CZ2003245A3 - Nové substituované ftalidy, způsob jejich přípravy a farmaceutické přípravky je obsahující - Google Patents
Nové substituované ftalidy, způsob jejich přípravy a farmaceutické přípravky je obsahující Download PDFInfo
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- CZ2003245A3 CZ2003245A3 CZ2003245A CZ2003245A CZ2003245A3 CZ 2003245 A3 CZ2003245 A3 CZ 2003245A3 CZ 2003245 A CZ2003245 A CZ 2003245A CZ 2003245 A CZ2003245 A CZ 2003245A CZ 2003245 A3 CZ2003245 A3 CZ 2003245A3
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- pharmaceutically acceptable
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- 238000002360 preparation method Methods 0.000 title claims description 17
- 238000000034 method Methods 0.000 title claims description 12
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- 125000000217 alkyl group Chemical group 0.000 claims abstract description 12
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 9
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- 239000002253 acid Substances 0.000 claims description 23
- 125000001424 substituent group Chemical group 0.000 claims description 19
- 150000003839 salts Chemical class 0.000 claims description 18
- 230000009471 action Effects 0.000 claims description 12
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 11
- 125000005843 halogen group Chemical group 0.000 claims description 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
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- ASKLDELUMSEZPN-UHFFFAOYSA-N 3-butyl-6-(propan-2-ylamino)-3h-2-benzofuran-1-one Chemical compound CC(C)NC1=CC=C2C(CCCC)OC(=O)C2=C1 ASKLDELUMSEZPN-UHFFFAOYSA-N 0.000 claims description 3
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- DQBGVUCLKLYTJM-UHFFFAOYSA-N 6-amino-3-butyl-3h-2-benzofuran-1-one Chemical compound NC1=CC=C2C(CCCC)OC(=O)C2=C1 DQBGVUCLKLYTJM-UHFFFAOYSA-N 0.000 claims description 3
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- YYDFTFDFORIGIP-UHFFFAOYSA-N 6-amino-3,3-dimethyl-2-benzofuran-1-one Chemical compound NC1=CC=C2C(C)(C)OC(=O)C2=C1 YYDFTFDFORIGIP-UHFFFAOYSA-N 0.000 claims description 2
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- 208000000609 Pick Disease of the Brain Diseases 0.000 claims description 2
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- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Natural products C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims description 2
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- 125000003884 phenylalkyl group Chemical group 0.000 claims description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
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- 230000002739 subcortical effect Effects 0.000 claims description 2
- 229910052717 sulfur Inorganic materials 0.000 claims description 2
- 239000011593 sulfur Substances 0.000 claims description 2
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims description 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 21
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- 239000003054 catalyst Substances 0.000 description 9
- 239000013078 crystal Substances 0.000 description 8
- WNZQDUSMALZDQF-UHFFFAOYSA-N isobenzofuranone Natural products C1=CC=C2C(=O)OCC2=C1 WNZQDUSMALZDQF-UHFFFAOYSA-N 0.000 description 8
- 239000007787 solid Substances 0.000 description 8
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 8
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 7
- 239000011777 magnesium Substances 0.000 description 7
- 229910052749 magnesium Inorganic materials 0.000 description 7
- 239000002904 solvent Substances 0.000 description 7
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 6
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- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium on carbon Substances [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 6
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- MPPPKRYCTPRNTB-UHFFFAOYSA-N 1-bromobutane Chemical compound CCCCBr MPPPKRYCTPRNTB-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
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- 241000699670 Mus sp. Species 0.000 description 3
- LGRFSURHDFAFJT-UHFFFAOYSA-N Phthalic anhydride Natural products C1=CC=C2C(=O)OC(=O)C2=C1 LGRFSURHDFAFJT-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
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- JHIWVOJDXOSYLW-UHFFFAOYSA-N butyl 2,2-difluorocyclopropane-1-carboxylate Chemical compound CCCCOC(=O)C1CC1(F)F JHIWVOJDXOSYLW-UHFFFAOYSA-N 0.000 description 3
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Indole Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001193295A CN1182127C (zh) | 2000-06-28 | 2000-06-28 | 新的取代的2-苯并[c]呋喃酮化合物,其制备方法以及包含它们的药物组合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CZ2003245A3 true CZ2003245A3 (cs) | 2003-05-14 |
Family
ID=4587601
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ2003245A CZ2003245A3 (cs) | 2000-06-28 | 2001-06-27 | Nové substituované ftalidy, způsob jejich přípravy a farmaceutické přípravky je obsahující |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6689808B2 (en:Method) |
| EP (1) | EP1320528A2 (en:Method) |
| JP (1) | JP2004501909A (en:Method) |
| KR (1) | KR20030024710A (en:Method) |
| CN (2) | CN1182127C (en:Method) |
| AR (1) | AR030239A1 (en:Method) |
| AU (1) | AU2001280004A1 (en:Method) |
| BR (1) | BR0112043A (en:Method) |
| CA (1) | CA2413752A1 (en:Method) |
| CZ (1) | CZ2003245A3 (en:Method) |
| EA (1) | EA200300044A1 (en:Method) |
| HU (1) | HUP0301567A3 (en:Method) |
| MX (1) | MXPA02012569A (en:Method) |
| NO (1) | NO20026154L (en:Method) |
| NZ (1) | NZ523174A (en:Method) |
| PL (1) | PL359373A1 (en:Method) |
| SK (1) | SK1062003A3 (en:Method) |
| WO (1) | WO2002000638A2 (en:Method) |
| ZA (1) | ZA200210004B (en:Method) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602004022035D1 (de) * | 2003-05-14 | 2009-08-27 | Dsm Ip Assets Bv | Verwendung von pthalide derivativen zur behandlung |
| JP2007505854A (ja) | 2003-09-23 | 2007-03-15 | ディーエスエム アイピー アセッツ ビー．ブイ． | 糖尿病の治療および予防用組成物 |
| CN1605336A (zh) | 2003-10-10 | 2005-04-13 | 中国医学科学院药物研究所 | 左旋丁基苯酞在制备预防和治疗脑梗塞的药物中的应用 |
| EP1757286B1 (en) * | 2004-06-18 | 2017-09-06 | CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | The application of l-n-butylphthalide in preventing and treating alzheimer's disease |
| CN106074497A (zh) * | 2010-01-13 | 2016-11-09 | 石药集团恩必普药业有限公司 | 丁苯酞及其衍生物在制备治疗帕金森病的药物中的应用 |
| CN102260233A (zh) * | 2011-05-04 | 2011-11-30 | 武汉科技大学 | 3-丁基-1(3h)-异苯并呋喃酮衍生物及其制备方法 |
| CN105367526B (zh) * | 2015-10-14 | 2017-07-28 | 济南诚汇双达化工有限公司 | 一种高纯度正丁基苯酞的制备方法 |
| CN108727352B (zh) * | 2017-04-14 | 2021-04-23 | 四川大学 | 一类哌啶烷氨甲酰基苯酞类化合物、其制备方法和用途 |
| PT3845524T (pt) * | 2018-03-19 | 2022-09-28 | Henan Genuine Biotech Co Ltd | Compostos de ácido benzoico e método de preparação destes e suas aplicações |
| CN108752300B (zh) * | 2018-05-16 | 2022-03-25 | 中国科学院昆明植物研究所 | 苄烯叉苯肽类化合物及其药物组合物和其应用 |
| CN109111415B (zh) * | 2018-10-25 | 2022-08-23 | 安徽中医药大学 | 一类石斛生物碱衍生物、制备方法和医药用途 |
| CN112010837B (zh) * | 2019-05-28 | 2021-12-17 | 四川大学 | 一类吡啶甲胺基苯酞类化合物、其制备方法和用途 |
| CN112010827A (zh) * | 2019-05-28 | 2020-12-01 | 四川大学 | 一类苄胺基苯酞类化合物、其制备方法和用途 |
| CN110452203B (zh) * | 2019-08-29 | 2021-04-13 | 忻州师范学院 | 一种1-氧代-1,3-二氢-3-羟基苯并呋喃-5-甲酸的制备方法 |
| CN112794831B (zh) * | 2021-04-06 | 2021-07-27 | 北京理工大学 | 3-(3′-羟基丁基)异苯并呋喃-1(3h)-酮衍生物及其组合物、制备方法和用途 |
| CN119176789B (zh) * | 2024-09-14 | 2025-11-07 | 中国药科大学 | 一种具有神经保护功能的含脒基新型iNOS抑制剂及其制备方法与应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1183053B (it) * | 1984-02-02 | 1987-10-05 | Farmaceutico Ct Lab | Derivati dell'alfa-amino-gamma-butirrolatton e, metodo per prepararli e composizioni farmaceutiche che li contengono |
| DE3615157A1 (de) * | 1986-05-05 | 1987-11-12 | Schwabe Willmar Gmbh & Co | 5-arylalkyl-4-alkoxy-2(5h)-furanone, zwischenprodukte und verfahren zu ihrer herstellung sowie ihre anwendung als therapeutische wirkstoffe |
| CA1330613C (en) * | 1988-05-06 | 1994-07-05 | Masanori Kawamura | Amino acid derivatives |
| TW270133B (en:Method) * | 1993-09-17 | 1996-02-11 | Ciba Geigy | |
| DE19618854A1 (de) * | 1996-05-10 | 1997-11-13 | Basf Ag | Verfahren zur Herstellung von Phthaliden |
| DE19626659A1 (de) * | 1996-07-03 | 1998-01-08 | Basf Ag | Verfahren zur Herstellung von Phthaliden |
-
2000
- 2000-06-28 CN CNB001193295A patent/CN1182127C/zh not_active Expired - Fee Related
-
2001
- 2001-06-27 CZ CZ2003245A patent/CZ2003245A3/cs unknown
- 2001-06-27 MX MXPA02012569A patent/MXPA02012569A/es unknown
- 2001-06-27 SK SK106-2003A patent/SK1062003A3/sk unknown
- 2001-06-27 CA CA002413752A patent/CA2413752A1/en not_active Abandoned
- 2001-06-27 CN CNB018120687A patent/CN100402515C/zh not_active Expired - Fee Related
- 2001-06-27 KR KR1020027017839A patent/KR20030024710A/ko not_active Ceased
- 2001-06-27 BR BR0112043-3A patent/BR0112043A/pt not_active IP Right Cessation
- 2001-06-27 US US10/312,650 patent/US6689808B2/en not_active Expired - Fee Related
- 2001-06-27 AR ARP010103051A patent/AR030239A1/es not_active Application Discontinuation
- 2001-06-27 NZ NZ523174A patent/NZ523174A/en unknown
- 2001-06-27 PL PL01359373A patent/PL359373A1/xx not_active Application Discontinuation
- 2001-06-27 EP EP01958282A patent/EP1320528A2/en not_active Withdrawn
- 2001-06-27 WO PCT/IB2001/001535 patent/WO2002000638A2/en not_active Ceased
- 2001-06-27 AU AU2001280004A patent/AU2001280004A1/en not_active Abandoned
- 2001-06-27 EA EA200300044A patent/EA200300044A1/ru unknown
- 2001-06-27 JP JP2002505386A patent/JP2004501909A/ja active Pending
- 2001-06-27 HU HU0301567A patent/HUP0301567A3/hu unknown
-
2002
- 2002-12-10 ZA ZA200210004A patent/ZA200210004B/en unknown
- 2002-12-20 NO NO20026154A patent/NO20026154L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR030239A1 (es) | 2003-08-13 |
| CN1182127C (zh) | 2004-12-29 |
| CN100402515C (zh) | 2008-07-16 |
| US20030220393A1 (en) | 2003-11-27 |
| EP1320528A2 (en) | 2003-06-25 |
| JP2004501909A (ja) | 2004-01-22 |
| EA200300044A1 (ru) | 2003-06-26 |
| MXPA02012569A (es) | 2004-05-17 |
| CA2413752A1 (en) | 2002-01-03 |
| NO20026154D0 (no) | 2002-12-20 |
| US6689808B2 (en) | 2004-02-10 |
| ZA200210004B (en) | 2003-12-10 |
| SK1062003A3 (en) | 2003-05-02 |
| PL359373A1 (en) | 2004-08-23 |
| AU2001280004A1 (en) | 2002-01-08 |
| NO20026154L (no) | 2003-02-20 |
| HUP0301567A2 (hu) | 2003-09-29 |
| BR0112043A (pt) | 2003-10-28 |
| WO2002000638A3 (en) | 2002-05-23 |
| CN1330069A (zh) | 2002-01-09 |
| WO2002000638A2 (en) | 2002-01-03 |
| NZ523174A (en) | 2004-06-25 |
| CN1440398A (zh) | 2003-09-03 |
| KR20030024710A (ko) | 2003-03-26 |
| WO2002000638A8 (en) | 2003-08-28 |
| HUP0301567A3 (en) | 2005-08-29 |
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