CY1121966T1 - Παραγωγα πεπτιδιου οπιορφινης ως ισχυροι αναστολεις εκτοπεπτιδασων αποδομησεως εγκεφαλινης - Google Patents

Παραγωγα πεπτιδιου οπιορφινης ως ισχυροι αναστολεις εκτοπεπτιδασων αποδομησεως εγκεφαλινης

Info

Publication number
CY1121966T1
CY1121966T1 CY20191100256T CY191100256T CY1121966T1 CY 1121966 T1 CY1121966 T1 CY 1121966T1 CY 20191100256 T CY20191100256 T CY 20191100256T CY 191100256 T CY191100256 T CY 191100256T CY 1121966 T1 CY1121966 T1 CY 1121966T1
Authority
CY
Cyprus
Prior art keywords
ectopeptides
peptide derivatives
potent inhibitors
opiorphin peptide
enkephalin degradation
Prior art date
Application number
CY20191100256T
Other languages
English (en)
Inventor
Catherine Rougeot
Original Assignee
Institut Pasteur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Pasteur filed Critical Institut Pasteur
Publication of CY1121966T1 publication Critical patent/CY1121966T1/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542Carboxylic acids, e.g. a fatty acid or an amino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε τροποποιημένα πεπτίδια οπιορφίνης ως νέους αναστολές μεταλλο-εκτοπεπτιδασών.
CY20191100256T 2008-04-07 2019-03-01 Παραγωγα πεπτιδιου οπιορφινης ως ισχυροι αναστολεις εκτοπεπτιδασων αποδομησεως εγκεφαλινης CY1121966T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4292208P 2008-04-07 2008-04-07
PCT/EP2009/054171 WO2009124948A1 (en) 2008-04-07 2009-04-07 Opiorphin peptide derivatives as potent inhibitors of enkephalin - degrading ectopetidases

Publications (1)

Publication Number Publication Date
CY1121966T1 true CY1121966T1 (el) 2020-10-14

Family

ID=40956908

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20191100256T CY1121966T1 (el) 2008-04-07 2019-03-01 Παραγωγα πεπτιδιου οπιορφινης ως ισχυροι αναστολεις εκτοπεπτιδασων αποδομησεως εγκεφαλινης

Country Status (21)

Country Link
US (3) US8889827B2 (el)
EP (1) EP2274321B1 (el)
JP (2) JP5788788B2 (el)
KR (1) KR20110028433A (el)
CN (1) CN102083851A (el)
AU (1) AU2009235484B2 (el)
BR (1) BRPI0906905B1 (el)
CA (1) CA2720778C (el)
CY (1) CY1121966T1 (el)
DK (1) DK2274321T3 (el)
ES (1) ES2714374T3 (el)
HR (1) HRP20190335T1 (el)
HU (1) HUE042998T2 (el)
IL (1) IL208543A (el)
LT (1) LT2274321T (el)
MX (1) MX2010011055A (el)
PL (1) PL2274321T3 (el)
PT (1) PT2274321T (el)
RU (2) RU2542365C2 (el)
SI (1) SI2274321T1 (el)
WO (1) WO2009124948A1 (el)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2390075T3 (es) 2004-03-19 2012-11-06 Institut Pasteur Péptidos derivados de la proteína BPLP humana, polinucleótidos que codifican dichos péptidos y anticuerpos dirigidos contra dichos péptidos
RU2542365C2 (ru) * 2008-04-07 2015-02-20 Энститю Пастёр Производные опиорфинного пептида как потенциальные ингибиторы эктопептидаз, участвующих в деградации энкефалинов
FR2931362B1 (fr) * 2008-05-26 2017-08-18 Pasteur Institut L'opiorphine pour une utilisation en tant que psychostimulant.

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2637600B1 (fr) 1988-10-11 1992-03-06 Pasteur Institut Peptides et polypeptides provenant de la glande sous maxillaire du rat, anticorps monoclonaux et polyclonaux correspondants, hybridomes correspondants et applications de ces produits au diagnostic, a la detection ou a des fins therapeutiques
US6184205B1 (en) * 1994-07-22 2001-02-06 University Of North Carolina At Chapel Hill GRB2 SH3 binding peptides and methods of isolating and using same
US6589750B2 (en) 1997-02-20 2003-07-08 Institut Pasteur Therapeutic use of the SMR1 protein, the SMR1 maturation products, specifically the QHNPR pentapeptide as well as its biologically active derivatives
DE60040878D1 (de) 1999-06-23 2009-01-02 Pasteur Institut Zusammensetzungen zur Behandlung von beeinträchtigten zwischenmenschlischen Störungen und Verhaltenstörungen
DE60018085T2 (de) 2000-12-22 2005-07-07 Institut Pasteur Prozess zum Screening von Molekülen, die spezifisch an die NEP-Bindungsstelle des QHNPR-pentapeptides binden
RU2223113C1 (ru) * 2002-05-29 2004-02-10 Золотарев Юрий Александрович Пептид, обладающий регулирующей биологической активностью на белковый синтез в гепатоцитах
ES2390075T3 (es) 2004-03-19 2012-11-06 Institut Pasteur Péptidos derivados de la proteína BPLP humana, polinucleótidos que codifican dichos péptidos y anticuerpos dirigidos contra dichos péptidos
WO2008009276A1 (de) * 2006-07-21 2008-01-24 Jenoptik Laser, Optik, Systeme Gmbh Lateral verstellbare fassung für optische elemente
US20100062052A1 (en) 2007-02-02 2010-03-11 Greenpharma Peptide-based compounds as new inhibitors of metalloectopeptidases, compositions comprising said compounds and their pharmaceutical and cosmetic uses
WO2009090265A1 (en) 2008-01-18 2009-07-23 Institut Pasteur Method for identifying bplp and opiorphin agonists or antagonists
RU2542365C2 (ru) 2008-04-07 2015-02-20 Энститю Пастёр Производные опиорфинного пептида как потенциальные ингибиторы эктопептидаз, участвующих в деградации энкефалинов
FR2931362B1 (fr) 2008-05-26 2017-08-18 Pasteur Institut L'opiorphine pour une utilisation en tant que psychostimulant.
CA2645452A1 (en) 2008-11-28 2010-05-28 Institut Pasteur Use of basic prolin-rich lacrimal gene products, such as opiorphin, as a biomarker

Also Published As

Publication number Publication date
MX2010011055A (es) 2011-02-21
US8642729B2 (en) 2014-02-04
SI2274321T1 (sl) 2019-04-30
HUE042998T2 (hu) 2019-07-29
IL208543A (en) 2016-10-31
US20110124571A1 (en) 2011-05-26
AU2009235484B2 (en) 2013-11-07
PL2274321T3 (pl) 2019-06-28
LT2274321T (lt) 2019-03-12
RU2014153924A (ru) 2016-07-20
CA2720778C (en) 2017-10-17
EP2274321B1 (en) 2018-12-05
WO2009124948A1 (en) 2009-10-15
EP2274321A1 (en) 2011-01-19
DK2274321T3 (en) 2019-03-18
US9273094B2 (en) 2016-03-01
IL208543A0 (en) 2010-12-30
AU2009235484A1 (en) 2009-10-15
US20090253639A1 (en) 2009-10-08
JP5788788B2 (ja) 2015-10-07
JP2011517940A (ja) 2011-06-23
RU2542365C2 (ru) 2015-02-20
US8889827B2 (en) 2014-11-18
PT2274321T (pt) 2019-03-21
JP2015110651A (ja) 2015-06-18
ES2714374T3 (es) 2019-05-28
BRPI0906905A2 (pt) 2021-06-29
BRPI0906905B1 (pt) 2022-09-13
US20150065683A1 (en) 2015-03-05
RU2010145158A (ru) 2012-05-20
CN102083851A (zh) 2011-06-01
CA2720778A1 (en) 2009-10-15
HRP20190335T1 (hr) 2019-05-03
KR20110028433A (ko) 2011-03-18

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