CY1121828T1 - Αναλυση βασει μεγεθους θραυσματος εμβρυϊκου dna στο μητρικο πλασμα - Google Patents
Αναλυση βασει μεγεθους θραυσματος εμβρυϊκου dna στο μητρικο πλασμαInfo
- Publication number
- CY1121828T1 CY1121828T1 CY20191100784T CY191100784T CY1121828T1 CY 1121828 T1 CY1121828 T1 CY 1121828T1 CY 20191100784 T CY20191100784 T CY 20191100784T CY 191100784 T CY191100784 T CY 191100784T CY 1121828 T1 CY1121828 T1 CY 1121828T1
- Authority
- CY
- Cyprus
- Prior art keywords
- dna fragment
- dna
- dna fragments
- maternal plasma
- fetal dna
- Prior art date
Links
- 239000012634 fragment Substances 0.000 title abstract 8
- 230000001605 fetal effect Effects 0.000 title abstract 3
- 230000008774 maternal effect Effects 0.000 title abstract 3
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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- C12Q2600/00—Oligonucleotides characterized by their use
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Abstract
Υπεβλήθη σε ανάλυση δείγμα μητρικού πλάσματος εγκύου γυναίκας. Το δείγμα περιλαμβάνει θραύσματα DNA ελεύθερα κυττάρων, προέλευσης από μητρικά κύτταρα και εμβρυϊκά κύτταρα. Για καθένα από πολλά θραύσματα DNA: λαμβάνονται μία ή περισσότερες καταγραφές αλληλουχιών, συμπεριλαμβανομένων αμφότερων των άκρων του θραύσματος DNA- οι καταγραφές αλληλουχιών ευθυγραμμίζονται με ένα γονιδίωμα αναφοράς, για να προκύψουν ευθυγραμμισμένες θέσεις για αμφότερα τα άκρα· τέλος, οι ευθυγραμμισμένες θέσεις χρησιμοποιούνται για τον καθορισμό του μεγέθους του θραύσματος DNA. Για καθένα από πολλαπλά μεγέθη, καθορίζεται μια ποσότητα από ένα σύνολο πολλαπλών θραυσμάτων DNA από το δείγμα πλάσματος που αντιστοιχεί στο καθορισμένο μέγεθος. Υπολογίζεται η τιμή μιας πρώτης παραμέτρου, βάσει των ποσοτήτων θραυσμάτων DNA σε πολλαπλά μεγέθη, η οποία παρέχει μια στατιστική μέτρηση ενός προφίλ μεγέθους θραυσμάτων DNA. Η τιμή συγκρίνεται με μια τιμή βαθμονόμησης, για να εκτιμηθεί μια κλασματική συγκέντρωση εμβρυϊκού DNA.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261608623P | 2012-03-08 | 2012-03-08 | |
US201261621451P | 2012-04-06 | 2012-04-06 | |
PCT/IB2013/000312 WO2013132305A1 (en) | 2012-03-08 | 2013-03-08 | Size-based analysis of fetal dna fraction in maternal plasma |
EP13757943.9A EP2823062B1 (en) | 2012-03-08 | 2013-03-08 | Size-based analysis of fetal dna fraction in maternal plasma |
Publications (1)
Publication Number | Publication Date |
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CY1121828T1 true CY1121828T1 (el) | 2020-07-31 |
Family
ID=49114635
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20191100784T CY1121828T1 (el) | 2012-03-08 | 2019-07-24 | Αναλυση βασει μεγεθους θραυσματος εμβρυϊκου dna στο μητρικο πλασμα |
Country Status (18)
Country | Link |
---|---|
US (7) | US9892230B2 (el) |
EP (9) | EP3575412B1 (el) |
JP (6) | JP6073382B2 (el) |
CN (3) | CN107630081B (el) |
AU (4) | AU2013229186B2 (el) |
CA (2) | CA3010254C (el) |
CY (1) | CY1121828T1 (el) |
DK (5) | DK3301193T3 (el) |
ES (3) | ES2729504T3 (el) |
HK (7) | HK1200194A1 (el) |
HR (1) | HRP20191300T1 (el) |
HU (1) | HUE044746T2 (el) |
LT (1) | LT3301193T (el) |
PL (1) | PL3301193T3 (el) |
PT (1) | PT3301193T (el) |
RS (1) | RS59073B1 (el) |
SI (1) | SI3301193T1 (el) |
WO (1) | WO2013132305A1 (el) |
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