DD283380A5 - Verfahren zur herstellung von flourmethoxyphenyl-dihydropyrindine - Google Patents

Verfahren zur herstellung von flourmethoxyphenyl-dihydropyrindine Download PDF

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Publication number
DD283380A5
DD283380A5 DD88321316A DD32131688A DD283380A5 DD 283380 A5 DD283380 A5 DD 283380A5 DD 88321316 A DD88321316 A DD 88321316A DD 32131688 A DD32131688 A DD 32131688A DD 283380 A5 DD283380 A5 DD 283380A5
Authority
DD
German Democratic Republic
Prior art keywords
carbon atoms
formula
optionally
ester
dihydro
Prior art date
Application number
DD88321316A
Other languages
German (de)
English (en)
Inventor
Gerhard Franckowiak
Juergen Stoltefuss
Martin Bechem
Rainer Gross
Michael Kayser
Siegbert Hebisch
Matthias Schramm
Original Assignee
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Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by �����@������������������k�� filed Critical �����@������������������k��
Publication of DD283380A5 publication Critical patent/DD283380A5/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DD88321316A 1987-11-04 1988-11-01 Verfahren zur herstellung von flourmethoxyphenyl-dihydropyrindine DD283380A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873737340 DE3737340A1 (de) 1987-11-04 1987-11-04 Neue fluormethoxyphenyl-dihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln

Publications (1)

Publication Number Publication Date
DD283380A5 true DD283380A5 (de) 1990-10-10

Family

ID=6339713

Family Applications (1)

Application Number Title Priority Date Filing Date
DD88321316A DD283380A5 (de) 1987-11-04 1988-11-01 Verfahren zur herstellung von flourmethoxyphenyl-dihydropyrindine

Country Status (15)

Country Link
US (1) US5008279A (pt)
EP (1) EP0315018A3 (pt)
JP (1) JPH01151555A (pt)
KR (1) KR890008097A (pt)
CN (1) CN1040192A (pt)
AU (1) AU613101B2 (pt)
DD (1) DD283380A5 (pt)
DE (1) DE3737340A1 (pt)
DK (1) DK614088A (pt)
FI (1) FI885056A (pt)
HU (1) HU201526B (pt)
IL (1) IL88237A0 (pt)
NO (1) NO884671L (pt)
PT (1) PT88920B (pt)
ZA (1) ZA888234B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5137889A (en) * 1983-12-02 1992-08-11 Otsuka Pharmaceutical Co., Ltd. Dihydropyridine derivatives and process for preparing the same
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US5770609A (en) * 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
EP0833624B1 (en) 1995-06-07 2007-11-07 Poniard Pharmaceuticals, Inc. Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
US6117911A (en) 1997-04-11 2000-09-12 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
AU7080698A (en) 1997-04-25 1998-11-24 Ajinomoto Co., Inc. Novel dihydropyridine derivative

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2752820A1 (de) * 1977-11-26 1979-05-31 Bayer Ag Neue nitrosubstituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4285955A (en) * 1978-10-31 1981-08-25 Bayer Aktiengesellschaft 1,4-Dihydropyridinecarboxylic acids
DE3447169A1 (de) * 1984-12-22 1986-07-03 Bayer Ag, 5090 Leverkusen Optisch aktive nitrodihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
US4868181A (en) * 1986-08-04 1989-09-19 E. I. Du Pont De Nemours And Company 1,4-dihydropyridine derivatives with calcium agonist and alpha1 -antagonist activity
US4920225A (en) * 1986-12-22 1990-04-24 Laboratoires Syntex S.A. Resolution of 1,4-dihydropyridine derivatives
DE3737341A1 (de) * 1987-11-04 1989-05-18 Bayer Ag Neue fluormethoxyphenyl-dihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
DE3821334A1 (de) * 1988-06-24 1989-12-28 Bayer Ag 1,4-dihydropyridin-threonin-derivate, verfahren zu ihrer herstellung, zwischenprodukte und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
IL88237A0 (en) 1989-06-30
DK614088A (da) 1989-05-05
CN1040192A (zh) 1990-03-07
PT88920A (pt) 1988-12-01
DK614088D0 (da) 1988-11-03
KR890008097A (ko) 1989-11-26
NO884671L (no) 1989-05-05
ZA888234B (en) 1989-07-26
HU201526B (en) 1990-11-28
US5008279A (en) 1991-04-16
AU2457688A (en) 1989-05-04
FI885056A (fi) 1989-05-05
AU613101B2 (en) 1991-07-25
FI885056A0 (fi) 1988-11-02
NO884671D0 (no) 1988-10-20
EP0315018A3 (de) 1990-07-18
HUT48591A (en) 1989-06-28
PT88920B (pt) 1993-01-29
JPH01151555A (ja) 1989-06-14
EP0315018A2 (de) 1989-05-10
DE3737340A1 (de) 1989-05-24

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