CZ242993A3 - Benzofuran derivatives, process of their preparation and pharmaceutical preparations in which they are comprised - Google Patents
Benzofuran derivatives, process of their preparation and pharmaceutical preparations in which they are comprised Download PDFInfo
- Publication number
- CZ242993A3 CZ242993A3 CS932429A CS242993A CZ242993A3 CZ 242993 A3 CZ242993 A3 CZ 242993A3 CS 932429 A CS932429 A CS 932429A CS 242993 A CS242993 A CS 242993A CZ 242993 A3 CZ242993 A3 CZ 242993A3
- Authority
- CZ
- Czechia
- Prior art keywords
- carbon atoms
- methyl
- alkyl
- ethyl
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919110633A GB9110633D0 (en) | 1991-05-16 | 1991-05-16 | Chemical compounds |
| GB929201358A GB9201358D0 (en) | 1992-01-22 | 1992-01-22 | Chemical compounds |
| GB929205174A GB9205174D0 (en) | 1992-03-10 | 1992-03-10 | Chemical compounds |
| PCT/GB1992/000887 WO1992020679A1 (en) | 1991-05-16 | 1992-05-15 | Benzofuran derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CZ242993A3 true CZ242993A3 (en) | 1994-03-16 |
Family
ID=27265657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS932429A CZ242993A3 (en) | 1991-05-16 | 1992-05-15 | Benzofuran derivatives, process of their preparation and pharmaceutical preparations in which they are comprised |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5317023A (OSRAM) |
| EP (1) | EP0514197A1 (OSRAM) |
| JP (1) | JPH06507608A (OSRAM) |
| KR (1) | KR920021542A (OSRAM) |
| AU (2) | AU1751192A (OSRAM) |
| CA (1) | CA2068756A1 (OSRAM) |
| CZ (1) | CZ242993A3 (OSRAM) |
| FI (1) | FI935043A7 (OSRAM) |
| HU (1) | HUT67014A (OSRAM) |
| IE (1) | IE921569A1 (OSRAM) |
| IL (1) | IL101888A0 (OSRAM) |
| MX (1) | MX9202300A (OSRAM) |
| NO (1) | NO921951L (OSRAM) |
| TW (1) | TW221997B (OSRAM) |
| WO (1) | WO1992020679A1 (OSRAM) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9110636D0 (en) * | 1991-05-16 | 1991-07-03 | Glaxo Group Ltd | Chemical compounds |
| DE4140519A1 (de) * | 1991-12-09 | 1993-06-17 | Merck Patent Gmbh | Benzofurane |
| GB9218449D0 (en) | 1992-08-29 | 1992-10-14 | Boots Co Plc | Therapeutic agents |
| GB9223860D0 (en) * | 1992-11-13 | 1993-01-06 | Glaxo Group Ltd | Chemical compounds |
| GB2279346A (en) * | 1993-07-01 | 1995-01-04 | Glaxo Group Ltd | Benzofuran intermediates |
| SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
| WO2005082904A1 (ja) * | 2004-02-26 | 2005-09-09 | Kyowa Hakko Kogyo Co., Ltd. | 好中球性炎症疾患の予防及び／または治療剤 |
| ES2559319T3 (es) | 2007-06-04 | 2016-02-11 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato cliclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| CA2726917C (en) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| WO2010009319A2 (en) | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
| WO2014197720A2 (en) | 2013-06-05 | 2014-12-11 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
| UY38912A (es) * | 2019-10-09 | 2021-05-31 | Biocryst Pharm Inc | Inhibidores del factor d del complemento para administración oral |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4880804A (en) * | 1988-01-07 | 1989-11-14 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking benzimidazoles |
| DE3928177A1 (de) * | 1989-04-08 | 1991-02-28 | Thomae Gmbh Dr K | Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| EP0400835A1 (en) * | 1989-05-15 | 1990-12-05 | Merck & Co. Inc. | Substituted benzimidazoles as angiotensin II antagonists |
| IE64514B1 (en) * | 1989-05-23 | 1995-08-09 | Zeneca Ltd | Azaindenes |
| GB8911854D0 (en) * | 1989-05-23 | 1989-07-12 | Ici Plc | Heterocyclic compounds |
| IL94390A (en) * | 1989-05-30 | 1996-03-31 | Merck & Co Inc | The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them |
| EP0415886A3 (en) * | 1989-08-30 | 1991-10-23 | Ciba-Geigy Ag | Aza compounds |
| IE70593B1 (en) * | 1989-09-29 | 1996-12-11 | Eisai Co Ltd | Biphenylmethane derivative the use of it and pharmacological compositions containing same |
| IL95975A (en) * | 1989-10-24 | 1997-06-10 | Takeda Chemical Industries Ltd | N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them |
| IL96019A0 (en) * | 1989-10-31 | 1991-07-18 | Fujisawa Pharmaceutical Co | Imidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
| EP0430300A3 (en) * | 1989-12-01 | 1992-03-25 | Takeda Chemical Industries, Ltd. | Xanthine derivatives, their production and use |
| GB8927277D0 (en) * | 1989-12-01 | 1990-01-31 | Glaxo Group Ltd | Chemical compounds |
| EP0434038A1 (en) * | 1989-12-22 | 1991-06-26 | Takeda Chemical Industries, Ltd. | Fused imidazole derivatives, their production and use |
| DE4006693A1 (de) * | 1990-03-01 | 1991-09-05 | Schering Ag | Neue benzimidazolderivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung |
| JPH04235974A (ja) * | 1990-06-08 | 1992-08-25 | Roussel Uclaf | 新規なイミダゾール誘導体、それらの製造法、得られる新規な中間体、それらの薬剤としての使用及びそれらを含有する製薬組成物 |
| DE4140519A1 (de) * | 1991-12-09 | 1993-06-17 | Merck Patent Gmbh | Benzofurane |
-
1992
- 1992-05-15 CZ CS932429A patent/CZ242993A3/cs unknown
- 1992-05-15 NO NO92921951A patent/NO921951L/no unknown
- 1992-05-15 AU AU17511/92A patent/AU1751192A/en not_active Abandoned
- 1992-05-15 CA CA002068756A patent/CA2068756A1/en not_active Abandoned
- 1992-05-15 MX MX9202300A patent/MX9202300A/es unknown
- 1992-05-15 TW TW081103781A patent/TW221997B/zh active
- 1992-05-15 JP JP4509260A patent/JPH06507608A/ja active Pending
- 1992-05-15 KR KR1019920008242A patent/KR920021542A/ko not_active Withdrawn
- 1992-05-15 EP EP92304419A patent/EP0514197A1/en not_active Withdrawn
- 1992-05-15 IL IL101888A patent/IL101888A0/xx unknown
- 1992-05-15 HU HU9303225A patent/HUT67014A/hu unknown
- 1992-05-15 AU AU16320/92A patent/AU654349B2/en not_active Ceased
- 1992-05-15 US US07/883,386 patent/US5317023A/en not_active Expired - Fee Related
- 1992-05-15 WO PCT/GB1992/000887 patent/WO1992020679A1/en not_active Ceased
- 1992-07-01 IE IE156992A patent/IE921569A1/en unknown
-
1993
- 1993-11-15 FI FI935043A patent/FI935043A7/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IE921569A1 (en) | 1992-11-18 |
| IL101888A0 (en) | 1992-12-30 |
| AU654349B2 (en) | 1994-11-03 |
| NO921951D0 (no) | 1992-05-15 |
| FI935043A0 (fi) | 1993-11-15 |
| JPH06507608A (ja) | 1994-09-01 |
| HUT67014A (en) | 1995-01-30 |
| AU1751192A (en) | 1992-12-30 |
| NO921951L (no) | 1992-11-17 |
| TW221997B (OSRAM) | 1994-04-01 |
| WO1992020679A1 (en) | 1992-11-26 |
| US5317023A (en) | 1994-05-31 |
| EP0514197A1 (en) | 1992-11-19 |
| MX9202300A (es) | 1992-11-01 |
| KR920021542A (ko) | 1992-12-18 |
| FI935043A7 (fi) | 1993-11-15 |
| CA2068756A1 (en) | 1992-11-17 |
| AU1632092A (en) | 1993-03-11 |
| HU9303225D0 (en) | 1994-03-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6457459B2 (ja) | インダゾール−３−カルボキサミドおよびＷＮＴ／β−カテニンシグナル伝達経路阻害剤としてのそれらの使用 | |
| RU2573569C2 (ru) | Ингибиторы фосфатидилинозитол-3-киназы на основе изоиндолинона | |
| JP6767875B2 (ja) | Ｔｇｆ−ベータ阻害剤としての２，３−二置換ピリジン化合物および使用方法 | |
| JP6444800B2 (ja) | キナーゼ活性の阻害剤 | |
| EP1666480B1 (en) | Aryl or Heteroaryl Fused Imidazole Compounds as intermediates for Anti-Inflammatory And Analgesic Agents. | |
| KR102007056B1 (ko) | 과증식성 질환 치료시 Bub1 키나제 저해제로 사용하기 위한 치환된 벤질인다졸 | |
| JP3260415B2 (ja) | アンギオテンシンｉｉ拮抗作用を有する複素環化合物 | |
| CA2409743C (en) | Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors | |
| TWI469977B (zh) | ７－苯氧基唍羧酸衍生物 | |
| US9073918B2 (en) | Pyrazolo[4,3-b]pyridine-7-amine inhibitors of ALK5 | |
| CZ242993A3 (en) | Benzofuran derivatives, process of their preparation and pharmaceutical preparations in which they are comprised | |
| KR20170135938A (ko) | 브로모도메인 억제제 | |
| JPWO2006051704A1 (ja) | イミン化合物 | |
| CN101437818A (zh) | At1和eta受体的新的双重作用受体拮抗剂(dara) | |
| CZ243093A3 (en) | Benzofuran derivatives, process of their preparation and pharmaceutical preparations in which they are comprised | |
| JPH04217975A (ja) | ベンゾフラン誘導体 | |
| HUP9903009A2 (hu) | Szubsztituált indazolszármazékok és IV típusú foszfodiészteráz (PDE) és tumornekrózis faktor (TNF) inhibítorokként történő alkalmazásuk | |
| ZA200602448B (en) | Thrombin receptor antagonists | |
| JPH06145170A (ja) | ヘテロ環式化合物、その製法及びこれを含有する高血圧及びうつ血性心不全治療用医薬組成物 | |
| CN103313970A (zh) | 新型二环式化合物或其盐 | |
| TW200400965A (en) | Antiviral compounds | |
| SK9162001A3 (en) | Substituted (aminoiminomethyl or aminomethyl)benzoheteroaryl compounds as factor xa inhibitors | |
| KR20220066277A (ko) | 인터페론 유전자의 자극인자 sting의 모노시클릭 효능제 | |
| EP3087074A1 (en) | Benzene sulfonamides as ccr9 inhibitors | |
| RU2530775C2 (ru) | ПРОИЗВОДНЫЕ 1Н-ПИРАЗОЛО[4,3-c]ИЗОХИНОЛИНОВ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЕ В ТЕРАПИИ |