CZ20021760A3 - Použití anti-CTLA-4 protilátek - Google Patents
Použití anti-CTLA-4 protilátek Download PDFInfo
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- CZ20021760A3 CZ20021760A3 CZ20021760A CZ20021760A CZ20021760A3 CZ 20021760 A3 CZ20021760 A3 CZ 20021760A3 CZ 20021760 A CZ20021760 A CZ 20021760A CZ 20021760 A CZ20021760 A CZ 20021760A CZ 20021760 A3 CZ20021760 A3 CZ 20021760A3
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| US7109003B2 (en) | 1998-12-23 | 2006-09-19 | Abgenix, Inc. | Methods for expressing and recovering human monoclonal antibodies to CTLA-4 |
| EE05627B1 (et) * | 1998-12-23 | 2013-02-15 | Pfizer Inc. | CTLA-4 vastased inimese monoklonaalsed antikehad |
| US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| US7030219B2 (en) | 2000-04-28 | 2006-04-18 | Johns Hopkins University | B7-DC, Dendritic cell co-stimulatory molecules |
| US7357928B2 (en) * | 2002-04-08 | 2008-04-15 | University Of Louisville Research Foundation, Inc. | Method for the diagnosis and prognosis of malignant diseases |
| NZ536420A (en) * | 2002-04-12 | 2008-04-30 | Medarex Inc | Methods of treatment using CTLA-4 antibodies |
| RS52889B (sr) | 2002-09-06 | 2014-02-28 | Amgen Inc | Terapijsko humano anti-il-1r1 monoklonsko antitelo |
| US20040197312A1 (en) * | 2003-04-02 | 2004-10-07 | Marina Moskalenko | Cytokine-expressing cellular vaccine combinations |
| US7465446B2 (en) | 2003-05-30 | 2008-12-16 | Medarex, Inc. | Surrogate therapeutic endpoint for anti-CTLA4-based immunotherapy of disease |
| BRPI0411803A (pt) | 2003-06-27 | 2006-05-23 | Abgenix Inc | anticorpos dirigidos aos mutantes de deleção de receptor de fator de crescimento epidérmico e seus usos |
| BRPI0412245A (pt) * | 2003-07-22 | 2006-09-19 | Schering Ag | anticorpos de rg1 e usos destes |
| US7273610B2 (en) | 2003-08-14 | 2007-09-25 | Dyax Corp. | Endotheliase-2 ligands |
| EP1515505A1 (en) * | 2003-09-12 | 2005-03-16 | Siemens Aktiengesellschaft | Reachability maintainance of a moving network based on temporary name identifiers |
| US20050136055A1 (en) * | 2003-12-22 | 2005-06-23 | Pfizer Inc | CD40 antibody formulation and methods |
| CA2554779A1 (en) * | 2004-02-03 | 2005-08-18 | The Regents Of The University Of Michigan | Compositions and methods for characterizing, regulating, diagnosing, and treating cancer |
| BRPI0509274A (pt) * | 2004-03-26 | 2007-09-04 | Pfizer Prod Inc | usos de anticorpos anti-ctla-4 |
| US7785591B2 (en) | 2004-10-14 | 2010-08-31 | Morphosys Ag | Identification and characterization of function-blocking anti-ED-B-fibronectin antibodies |
| WO2006048749A1 (en) * | 2004-11-04 | 2006-05-11 | Pfizer Products Inc. | Ctla-4 antibody and aromatase inhibitor or combination treatment for breast cancer |
| BRPI0608815B1 (pt) | 2005-03-08 | 2021-10-13 | Pfizer Products Inc | Composições de anticorpo anti-ctla-4 |
| JP2006265244A (ja) * | 2005-03-23 | 2006-10-05 | Pfizer Prod Inc | Ｃｔｌａ４抗体とホルモン治療を用いた前立腺癌の治療 |
| NZ561138A (en) * | 2005-03-23 | 2009-06-26 | Pfizer Prod Inc | Anti-CTLA4 antibody and indolinone combination therapy for treatment of cancer |
| PL2161336T5 (pl) * | 2005-05-09 | 2017-10-31 | Ono Pharmaceutical Co | Ludzkie przeciwciała monoklonalne przeciwko białku Programmed Death 1 (PD-1) oraz sposoby leczenia raka z zastosowaniem samych przeciwciał anty-PD-1 lub w połączeniu z innymi środkami immunoterapeutycznymi |
| DK1907000T4 (da) | 2005-06-08 | 2020-03-30 | The President And Fellows Of Harvard College | Fremgangsmåder og sammensætninger til behandling af persisterende HIV-infektioner ved hæmning af reaktionsvejen for programmeret celledød 1 (PD-1). |
| AU2006269555A1 (en) * | 2005-07-07 | 2007-01-18 | Coley Pharmaceutical Group, Inc. | Anti-CTLA-4 antibody and CpG-motif-containing synthetic oligodeoxynucleotide combination therapy for cancer treatment |
| WO2007067959A2 (en) | 2005-12-07 | 2007-06-14 | Medarex, Inc. | Ctla-4 antibody dosage escalation regimens |
| CA2647282A1 (en) * | 2006-04-05 | 2007-10-11 | Pfizer Products Inc. | Ctla4 antibody combination therapy |
| EP2176292A1 (en) * | 2007-07-27 | 2010-04-21 | Pfizer Limited | Antibody purification process by precipitation |
| KR101666228B1 (ko) | 2007-09-28 | 2016-10-13 | 인트렉손 코포레이션 | 생물치료학적 분자를 발현시키기 위한 치료학적 유전자-스위치 작제물 및 생물반응기, 및 이의 용도 |
| RU2373836C2 (ru) * | 2007-12-18 | 2009-11-27 | Федеральное государственное учреждение "Научно-исследовательский институт онкологии имени Н.Н. Петрова Федерального агентства по высокотехнологичной медицинской помощи" | Способ оптимизации лечебной тактики при лимфоме ходжкина у детей и подростков |
| AU2009204194A1 (en) * | 2008-01-08 | 2009-07-16 | Bristol-Myers Squibb Company | Combination of anti-CTLA4 antibody with tubulin modulating agents for the treatment of proliferative diseases |
| WO2010014784A2 (en) * | 2008-08-01 | 2010-02-04 | Bristol-Myers Squibb Company | Combination of anti-ctla4 antibody with diverse therapeutic regimens for the synergistic treatment of proliferative diseases |
| CN102822200A (zh) * | 2009-07-20 | 2012-12-12 | 百时美施贵宝公司 | 对增殖性疾病进行协同性治疗的抗ctla-4抗体与各种治疗方案的组合 |
| RU2421217C2 (ru) * | 2009-09-03 | 2011-06-20 | Учреждение Российской академии медицинских наук Гематологический научный центр РАМН (ГНЦ РАМН) | Способ дифференцированного лечения диффузных в-крупноклеточных лимфосарком лимфоидных органов взрослых |
| WO2012145183A2 (en) | 2011-04-19 | 2012-10-26 | Pfizer Inc. | Combinations of anti-4-1bb antibodies and adcc-inducing antibodies for the treatment of cancer |
| ES2690557T3 (es) | 2011-06-02 | 2018-11-21 | University Of Louisville Research Foundation, Inc. | Nanopartículas conjugadas a un agente antinucleolina |
| PT2825558T (pt) | 2012-03-13 | 2019-07-11 | Hoffmann La Roche | Terapêutica combinada para o tratamento do cancro do ovário |
| KR101728483B1 (ko) | 2012-05-04 | 2017-04-19 | 화이자 인코포레이티드 | 전립선 관련된 항원 및 백신 기재 면역치료 요법 |
| AR092219A1 (es) * | 2012-08-23 | 2015-04-08 | Seattle Genetics Inc | Conjugados anticuerpo-farmaco (adc) que se unen a proteinas 158p1d7 |
| SMT201900242T1 (it) * | 2012-12-03 | 2019-05-10 | Bristol Myers Squibb Co | Incremento dell'attivita' anti-cancro di proteine di fuzione a fc immunomodulatrici |
| DK3030575T3 (en) | 2013-08-08 | 2018-10-22 | Cytune Pharma | IL-15 AND IL-15R-ALFA-SUSHI DOMAIN-BASED MODULOKINES |
| ES2760249T3 (es) | 2013-08-08 | 2020-05-13 | Cytune Pharma | Composición farmacéutica combinada |
| EA037890B1 (ru) * | 2013-10-18 | 2021-06-01 | Ридженерон Фармасьютикалз, Инк. | Способы и композиции, включающие комбинацию антагониста vegf и анти-ctla-4 антитела |
| JP6712952B2 (ja) * | 2014-03-31 | 2020-06-24 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 固形腫瘍悪性病変を処置するための、抗ｃｔｌａ−４抗体および／または抗ｐｄ−１抗体と組み合わせた、細菌、細菌産物、および他の免疫調節性実体の使用 |
| SG10201809450VA (en) * | 2014-05-01 | 2018-11-29 | Anaeropharma Science Inc | Heterogeneous polypeptide expression cassette |
| EA201692458A1 (ru) | 2014-05-28 | 2017-06-30 | Агенус Инк. | Анти-gitr антитела и способы их применения |
| CN105296433B (zh) | 2014-08-01 | 2018-02-09 | 中山康方生物医药有限公司 | 一种ctla4抗体、其药物组合物及其用途 |
| WO2016033555A1 (en) | 2014-08-28 | 2016-03-03 | Halozyme, Inc. | Combination therapy with a hyaluronan-degrading enzyme and an immune checkpoint inhibitor |
| US20170248603A1 (en) | 2014-10-06 | 2017-08-31 | Dana-Farber Cancer Institute, Inc. | Angiopoiten-2 biomarkers predictive of anti-immune checkpoint response |
| CA2964317C (en) | 2014-10-14 | 2021-10-05 | Halozyme, Inc. | Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same |
| CA2972757A1 (en) | 2014-12-31 | 2016-07-07 | Arthur M. Krieg | Combination tumor immunotherapy |
| WO2016130986A1 (en) * | 2015-02-13 | 2016-08-18 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind ctla4 |
| WO2016179394A1 (en) | 2015-05-05 | 2016-11-10 | Malik Mohammad Tariq | Anti-nucleolin agent-conjugated nanoparticles as radio-sensitizers and mri and/or x-ray contrast agents |
| EP3303394B1 (en) | 2015-05-29 | 2020-04-08 | Agenus Inc. | Anti-ctla-4 antibodies and methods of use thereof |
| CA2993177A1 (en) * | 2015-07-22 | 2017-01-26 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind lag3 |
| US11419934B2 (en) * | 2015-08-18 | 2022-08-23 | Oncotelic Therapeutics, Inc. | Use of VDAS to enhance immunomodulating therapies against tumors |
| AU2016364889B2 (en) | 2015-12-02 | 2024-01-04 | Agenus Inc. | Antibodies and methods of use thereof |
| WO2017165742A1 (en) | 2016-03-24 | 2017-09-28 | Millennium Pharmaceuticals, Inc. | Methods of treating gastrointestinal immune-related adverse events in anti-ctla4 anti-pd-1 combination treatments |
| US11760803B2 (en) | 2016-03-24 | 2023-09-19 | Takeda Pharmaceutical Company Limited | Methods of treating gastrointestinal immune-related adverse events in immune oncology treatments |
| US20190046638A1 (en) | 2016-04-01 | 2019-02-14 | Checkmate Pharmaceuticals, Inc. | Fc RECEPTOR-MEDIATED DRUG DELIVERY |
| EA039322B1 (ru) * | 2016-04-15 | 2022-01-13 | Эйдженус Инк. | Антитела против ctla-4 и способы их применения |
| WO2018035710A1 (en) | 2016-08-23 | 2018-03-01 | Akeso Biopharma, Inc. | Anti-ctla4 antibodies |
| JP7198666B2 (ja) * | 2016-08-26 | 2023-01-04 | 哲治 奥野 | 微小血管血流低減剤およびその利用 |
| EP3551225A1 (en) | 2016-12-07 | 2019-10-16 | Agenus Inc. | Antibodies and methods of use thereof |
| KR102504605B1 (ko) | 2016-12-07 | 2023-03-02 | 아게누스 인코포레이티드 | 항-ctla-4 항체 및 이의 사용 방법 |
| JP7490923B2 (ja) | 2018-02-02 | 2024-05-28 | オンコシーフォー、インク． | 免疫療法効果が向上し副作用が軽減した変異抗ｃｔｌａ－４抗体 |
| US12246031B2 (en) | 2018-02-13 | 2025-03-11 | Checkmate Pharmaceuticals, Inc. | Compositions and methods for tumor immunotherapy |
| CN112218892B (zh) * | 2018-03-19 | 2023-04-25 | 上海药明生物技术有限公司 | 新型抗ctla-4抗体多肽 |
| EP3775218A1 (en) | 2018-04-09 | 2021-02-17 | Checkmate Pharmaceuticals | Packaging oligonucleotides into virus-like particles |
| AU2019301699C1 (en) | 2018-07-11 | 2024-10-10 | Actym Therapeutics, Inc. | Engineered immunostimulatory bacterial strains and uses thereof |
| CN110092826B (zh) * | 2019-02-28 | 2022-04-15 | 天津大学 | CTLA-4类似物CFN13及CFN13-Fc基因和蛋白 |
| WO2021238932A1 (zh) * | 2020-05-26 | 2021-12-02 | 百奥泰生物制药股份有限公司 | 多特异性抗体及其应用 |
| US11858925B2 (en) | 2020-07-10 | 2024-01-02 | The Regents Of The University Of Michigan | GAS41 inhibitors and methods of use thereof |
| WO2022086852A2 (en) | 2020-10-19 | 2022-04-28 | Dana-Farber Cancer Institute, Inc. | Germline biomarkers of clinical response and benefit to immune checkpoint inhibitor therapy |
| JP2024517131A (ja) | 2021-04-20 | 2024-04-19 | アンスティテュ・クリー | 免疫療法における使用のための組成物及び方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5994362A (en) * | 1992-03-11 | 1999-11-30 | Merck & Co., Inc. | Method of treatment for prostatic cancer |
| US5811097A (en) * | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| ZA98533B (en) * | 1997-01-31 | 1999-07-22 | Bristol Myers Squibb Co | Soluble CTLA4 mutant molecules and uses thereof. |
| EE05627B1 (et) * | 1998-12-23 | 2013-02-15 | Pfizer Inc. | CTLA-4 vastased inimese monoklonaalsed antikehad |
| DE69942037D1 (de) * | 1998-12-23 | 2010-04-01 | Amgen Fremont Inc | Humane monoklonale antikörper gegen ctla-4 |
| US7605238B2 (en) * | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| NZ517202A (en) * | 1999-08-24 | 2004-05-28 | Medarex Inc | Human CTLA-4 antibodies and their uses |
| US7183376B2 (en) * | 2000-06-23 | 2007-02-27 | Maxygen, Inc. | Variant B7 co-stimulatory molecules |
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- 2002-05-17 CA CA002382443A patent/CA2382443A1/en not_active Abandoned
- 2002-05-21 ZA ZA200204020A patent/ZA200204020B/xx unknown
- 2002-05-21 AU AU42421/02A patent/AU4242102A/en not_active Abandoned
- 2002-05-21 CZ CZ20021760A patent/CZ20021760A3/cs unknown
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- 2002-05-22 MY MYPI20021892A patent/MY136095A/en unknown
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| MY136095A (en) | 2008-08-29 |
| SK7242002A3 (en) | 2003-07-01 |
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| KR20020090873A (ko) | 2002-12-05 |
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