DD279405A1 - Verfahren zur herstellung eines parenteral applizierbaren analgetikums/antipyretikums - Google Patents
Verfahren zur herstellung eines parenteral applizierbaren analgetikums/antipyretikums Download PDFInfo
- Publication number
- DD279405A1 DD279405A1 DD32495389A DD32495389A DD279405A1 DD 279405 A1 DD279405 A1 DD 279405A1 DD 32495389 A DD32495389 A DD 32495389A DD 32495389 A DD32495389 A DD 32495389A DD 279405 A1 DD279405 A1 DD 279405A1
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- preparation
- antipyretics
- paracetamol
- analgesic
- water
- Prior art date
Links
- 239000002221 antipyretic Substances 0.000 title claims abstract description 7
- 229940125716 antipyretic agent Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000002360 preparation method Methods 0.000 claims abstract description 9
- 230000000202 analgesic effect Effects 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims abstract description 8
- 230000001754 anti-pyretic effect Effects 0.000 claims abstract description 7
- 239000011877 solvent mixture Substances 0.000 claims abstract description 6
- 150000001298 alcohols Chemical class 0.000 claims abstract description 4
- 239000002904 solvent Substances 0.000 claims abstract description 3
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 13
- 229960005489 paracetamol Drugs 0.000 claims description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- VEQOALNAAJBPNY-UHFFFAOYSA-N antipyrine Chemical compound CN1C(C)=CC(=O)N1C1=CC=CC=C1 VEQOALNAAJBPNY-UHFFFAOYSA-N 0.000 claims description 7
- 229960005222 phenazone Drugs 0.000 claims description 7
- 239000004698 Polyethylene Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- -1 polyethylene Polymers 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 abstract description 7
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000003381 solubilizing effect Effects 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
- 239000003814 drug Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 5
- 239000007924 injection Substances 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 239000008215 water for injection Substances 0.000 description 4
- 239000001913 cellulose Substances 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- CPJSUEIXXCENMM-UHFFFAOYSA-N phenacetin Chemical class CCOC1=CC=C(NC(C)=O)C=C1 CPJSUEIXXCENMM-UHFFFAOYSA-N 0.000 description 3
- 238000011146 sterile filtration Methods 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 208000035473 Communicable disease Diseases 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 238000007911 parenteral administration Methods 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000008174 sterile solution Substances 0.000 description 2
- RLFWWDJHLFCNIJ-UHFFFAOYSA-N Aminoantipyrine Natural products CN1C(C)=C(N)C(=O)N1C1=CC=CC=C1 RLFWWDJHLFCNIJ-UHFFFAOYSA-N 0.000 description 1
- RMMXTBMQSGEXHJ-UHFFFAOYSA-N Aminophenazone Chemical compound O=C1C(N(C)C)=C(C)N(C)N1C1=CC=CC=C1 RMMXTBMQSGEXHJ-UHFFFAOYSA-N 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 229960000212 aminophenazone Drugs 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009918 complex formation Effects 0.000 description 1
- 238000003958 fumigation Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 229960003893 phenacetin Drugs 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DD32495389A DD279405A1 (de) | 1989-01-10 | 1989-01-10 | Verfahren zur herstellung eines parenteral applizierbaren analgetikums/antipyretikums |
| CS13690A CS9000136A3 (en) | 1989-01-10 | 1990-01-10 | Parenterally administered analgesic and antipyretic and process for preparing thereof |
| HU9890A HU202744B (en) | 1989-01-10 | 1990-01-10 | Process for producing parenteral analgetic/antipyretic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DD32495389A DD279405A1 (de) | 1989-01-10 | 1989-01-10 | Verfahren zur herstellung eines parenteral applizierbaren analgetikums/antipyretikums |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD279405A1 true DD279405A1 (de) | 1990-06-06 |
Family
ID=5606553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD32495389A DD279405A1 (de) | 1989-01-10 | 1989-01-10 | Verfahren zur herstellung eines parenteral applizierbaren analgetikums/antipyretikums |
Country Status (3)
| Country | Link |
|---|---|
| CS (1) | CS9000136A3 (cs) |
| DD (1) | DD279405A1 (cs) |
| HU (1) | HU202744B (cs) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000007588A1 (en) * | 1998-07-31 | 2000-02-17 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | Pharmaceutical composition for injection based on paracetamol |
| FR2862872A1 (fr) * | 2003-12-02 | 2005-06-03 | Palbian Snc | Composition a l'etat aqueux pour l'application perfusable d'un principe actif, notamment pharmacologique tel que le paracetamol. |
| EP2421522A1 (de) | 2009-04-22 | 2012-02-29 | Fresenius Kabi Deutschland GmbH | Paracetamol zur parenteralen verabreichung |
| US8404891B2 (en) | 2009-08-13 | 2013-03-26 | Neogen N.V. | Storage-stable formulation of paracetamol in aqueous solution |
| US9399012B2 (en) | 2007-11-13 | 2016-07-26 | Mallinckrodt Ip | Reduced dose intravenous acetaminophen |
-
1989
- 1989-01-10 DD DD32495389A patent/DD279405A1/de not_active IP Right Cessation
-
1990
- 1990-01-10 CS CS13690A patent/CS9000136A3/cs unknown
- 1990-01-10 HU HU9890A patent/HU202744B/hu not_active IP Right Cessation
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000007588A1 (en) * | 1998-07-31 | 2000-02-17 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | Pharmaceutical composition for injection based on paracetamol |
| US6423749B1 (en) | 1998-07-31 | 2002-07-23 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | Pharmaceutical composition for injection based on paracetamol |
| FR2862872A1 (fr) * | 2003-12-02 | 2005-06-03 | Palbian Snc | Composition a l'etat aqueux pour l'application perfusable d'un principe actif, notamment pharmacologique tel que le paracetamol. |
| WO2005053747A1 (fr) * | 2003-12-02 | 2005-06-16 | Zeeweld Bv | Composition pour perfusion d’un principe actif, notamment le paracetamol, contenant peg |
| US9399012B2 (en) | 2007-11-13 | 2016-07-26 | Mallinckrodt Ip | Reduced dose intravenous acetaminophen |
| US9610265B2 (en) | 2007-11-13 | 2017-04-04 | Mallinckrodt Ip | Reduced dose intravenous acetaminophen |
| US9987238B2 (en) | 2007-11-13 | 2018-06-05 | Mallinckrodt Ip | Reduced dose intravenous acetaminophen |
| EP2421522A1 (de) | 2009-04-22 | 2012-02-29 | Fresenius Kabi Deutschland GmbH | Paracetamol zur parenteralen verabreichung |
| US8741959B2 (en) | 2009-04-22 | 2014-06-03 | Fresenius Kabi Deutschland Gmbh | Paracetamol for parenteral administration |
| US8404891B2 (en) | 2009-08-13 | 2013-03-26 | Neogen N.V. | Storage-stable formulation of paracetamol in aqueous solution |
| US8404748B2 (en) | 2009-08-13 | 2013-03-26 | Neogen N.V. | Storage-stable formulation of paracetamol in aqueous solution |
Also Published As
| Publication number | Publication date |
|---|---|
| HU202744B (en) | 1991-04-29 |
| CS275358B2 (en) | 1992-02-19 |
| CS9000136A3 (en) | 1992-02-19 |
| HUT53278A (en) | 1990-10-28 |
| HU900098D0 (en) | 1990-03-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60011589T2 (de) | Hochwirksame dihydroergotaminhaltige arzneizusammensetzungen | |
| DE1617576C3 (de) | Verfahren zur Herstellung eines Injektionspräparates auf Basis einer wäßrigen Lösung eines Oxytetracyclin-Magnesium-Komplexes | |
| DE69108200T2 (de) | 3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indol-5-methansulfonamid Sulfat (2:1). | |
| US5082863A (en) | Pharmaceutical composition of florfenicol | |
| DE1492015A1 (de) | Verbesserte Verabreichungsform pharmazeutischer Praeparate | |
| EP0185210B1 (de) | Verwendung von Dipeptidderivaten für die Herstellung von Arzneimitteln zur Behandlung von an amyotropher Lateralsklerose Erkrankten | |
| EP0856312B1 (de) | Verwendung von Trospiumchlorid zur Herstellung eines Arzneimittels zur Behandlung von Blasenkrankheiten | |
| DE60018967T2 (de) | Inierzierbare valnemulin formulierung | |
| DD279405A1 (de) | Verfahren zur herstellung eines parenteral applizierbaren analgetikums/antipyretikums | |
| DE19912436A1 (de) | Ibuprofen-Lösung | |
| DE3787448T2 (de) | Verwendung von Otiloniumbromid für die topische Anwendung im Gastrointestinaltrakt und entsprechende geeignete pharmazeutische Formulierung. | |
| EP0204737B1 (de) | Präparat zur intramuskulären injektion von medikamenten, vitaminen oder impfstoffen | |
| DE4220616C2 (de) | Dexniguldipin zur intravenösen Verabreichung | |
| DE3689254T2 (de) | Arzneimittel auf Dextrorphanbasis zur intranasalen Applikation. | |
| DD291924A5 (de) | Verfahren zur herstellung einer waessrigen loesung eines pentamidinsalzes | |
| DE3044753C2 (cs) | ||
| DE2342214C3 (de) | Heilmittel | |
| DE69109815T2 (de) | Lactulose enthaltende wasserfreie Zusammensetzung. | |
| DE2538678A1 (de) | Injizierbare loesungen | |
| DE2721034C2 (cs) | ||
| DE1617433C (de) | Verfahren zur Herstellung von 5,5 Diphenyl hydantoin Natrium Losungen fur Injektionszwecke | |
| EP1309353B1 (de) | Flavonhaltige pflanzenextraktlösungen mit verbesserter lager- und hitzestabilität | |
| DE10234784A1 (de) | Intravenös applizierbare, pharmazeutische Darreichungsform | |
| DE69814092T2 (de) | Wassermischbare Arzneizusammensetzung von Nimesulide | |
| DE4130918A1 (de) | Arzneimittel zur unterbrechung der vasokonstriktion nach gabe von lokalanaesthetika mit vasokonstriktorischer wirkung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| VZ | Disclaimer of patent (art. 11 and 12 extension act) |