CY2295B1 - Phosphonooxymethyl or methylthiomethyl ethers of taxane derivatives as antitumor agents - Google Patents
Phosphonooxymethyl or methylthiomethyl ethers of taxane derivatives as antitumor agentsInfo
- Publication number
- CY2295B1 CY2295B1 CY0200054A CY0200054A CY2295B1 CY 2295 B1 CY2295 B1 CY 2295B1 CY 0200054 A CY0200054 A CY 0200054A CY 0200054 A CY0200054 A CY 0200054A CY 2295 B1 CY2295 B1 CY 2295B1
- Authority
- CY
- Cyprus
- Prior art keywords
- phosphonooxymethyl
- antitumor agents
- taxane derivatives
- methylthiomethyl ethers
- methylthiomethyl
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title abstract 2
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 title abstract 2
- -1 Phosphonooxymethyl Chemical group 0.000 title 1
- CPZBTYRIGVOOMI-UHFFFAOYSA-N methylsulfanyl(methylsulfanylmethoxy)methane Chemical class CSCOCSC CPZBTYRIGVOOMI-UHFFFAOYSA-N 0.000 title 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6551—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring
- C07F9/65512—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L21/00—Processes or apparatus adapted for the manufacture or treatment of semiconductor or solid state devices or of parts thereof
- H01L21/02—Manufacture or treatment of semiconductor devices or of parts thereof
- H01L21/04—Manufacture or treatment of semiconductor devices or of parts thereof the devices having potential barriers, e.g. a PN junction, depletion layer or carrier concentration layer
- H01L21/48—Manufacture or treatment of parts, e.g. containers, prior to assembly of the devices, using processes not provided for in a single one of the subgroups H01L21/06 - H01L21/326
- H01L21/4814—Conductive parts
- H01L21/4821—Flat leads, e.g. lead frames with or without insulating supports
- H01L21/4839—Assembly of a flat lead with an insulating support, e.g. for TAB
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Manufacturing & Machinery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Computer Hardware Design (AREA)
- Epidemiology (AREA)
- Power Engineering (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10801593A | 1993-08-17 | 1993-08-17 | |
| US15484093A | 1993-11-24 | 1993-11-24 | |
| US24511994A | 1994-05-17 | 1994-05-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY2295B1 true CY2295B1 (en) | 2003-07-04 |
Family
ID=27380403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY0200054A CY2295B1 (en) | 1993-08-17 | 2002-09-05 | Phosphonooxymethyl or methylthiomethyl ethers of taxane derivatives as antitumor agents |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0639577B1 (xx) |
| JP (1) | JP3062986B2 (xx) |
| KR (1) | KR100249306B1 (xx) |
| CN (2) | CN1051315C (xx) |
| AT (1) | ATE217629T1 (xx) |
| AU (2) | AU694941B2 (xx) |
| CA (1) | CA2129288C (xx) |
| CY (1) | CY2295B1 (xx) |
| CZ (1) | CZ194794A3 (xx) |
| DE (1) | DE69430611T2 (xx) |
| DK (1) | DK0639577T3 (xx) |
| ES (1) | ES2176212T3 (xx) |
| FI (1) | FI113271B (xx) |
| HU (1) | HUT67742A (xx) |
| IL (2) | IL110660A0 (xx) |
| NO (1) | NO309093B1 (xx) |
| NZ (1) | NZ264240A (xx) |
| PL (1) | PL179636B1 (xx) |
| PT (1) | PT639577E (xx) |
| RU (1) | RU2128661C1 (xx) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| FR2698871B1 (fr) | 1992-12-09 | 1995-02-24 | Rhone Poulenc Rorer Sa | Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| CA2111527C (en) * | 1992-12-24 | 2000-07-18 | Jerzy Golik | Phosphonooxymethyl ethers of taxane derivatives |
| US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6593482B2 (en) | 1993-02-01 | 2003-07-15 | Aventis Pharma S.A. | Methods for preparing new taxoids and pharmaceutical compositions containing them |
| FR2732340B1 (fr) * | 1995-03-27 | 1997-04-30 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US6040466A (en) * | 1996-03-25 | 2000-03-21 | Rhone Poulenc Rorer Sa | Taxoids, their preparation and pharmaceutical compositions containing them |
| US6232477B1 (en) | 1996-03-25 | 2001-05-15 | Aventis Pharma S.A. | Methods of preparing new taxoids and pharmaceutical compositions containing them |
| US5677470A (en) * | 1994-06-28 | 1997-10-14 | Tanabe Seiyaku Co., Ltd. | Baccatin derivatives and processes for preparing the same |
| US6458976B1 (en) | 1994-10-28 | 2002-10-01 | The Research Foundation Of State University Of New York | Taxoid anti-tumor agents, pharmaceutical compositions, and treatment methods |
| US6500858B2 (en) | 1994-10-28 | 2002-12-31 | The Research Foundation Of The State University Of New York | Taxoid anti-tumor agents and pharmaceutical compositions thereof |
| AU4133096A (en) * | 1994-10-28 | 1996-05-23 | Research Foundation Of The State University Of New York, The | Taxoid derivatives, their preparation and their use as antitumor agents |
| CA2162759A1 (en) * | 1994-11-17 | 1996-05-18 | Kenji Tsujihara | Baccatin derivatives and processes for preparing the same |
| US6372780B2 (en) | 1995-03-27 | 2002-04-16 | Aventis Pharma S.A. | Methods of treating cell lines expressing multidrug resistance P-glycoprotein |
| MA23823A1 (fr) * | 1995-03-27 | 1996-10-01 | Aventis Pharma Sa | Nouveaux taxoides, leur preparation et les compositions qui les contiennent |
| US5847170A (en) * | 1995-03-27 | 1998-12-08 | Rhone-Poulenc Rorer, S.A. | Taxoids, their preparation and pharmaceutical compositions containing them |
| TW354293B (en) * | 1995-06-06 | 1999-03-11 | Bristol Myers Squibb Co | Prodrugs of paclitaxel derivatives |
| US6245805B1 (en) * | 1995-10-26 | 2001-06-12 | Baker Norton Pharmaceuticals, Inc. | Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
| EP0822815A4 (en) * | 1996-01-31 | 1998-04-01 | Bristol Myers Squibb Co | PROCESS FOR MAKING ORAL-LIKE TAXANES ACTIVE FROM THE PHARMACEUTICAL VIEW |
| JP2001521503A (ja) | 1997-03-31 | 2001-11-06 | ネオルックス コーポレイション | 血管平滑筋細胞の治療的阻害物質 |
| US6156789A (en) * | 1998-03-17 | 2000-12-05 | Rhone-Poulenc Rorer S.A. | Method for treating abnormal cell proliferation in the brain |
| US6204257B1 (en) * | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
| EP1020188A1 (en) * | 1999-01-13 | 2000-07-19 | Aventis Pharma S.A. | New use of taxoid derivatives |
| US6362172B2 (en) * | 2000-01-20 | 2002-03-26 | Bristol-Myers Squibb Company | Water soluble prodrugs of azole compounds |
| PL350315A1 (en) | 2000-02-02 | 2002-12-02 | Univ Florida State Res Found | C7 carbonate substituted taxanes as antitumor agents |
| US6649632B2 (en) | 2000-02-02 | 2003-11-18 | Fsu Research Foundation, Inc. | C10 ester substituted taxanes |
| CA2368151A1 (en) | 2000-02-02 | 2001-08-09 | Florida State University Research Foundation, Inc. | C10 carbonate substituted taxanes as antitumor agents |
| DE60131537T2 (de) | 2000-06-22 | 2008-10-23 | Nitromed, Inc., Lexington | Nitrosierte und nitrosylierte taxane, zubereitungen und methoden der verwendung |
| US6448401B1 (en) | 2000-11-20 | 2002-09-10 | Bristol-Myers Squibb Company | Process for water soluble azole compounds |
| EP1497275A4 (en) * | 2002-04-05 | 2006-04-12 | Natural Pharmaceuticals Inc | SELECTIVE ACYLATION OF SECONDARY HYDROXYL GROUPS |
| EP1534674A4 (en) | 2002-08-02 | 2007-11-28 | Immunogen Inc | CYTOTOXIC AGENTS CONTAINING NEW, EFFECTIVE TAXANES AND THEIR THERAPEUTIC USE |
| US7390898B2 (en) * | 2002-08-02 | 2008-06-24 | Immunogen Inc. | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
| US8703982B2 (en) | 2003-03-17 | 2014-04-22 | Phyton Holdings Llc | Purification of taxanes |
| HN2005000054A (es) | 2004-02-13 | 2009-02-18 | Florida State University Foundation Inc | Taxanos sustituidos con esteres de ciclopentilo en c10 |
| JP2011517455A (ja) | 2008-03-31 | 2011-06-09 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | Ｃ（１０）エチルエステルおよびｃ（１０）シクロプロピルエステル置換タキサン |
| EP2896632B1 (en) | 2009-11-13 | 2017-10-25 | Daiichi Sankyo Europe GmbH | Material and methods for treating or preventing HER-3 associated diseases |
| CA2815154A1 (en) | 2010-08-06 | 2012-02-09 | U3 Pharma Gmbh | Use of her3 binding agents in prostate treatment |
| BR112014004313A8 (pt) | 2011-08-25 | 2023-02-07 | Bonac Corp | Composto glicosídeo, métodos de produção de um tioéter, de éter e de composto glicosídeo, e, éter. |
| CN104650012A (zh) | 2013-11-22 | 2015-05-27 | 天士力控股集团有限公司 | 一种紫杉烷类化合物 |
| WO2016159374A1 (ja) * | 2015-04-02 | 2016-10-06 | 株式会社ボナック | 配糖体化合物の製造方法 |
| CN110862410A (zh) * | 2018-08-27 | 2020-03-06 | 深圳福山生物科技有限公司 | 三氟甲基硒化合物及其用途 |
| US11976035B2 (en) | 2019-06-12 | 2024-05-07 | Nouryon Chemicals International B.V. | Process for the production of diacyl peroxides |
| WO2020249691A1 (en) | 2019-06-12 | 2020-12-17 | Nouryon Chemicals International B.V. | Process for the production of diacyl peroxides |
| ES2963356T3 (es) * | 2019-06-12 | 2024-03-26 | Nouryon Chemicals Int Bv | Método para aislar ácido carboxílico a partir de una corriente lateral acuosa |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2678930B1 (fr) * | 1991-07-10 | 1995-01-13 | Rhone Poulenc Rorer Sa | Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii. |
| FR2679230B1 (fr) * | 1991-07-16 | 1993-11-19 | Rhone Poulenc Rorer Sa | Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent. |
| US5229526A (en) * | 1991-09-23 | 1993-07-20 | Florida State University | Metal alkoxides |
| US5272171A (en) * | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
| CA2111527C (en) * | 1992-12-24 | 2000-07-18 | Jerzy Golik | Phosphonooxymethyl ethers of taxane derivatives |
-
1994
- 1994-08-02 CA CA002129288A patent/CA2129288C/en not_active Expired - Fee Related
- 1994-08-11 CZ CZ941947A patent/CZ194794A3/cs unknown
- 1994-08-12 JP JP6250219A patent/JP3062986B2/ja not_active Expired - Fee Related
- 1994-08-12 HU HU9402342A patent/HUT67742A/hu active IP Right Revival
- 1994-08-15 IL IL11066094A patent/IL110660A0/xx unknown
- 1994-08-15 NZ NZ264240A patent/NZ264240A/en unknown
- 1994-08-15 NO NO943002A patent/NO309093B1/no unknown
- 1994-08-15 FI FI943749A patent/FI113271B/fi not_active IP Right Cessation
- 1994-08-15 RU RU94029662A patent/RU2128661C1/ru not_active IP Right Cessation
- 1994-08-15 CN CN94109468A patent/CN1051315C/zh not_active Expired - Fee Related
- 1994-08-15 AU AU70267/94A patent/AU694941B2/en not_active Ceased
- 1994-08-16 KR KR1019940020177A patent/KR100249306B1/ko not_active IP Right Cessation
- 1994-08-16 AT AT94112803T patent/ATE217629T1/de not_active IP Right Cessation
- 1994-08-16 ES ES94112803T patent/ES2176212T3/es not_active Expired - Lifetime
- 1994-08-16 DE DE69430611T patent/DE69430611T2/de not_active Expired - Fee Related
- 1994-08-16 EP EP94112803A patent/EP0639577B1/en not_active Expired - Lifetime
- 1994-08-16 DK DK94112803T patent/DK0639577T3/da active
- 1994-08-16 PL PL94304649A patent/PL179636B1/pl not_active IP Right Cessation
- 1994-08-16 PT PT94112803T patent/PT639577E/pt unknown
-
1998
- 1998-11-06 AU AU91356/98A patent/AU706511B2/en not_active Ceased
-
1999
- 1999-02-08 IL IL12842599A patent/IL128425A0/xx unknown
- 1999-04-29 CN CN99105343A patent/CN1100771C/zh not_active Expired - Fee Related
-
2002
- 2002-09-05 CY CY0200054A patent/CY2295B1/xx unknown
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