CY2454B1 - Process for r-epimer enrichment of 16,17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11-beta-, 16.alpha.,17.alpha.-triol-3,20-dione derivatives. - Google Patents

Process for r-epimer enrichment of 16,17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11-beta-, 16.alpha.,17.alpha.-triol-3,20-dione derivatives.

Info

Publication number
CY2454B1
CY2454B1 CY0400039A CY0400039A CY2454B1 CY 2454 B1 CY2454 B1 CY 2454B1 CY 0400039 A CY0400039 A CY 0400039A CY 0400039 A CY0400039 A CY 0400039A CY 2454 B1 CY2454 B1 CY 2454B1
Authority
CY
Cyprus
Prior art keywords
alpha
derivatives
dien
triol
acyloxy
Prior art date
Application number
CY0400039A
Other languages
English (en)
Inventor
Hermann Amschler
Dieter Flockerzi
Beate Gutterer
Original Assignee
Byk Gulden Lomberg Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7804358&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2454(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Byk Gulden Lomberg Chem Fab filed Critical Byk Gulden Lomberg Chem Fab
Publication of CY2454B1 publication Critical patent/CY2454B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
CY0400039A 1996-09-03 2004-05-18 Process for r-epimer enrichment of 16,17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11-beta-, 16.alpha.,17.alpha.-triol-3,20-dione derivatives. CY2454B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19635498A DE19635498A1 (de) 1996-09-03 1996-09-03 Verfahren zur Epimerenanreicherung

Publications (1)

Publication Number Publication Date
CY2454B1 true CY2454B1 (en) 2005-06-03

Family

ID=7804358

Family Applications (2)

Application Number Title Priority Date Filing Date
CY0400039A CY2454B1 (en) 1996-09-03 2004-05-18 Process for r-epimer enrichment of 16,17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11-beta-, 16.alpha.,17.alpha.-triol-3,20-dione derivatives.
CY2009010C CY2009010I1 (el) 1996-09-03 2009-07-24 Μεθοδος για εμπλουτισμο r-επιμερους 16,17-ακεταλης παραγωγων των 21-ακυλοξυ πρεγνα-1,4-διεν-11.βητα., 16.αλφα., 17.αλφα.-τριολ-3,20-διονης

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY2009010C CY2009010I1 (el) 1996-09-03 2009-07-24 Μεθοδος για εμπλουτισμο r-επιμερους 16,17-ακεταλης παραγωγων των 21-ακυλοξυ πρεγνα-1,4-διεν-11.βητα., 16.αλφα., 17.αλφα.-τριολ-3,20-διονης

Country Status (18)

Country Link
US (1) US6787533B1 (da)
EP (1) EP0929566B1 (da)
JP (1) JP3807509B2 (da)
AT (1) ATE229539T1 (da)
AU (1) AU736840B2 (da)
CA (1) CA2264863C (da)
CL (1) CL2004001297A1 (da)
CY (2) CY2454B1 (da)
CZ (1) CZ298789B6 (da)
DE (2) DE19635498A1 (da)
DK (1) DK0929566T3 (da)
EE (1) EE03927B1 (da)
ES (1) ES2188984T3 (da)
HU (1) HU228766B1 (da)
IL (1) IL128535A (da)
PL (1) PL186063B1 (da)
PT (1) PT929566E (da)
WO (1) WO1998009982A1 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6264923B1 (en) * 1998-05-13 2001-07-24 3M Innovative Properties Company Medicinal aerosol formulation of ciclesonide and related compounds
EA006231B1 (ru) * 2000-11-10 2005-10-27 Алтана Фарма Аг Способ получения 16,17-[(циклогексилметилен)бис(окси)]-11,21-дигидроксипрегна-1,4-диен-3,20-диона или его 21-изобутирата транскетализацией
DE10055820C1 (de) * 2000-11-10 2002-07-25 Byk Gulden Lomberg Chem Fab Verfahren zur Herstellung eines Glucocorticoids
WO2004033478A2 (en) 2002-10-08 2004-04-22 Sepracor Inc. Fatty acid modified forms of glucocorticoids and their use as anti-inflammatory
PT1572217E (pt) 2002-12-12 2008-11-28 Nycomed Gmbh Medicamento combinado de r,r-formoterol e ciclesonida
MY143936A (en) * 2003-03-27 2011-07-29 Nycomed Gmbh Process for preparing crystalline ciclesonide with defined particle size
US8371292B2 (en) 2003-09-16 2013-02-12 Nycomed Gmbh Use of ciclesonide for the treatment of respiratory diseases
PE20050941A1 (es) 2003-12-16 2005-11-08 Nycomed Gmbh Suspensiones acuosas de ciclesonida para nebulizacion
CN100345864C (zh) * 2004-10-29 2007-10-31 天津药业研究院有限公司 一种治疗呼吸道疾病的甾体药物的制备方法及其中间体
US20070135398A1 (en) * 2005-11-02 2007-06-14 Pierluigi Rossetto Process for the preparation of ciclesonide
EP1904514A2 (en) * 2006-02-08 2008-04-02 Sicor, Inc. Crystalline forms of ciclesonide
WO2008015696A2 (en) * 2006-05-23 2008-02-07 Cadila Healthcare Limited Process for preparing ciclesonide
WO2008062450A2 (en) * 2006-09-18 2008-05-29 Cadila Healthcare Limited Crystalline polymorphs of ciclesonide
CA2663737A1 (en) 2006-09-19 2008-03-27 Cipla Limited Processes for the preparation of ciclesonide and its crystal form
IT1397499B1 (it) * 2009-01-09 2013-01-16 Farmabios Spa Processo per la preparazione di ciclesonide
EP2262823B1 (en) * 2008-03-13 2013-01-23 Farmabios S.p.A. Process for the preparation of pregnane derivatives
US20100120737A1 (en) * 2008-11-10 2010-05-13 Martin Feth Amorphous ciclesonide
US9109005B2 (en) 2012-02-23 2015-08-18 Boehringer Ingelheim International Gmbh Method for manufacturing of ciclesonide
PE20190622A1 (es) 2016-06-02 2019-04-26 Abbvie Inc Agonista del receptor de glucocorticoides e inmunoconjugados del mismo
MA49796A (fr) 2017-12-01 2020-06-03 Abbvie Inc Agoniste du récepteur des glucocorticoïdes et immunoconjugués de celui-ci
CN109293730A (zh) * 2018-10-23 2019-02-01 山东泰华生物科技股份有限公司 一种环索奈德的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE378110B (da) * 1972-05-19 1975-08-18 Bofors Ab
US3996359A (en) * 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
US3992534A (en) * 1972-05-19 1976-11-16 Ab Bofors Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods
US4036831A (en) * 1975-10-28 1977-07-19 Steroid Development Company Establishment Trimethyl siloxane steroid intermediates
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8604059D0 (sv) * 1986-09-25 1986-09-25 Astra Pharma Prod A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
GR1001529B (el) * 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
PL164294B1 (pl) * 1990-12-20 1994-07-29 Inst Farmaceutyczny Sposób otrzymywania diastereoizomeru /22R/-16a , 17a-butylidenodioksy-11 ß 21-dihydroksy-1,4-pregnadien-3,20-dionu PL
US5482935A (en) 1993-01-05 1996-01-09 American Home Product Corporation Anti-atherosclerotic use of 17 alpha-dihydroequilin
ATE172739T1 (de) * 1993-04-02 1998-11-15 Byk Gulden Lomberg Chem Fab Neue prednisolonderivate
DK0749438T3 (da) 1994-03-09 2001-04-02 Byk Gulden Lomberg Chem Fab Hidtil ukendte silylforbindelser og deres anvendelse

Also Published As

Publication number Publication date
CZ298789B6 (cs) 2008-01-30
HUP9904127A3 (en) 2001-02-28
PL186063B1 (pl) 2003-09-30
PT929566E (pt) 2003-04-30
JP3807509B2 (ja) 2006-08-09
EP0929566B1 (en) 2002-12-11
ATE229539T1 (de) 2002-12-15
CY2009010I2 (el) 2010-07-28
CA2264863A1 (en) 1998-03-12
CZ72799A3 (cs) 1999-09-15
DE69717836D1 (de) 2003-01-23
EP0929566A1 (en) 1999-07-21
DK0929566T3 (da) 2003-04-07
HU228766B1 (hu) 2013-05-28
US6787533B1 (en) 2004-09-07
CA2264863C (en) 2007-07-31
EE9900079A (et) 1999-10-15
IL128535A (en) 2003-07-06
DE19635498A1 (de) 1998-03-26
AU736840B2 (en) 2001-08-02
JP2000517330A (ja) 2000-12-26
ES2188984T3 (es) 2003-07-01
EE03927B1 (et) 2002-12-16
AU4456797A (en) 1998-03-26
CL2004001297A1 (es) 2005-04-15
CY2009010I1 (el) 2010-07-28
IL128535A0 (en) 2000-01-31
PL331699A1 (en) 1999-08-02
DE69717836T2 (de) 2003-09-18
WO1998009982A1 (en) 1998-03-12
HUP9904127A2 (hu) 2000-04-28

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