DD258006A5 - Verfahren zur herstellung von hydrozon-derivaten - Google Patents

Verfahren zur herstellung von hydrozon-derivaten Download PDF

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Publication number
DD258006A5
DD258006A5 DD86290095A DD29009586A DD258006A5 DD 258006 A5 DD258006 A5 DD 258006A5 DD 86290095 A DD86290095 A DD 86290095A DD 29009586 A DD29009586 A DD 29009586A DD 258006 A5 DD258006 A5 DD 258006A5
Authority
DD
German Democratic Republic
Prior art keywords
general formula
mixture
trans
nmr
hydrogen
Prior art date
Application number
DD86290095A
Other languages
German (de)
English (en)
Inventor
Sandor Makleit
Laszlo Szilagyi
Kalman Zsupan
Sandor Hosztafi
Original Assignee
Alkaloida Vegyeszeti Gyar Of Tiszavasvari,Hu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU5685A external-priority patent/HU199901B/hu
Priority to IN291/MAS/86A priority Critical patent/IN163125B/en
Priority to EP86105584A priority patent/EP0242417B1/en
Priority to JP61094988A priority patent/JPS62258380A/ja
Application filed by Alkaloida Vegyeszeti Gyar Of Tiszavasvari,Hu filed Critical Alkaloida Vegyeszeti Gyar Of Tiszavasvari,Hu
Priority to DD86290095A priority patent/DD258006A5/de
Priority to SU864027475A priority patent/SU1487812A3/ru
Publication of DD258006A5 publication Critical patent/DD258006A5/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DD86290095A 1985-01-08 1986-05-09 Verfahren zur herstellung von hydrozon-derivaten DD258006A5 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IN291/MAS/86A IN163125B (th) 1985-01-08 1986-04-18
EP86105584A EP0242417B1 (en) 1985-01-08 1986-04-23 Morphinane-skeletoned hydrazone derivatives, process for preparing them, pharmaceutical composition and use
JP61094988A JPS62258380A (ja) 1985-01-08 1986-04-25 モルフイナン骨格化合物
DD86290095A DD258006A5 (de) 1985-01-08 1986-05-09 Verfahren zur herstellung von hydrozon-derivaten
SU864027475A SU1487812A3 (ru) 1985-01-08 1986-05-19 Способ получения гидразонпроизводных морфинана в виде стереоизомеров или их смеси

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU5685A HU199901B (en) 1985-01-08 1985-01-08 Process for production of derivatives of hydrazon with morfinane carcass
DD86290095A DD258006A5 (de) 1985-01-08 1986-05-09 Verfahren zur herstellung von hydrozon-derivaten

Publications (1)

Publication Number Publication Date
DD258006A5 true DD258006A5 (de) 1988-07-06

Family

ID=25748053

Family Applications (1)

Application Number Title Priority Date Filing Date
DD86290095A DD258006A5 (de) 1985-01-08 1986-05-09 Verfahren zur herstellung von hydrozon-derivaten

Country Status (4)

Country Link
EP (1) EP0242417B1 (th)
JP (1) JPS62258380A (th)
DD (1) DD258006A5 (th)
IN (1) IN163125B (th)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU208633B (en) * 1991-02-04 1993-12-28 Alkaloida Vegyeszeti Gyar Process for production of analgetic compositions as applicable for blocking of opioid-binding spaces /2-receptors/ causing respiration depression
US6323212B1 (en) 1992-01-23 2001-11-27 Toray Industries, Inc. Morphinan derivative and its pharmaceutical applications
EP0663401B1 (en) 1993-07-23 2000-06-07 Toray Industries, Inc. Morphinan derivative and medicinal use
US7501433B2 (en) 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
JP5438250B2 (ja) 2002-05-17 2014-03-12 ジェンケン バイオサイエンスィズ，インコーポレイテッド オピオイド及びオピオイド様の化合物並びにそれらの使用
US7923454B2 (en) 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US8017622B2 (en) 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1078467A (fr) * 1952-02-18 1954-11-18 Merck & Co Inc Procédé de synthèse totale de la morphine
US2797221A (en) * 1954-06-22 1957-06-25 Merck & Co Inc Process and intermediates for producing 1-bromocodeinone
US4608376A (en) * 1981-10-16 1986-08-26 Carolyn McGinnis Opiate agonists and antagonists
CA1258674A (en) * 1981-10-16 1989-08-22 Sloan-Kettering Institute For Cancer Research Opiate agonists and antagonists

Also Published As

Publication number Publication date
EP0242417B1 (en) 1993-02-10
JPS62258380A (ja) 1987-11-10
EP0242417A1 (en) 1987-10-28
IN163125B (th) 1988-08-13

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Legal Events

Date Code Title Description
EP Request for examination under paragraph 12(1) filed