DD139859A5 - Verfahren zur herstellung von 21-hydroxy-20-methylpregnanen - Google Patents
Verfahren zur herstellung von 21-hydroxy-20-methylpregnanen Download PDFInfo
- Publication number
- DD139859A5 DD139859A5 DD78209813A DD20981378A DD139859A5 DD 139859 A5 DD139859 A5 DD 139859A5 DD 78209813 A DD78209813 A DD 78209813A DD 20981378 A DD20981378 A DD 20981378A DD 139859 A5 DD139859 A5 DD 139859A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- borate
- fermentation
- item
- culture
- hydroxy
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000855 fermentation Methods 0.000 claims description 16
- 230000004151 fermentation Effects 0.000 claims description 16
- 241000187488 Mycobacterium sp. Species 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 13
- -1 borate ions Chemical class 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 150000001639 boron compounds Chemical class 0.000 claims description 5
- 229940068065 phytosterols Drugs 0.000 claims description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- MDCWDBMBZLORER-UHFFFAOYSA-N triphenyl borate Chemical compound C=1C=CC=CC=1OB(OC=1C=CC=CC=1)OC1=CC=CC=C1 MDCWDBMBZLORER-UHFFFAOYSA-N 0.000 claims description 3
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims description 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 229960002645 boric acid Drugs 0.000 claims 1
- 235000010338 boric acid Nutrition 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- VGTPKLINSHNZRD-UHFFFAOYSA-N oxoborinic acid Chemical compound OB=O VGTPKLINSHNZRD-UHFFFAOYSA-N 0.000 claims 1
- 239000000758 substrate Substances 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
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- 238000002844 melting Methods 0.000 description 5
- 230000008018 melting Effects 0.000 description 5
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- 239000002904 solvent Substances 0.000 description 3
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- UQGFMSUEHSUPRD-UHFFFAOYSA-N disodium;3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane Chemical compound [Na+].[Na+].O1B([O-])OB2OB([O-])OB1O2 UQGFMSUEHSUPRD-UHFFFAOYSA-N 0.000 description 2
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- 239000000543 intermediate Substances 0.000 description 2
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 2
- 235000019796 monopotassium phosphate Nutrition 0.000 description 2
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 2
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- GDTSJMKGXGJFGQ-UHFFFAOYSA-N 3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane Chemical compound O1B([O-])OB2OB([O-])OB1O2 GDTSJMKGXGJFGQ-UHFFFAOYSA-N 0.000 description 1
- XMRPGKVKISIQBV-BJMCWZGWSA-N 5alpha-pregnane-3,20-dione Chemical class C([C@@H]1CC2)C(=O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)C)[C@@]2(C)CC1 XMRPGKVKISIQBV-BJMCWZGWSA-N 0.000 description 1
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- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
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- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
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- AJFXNBUVIBKWBT-UHFFFAOYSA-N disodium;boric acid;hydrogen borate Chemical compound [Na+].[Na+].OB(O)O.OB(O)O.OB(O)O.OB([O-])[O-] AJFXNBUVIBKWBT-UHFFFAOYSA-N 0.000 description 1
- NBEMQPLNBYYUAZ-UHFFFAOYSA-N ethyl acetate;propan-2-one Chemical compound CC(C)=O.CCOC(C)=O NBEMQPLNBYYUAZ-UHFFFAOYSA-N 0.000 description 1
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- WRUGWIBCXHJTDG-UHFFFAOYSA-L magnesium sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Mg+2].[O-]S([O-])(=O)=O WRUGWIBCXHJTDG-UHFFFAOYSA-L 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
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- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 239000003471 mutagenic agent Substances 0.000 description 1
- 231100000707 mutagenic chemical Toxicity 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
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- 239000000047 product Substances 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
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- 239000011780 sodium chloride Substances 0.000 description 1
- NVIFVTYDZMXWGX-UHFFFAOYSA-N sodium metaborate Chemical compound [Na+].[O-]B=O NVIFVTYDZMXWGX-UHFFFAOYSA-N 0.000 description 1
- 241000894007 species Species 0.000 description 1
- HCXVJBMSMIARIN-PHZDYDNGSA-N stigmasterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)/C=C/[C@@H](CC)C(C)C)[C@@]1(C)CC2 HCXVJBMSMIARIN-PHZDYDNGSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/005—Degradation of the lateral chains at position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19772757156 DE2757156A1 (de) | 1977-12-19 | 1977-12-19 | Verfahren zur herstellung von 21-hydroxy-20-methyl-pregnan-derivaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD139859A5 true DD139859A5 (de) | 1980-01-23 |
Family
ID=6026798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD78209813A DD139859A5 (de) | 1977-12-19 | 1978-12-15 | Verfahren zur herstellung von 21-hydroxy-20-methylpregnanen |
Country Status (12)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4800072A (en) * | 1988-01-14 | 1989-01-24 | Rhone Poulenc, Inc. | Anhydrous cerous nitrate-ammonium nitrate complex and a process for its preparation from ceric ammonium nitrate |
| KR20180028544A (ko) * | 2015-08-07 | 2018-03-16 | 인터셉트 파마슈티컬즈, 인크. | 담즙산 및 이의 유도체의 제조 방법 |
| CN111596791A (zh) | 2020-04-28 | 2020-08-28 | 北京载诚科技有限公司 | 一种触控面板 |
| CN111651099A (zh) | 2020-04-28 | 2020-09-11 | 北京载诚科技有限公司 | 一种触控装置 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3684657A (en) * | 1970-05-11 | 1972-08-15 | Searle & Co | Selective microbiological degradation of steroidal 17-alkyls |
| US3759791A (en) * | 1970-12-10 | 1973-09-18 | Searle & Co | Selective microbiological preparation of androst-4-ene-3,17-dione |
-
1977
- 1977-12-19 DE DE19772757156 patent/DE2757156A1/de not_active Withdrawn
-
1978
- 1978-12-04 SU SU782691554A patent/SU862830A3/ru active
- 1978-12-06 YU YU02855/78A patent/YU285578A/xx unknown
- 1978-12-15 DD DD78209813A patent/DD139859A5/de unknown
- 1978-12-15 DE DE7878101711T patent/DE2861249D1/de not_active Expired
- 1978-12-15 EP EP78101711A patent/EP0002535B1/de not_active Expired
- 1978-12-18 JP JP15502178A patent/JPS5581A/ja active Granted
- 1978-12-18 IE IE2486/78A patent/IE47691B1/en unknown
- 1978-12-18 AT AT0904778A patent/AT363625B/de not_active IP Right Cessation
- 1978-12-18 HU HU78SCHE665A patent/HU181505B/hu not_active IP Right Cessation
- 1978-12-19 GB GB7848989A patent/GB2010276B/en not_active Expired
- 1978-12-19 CS CS788574A patent/CS202517B2/cs unknown
- 1978-12-19 DK DK570578A patent/DK144708C/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK144708C (da) | 1982-10-11 |
| SU862830A3 (ru) | 1981-09-07 |
| DK144708B (da) | 1982-05-17 |
| GB2010276A (en) | 1979-06-27 |
| IE47691B1 (en) | 1984-05-30 |
| DE2861249D1 (en) | 1981-12-10 |
| EP0002535B1 (de) | 1981-09-30 |
| IE782486L (en) | 1979-06-19 |
| DE2757156A1 (de) | 1979-06-21 |
| GB2010276B (en) | 1982-08-04 |
| HU181505B (en) | 1983-10-28 |
| EP0002535A2 (de) | 1979-06-27 |
| DK570578A (da) | 1979-06-20 |
| CS202517B2 (en) | 1981-01-30 |
| JPS6350000B2 (enrdf_load_stackoverflow) | 1988-10-06 |
| ATA904778A (de) | 1981-01-15 |
| YU285578A (en) | 1982-10-31 |
| AT363625B (de) | 1981-08-25 |
| EP0002535A3 (en) | 1979-07-11 |
| JPS5581A (en) | 1980-01-05 |
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