JP2741286B2 - 改良された抗アンドロゲン - Google Patents

改良された抗アンドロゲン

Info

Publication number
JP2741286B2
JP2741286B2 JP6501832A JP50183293A JP2741286B2 JP 2741286 B2 JP2741286 B2 JP 2741286B2 JP 6501832 A JP6501832 A JP 6501832A JP 50183293 A JP50183293 A JP 50183293A JP 2741286 B2 JP2741286 B2 JP 2741286B2
Authority
JP
Japan
Prior art keywords
mixture
ring
intervening atoms
mmol
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP6501832A
Other languages
English (en)
Japanese (ja)
Other versions
JPH08510988A (ja
Inventor
ラブリー，フェルナン
メラン，イブ
サン，シャンカール・エム
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Endorecherche Inc
Original Assignee
Endorecherche Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endorecherche Inc filed Critical Endorecherche Inc
Publication of JPH08510988A publication Critical patent/JPH08510988A/ja
Application granted granted Critical
Publication of JP2741286B2 publication Critical patent/JP2741286B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/0037—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/004—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0044—Alkenyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/004—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0048—Alkynyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/006—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP6501832A 1993-05-17 1993-05-20 改良された抗アンドロゲン Expired - Lifetime JP2741286B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6061293A 1993-05-17 1993-05-17
US8/60,612 1993-05-17
US08/060,612 1993-05-17

Publications (2)

Publication Number Publication Date
JPH08510988A JPH08510988A (ja) 1996-11-19
JP2741286B2 true JP2741286B2 (ja) 1998-04-15

Family

ID=22030624

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6501832A Expired - Lifetime JP2741286B2 (ja) 1993-05-17 1993-05-20 改良された抗アンドロゲン

Country Status (14)

Country Link
EP (1) EP0650495B1 (cg-RX-API-DMAC10.html)
JP (1) JP2741286B2 (cg-RX-API-DMAC10.html)
KR (1) KR100241228B1 (cg-RX-API-DMAC10.html)
AT (1) ATE197458T1 (cg-RX-API-DMAC10.html)
CA (1) CA2136303A1 (cg-RX-API-DMAC10.html)
CZ (2) CZ285893B6 (cg-RX-API-DMAC10.html)
DE (1) DE69329649D1 (cg-RX-API-DMAC10.html)
FI (1) FI945458L (cg-RX-API-DMAC10.html)
HU (1) HUT69408A (cg-RX-API-DMAC10.html)
PL (1) PL307333A1 (cg-RX-API-DMAC10.html)
RU (1) RU2141966C1 (cg-RX-API-DMAC10.html)
SK (1) SK139194A3 (cg-RX-API-DMAC10.html)
TW (1) TW259791B (cg-RX-API-DMAC10.html)
WO (1) WO1994026767A1 (cg-RX-API-DMAC10.html)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5879711A (en) * 1997-11-07 1999-03-09 Sequeira; Joel A. Stable antiandrogenic gel composition
BR9908592A (pt) 1998-03-11 2001-04-24 Endorech Inc Processo para inibir a atividade de 17ß-hidroxiesteróide desidrogenase tipo 5, composição farmacêutica, inibidor de 17ß-hidroxiesteróide desidrogenase tipo 5, processo para inibir 17ß-hidroxiesteróide desidrogenase tipo 3, inibidor de 17ß-hidroxiesteróide desidrogenase tipo 3, processos para tratar, ou reduzir o risco de desenvolver, câncer da próstata, hiperplasia prostática benigna, acne, seborréia, hirsutismo ou alopécia androgênica, sìndrome de ovário policìstico, câncer de mama, endometriose ou leiomioma, para inibir as secreções hormonais testiculares, para tratar puberdade precoce, e, kit
WO2002089802A2 (en) 2001-05-08 2002-11-14 Schering Corporation Use of neurokinin receptor antagonists to treat androgen-dependent diseases
EP1423381B1 (en) 2001-09-06 2007-01-03 Schering Corporation 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
JP4309761B2 (ja) 2001-10-17 2009-08-05 シェーリング コーポレイション アンドロゲン依存性疾患の治療を目的とする１７βヒドロキシステロイドデヒドロゲナーゼ３型の阻害剤としてのピペリジンアセトアミンおよびピペラジンアセトアミン
AU2003219656B2 (en) * 2002-01-15 2007-05-17 Merck Sharp & Dohme Corp. 17-hydroxy-4-aza-androstan-3-ones as androgen receptor modulators
ATE469886T1 (de) 2002-11-18 2010-06-15 Schering Corp 17beta-hydroxysteroid dehydrogenase typ-3 hemmer zur behandlung von androgen abhängigen erkrankungen
DE60323765D1 (de) 2002-12-17 2008-11-06 Schering Corp Inhibitoren der 17 beta-hydroxysteroiddehydrogenase des typs 3 zur behandlung androgenabhängiger krankheiten
GB0513702D0 (en) 2005-07-04 2005-08-10 Sterix Ltd Compound
GB0722779D0 (en) 2007-11-20 2008-01-02 Sterix Ltd Compound

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1081494A (en) * 1965-09-14 1967-08-31 British Drug Houses Ltd 17ª‡-(alka-1',3'-diynyl)-steroids
US3875188A (en) * 1968-04-10 1975-04-01 Eugene E Galantay 17-Beta-alpha-lower alkyl allene-substituted steroids
JPS5513273A (en) * 1978-07-13 1980-01-30 Kanebo Ltd Readily absorbable thiazolidine prodrug of anti- inflammatory corticosteroid and its drug composition
FR2430952A1 (fr) * 1978-07-13 1980-02-08 Roussel Uclaf Nouveaux derives acetyleniques de l'androst 4-ene, leur procede de preparation et leur application comme medicament
AU5856090A (en) * 1989-07-07 1991-02-06 Endorecherche Inc. Androgen derivatives for use in the inhibition of sex steroid activity

Also Published As

Publication number Publication date
CZ287991B6 (cs) 2001-03-14
ATE197458T1 (de) 2000-11-11
EP0650495B1 (en) 2000-11-08
RU94046463A (ru) 1997-02-27
SK139194A3 (en) 1995-07-11
TW259791B (cg-RX-API-DMAC10.html) 1995-10-11
CZ285893B6 (cs) 1999-11-17
FI945458A0 (fi) 1994-11-21
KR100241228B1 (ko) 2000-02-01
FI945458A7 (fi) 1995-01-16
WO1994026767A1 (en) 1994-11-24
PL307333A1 (en) 1995-05-15
HUT69408A (en) 1995-09-28
FI945458L (fi) 1995-01-16
CA2136303A1 (en) 1994-11-24
DE69329649D1 (de) 2000-12-14
EP0650495A1 (en) 1995-05-03
CZ282494A3 (en) 1995-12-13
RU2141966C1 (ru) 1999-11-27
JPH08510988A (ja) 1996-11-19

Similar Documents

Publication Publication Date Title
RU2141967C1 (ru) ИНГИБИТОРЫ ТЕСТОСТЕРОН 5α-РЕДУКТАЗЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ИНГИБИРОВАНИЯ АКТИВНОСТИ ТЕСТОСТЕРОН 5α-РЕДУКТАЗЫ
EP2147014B1 (en) 17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators
KR101536701B1 (ko) 헬릭스 12 배향형 스테로이드계 약학 제품
KR0142881B1 (ko) 성스테로이드 활성 억제용 에스트로겐 핵유도체
US5686437A (en) Estrogen nucleus derivatives for use in the inhibition of sex steroid activity
US5227375A (en) Aromatase inhibitors
JP2741286B2 (ja) 改良された抗アンドロゲン
JPH08507535A (ja) １５−置換４−アザステロイド
JPH10507755A (ja) ７−置換４−アザコラン酸誘導体とその使用
US6015806A (en) Antiandrogens
US6413951B2 (en) 20-fluoro-17(20)-vinyl steroids
EP1409512A1 (en) 20-fluoro-17(20)-vinyl steroids as inhibitors of c17-20-lyase and 5-alpha reductase
AU3405600A (en) Sex steroid activity inhibitors