=) |
| AT (1) | ATE446756T1 (https=) |
| AU (1) | AU2002316935A1 (https=) |
| CA (1) | CA2455167C (https=) |
| CY (1) | CY1109712T1 (https=) |
| DE (2) | DE10130371A1 (https=) |
| DK (1) | DK1408967T3 (https=) |
| ES (1) | ES2332883T3 (https=) |
| MX (1) | MXPA03011515A (https=) |
| PT (1) | PT1408967E (https=) |
| SI (1) | SI1408967T1 (https=) |
| WO (1) | WO2003000241A2 (https=) |
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| SI1775305T1 (sl) | 2000-08-05 | 2015-01-30 | Glaxo Group Limited | S-fluorometil ester 6alfa,9alfa-difluoro-17alfa-((2-furanilkarboksil)oksi)- 11beta-hidroksi-16alfa-metil-3-okso-androst-1,4-dien-17-karbotiojske kisline kot protivnetno sredstvo |
| GB0019172D0 (en) | 2000-08-05 | 2000-09-27 | Glaxo Group Ltd | Novel compounds |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4003270A1 (de) * | 1990-02-03 | 1991-08-08 | Boehringer Ingelheim Kg | Neue treibgase und ihre verwendung in arzneimittelzubereitungen |
| UA62917C2 (en) * | 1995-06-27 | 2004-01-15 | Berinher Inhelheim Kg | Medicinal composition for generating propellant-free aerosols |
| BR9911351A (pt) * | 1998-06-18 | 2001-03-13 | Boehringer Ingelheim Pharma | Formulações farmacêuticas para aerossóis com duas ou mais substâncias ativas |
| ES2234266T3 (es) * | 1998-07-24 | 2005-06-16 | Jago Research Ag | Formulaciones medicas para aerosoles. |
| PL200941B1 (pl) * | 1998-11-13 | 2009-02-27 | Jagotec Ag | Suchy proszkowy preparat inhalacyjny |
| DZ2947A1 (fr) * | 1998-11-25 | 2004-03-15 | Chiesi Farma Spa | Inhalateur à compteur de dose sous pression. |
| GB0009605D0 (en) * | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Medicaments |
| GB0009613D0 (en) * | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Pharmaceutical compositions |
| GB0009592D0 (en) * | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Respiratory combinations |
| GB0009609D0 (en) * | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Therapeutic compositions |
| GB0009612D0 (en) * | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Therapeutic formulations |
| GB0009606D0 (en) * | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Therapeutic combinations |
| GB0009591D0 (en) * | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Medical combinations |
| GB0009607D0 (en) * | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Medical compositions |
| GB0009583D0 (en) * | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Respiratory formulations |
| GB0009584D0 (en) * | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Pharmaceutical compositions |
| US20020183292A1 (en) * | 2000-10-31 | 2002-12-05 | Michel Pairet | Pharmaceutical compositions based on anticholinergics and corticosteroids |
-
2001
- 2001-06-23 DE DE10130371A patent/DE10130371A1/de not_active Withdrawn
-
2002
- 2002-05-29 WO PCT/EP2002/005896 patent/WO2003000241A2/de not_active Ceased
- 2002-05-29 AU AU2002316935A patent/AU2002316935A1/en not_active Abandoned
- 2002-05-29 MX MXPA03011515A patent/MXPA03011515A/es active IP Right Grant
- 2002-05-29 DK DK02745329.9T patent/DK1408967T3/da active
- 2002-05-29 ES ES02745329T patent/ES2332883T3/es not_active Expired - Lifetime
- 2002-05-29 CA CA2455167A patent/CA2455167C/en not_active Expired - Fee Related
- 2002-05-29 PT PT02745329T patent/PT1408967E/pt unknown
- 2002-05-29 EP EP02745329A patent/EP1408967B1/de not_active Expired - Lifetime
- 2002-05-29 JP JP2003506888A patent/JP2005502608A/ja active Pending
- 2002-05-29 DE DE50213966T patent/DE50213966D1/de not_active Expired - Lifetime
- 2002-05-29 SI SI200230873T patent/SI1408967T1/sl unknown
- 2002-05-29 AT AT02745329T patent/ATE446756T1/de active
-
2008
- 2008-08-29 US US12/201,149 patent/US20090088408A1/en not_active Abandoned
-
2010
- 2010-01-05 CY CY20101100016T patent/CY1109712T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE50213966D1 (de) | 2009-12-10 |
| EP1408967B1 (de) | 2009-10-28 |
| ES2332883T3 (es) | 2010-02-15 |
| CY1109712T1 (el) | 2014-08-13 |
| SI1408967T1 (sl) | 2010-02-26 |
| AU2002316935A1 (en) | 2003-01-08 |
| WO2003000241A2 (de) | 2003-01-03 |
| WO2003000241A3 (de) | 2003-12-11 |
| CA2455167C (en) | 2010-10-05 |
| CA2455167A1 (en) | 2003-01-03 |
| PT1408967E (pt) | 2009-11-25 |
| DK1408967T3 (da) | 2010-03-08 |
| US20090088408A1 (en) | 2009-04-02 |
| MXPA03011515A (es) | 2004-03-18 |
| JP2005502608A (ja) | 2005-01-27 |
| ATE446756T1 (de) | 2009-11-15 |
| EP1408967A2 (de) | 2004-04-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8127 | New person/name/address of the applicant |
Owner name: BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG, 55218 IN |
|
| 8141 | Disposal/no request for examination |