CZ285893B6 - Antiandrogenní sloučenina, její prekursor a farmaceutický prostředek ji obsahující - Google Patents
Antiandrogenní sloučenina, její prekursor a farmaceutický prostředek ji obsahující Download PDFInfo
- Publication number
- CZ285893B6 CZ285893B6 CZ942824A CZ282494A CZ285893B6 CZ 285893 B6 CZ285893 B6 CZ 285893B6 CZ 942824 A CZ942824 A CZ 942824A CZ 282494 A CZ282494 A CZ 282494A CZ 285893 B6 CZ285893 B6 CZ 285893B6
- Authority
- CZ
- Czechia
- Prior art keywords
- mixture
- mmol
- added
- compound
- hydroxy
- Prior art date
Links
- 0 C[C@](CC1)(C(CC2)C(CC3)C1[C@@](C)(CC1)[C@@]3CC1=O)[C@@]2(*)O Chemical compound C[C@](CC1)(C(CC2)C(CC3)C1[C@@](C)(CC1)[C@@]3CC1=O)[C@@]2(*)O 0.000 description 2
- AZNYYTKWJVPYCX-BAXNNAIZSA-N CC(CC1)(C(CC2)C(CC3)C1[C@@](C)(CC1)[C@H]3CC11[O]=CCO1)[C@H]2O Chemical compound CC(CC1)(C(CC2)C(CC3)C1[C@@](C)(CC1)[C@H]3CC11[O]=CCO1)[C@H]2O AZNYYTKWJVPYCX-BAXNNAIZSA-N 0.000 description 1
- FYVKKXPWOJKVKR-YAQFZYRKSA-N C[C@](CC1)(C(CC2)C(CC3)C1[C@@](C)(CC1)C3CC11OCCO1)[C@H]2O Chemical compound C[C@](CC1)(C(CC2)C(CC3)C1[C@@](C)(CC1)C3CC11OCCO1)[C@H]2O FYVKKXPWOJKVKR-YAQFZYRKSA-N 0.000 description 1
- RBUSNCUWXFLPEW-GNCLCZFSSA-N C[C@](CC1)(C(CC2)C(CC3)C1[C@@](C)(CC1)[C@H]3CC11O[IH]CO1)C2O Chemical compound C[C@](CC1)(C(CC2)C(CC3)C1[C@@](C)(CC1)[C@H]3CC11O[IH]CO1)C2O RBUSNCUWXFLPEW-GNCLCZFSSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
- C07J1/0037—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
- C07J1/004—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0044—Alkenyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
- C07J1/004—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0048—Alkynyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/006—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6061293A | 1993-05-17 | 1993-05-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CZ282494A3 CZ282494A3 (en) | 1995-12-13 |
| CZ285893B6 true CZ285893B6 (cs) | 1999-11-17 |
Family
ID=22030624
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ942824A CZ285893B6 (cs) | 1993-05-17 | 1993-05-20 | Antiandrogenní sloučenina, její prekursor a farmaceutický prostředek ji obsahující |
| CZ19991917A CZ287991B6 (cs) | 1993-05-17 | 1999-05-31 | Antiandrogenní sloučenina, farmaceutický prostředek ji obsahující a její použití |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ19991917A CZ287991B6 (cs) | 1993-05-17 | 1999-05-31 | Antiandrogenní sloučenina, farmaceutický prostředek ji obsahující a její použití |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0650495B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2741286B2 (cg-RX-API-DMAC10.html) |
| KR (1) | KR100241228B1 (cg-RX-API-DMAC10.html) |
| AT (1) | ATE197458T1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2136303A1 (cg-RX-API-DMAC10.html) |
| CZ (2) | CZ285893B6 (cg-RX-API-DMAC10.html) |
| DE (1) | DE69329649D1 (cg-RX-API-DMAC10.html) |
| FI (1) | FI945458L (cg-RX-API-DMAC10.html) |
| HU (1) | HUT69408A (cg-RX-API-DMAC10.html) |
| PL (1) | PL307333A1 (cg-RX-API-DMAC10.html) |
| RU (1) | RU2141966C1 (cg-RX-API-DMAC10.html) |
| SK (1) | SK139194A3 (cg-RX-API-DMAC10.html) |
| TW (1) | TW259791B (cg-RX-API-DMAC10.html) |
| WO (1) | WO1994026767A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5879711A (en) * | 1997-11-07 | 1999-03-09 | Sequeira; Joel A. | Stable antiandrogenic gel composition |
| BR9908592A (pt) | 1998-03-11 | 2001-04-24 | Endorech Inc | Processo para inibir a atividade de 17ß-hidroxiesteróide desidrogenase tipo 5, composição farmacêutica, inibidor de 17ß-hidroxiesteróide desidrogenase tipo 5, processo para inibir 17ß-hidroxiesteróide desidrogenase tipo 3, inibidor de 17ß-hidroxiesteróide desidrogenase tipo 3, processos para tratar, ou reduzir o risco de desenvolver, câncer da próstata, hiperplasia prostática benigna, acne, seborréia, hirsutismo ou alopécia androgênica, sìndrome de ovário policìstico, câncer de mama, endometriose ou leiomioma, para inibir as secreções hormonais testiculares, para tratar puberdade precoce, e, kit |
| WO2002089802A2 (en) | 2001-05-08 | 2002-11-14 | Schering Corporation | Use of neurokinin receptor antagonists to treat androgen-dependent diseases |
| EP1423381B1 (en) | 2001-09-06 | 2007-01-03 | Schering Corporation | 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases |
| JP4309761B2 (ja) | 2001-10-17 | 2009-08-05 | シェーリング コーポレイション | アンドロゲン依存性疾患の治療を目的とする１７βヒドロキシステロイドデヒドロゲナーゼ３型の阻害剤としてのピペリジンアセトアミンおよびピペラジンアセトアミン |
| AU2003219656B2 (en) * | 2002-01-15 | 2007-05-17 | Merck Sharp & Dohme Corp. | 17-hydroxy-4-aza-androstan-3-ones as androgen receptor modulators |
| ATE469886T1 (de) | 2002-11-18 | 2010-06-15 | Schering Corp | 17beta-hydroxysteroid dehydrogenase typ-3 hemmer zur behandlung von androgen abhängigen erkrankungen |
| DE60323765D1 (de) | 2002-12-17 | 2008-11-06 | Schering Corp | Inhibitoren der 17 beta-hydroxysteroiddehydrogenase des typs 3 zur behandlung androgenabhängiger krankheiten |
| GB0513702D0 (en) | 2005-07-04 | 2005-08-10 | Sterix Ltd | Compound |
| GB0722779D0 (en) | 2007-11-20 | 2008-01-02 | Sterix Ltd | Compound |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1081494A (en) * | 1965-09-14 | 1967-08-31 | British Drug Houses Ltd | 17ª-(alka-1',3'-diynyl)-steroids |
| US3875188A (en) * | 1968-04-10 | 1975-04-01 | Eugene E Galantay | 17-Beta-alpha-lower alkyl allene-substituted steroids |
| JPS5513273A (en) * | 1978-07-13 | 1980-01-30 | Kanebo Ltd | Readily absorbable thiazolidine prodrug of anti- inflammatory corticosteroid and its drug composition |
| FR2430952A1 (fr) * | 1978-07-13 | 1980-02-08 | Roussel Uclaf | Nouveaux derives acetyleniques de l'androst 4-ene, leur procede de preparation et leur application comme medicament |
| AU5856090A (en) * | 1989-07-07 | 1991-02-06 | Endorecherche Inc. | Androgen derivatives for use in the inhibition of sex steroid activity |
-
1993
- 1993-05-20 EP EP93909730A patent/EP0650495B1/en not_active Expired - Lifetime
- 1993-05-20 RU RU94046463A patent/RU2141966C1/ru active
- 1993-05-20 PL PL93307333A patent/PL307333A1/xx unknown
- 1993-05-20 KR KR1019940704184A patent/KR100241228B1/ko not_active Expired - Fee Related
- 1993-05-20 AT AT93909730T patent/ATE197458T1/de not_active IP Right Cessation
- 1993-05-20 WO PCT/CA1993/000216 patent/WO1994026767A1/en not_active Ceased
- 1993-05-20 HU HU9403262A patent/HUT69408A/hu unknown
- 1993-05-20 FI FI945458A patent/FI945458L/fi unknown
- 1993-05-20 SK SK1391-94A patent/SK139194A3/sk unknown
- 1993-05-20 CA CA002136303A patent/CA2136303A1/en not_active Abandoned
- 1993-05-20 JP JP6501832A patent/JP2741286B2/ja not_active Expired - Lifetime
- 1993-05-20 DE DE69329649T patent/DE69329649D1/de not_active Expired - Lifetime
- 1993-05-20 CZ CZ942824A patent/CZ285893B6/cs not_active IP Right Cessation
- 1993-05-21 TW TW082104024A patent/TW259791B/zh active
-
1999
- 1999-05-31 CZ CZ19991917A patent/CZ287991B6/cs not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CZ287991B6 (cs) | 2001-03-14 |
| ATE197458T1 (de) | 2000-11-11 |
| EP0650495B1 (en) | 2000-11-08 |
| RU94046463A (ru) | 1997-02-27 |
| SK139194A3 (en) | 1995-07-11 |
| TW259791B (cg-RX-API-DMAC10.html) | 1995-10-11 |
| FI945458A0 (fi) | 1994-11-21 |
| KR100241228B1 (ko) | 2000-02-01 |
| FI945458A7 (fi) | 1995-01-16 |
| WO1994026767A1 (en) | 1994-11-24 |
| PL307333A1 (en) | 1995-05-15 |
| HUT69408A (en) | 1995-09-28 |
| FI945458L (fi) | 1995-01-16 |
| CA2136303A1 (en) | 1994-11-24 |
| DE69329649D1 (de) | 2000-12-14 |
| EP0650495A1 (en) | 1995-05-03 |
| CZ282494A3 (en) | 1995-12-13 |
| JP2741286B2 (ja) | 1998-04-15 |
| RU2141966C1 (ru) | 1999-11-27 |
| JPH08510988A (ja) | 1996-11-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF00 | In force as of 2000-06-30 in czech republic | ||
| MM4A | Patent lapsed due to non-payment of fee |
Effective date: 20010520 |