CZ291932B6 - Farmaceutický prostředek s antivirovým účinkem, obsahující kyselinu glycyrrhizovou a alespoň jeden protein projevující antivirový účinek - Google Patents
Farmaceutický prostředek s antivirovým účinkem, obsahující kyselinu glycyrrhizovou a alespoň jeden protein projevující antivirový účinek Download PDFInfo
- Publication number
- CZ291932B6 CZ291932B6 CZ19993991A CZ399199A CZ291932B6 CZ 291932 B6 CZ291932 B6 CZ 291932B6 CZ 19993991 A CZ19993991 A CZ 19993991A CZ 399199 A CZ399199 A CZ 399199A CZ 291932 B6 CZ291932 B6 CZ 291932B6
- Authority
- CZ
- Czechia
- Prior art keywords
- lysozyme
- glycyrrhizic acid
- antiviral activity
- lactoferrin
- protein
- Prior art date
Links
- 230000000840 anti-viral effect Effects 0.000 title claims abstract description 13
- 102000004169 proteins and genes Human genes 0.000 title claims abstract description 9
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 9
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 title abstract description 31
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 title abstract description 31
- 229960004949 glycyrrhizic acid Drugs 0.000 title abstract description 31
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 title abstract description 31
- 239000001685 glycyrrhizic acid Substances 0.000 title abstract description 31
- 235000019410 glycyrrhizin Nutrition 0.000 title abstract description 31
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 title abstract description 31
- 230000001747 exhibiting effect Effects 0.000 title abstract description 5
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
- 235000010335 lysozyme Nutrition 0.000 claims description 39
- 108010014251 Muramidase Proteins 0.000 claims description 36
- 102000016943 Muramidase Human genes 0.000 claims description 36
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims description 36
- 229960000274 lysozyme Drugs 0.000 claims description 36
- 239000004325 lysozyme Substances 0.000 claims description 36
- 241000287828 Gallus gallus Species 0.000 claims description 22
- 235000021242 lactoferrin Nutrition 0.000 claims description 17
- 102000010445 Lactoferrin Human genes 0.000 claims description 15
- 108010063045 Lactoferrin Proteins 0.000 claims description 15
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims description 15
- 229940078795 lactoferrin Drugs 0.000 claims description 15
- 101000798114 Homo sapiens Lactotransferrin Proteins 0.000 claims description 8
- 235000018102 proteins Nutrition 0.000 claims description 7
- 101001018100 Homo sapiens Lysozyme C Proteins 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 101000798100 Bos taurus Lactotransferrin Proteins 0.000 claims description 3
- 102000004142 Trypsin Human genes 0.000 claims description 3
- 108090000631 Trypsin Proteins 0.000 claims description 3
- 239000012588 trypsin Substances 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 150000001340 alkali metals Chemical class 0.000 claims 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 1
- -1 alkaline earth metal salt Chemical class 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 229940072440 bovine lactoferrin Drugs 0.000 claims 1
- 241000700588 Human alphaherpesvirus 1 Species 0.000 description 19
- 210000004027 cell Anatomy 0.000 description 17
- 230000005764 inhibitory process Effects 0.000 description 17
- 230000003612 virological effect Effects 0.000 description 15
- 230000015572 biosynthetic process Effects 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 208000015181 infectious disease Diseases 0.000 description 8
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- 210000003501 vero cell Anatomy 0.000 description 7
- 239000002356 single layer Substances 0.000 description 6
- 238000003786 synthesis reaction Methods 0.000 description 6
- 102000003886 Glycoproteins Human genes 0.000 description 5
- 108090000288 Glycoproteins Proteins 0.000 description 5
- 239000002552 dosage form Substances 0.000 description 5
- 230000002401 inhibitory effect Effects 0.000 description 5
- 241000700605 Viruses Species 0.000 description 4
- 230000002195 synergetic effect Effects 0.000 description 4
- 208000035415 Reinfection Diseases 0.000 description 3
- 229960004150 aciclovir Drugs 0.000 description 3
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 3
- 230000003602 anti-herpes Effects 0.000 description 3
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- 231100000816 toxic dose Toxicity 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
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- 206010012735 Diarrhoea Diseases 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 241000725303 Human immunodeficiency virus Species 0.000 description 1
- 101150021503 Mesd gene Proteins 0.000 description 1
- 102000014171 Milk Proteins Human genes 0.000 description 1
- 108010011756 Milk Proteins Proteins 0.000 description 1
- 206010029155 Nephropathy toxic Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- OIRDTQYFTABQOQ-UHTZMRCNSA-N Vidarabine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O OIRDTQYFTABQOQ-UHTZMRCNSA-N 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
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- 235000013355 food flavoring agent Nutrition 0.000 description 1
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- 229960002442 glucosamine Drugs 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
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- 239000000463 material Substances 0.000 description 1
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- 230000007694 nephrotoxicity Effects 0.000 description 1
- 231100000417 nephrotoxicity Toxicity 0.000 description 1
- PGSADBUBUOPOJS-UHFFFAOYSA-N neutral red Chemical compound Cl.C1=C(C)C(N)=CC2=NC3=CC(N(C)C)=CC=C3N=C21 PGSADBUBUOPOJS-UHFFFAOYSA-N 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
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- 229960003636 vidarabine Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI001119A IT1291366B1 (it) | 1997-05-14 | 1997-05-14 | Composizione farmaceutica antivirale comprendente acido glicirrizico ed almeno una proteina dotata di attivita' antivirale |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CZ399199A3 CZ399199A3 (cs) | 2000-04-12 |
| CZ291932B6 true CZ291932B6 (cs) | 2003-06-18 |
Family
ID=11377123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ19993991A CZ291932B6 (cs) | 1997-05-14 | 1998-05-06 | Farmaceutický prostředek s antivirovým účinkem, obsahující kyselinu glycyrrhizovou a alespoň jeden protein projevující antivirový účinek |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6329339B1 (en:Method) |
| EP (1) | EP0980254B1 (en:Method) |
| JP (2) | JP2001525814A (en:Method) |
| KR (1) | KR100592193B1 (en:Method) |
| CN (1) | CN1114447C (en:Method) |
| AR (1) | AR012849A1 (en:Method) |
| AT (1) | ATE212232T1 (en:Method) |
| AU (1) | AU740944B2 (en:Method) |
| BG (1) | BG64748B1 (en:Method) |
| CA (1) | CA2289550A1 (en:Method) |
| CZ (1) | CZ291932B6 (en:Method) |
| DE (1) | DE69803565T2 (en:Method) |
| DK (1) | DK0980254T3 (en:Method) |
| EA (1) | EA003126B1 (en:Method) |
| ES (1) | ES2170501T3 (en:Method) |
| GE (1) | GEP20022672B (en:Method) |
| HU (1) | HU224956B1 (en:Method) |
| IL (2) | IL132651A0 (en:Method) |
| IT (1) | IT1291366B1 (en:Method) |
| PL (1) | PL189218B1 (en:Method) |
| PT (1) | PT980254E (en:Method) |
| SK (1) | SK283584B6 (en:Method) |
| TR (1) | TR199902730T2 (en:Method) |
| UA (1) | UA63955C2 (en:Method) |
| WO (1) | WO1998051334A1 (en:Method) |
| ZA (1) | ZA983917B (en:Method) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7151082B2 (en) * | 1999-02-11 | 2006-12-19 | The Feinstein Institute For Medical Research | Antagonists of HMG1 for treating inflammatory conditions |
| US6303321B1 (en) * | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
| US7304034B2 (en) | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
| AU2003225073A1 (en) * | 2002-04-18 | 2003-11-03 | The University Of Iowa Research Foundation | Methods of inhibiting and treating bacterial biofilms by metal chelators |
| US7696169B2 (en) * | 2003-06-06 | 2010-04-13 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
| CA2882022A1 (en) * | 2003-09-11 | 2005-03-24 | Walter Newman | Monoclonal antibodies against hmgb1 |
| WO2007011606A2 (en) * | 2005-07-18 | 2007-01-25 | Critical Therapeutics, Inc. | USE OF HMGBl ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY SKIN CONDITIONS |
| JP2009517404A (ja) * | 2005-11-28 | 2009-04-30 | メディミューン，エルエルシー | Ｈｍｇｂ１および／またはｒａｇｅのアンタゴニストならびにその使用方法 |
| IT1391170B1 (it) * | 2008-08-07 | 2011-11-18 | D M G Italia S R L | Composizione topica intra-nasale utilizzabile in caso di ostruzione nasale |
| US9416151B2 (en) | 2010-08-25 | 2016-08-16 | Lurong ZHANG | Use of glycyrrhetinic acid, glycyrrhizic acid and related compounds for prevention and/or treatment of pulmonary fibrosis |
| CA2809031C (en) * | 2010-08-25 | 2018-10-16 | Weijian Zhang | Use of glycyrrhetinic acid, glycyrrhizic acid and related compounds for prevention and/or treatment of pulmonary fibrosis |
| EP3108894B1 (en) * | 2014-02-21 | 2022-01-26 | Kewpie Corporation | Non-therapeutic method of deactivating norovirus, use of lysozyme component for non-therapeutic norovirus deactivation, and lysozyme component for use in the prevention or treatment of norovirus infection |
| US12447166B2 (en) | 2016-02-25 | 2025-10-21 | Applied Biological Laboratories, Inc. | Compositions and methods for protecting against airborne pathogens and irritants |
| KR102844566B1 (ko) * | 2016-02-25 | 2025-08-08 | 어플라이드 바이올로지컬 래버러토리즈 인코포레이티드 | 공기 매개 병원체 및 자극물질에 대한 보호용 조성물 및 방법 |
| CN109022351B (zh) * | 2018-09-28 | 2021-10-19 | 广州奇龙生物科技有限公司 | 重组人溶菌酶的新应用 |
| EP3928785B1 (en) * | 2020-04-27 | 2024-07-31 | Guangzhou Century Clinical Research Co., Ltd | Medicament and food for use in preventing or treating novel coronavirus pneumonia covid-19 |
| JP7543427B2 (ja) * | 2020-04-27 | 2024-09-02 | 広州新創憶薬物臨床研究有限公司 | 抗新型コロナウイルス感染症の医薬品、食品、及び使用 |
| CN112135625B (zh) * | 2020-04-27 | 2021-07-06 | 广州新创忆药物临床研究有限公司 | 一种预防或治疗covid-19新冠肺炎的药物及其应用 |
| MX2021005280A (es) | 2021-05-04 | 2022-02-23 | Spv Timser S A P I De C V | Composicion farmaceutica que contiene triterpenoides pentaciclicos. |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH085800B2 (ja) * | 1986-12-19 | 1996-01-24 | エーザイ株式会社 | 塩化リゾチ−ム及びグリチルリチン酸ジカリウム含有水溶液製剤 |
| JP2838720B2 (ja) * | 1989-10-31 | 1998-12-16 | ゼリア新薬工業株式会社 | 安定な点眼剤 |
| JP4056099B2 (ja) * | 1996-05-09 | 2008-03-05 | 森永乳業株式会社 | 水生動物の寄生生物性疾患の予防および治療剤 |
-
1997
- 1997-05-14 IT IT97MI001119A patent/IT1291366B1/it active IP Right Grant
-
1998
- 1998-05-06 AU AU77646/98A patent/AU740944B2/en not_active Ceased
- 1998-05-06 JP JP54879998A patent/JP2001525814A/ja not_active Ceased
- 1998-05-06 KR KR1019997010372A patent/KR100592193B1/ko not_active Expired - Fee Related
- 1998-05-06 ES ES98925588T patent/ES2170501T3/es not_active Expired - Lifetime
- 1998-05-06 CA CA002289550A patent/CA2289550A1/en not_active Abandoned
- 1998-05-06 SK SK1544-99A patent/SK283584B6/sk not_active IP Right Cessation
- 1998-05-06 CN CN98805037A patent/CN1114447C/zh not_active Expired - Fee Related
- 1998-05-06 IL IL13265198A patent/IL132651A0/xx active IP Right Grant
- 1998-05-06 CZ CZ19993991A patent/CZ291932B6/cs not_active IP Right Cessation
- 1998-05-06 DK DK98925588T patent/DK0980254T3/da active
- 1998-05-06 GE GEAP19985126A patent/GEP20022672B/en unknown
- 1998-05-06 WO PCT/EP1998/002797 patent/WO1998051334A1/en not_active Ceased
- 1998-05-06 HU HU0002985A patent/HU224956B1/hu not_active IP Right Cessation
- 1998-05-06 AT AT98925588T patent/ATE212232T1/de not_active IP Right Cessation
- 1998-05-06 EP EP98925588A patent/EP0980254B1/en not_active Expired - Lifetime
- 1998-05-06 TR TR1999/02730T patent/TR199902730T2/xx unknown
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- 1998-06-05 UA UA99126790A patent/UA63955C2/uk unknown
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1999
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2008
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD00 | Pending as of 2000-06-30 in czech republic | ||
| MM4A | Patent lapsed due to non-payment of fee |
Effective date: 20090506 |