CZ282881B6 - Způsob výroby peptidů - Google Patents
Způsob výroby peptidů Download PDFInfo
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- CZ282881B6 CZ282881B6 CS912666A CS266691A CZ282881B6 CZ 282881 B6 CZ282881 B6 CZ 282881B6 CS 912666 A CS912666 A CS 912666A CS 266691 A CS266691 A CS 266691A CZ 282881 B6 CZ282881 B6 CZ 282881B6
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 23
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- 238000004519 manufacturing process Methods 0.000 title claims description 7
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- 238000003556 assay Methods 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 description 1
- 239000012964 benzotriazole Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 229920001429 chelating resin Polymers 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 229930003836 cresol Natural products 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 description 1
- IOPLHGOSNCJOOO-UHFFFAOYSA-N methyl 3,4-diaminobenzoate Chemical compound COC(=O)C1=CC=C(N)C(N)=C1 IOPLHGOSNCJOOO-UHFFFAOYSA-N 0.000 description 1
- MUJNAWXXOJRNGK-UHFFFAOYSA-N n-[3-(6-methyl-1,2,3,4-tetrahydrocarbazol-9-yl)propyl]cyclohexanamine Chemical compound C1=2CCCCC=2C2=CC(C)=CC=C2N1CCCNC1CCCCC1 MUJNAWXXOJRNGK-UHFFFAOYSA-N 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 229910000343 potassium bisulfate Inorganic materials 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 1
- 229910052939 potassium sulfate Inorganic materials 0.000 description 1
- 235000011151 potassium sulphates Nutrition 0.000 description 1
- 108010087791 pyroglutamylhistidine Proteins 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- ZERULLAPCVRMCO-UHFFFAOYSA-N sulfure de di n-propyle Natural products CCCSCCC ZERULLAPCVRMCO-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- HNKJADCVZUBCPG-UHFFFAOYSA-N thioanisole Chemical compound CSC1=CC=CC=C1 HNKJADCVZUBCPG-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229940033942 zoladex Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4027394 | 1990-08-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS266691A3 CS266691A3 (en) | 1992-03-18 |
| CZ282881B6 true CZ282881B6 (cs) | 1997-11-12 |
Family
ID=6413202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS912666A CZ282881B6 (cs) | 1990-08-30 | 1991-08-29 | Způsob výroby peptidů |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0475184B1 (enExample) |
| JP (1) | JP3177269B2 (enExample) |
| KR (1) | KR100203548B1 (enExample) |
| AU (1) | AU646488B2 (enExample) |
| CA (1) | CA2050216C (enExample) |
| CZ (1) | CZ282881B6 (enExample) |
| DE (1) | DE59104538D1 (enExample) |
| DK (1) | DK0475184T3 (enExample) |
| ES (1) | ES2069148T3 (enExample) |
| FI (1) | FI102380B (enExample) |
| GR (1) | GR3015359T3 (enExample) |
| HU (1) | HU208838B (enExample) |
| IE (1) | IE66524B1 (enExample) |
| IL (1) | IL99338A (enExample) |
| NO (1) | NO300216B1 (enExample) |
| NZ (1) | NZ239575A (enExample) |
| PL (1) | PL167504B1 (enExample) |
| PT (1) | PT98813B (enExample) |
| RU (1) | RU2036200C1 (enExample) |
| SK (1) | SK280319B6 (enExample) |
| TW (1) | TW295589B (enExample) |
| ZA (1) | ZA916848B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9112825D0 (en) * | 1991-06-14 | 1991-07-31 | Ici Plc | Process for making peptides |
| GB9727123D0 (en) * | 1997-12-22 | 1998-02-25 | Int Centre Genetic Eng & Bio | Synthesis of diamines |
| ES2154590B1 (es) * | 1999-05-20 | 2001-11-01 | Lipotec Sa | Procedimiento de sintesis de peptidos en fase solida |
| CA2594477C (en) | 2005-01-21 | 2016-07-12 | Astex Therapeutics Limited | Pharmaceutical compounds |
| US8916552B2 (en) | 2006-10-12 | 2014-12-23 | Astex Therapeutics Limited | Pharmaceutical combinations |
| US8883790B2 (en) | 2006-10-12 | 2014-11-11 | Astex Therapeutics Limited | Pharmaceutical combinations |
| DK2976325T3 (en) | 2013-03-21 | 2017-06-06 | Sanofi Aventis Deutschland | SYNTHESIS OF PEPTIDE PRODUCTS CONTAINING CYCLIC IMID |
| AU2014234400B2 (en) | 2013-03-21 | 2017-11-16 | Sanofi-Aventis Deutschland Gmbh | Synthesis of hydantoin containing peptide products |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0322348B1 (de) * | 1987-12-22 | 1994-02-02 | Hoechst Aktiengesellschaft | Säurelabile Ankergruppen zur Synthese von Peptidamiden mittels Festphasenmethode |
-
1991
- 1991-08-17 TW TW080106522A patent/TW295589B/zh active
- 1991-08-27 ES ES91114332T patent/ES2069148T3/es not_active Expired - Lifetime
- 1991-08-27 DE DE59104538T patent/DE59104538D1/de not_active Expired - Lifetime
- 1991-08-27 DK DK91114332.9T patent/DK0475184T3/da active
- 1991-08-27 EP EP91114332A patent/EP0475184B1/de not_active Expired - Lifetime
- 1991-08-28 IL IL9933891A patent/IL99338A/en not_active IP Right Cessation
- 1991-08-28 FI FI914064A patent/FI102380B/fi not_active IP Right Cessation
- 1991-08-28 NZ NZ239575A patent/NZ239575A/xx not_active IP Right Cessation
- 1991-08-29 NO NO913396A patent/NO300216B1/no not_active IP Right Cessation
- 1991-08-29 KR KR1019910014992A patent/KR100203548B1/ko not_active Expired - Lifetime
- 1991-08-29 RU SU915001313A patent/RU2036200C1/ru active
- 1991-08-29 CZ CS912666A patent/CZ282881B6/cs not_active IP Right Cessation
- 1991-08-29 SK SK2666-91A patent/SK280319B6/sk not_active IP Right Cessation
- 1991-08-29 ZA ZA916848A patent/ZA916848B/xx unknown
- 1991-08-29 CA CA002050216A patent/CA2050216C/en not_active Expired - Lifetime
- 1991-08-29 IE IE305191A patent/IE66524B1/en not_active IP Right Cessation
- 1991-08-29 AU AU83402/91A patent/AU646488B2/en not_active Expired
- 1991-08-29 JP JP21852591A patent/JP3177269B2/ja not_active Expired - Lifetime
- 1991-08-29 PT PT98813A patent/PT98813B/pt not_active IP Right Cessation
- 1991-08-29 PL PL91291561A patent/PL167504B1/pl unknown
- 1991-08-30 HU HU912825A patent/HU208838B/hu unknown
-
1995
- 1995-03-10 GR GR950400517T patent/GR3015359T3/el unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF00 | In force as of 2000-06-30 in czech republic | ||
| MK4A | Patent expired |
Effective date: 20110829 |