DE10110772A1 - Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und PDE-IV-Inhibitoren - Google Patents
Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und PDE-IV-InhibitorenInfo
- Publication number
- DE10110772A1 DE10110772A1 DE10110772A DE10110772A DE10110772A1 DE 10110772 A1 DE10110772 A1 DE 10110772A1 DE 10110772 A DE10110772 A DE 10110772A DE 10110772 A DE10110772 A DE 10110772A DE 10110772 A1 DE10110772 A1 DE 10110772A1
- Authority
- DE
- Germany
- Prior art keywords
- acid
- propellant
- inhalable
- inhalation
- suspension
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 38
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 title claims abstract description 12
- 229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 title claims abstract description 6
- 239000000812 cholinergic antagonist Substances 0.000 title claims abstract description 6
- 239000002547 new drug Substances 0.000 title 1
- 239000003814 drug Substances 0.000 claims abstract description 30
- 239000000443 aerosol Substances 0.000 claims description 39
- 239000000725 suspension Substances 0.000 claims description 27
- 239000000843 powder Substances 0.000 claims description 25
- 239000003380 propellant Substances 0.000 claims description 25
- 150000001875 compounds Chemical class 0.000 claims description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 21
- 239000004480 active ingredient Substances 0.000 claims description 19
- 150000003839 salts Chemical class 0.000 claims description 18
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
- DPHDSIQHVGSITN-UHFFFAOYSA-N n-(3,5-dichloropyridin-4-yl)-2-[1-[(4-fluorophenyl)methyl]-5-hydroxyindol-3-yl]-2-oxoacetamide Chemical compound C1=C(C(=O)C(=O)NC=2C(=CN=CC=2Cl)Cl)C2=CC(O)=CC=C2N1CC1=CC=C(F)C=C1 DPHDSIQHVGSITN-UHFFFAOYSA-N 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 239000002775 capsule Substances 0.000 claims description 13
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 13
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 12
- 239000002253 acid Substances 0.000 claims description 12
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 11
- 239000002552 dosage form Substances 0.000 claims description 10
- -1 glycol ethers Chemical class 0.000 claims description 10
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- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 8
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 7
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
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- 229960000686 benzalkonium chloride Drugs 0.000 claims description 5
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 5
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- 239000003381 stabilizer Substances 0.000 claims description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 4
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 4
- 150000001298 alcohols Chemical class 0.000 claims description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
- CFBUZOUXXHZCFB-OYOVHJISSA-N chembl511115 Chemical compound COC1=CC=C([C@@]2(CC[C@H](CC2)C(O)=O)C#N)C=C1OC1CCCC1 CFBUZOUXXHZCFB-OYOVHJISSA-N 0.000 claims description 4
- 229940125904 compound 1 Drugs 0.000 claims description 4
- 239000000470 constituent Substances 0.000 claims description 4
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 4
- QVDKSPUZWYTNQA-UHFFFAOYSA-N enprofylline Chemical compound O=C1NC(=O)N(CCC)C2=NC=N[C]21 QVDKSPUZWYTNQA-UHFFFAOYSA-N 0.000 claims description 4
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- 239000001530 fumaric acid Substances 0.000 claims description 4
- 150000004677 hydrates Chemical class 0.000 claims description 4
- 230000002757 inflammatory effect Effects 0.000 claims description 4
- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 claims description 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 4
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 claims description 4
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 claims description 4
- 229960002586 roflumilast Drugs 0.000 claims description 4
- 239000004094 surface-active agent Substances 0.000 claims description 4
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 claims description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 3
- 235000011054 acetic acid Nutrition 0.000 claims description 3
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims description 3
- 150000002016 disaccharides Chemical class 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims description 3
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 3
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- 208000023504 respiratory system disease Diseases 0.000 claims description 3
- 239000012453 solvate Substances 0.000 claims description 3
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- 238000002604 ultrasonography Methods 0.000 claims description 3
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- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 2
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- LVZWSLJZHVFIQJ-UHFFFAOYSA-N Cyclopropane Chemical class C1CC1 LVZWSLJZHVFIQJ-UHFFFAOYSA-N 0.000 claims description 2
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- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims description 2
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- RUOGJYKOQBFJIG-UHFFFAOYSA-N SCH-351591 Chemical compound C12=CC=C(C(F)(F)F)N=C2C(OC)=CC=C1C(=O)NC1=C(Cl)C=[N+]([O-])C=C1Cl RUOGJYKOQBFJIG-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (22)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10110772A DE10110772A1 (de) | 2001-03-07 | 2001-03-07 | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und PDE-IV-Inhibitoren |
| HU0400782A HUP0400782A3 (en) | 2001-03-07 | 2002-02-26 | Novel medicament compositions on the basis of anticholinergics and pde iv inhibitors |
| MXPA03008045A MXPA03008045A (es) | 2001-03-07 | 2002-02-26 | Nuevas composiciones de medicamentos en base a agentes anticolinergicos e inhibidores de pde-iv. |
| BR0207883-0A BR0207883A (pt) | 2001-03-07 | 2002-02-26 | Composições de medicamentos à base de anticolenérgicos e inibidores de pde-iv |
| IL15732602A IL157326A0 (en) | 2001-03-07 | 2002-02-26 | Novel medicament compositions on the basis of anticholinergics and pde iv inhibitors |
| PL02363078A PL363078A1 (en) | 2001-03-07 | 2002-02-26 | Novel medicament compositions on the basis of anticholinergics and pde iv inhibitors |
| EP02727329A EP1372649B1 (de) | 2001-03-07 | 2002-02-26 | Neue arzneimittelkompositionen auf der basis von anticholinergika und pde-iv-inhibitoren |
| KR10-2003-7011716A KR20030081501A (ko) | 2001-03-07 | 2002-02-26 | 항콜린성작용제 및 ｐｄｅ ⅳ 억제제를 주성분으로 하는신규한 약제학적 조성물 |
| JP2002569122A JP2004521134A (ja) | 2001-03-07 | 2002-02-26 | 抗コリン作動薬およびｐｄｅ−ｉｖ阻害剤を主成分とする新規な医薬組成物 |
| PCT/EP2002/001988 WO2002069945A2 (de) | 2001-03-07 | 2002-02-26 | Neue arzneimittelkompositionen auf der basis von anticholinergika und pde-iv-inhibitoren |
| EA200300929A EA009989B1 (ru) | 2001-03-07 | 2002-02-26 | Лекарственное средство и его применение для лечения воспалительных и/или обструктивных заболеваний дыхательных путей |
| CA2439763A CA2439763C (en) | 2001-03-07 | 2002-02-26 | Pharmaceutical compositions based on anticholinergics and pde-iv inhibitors |
| AU2002257587A AU2002257587B2 (en) | 2001-03-07 | 2002-02-26 | Novel medicament compositions on the basis of anticholinergics and PDE IV inhibitors |
| CNA02805346XA CN1649588A (zh) | 2001-03-07 | 2002-02-26 | 基于抗胆碱能药物及pde－iv抑制剂的新颖药物组合物 |
| CZ20032635A CZ20032635A3 (cs) | 2001-03-07 | 2002-02-26 | Farmaceutický prostředek na bázi anticholinergik a inhibitorů PDE-IV, způsob jeho výroby a použití |
| NZ528621A NZ528621A (en) | 2001-03-07 | 2002-02-26 | Novel medicament compositions on the basis of anticholinergics and PDE IV inhibitors |
| ARP020100808A AR034213A1 (es) | 2001-03-07 | 2002-03-06 | Composiciones de medicamentos sobre la base de agentes anticolinergicos e inhibidores de pde-iv |
| TW091104144A TWI332833B (en) | 2001-03-07 | 2002-03-06 | New pharmaceutical compositions based on anticholinergics and pde-iv inhibitors |
| US10/093,240 US20020193393A1 (en) | 2001-03-07 | 2002-03-07 | Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors |
| US10/613,783 US20040024007A1 (en) | 2001-03-07 | 2003-07-03 | Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors |
| IL157326A IL157326A (en) | 2001-03-07 | 2003-08-11 | Pharmaceutical compositions containing tiotropium salts and pde-iv inhibitor, optionally in the form of inhalable powders, propellant-containing inhalable aerosols and inhalable solutions or suspensions comprising said compositions |
| US11/006,940 US7776315B2 (en) | 2000-10-31 | 2004-12-08 | Pharmaceutical compositions based on anticholinergics and additional active ingredients |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10110772A DE10110772A1 (de) | 2001-03-07 | 2001-03-07 | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und PDE-IV-Inhibitoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE10110772A1 true DE10110772A1 (de) | 2002-09-12 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10110772A Withdrawn DE10110772A1 (de) | 2000-10-31 | 2001-03-07 | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und PDE-IV-Inhibitoren |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1372649B1 (enExample) |
| JP (1) | JP2004521134A (enExample) |
| KR (1) | KR20030081501A (enExample) |
| CN (1) | CN1649588A (enExample) |
| AR (1) | AR034213A1 (enExample) |
| AU (1) | AU2002257587B2 (enExample) |
| BR (1) | BR0207883A (enExample) |
| CA (1) | CA2439763C (enExample) |
| CZ (1) | CZ20032635A3 (enExample) |
| DE (1) | DE10110772A1 (enExample) |
| EA (1) | EA009989B1 (enExample) |
| HU (1) | HUP0400782A3 (enExample) |
| IL (2) | IL157326A0 (enExample) |
| MX (1) | MXPA03008045A (enExample) |
| NZ (1) | NZ528621A (enExample) |
| PL (1) | PL363078A1 (enExample) |
| TW (1) | TWI332833B (enExample) |
| WO (1) | WO2002069945A2 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| ES2276942T3 (es) * | 2001-05-25 | 2007-07-01 | BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG | Combinacion de un inhibidor de pde4 y tiotropio o un derivado del mismo para tratar vias respiratorias obstructivas y otras enfermedades inflamatorias. |
| GB0118373D0 (en) * | 2001-07-27 | 2001-09-19 | Glaxo Group Ltd | Novel therapeutic method |
| US20030235538A1 (en) | 2002-04-09 | 2003-12-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Method for the administration of an anticholinergic by inhalation |
| DE10230769A1 (de) * | 2002-07-09 | 2004-01-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittelkompositionen auf der Basis neuer Anticholinergika und PDE-IV-Inhibitoren |
| WO2004084894A1 (en) * | 2003-03-28 | 2004-10-07 | Altana Pharma Ag | Synergistic combination comprising roflumilast and revatropate for the treatment of respiratory diseases |
| CA2519682A1 (en) * | 2003-03-28 | 2004-10-07 | Altana Pharma Ag | Synergistic combination comprising roflumilast and an anticholinergic agent selected from ipratropium, oxitropium and tiotropium salts for the treatment of respiratory diseases |
| ATE384529T1 (de) * | 2003-03-28 | 2008-02-15 | Nycomed Gmbh | Synergistische kombination enthaltend roflumilast und einen anticholinergischen wirkstoff ausgewählt aus tiotropiumsalzen für die behandlung von atemwegserkrankungen |
| TWI328009B (en) | 2003-05-21 | 2010-08-01 | Glaxo Group Ltd | Quinoline derivatives as phosphodiesterase inhibitors |
| EP1651208A1 (en) * | 2003-07-28 | 2006-05-03 | Boehringer Ingelheim International GmbH | Medicaments comprising pde iv inhibitors and a novel anticholinergic and their use for treating respiratory disorders |
| US7071333B2 (en) | 2003-07-30 | 2006-07-04 | Bristol-Myers Squibb Company | Triazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same |
| EP1504756A1 (en) * | 2003-08-06 | 2005-02-09 | Kyowa Hakko Kogyo Co., Ltd | Medicament compositions comprising a heterocyclic compound and an anticholinergic |
| EP1706118A1 (en) * | 2004-01-09 | 2006-10-04 | Boehringer Ingelheim International GmbH | New pharmaceutical compositions based on a scopineester and nicotinamide derivatives |
| RU2006132043A (ru) * | 2004-02-06 | 2008-03-20 | МЕДА Фарма ГмбХ унд Ко.КГ (DE) | Комбинация и фармацевтический препарат для лечения ринита |
| PL1713471T3 (pl) * | 2004-02-06 | 2012-06-29 | Meda Pharma Gmbh & Co Kg | Kombinacja środków antycholinergicznych i inhibitorów fosfodiesterazy typu 4 do leczenia chorób oddechowych |
| AU2005210085B2 (en) | 2004-02-06 | 2010-06-24 | Meda Pharma Gmbh & Co. Kg | The combination of anticholinergics and glucocorticoids for the long-term treatment of asthma and COPD |
| EP1720543A1 (en) * | 2004-02-27 | 2006-11-15 | Altana Pharma AG | Roflumilast and glycopryrronium combination |
| EP1616567A1 (en) * | 2004-07-16 | 2006-01-18 | Boehringer Ingelheim Pharma GmbH & Co.KG | Medicaments for inhalation comprising PDE IV inhibitors and glycopyrrolate salts |
| MX2007011273A (es) | 2005-03-16 | 2007-11-08 | Meda Pharma Gmbh & Co Kg | La combinacion de anticolinergicos y antagonistas del receptor de leucotrieno para el tratamiento de enfermedades respiratorias. |
| GB0521563D0 (en) | 2005-10-21 | 2005-11-30 | Glaxo Group Ltd | Novel compounds |
| WO2007071313A2 (en) | 2005-12-21 | 2007-06-28 | Meda Pharma Gmbh & Co Kg | Combination of anticholinergics, glucocorticoids, beta2-ag0nists, pde4 inhibitor and antileukotriene for the treatment of inflammatory diseases |
| PT2046787E (pt) | 2006-08-01 | 2011-06-15 | Glaxo Group Ltd | Compostos de pirazolo[3,4-b]piridina e sua utilização como inibidores de pde4 |
| EP2100599A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
| EP2100598A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
| MX2011007499A (es) | 2009-01-13 | 2011-08-04 | Glaxo Group Ltd | Derivados de pirimidin-carboxamida como inhibidores de la cinasa syk. |
| WO2012025474A1 (en) | 2010-08-24 | 2012-03-01 | Glaxo Group Limited | Indazole compounds |
| WO2012025473A1 (en) | 2010-08-24 | 2012-03-01 | Glaxo Group Limited | Cc.chemokine receptor 4 antagonists |
| EP2510928A1 (en) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium for use in improving the quality of sleep in respiratory patients |
| CN102670607A (zh) * | 2012-05-28 | 2012-09-19 | 海南卫康制药(潜山)有限公司 | 复方盐酸氨溴索组合物及其制备方法 |
| SI2968313T1 (en) | 2013-03-15 | 2018-05-31 | Verona Pharma Plc | Combination of medicines |
| CN105358077A (zh) * | 2013-05-31 | 2016-02-24 | 因西坡设备公司 | 髋臼扩孔钻组件 |
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|---|---|---|---|---|
| JP2000198734A (ja) * | 1998-12-30 | 2000-07-18 | Pfizer Inc | 胃運動性減弱および関連疾患の治療のための運動性増強薬 |
| MY134008A (en) * | 1999-12-22 | 2007-11-30 | Merck Frosst Canada Inc | Subtituted 8-arylquinoline phospohodiestrase-4 inhibitors |
| AU2700301A (en) * | 2000-01-31 | 2001-08-14 | Pfizer Products Inc. | Pyrimidine carboxamides useful as inhibitors of pde4 isozymes |
| DE60125026T2 (de) * | 2000-03-23 | 2007-06-28 | Takeda Pharmaceutical Co. Ltd. | Fluorisochinolinderivate, verfahren zu ihrer herstellung und ihre anwendung |
| GB0009583D0 (en) * | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Respiratory formulations |
| US20020052312A1 (en) * | 2000-05-30 | 2002-05-02 | Reiss Theodore F. | Combination therapy of chronic obstructive pulmonary disease using muscarinic receptor antagonists |
| AR029984A1 (es) * | 2000-07-27 | 2003-07-23 | Smithkline Beecham Corp | Metodo para reducir las exacerbaciones asociadas copd ambito |
-
2001
- 2001-03-07 DE DE10110772A patent/DE10110772A1/de not_active Withdrawn
-
2002
- 2002-02-26 IL IL15732602A patent/IL157326A0/xx unknown
- 2002-02-26 CA CA2439763A patent/CA2439763C/en not_active Expired - Fee Related
- 2002-02-26 NZ NZ528621A patent/NZ528621A/en not_active IP Right Cessation
- 2002-02-26 HU HU0400782A patent/HUP0400782A3/hu not_active Application Discontinuation
- 2002-02-26 EA EA200300929A patent/EA009989B1/ru not_active IP Right Cessation
- 2002-02-26 AU AU2002257587A patent/AU2002257587B2/en not_active Ceased
- 2002-02-26 EP EP02727329A patent/EP1372649B1/de not_active Expired - Lifetime
- 2002-02-26 WO PCT/EP2002/001988 patent/WO2002069945A2/de not_active Ceased
- 2002-02-26 KR KR10-2003-7011716A patent/KR20030081501A/ko not_active Ceased
- 2002-02-26 BR BR0207883-0A patent/BR0207883A/pt not_active IP Right Cessation
- 2002-02-26 MX MXPA03008045A patent/MXPA03008045A/es active IP Right Grant
- 2002-02-26 JP JP2002569122A patent/JP2004521134A/ja active Pending
- 2002-02-26 CZ CZ20032635A patent/CZ20032635A3/cs unknown
- 2002-02-26 PL PL02363078A patent/PL363078A1/xx not_active Application Discontinuation
- 2002-02-26 CN CNA02805346XA patent/CN1649588A/zh active Pending
- 2002-03-06 TW TW091104144A patent/TWI332833B/zh active
- 2002-03-06 AR ARP020100808A patent/AR034213A1/es not_active Application Discontinuation
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2003
- 2003-08-11 IL IL157326A patent/IL157326A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0400782A3 (en) | 2012-09-28 |
| EP1372649A2 (de) | 2004-01-02 |
| JP2004521134A (ja) | 2004-07-15 |
| KR20030081501A (ko) | 2003-10-17 |
| NZ528621A (en) | 2005-04-29 |
| PL363078A1 (en) | 2004-11-15 |
| CA2439763A1 (en) | 2002-09-12 |
| CZ20032635A3 (cs) | 2004-09-15 |
| IL157326A0 (en) | 2004-02-19 |
| WO2002069945A3 (de) | 2003-01-30 |
| CA2439763C (en) | 2012-10-16 |
| WO2002069945A2 (de) | 2002-09-12 |
| AR034213A1 (es) | 2004-02-04 |
| HUP0400782A2 (hu) | 2004-07-28 |
| EP1372649B1 (de) | 2012-07-25 |
| IL157326A (en) | 2011-12-29 |
| BR0207883A (pt) | 2004-07-27 |
| TWI332833B (en) | 2010-11-11 |
| EA009989B1 (ru) | 2008-04-28 |
| AU2002257587B2 (en) | 2007-05-10 |
| EA200300929A1 (ru) | 2004-04-29 |
| CN1649588A (zh) | 2005-08-03 |
| MXPA03008045A (es) | 2003-12-04 |
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| Date | Code | Title | Description |
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| 8127 | New person/name/address of the applicant |
Owner name: BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG, 55218 IN |
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| 8141 | Disposal/no request for examination |