DE10021069A1 - Substituiertes Pyrazolderivat - Google Patents

Substituiertes Pyrazolderivat

Info

Publication number
DE10021069A1
DE10021069A1 DE10021069A DE10021069A DE10021069A1 DE 10021069 A1 DE10021069 A1 DE 10021069A1 DE 10021069 A DE10021069 A DE 10021069A DE 10021069 A DE10021069 A DE 10021069A DE 10021069 A1 DE10021069 A1 DE 10021069A1
Authority
DE
Germany
Prior art keywords
compound
formula
combination
cgmp
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10021069A
Other languages
German (de)
English (en)
Inventor
Alexander Straub
Cristina Alonso-Alija
Armin Kern
Johannes-Peter Stasch
Klaus Dembowsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to DE10021069A priority Critical patent/DE10021069A1/de
Priority to PCT/EP2001/004418 priority patent/WO2001083490A1/fr
Priority to AU2001256305A priority patent/AU2001256305A1/en
Publication of DE10021069A1 publication Critical patent/DE10021069A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE10021069A 2000-04-28 2000-04-28 Substituiertes Pyrazolderivat Withdrawn DE10021069A1 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE10021069A DE10021069A1 (de) 2000-04-28 2000-04-28 Substituiertes Pyrazolderivat
PCT/EP2001/004418 WO2001083490A1 (fr) 2000-04-28 2001-04-19 Derive de pyrazole substitue
AU2001256305A AU2001256305A1 (en) 2000-04-28 2001-04-19 Substituted pyrazole derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10021069A DE10021069A1 (de) 2000-04-28 2000-04-28 Substituiertes Pyrazolderivat

Publications (1)

Publication Number Publication Date
DE10021069A1 true DE10021069A1 (de) 2001-10-31

Family

ID=7640347

Family Applications (1)

Application Number Title Priority Date Filing Date
DE10021069A Withdrawn DE10021069A1 (de) 2000-04-28 2000-04-28 Substituiertes Pyrazolderivat

Country Status (3)

Country Link
AU (1) AU2001256305A1 (fr)
DE (1) DE10021069A1 (fr)
WO (1) WO2001083490A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002042301A1 (fr) * 2000-11-22 2002-05-30 Bayer Aktiengesellschaft Nouveaux derives de pyrazolopyridine a substitution pyridine
WO2003004503A1 (fr) * 2001-07-04 2003-01-16 Bayer Healthcare Ag Derives de pyrazolopyridine pontes avec la morpholine

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20011308A1 (it) 2001-06-21 2002-12-21 Nicox Sa Farmaci per il dolore cronico
DE10224462A1 (de) * 2002-06-03 2003-12-11 Bayer Ag Verwendung von cGMP stimulierenden Verbindungen
WO2004002531A1 (fr) * 2002-06-26 2004-01-08 Ono Pharmaceutical Co., Ltd. Remedes pour les maladies provoquees par la contraction ou la dilatation vasculaire
DE102007026392A1 (de) 2007-06-06 2008-12-11 Bayer Healthcare Ag Lösungen für die Perfusion und Konservierung von Organen und Geweben
CA2743864A1 (fr) 2008-11-25 2010-06-10 Merck Sharp & Dohme Corp. Activateurs de guanylate cyclase soluble
EP2549875B1 (fr) 2010-03-25 2015-05-13 Merck Sharp & Dohme Corp. Activateurs de guanylate cyclase solubles
MA34330B1 (fr) 2010-05-27 2013-06-01 Merck Sharp & Dohme Activateurs de guanylate cyclase soluble
EP2590979A1 (fr) 2010-07-09 2013-05-15 Bayer Intellectual Property GmbH Pyrimidines et triazines annelées et leur utilisation pour traiter ou prévenir des affections du système cardio-vasculaire
CN103180327B (zh) 2010-07-09 2016-08-10 拜耳知识产权有限责任公司 稠环的4-氨基嘧啶及其作为可溶性鸟甘酸环化酶的刺激物的用途
DE102010040233A1 (de) 2010-09-03 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Bicyclische Aza-Heterocyclen und ihre Verwendung
CA2833698A1 (fr) 2011-04-21 2012-10-26 Bayer Intellectual Property Gmbh Pyrazolopyridines substituees par un fluoro-alkyle et leur utilisation
CN103608347B (zh) 2011-05-30 2016-04-27 安斯泰来制药株式会社 咪唑并吡啶化合物
JP6109161B2 (ja) * 2011-07-06 2017-04-05 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ ヘテロアリール置換ピラゾロピリジン類およびその使用
MX348470B (es) 2011-09-02 2017-06-13 Bayer Ip Gmbh Pirimidinas anilladas sustituidas y uso de las mismas.
DE102012200349A1 (de) 2012-01-11 2013-07-11 Bayer Intellectual Property Gmbh Substituierte annellierte Pyrimidine und Triazine und ihre Verwendung
DE102012200352A1 (de) 2012-01-11 2013-07-11 Bayer Intellectual Property Gmbh Substituierte, annellierte Imidazole und Pyrazole und ihre Verwendung
DE102012200360A1 (de) 2012-01-11 2013-07-11 Bayer Intellectual Property Gmbh Substituierte Triazine und ihre Verwendung
CN104395313B (zh) 2012-03-06 2017-03-08 拜耳知识产权有限责任公司 取代的氮杂双环及其用途
ES2644611T3 (es) 2012-11-30 2017-11-29 Astellas Pharma Inc. Compuestos de imidazopiridina
BR112015020298A2 (pt) 2013-03-01 2017-07-18 Bayer Pharma AG pirimidinas de anel fundido substituídas com trifluormetil e uso das mesmas
AP2016008970A0 (en) 2013-07-10 2016-01-31 Bayer Pharma AG Benzyl-1h-pyrazolo[3,4-b]pyridines and use thereof
KR20180094965A (ko) 2015-12-14 2018-08-24 아이언우드 파마슈티컬스, 인코포레이티드 위장 괄약근 기능장애의 치료를 위한 sGC 자극제의 용도
WO2018111795A2 (fr) 2016-12-13 2018-06-21 Ironwood Pharmaceuticals, Inc. Utilisation de stimulateurs de sgc pour le traitement de la motilité œsophagienne
CA3056501A1 (fr) 2017-04-11 2018-10-18 Sunshine Lake Pharma Co., Ltd. Composes indazole substitues par fluor et leurs utilisations
SG11202100092QA (en) 2018-07-11 2021-02-25 Cyclerion Therapeutics Inc USE OF sGC STIMULATORS FOR THE TREATMENT OF MITOCHONRIAL DISORDERS
EP4106741A1 (fr) 2020-02-21 2022-12-28 Universiteit Maastricht Utilisation d'un stimulateur de guanylate cyclase soluble (sgc) ou d'une combinaison d'un stimulateur de sgc et d'un activateur de sgc dans des conditions dans lesquelles le groupe hème de sgc est oxydé ou sgc est déficient en hème

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19642255A1 (de) * 1996-10-14 1998-04-16 Bayer Ag Verwendung von 1-Benzyl-3-(substituierten-hetaryl) -kondensierten Pyrazol-Derivaten
DE19649460A1 (de) * 1996-11-26 1998-05-28 Bayer Ag Neue substituierte Pyrazolderivate
DE19834045A1 (de) * 1998-07-29 2000-02-03 Bayer Ag (4-Amino-5-ethylpyrimidin-2-yl)-1-(2-fluorbenzyl)-1H-pyrazolo[3,4-b]pyridin
DE19920352A1 (de) * 1999-05-04 2000-11-09 Bayer Ag Substituiertes Pyrazolderivat

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002042301A1 (fr) * 2000-11-22 2002-05-30 Bayer Aktiengesellschaft Nouveaux derives de pyrazolopyridine a substitution pyridine
US6693102B2 (en) 2000-11-22 2004-02-17 Bayer Aktiengesellschaft Pyridine-substituted pyrazolopyridine derivatives
WO2003004503A1 (fr) * 2001-07-04 2003-01-16 Bayer Healthcare Ag Derives de pyrazolopyridine pontes avec la morpholine

Also Published As

Publication number Publication date
WO2001083490A1 (fr) 2001-11-08
AU2001256305A1 (en) 2001-11-12

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Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee