CY1125275T1 - Συνθεσεις ινσουλινης ταχειας δρασης - Google Patents
Συνθεσεις ινσουλινης ταχειας δρασηςInfo
- Publication number
- CY1125275T1 CY1125275T1 CY20221100329T CY221100329T CY1125275T1 CY 1125275 T1 CY1125275 T1 CY 1125275T1 CY 20221100329 T CY20221100329 T CY 20221100329T CY 221100329 T CY221100329 T CY 221100329T CY 1125275 T1 CY1125275 T1 CY 1125275T1
- Authority
- CY
- Cyprus
- Prior art keywords
- fast
- acting insulin
- insulin compounds
- chloride
- insulin analog
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 3
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 239000004026 insulin derivative Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
- 101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical group C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
- 229910001629 magnesium chloride Inorganic materials 0.000 abstract 1
- 230000003285 pharmacodynamic effect Effects 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 239000011701 zinc Substances 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462092407P | 2014-12-16 | 2014-12-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1125275T1 true CY1125275T1 (el) | 2024-12-13 |
Family
ID=55066806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20221100329T CY1125275T1 (el) | 2014-12-16 | 2022-05-11 | Συνθεσεις ινσουλινης ταχειας δρασης |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US9993555B2 (enExample) |
| EP (2) | EP3233108B1 (enExample) |
| JP (5) | JP6328855B2 (enExample) |
| AR (1) | AR102869A1 (enExample) |
| CY (1) | CY1125275T1 (enExample) |
| DK (1) | DK3233108T3 (enExample) |
| ES (1) | ES2911207T3 (enExample) |
| HR (1) | HRP20220692T1 (enExample) |
| HU (1) | HUE058764T2 (enExample) |
| LT (1) | LT3233108T (enExample) |
| MA (1) | MA41188B1 (enExample) |
| MD (1) | MD3233108T2 (enExample) |
| PL (1) | PL3233108T3 (enExample) |
| PT (1) | PT3233108T (enExample) |
| RS (1) | RS63174B1 (enExample) |
| SI (1) | SI3233108T1 (enExample) |
| TW (1) | TW201630622A (enExample) |
| WO (1) | WO2016100042A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2010009850A (es) | 2008-03-18 | 2010-09-30 | Novo Nordisk As | Analogos de insulina acilados y etabilizados contra proteasas. |
| EP2919804B1 (fr) | 2012-11-13 | 2018-01-31 | Adocia | Formulation à action rapide d'insuline comprenant un composé anionique substitué |
| AR102869A1 (es) | 2014-12-16 | 2017-03-29 | Lilly Co Eli | Composiciones de insulina de rápida acción |
| JO3749B1 (ar) | 2015-08-27 | 2021-01-31 | Lilly Co Eli | تركيبات إنسولين سريعة المفعول |
| GB201607918D0 (en) | 2016-05-06 | 2016-06-22 | Arecor Ltd | Novel formulations |
| DK3518892T5 (da) * | 2016-09-29 | 2024-09-02 | Arecor Ltd | Farmaceutisk formulering, der indeholder en insulinforbindelse |
| AU2017378102B2 (en) | 2016-12-16 | 2022-10-13 | Novo Nordisk A/S | Insulin containing pharmaceutical compositions |
| US20180236080A1 (en) * | 2017-02-22 | 2018-08-23 | Adocia | Fast-acting insulin composition comprising a citric acid salt |
| CN110582264B (zh) * | 2017-03-26 | 2022-11-11 | V·R·斯塔福德 | 眼睑皮肤状况的处理方法 |
| WO2018222787A1 (en) * | 2017-06-01 | 2018-12-06 | Eli Lilly And Company | Rapid-acting insulin compositions |
| IL277731B2 (en) * | 2018-04-04 | 2024-03-01 | Arecor Ltd | Medical infusion pump system for the delivery of an insulin compound |
| IL277721B2 (en) | 2018-04-04 | 2024-03-01 | Arecor Ltd | Medical infusion pump system for the delivery of an insulin compound |
| CN112040928A (zh) * | 2018-04-04 | 2020-12-04 | 艾瑞克有限公司 | 用于递送胰岛素化合物的医用输注泵系统 |
| FR3083985A1 (fr) | 2018-07-23 | 2020-01-24 | Adocia | Dispositif pour injecter une solution d'insuline(s) |
| WO2019243627A1 (fr) | 2018-06-23 | 2019-12-26 | Adocia | Dispositif pour injecter une solution d'insuline(s) |
| EP3937920B1 (en) * | 2019-03-14 | 2025-07-09 | The Regents of the University of California | Compositions comprising beta-hydroxybutyrate and citrate for supporting renal health |
| US10639328B1 (en) * | 2019-03-27 | 2020-05-05 | College Of William & Mary | Compositions and methods for reducing hyperglycemia and treating diabetes |
| US10799564B1 (en) | 2019-05-06 | 2020-10-13 | Baxter International Inc. | Insulin premix formulation and product, methods of preparing same, and methods of using same |
| CA3153645A1 (en) * | 2019-09-17 | 2021-03-25 | Cass Pharmaceuticals, Inc. | Subcutaneously injectable insulin and glucagon formulations and methods of administration |
| BR112022007593A2 (pt) | 2019-10-25 | 2022-08-23 | Cercacor Lab Inc | Compostos indicadores, dispositivos que compreendem compostos indicadores e métodos de fabricação e uso dos mesmos |
| IL296090A (en) * | 2020-03-02 | 2022-11-01 | Thermalin Inc | Preparations containing fast-acting analogues of insulin |
| GB202004814D0 (en) | 2020-04-01 | 2020-05-13 | Arecor Ltd | Novel formulations |
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| DK116527B (da) | 1967-03-01 | 1970-01-19 | Nordisk Insulinlab | Fremgangsmåde til fremstilling af en hurtigtvirkende, holdbar, neutral opløsning af rent krystallinsk okseinsulin eller okseinsulin, der ved tilsætning af Zn er krystalliserbart i vand, eller blandinger af okseinsulin og insulin af anden oprindelse. |
| EP0018609B1 (de) | 1979-04-30 | 1983-09-21 | Hoechst Aktiengesellschaft | Gegen Denaturierung beständige, wässrige Protein-Lösungen, Verfahren zu ihrer Herstellung und ihre Verwendung |
| FI78616C (fi) | 1982-02-05 | 1989-09-11 | Novo Industri As | Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt. |
| US4839341A (en) * | 1984-05-29 | 1989-06-13 | Eli Lilly And Company | Stabilized insulin formulations |
| PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| NO162160C (no) | 1987-01-09 | 1989-11-15 | Medi Cult As | Serumfritt vekstmedium, samt anvendelse derav. |
| AU612141B2 (en) | 1987-02-25 | 1991-07-04 | Novo Nordisk A/S | Novel insulin derivatives |
| FI913037A7 (fi) | 1988-12-23 | 1991-06-20 | Novo Nordisk As | Ihmisen insuliinianalogit |
| US5716927A (en) | 1988-12-23 | 1998-02-10 | Novo Nordisk A/S | Insulin analogs having a modified B-chain |
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| DK1146896T3 (da) | 1999-01-26 | 2002-09-02 | Lilly Co Eli | Formuleringer, som indeholder monodisperse hexamere acylerede insulin-analoger |
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| BRPI1014760B8 (pt) | 2009-06-26 | 2021-05-25 | Novo Nordisk As | preparação compreendendo insulina, nicotinamida e arginina |
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| US20130011378A1 (en) | 2011-06-17 | 2013-01-10 | Tzung-Horng Yang | Stable formulations of a hyaluronan-degrading enzyme |
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| NZ618331A (en) | 2011-06-17 | 2016-04-29 | Halozyme Inc | Stable formulations of a hyaluronan-degrading enzyme |
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| CN104244968B (zh) | 2011-12-30 | 2017-07-25 | 哈洛齐梅公司 | Ph20多肽变体、配制物及其应用 |
| US9399065B2 (en) * | 2012-04-16 | 2016-07-26 | Biodel Inc. | Magnesium compositions for modulating the pharmacokinetics and injection site pain of insulin |
| US9381247B2 (en) | 2012-04-16 | 2016-07-05 | Biodel Inc. | Magnesium compositions for modulating the pharmacokinetics and pharmacodynamics of insulin and insulin analogs, and injection site pain |
| WO2013177565A1 (en) | 2012-05-25 | 2013-11-28 | Amylin Pharmaceuticals, Llc | Insulin-pramlintide compositions and methods for making and using them |
| EP2919804B1 (fr) | 2012-11-13 | 2018-01-31 | Adocia | Formulation à action rapide d'insuline comprenant un composé anionique substitué |
| US20150065423A1 (en) | 2013-08-30 | 2015-03-05 | Perosphere, Inc. | Rapid acting injectable formulations |
| AU2015204491B2 (en) | 2014-01-13 | 2021-01-07 | Thermalin Inc. | Rapid action insulin formulations and pharmaceutical delivery systems |
| US20150273022A1 (en) | 2014-02-10 | 2015-10-01 | Biodel Inc. | Stabilized ultra-rapid-acting insulin formulations |
| US9795678B2 (en) | 2014-05-14 | 2017-10-24 | Adocia | Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound |
| AR102869A1 (es) | 2014-12-16 | 2017-03-29 | Lilly Co Eli | Composiciones de insulina de rápida acción |
| JO3749B1 (ar) * | 2015-08-27 | 2021-01-31 | Lilly Co Eli | تركيبات إنسولين سريعة المفعول |
-
2015
- 2015-12-01 AR ARP150103921A patent/AR102869A1/es unknown
- 2015-12-01 TW TW104140209A patent/TW201630622A/zh unknown
- 2015-12-09 JP JP2017531725A patent/JP6328855B2/ja active Active
- 2015-12-09 ES ES15817678T patent/ES2911207T3/es active Active
- 2015-12-09 RS RS20220416A patent/RS63174B1/sr unknown
- 2015-12-09 US US14/963,279 patent/US9993555B2/en active Active
- 2015-12-09 LT LTEPPCT/US2015/064744T patent/LT3233108T/lt unknown
- 2015-12-09 HR HRP20220692TT patent/HRP20220692T1/hr unknown
- 2015-12-09 DK DK15817678.4T patent/DK3233108T3/da active
- 2015-12-09 PL PL15817678T patent/PL3233108T3/pl unknown
- 2015-12-09 MA MA41188A patent/MA41188B1/fr unknown
- 2015-12-09 EP EP15817678.4A patent/EP3233108B1/en active Active
- 2015-12-09 PT PT158176784T patent/PT3233108T/pt unknown
- 2015-12-09 SI SI201531823T patent/SI3233108T1/sl unknown
- 2015-12-09 WO PCT/US2015/064744 patent/WO2016100042A1/en not_active Ceased
- 2015-12-09 EP EP22164140.0A patent/EP4108253A1/en active Pending
- 2015-12-09 MD MDE20170200T patent/MD3233108T2/ro unknown
- 2015-12-09 HU HUE15817678A patent/HUE058764T2/hu unknown
-
2018
- 2018-04-18 JP JP2018079985A patent/JP7093669B2/ja active Active
- 2018-05-14 US US15/978,329 patent/US11123406B2/en active Active
-
2020
- 2020-12-24 JP JP2020214703A patent/JP7159277B2/ja active Active
-
2021
- 2021-09-17 US US17/478,747 patent/US11872266B2/en active Active
-
2022
- 2022-05-11 CY CY20221100329T patent/CY1125275T1/el unknown
- 2022-10-12 JP JP2022163910A patent/JP2023011641A/ja active Pending
-
2023
- 2023-12-14 US US18/540,193 patent/US20240238382A1/en active Pending
-
2024
- 2024-11-15 JP JP2024199464A patent/JP2025032126A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018500314A (ja) | 2018-01-11 |
| JP7159277B2 (ja) | 2022-10-24 |
| LT3233108T (lt) | 2022-05-10 |
| EP4108253A1 (en) | 2022-12-28 |
| PL3233108T3 (pl) | 2022-06-20 |
| JP6328855B2 (ja) | 2018-05-23 |
| MA41188B1 (fr) | 2022-08-31 |
| EP3233108B1 (en) | 2022-03-30 |
| AR102869A1 (es) | 2017-03-29 |
| ES2911207T3 (es) | 2022-05-18 |
| HRP20220692T1 (hr) | 2022-07-08 |
| JP2023011641A (ja) | 2023-01-24 |
| JP2025032126A (ja) | 2025-03-11 |
| US20240238382A1 (en) | 2024-07-18 |
| EP3233108A1 (en) | 2017-10-25 |
| US20220072105A1 (en) | 2022-03-10 |
| MA41188A (fr) | 2017-10-24 |
| HUE058764T2 (hu) | 2022-09-28 |
| JP2018138578A (ja) | 2018-09-06 |
| JP2021073187A (ja) | 2021-05-13 |
| US11872266B2 (en) | 2024-01-16 |
| DK3233108T3 (da) | 2022-04-11 |
| US9993555B2 (en) | 2018-06-12 |
| WO2016100042A1 (en) | 2016-06-23 |
| MD3233108T2 (ro) | 2022-09-30 |
| SI3233108T1 (sl) | 2022-05-31 |
| RS63174B1 (sr) | 2022-05-31 |
| TW201630622A (zh) | 2016-09-01 |
| US20190231851A1 (en) | 2019-08-01 |
| PT3233108T (pt) | 2022-05-05 |
| US20160166695A1 (en) | 2016-06-16 |
| US11123406B2 (en) | 2021-09-21 |
| JP7093669B2 (ja) | 2022-06-30 |
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